IMP: Integrative Multi-species Prediction

Homo sapiens

24 genes annotated in human

coenzyme biosynthetic process

The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "coenzyme biosynthetic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "coenzyme biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.995	Yeast
DLAT	dihydrolipoamide S-acetyltransferase	0.993	Yeast Rat
PDHX	pyruvate dehydrogenase complex, component X	0.966
PDHB	pyruvate dehydrogenase (lipoamide) beta	0.963
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.778	Yeast
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.769	Yeast
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.725	Yeast
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.573
RNF11	ring finger protein 11	0.529
ZFYVE9	zinc finger, FYVE domain containing 9	0.526
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.429
SMAD4	SMAD family member 4	0.410
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.402
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.316	Yeast
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.297	Yeast
ANKRD13A	ankyrin repeat domain 13A	0.278
MAPT	microtubule-associated protein tau	0.199
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.171
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.145
FTL	ferritin, light polypeptide	0.138
ND1	NADH dehydrogenase, subunit 1 (complex I)	0.102
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.087
CXXC5	CXXC finger protein 5	0.084
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.081
SMAD1	SMAD family member 1	0.073
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.073	Yeast
SMAD7	SMAD family member 7	0.073
FBXL15	F-box and leucine-rich repeat protein 15	0.073
RTN4IP1	reticulon 4 interacting protein 1	0.072
TKT	transketolase	0.071
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.066
ISOC2	isochorismatase domain containing 2	0.063
CTPS	CTP synthase	0.057
GLA	galactosidase, alpha	0.052
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.052
HSPB1	heat shock 27kDa protein 1	0.051
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.050
ACADM	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	0.044
PFDN1	prefoldin subunit 1	0.040
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.039
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.037
RNF168	ring finger protein 168	0.036
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.035
RAP1B	RAP1B, member of RAS oncogene family	0.034
MRPL35	mitochondrial ribosomal protein L35	0.034
SNCAIP	synuclein, alpha interacting protein	0.031
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.031
PGD	phosphogluconate dehydrogenase	0.031
CCDC127	coiled-coil domain containing 127	0.030
PPIF	peptidylprolyl isomerase F	0.028
TUBA1C	tubulin, alpha 1c	0.028
SNX9	sorting nexin 9	0.028
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.028	Human
SOX7	SRY (sex determining region Y)-box 7	0.027
BCKDK	branched chain ketoacid dehydrogenase kinase	0.027
ZFAND5	zinc finger, AN1-type domain 5	0.026
LARS2	leucyl-tRNA synthetase 2, mitochondrial	0.026
OPTN	optineurin	0.026
SOD2	superoxide dismutase 2, mitochondrial	0.026
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.025
ETFDH	electron-transferring-flavoprotein dehydrogenase	0.025
VDAC1	voltage-dependent anion channel 1	0.024
GCH1	GTP cyclohydrolase 1	0.024
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.023
PLSCR1	phospholipid scramblase 1	0.023
KIAA1279	KIAA1279	0.021
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.021
FH	fumarate hydratase	0.021
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.021
NFIL3	nuclear factor, interleukin 3 regulated	0.020
CPT2	carnitine palmitoyltransferase 2	0.020
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.020	Human
EIF4E	eukaryotic translation initiation factor 4E	0.019
VASP	vasodilator-stimulated phosphoprotein	0.018
TPPP	tubulin polymerization promoting protein	0.018
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.018	Human Mouse
ALAS1	aminolevulinate, delta-, synthase 1	0.018
APLP1	amyloid beta (A4) precursor-like protein 1	0.018
ICMT	isoprenylcysteine carboxyl methyltransferase	0.017
HIBCH	3-hydroxyisobutyryl-CoA hydrolase	0.017
PEX7	peroxisomal biogenesis factor 7	0.017
POU5F1	POU class 5 homeobox 1	0.017
NFS1	NFS1 nitrogen fixation 1 homolog (S. cerevisiae)	0.017
SMAD6	SMAD family member 6	0.017
OXSM	3-oxoacyl-ACP synthase, mitochondrial	0.017
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.017
TRAF4	TNF receptor-associated factor 4	0.017
WNK1	WNK lysine deficient protein kinase 1	0.017
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.016
TSFM	Ts translation elongation factor, mitochondrial	0.016
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.016
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.016	Human
EDC4	enhancer of mRNA decapping 4	0.016
GRPEL1	GrpE-like 1, mitochondrial (E. coli)	0.016
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.015
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.015
SLC25A12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	0.015
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.014
ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	0.014
POR	P450 (cytochrome) oxidoreductase	0.014
SMAD5	SMAD family member 5	0.014
ACAD8	acyl-CoA dehydrogenase family, member 8	0.014
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.014
XRN2	5'-3' exoribonuclease 2	0.014
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.014
UPP1	uridine phosphorylase 1	0.014
KATNB1	katanin p80 (WD repeat containing) subunit B 1	0.014
ACSL1	acyl-CoA synthetase long-chain family member 1	0.013
TFRC	transferrin receptor (p90, CD71)	0.013
UBQLN2	ubiquilin 2	0.013
NEK3	NIMA (never in mitosis gene a)-related kinase 3	0.013
BCS1L	BCS1-like (S. cerevisiae)	0.013
MYO6	myosin VI	0.013
EIF2B3	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	0.013
ISOC1	isochorismatase domain containing 1	0.013
MARK1	MAP/microtubule affinity-regulating kinase 1	0.013
DEDD	death effector domain containing	0.013
KLF5	Kruppel-like factor 5 (intestinal)	0.012
ARRDC3	arrestin domain containing 3	0.012
C4BPA	complement component 4 binding protein, alpha	0.012
DOCK9	dedicator of cytokinesis 9	0.012
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.012
NOL6	nucleolar protein family 6 (RNA-associated)	0.012
ARF3	ADP-ribosylation factor 3	0.012
ME2	malic enzyme 2, NAD(+)-dependent, mitochondrial	0.012
NDFIP2	Nedd4 family interacting protein 2	0.012
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.012
QRSL1	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	0.012
MTMR4	myotubularin related protein 4	0.012
ADARB1	adenosine deaminase, RNA-specific, B1	0.012
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.011
PNP	purine nucleoside phosphorylase	0.011
MRS2	MRS2 magnesium homeostasis factor homolog (S. cerevisiae)	0.011
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.011
PPPDE2	PPPDE peptidase domain containing 2	0.011
CREM	cAMP responsive element modulator	0.011
SRSF6	serine/arginine-rich splicing factor 6	0.011
MMACHC	methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria	0.011
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.011
ECHDC1	enoyl CoA hydratase domain containing 1	0.011
FABP1	fatty acid binding protein 1, liver	0.011
FDX1	ferredoxin 1	0.011
CSNK1D	casein kinase 1, delta	0.011
SRSF5	serine/arginine-rich splicing factor 5	0.011
EPAS1	endothelial PAS domain protein 1	0.011
EPHX2	epoxide hydrolase 2, cytoplasmic	0.011
FOXRED1	FAD-dependent oxidoreductase domain containing 1	0.011
SLC25A19	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	0.011
PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	0.011
CALCOCO2	calcium binding and coiled-coil domain 2	0.011
SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	0.011
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.011
ACSF2	acyl-CoA synthetase family member 2	0.011
PMM2	phosphomannomutase 2	0.010
MIPEP	mitochondrial intermediate peptidase	0.010
SRI	sorcin	0.010
HAL	histidine ammonia-lyase	0.010
LMNB1	lamin B1	0.010
NDUFAF1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1	0.010
KNG1	kininogen 1	0.010
ACAT1	acetyl-CoA acetyltransferase 1	0.010
SEPX1	selenoprotein X, 1	0.010