IMP: Integrative Multi-species Prediction

Homo sapiens

26 genes annotated in human

Multi-species View

alpha amino acid catabolic process

GO:1901606

The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "alpha amino acid catabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "alpha amino acid catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.978
NOSTRIN	nitric oxide synthase trafficker	0.686
ALDOB	aldolase B, fructose-bisphosphate	0.612
GARS	glycyl-tRNA synthetase	0.544
YARS	tyrosyl-tRNA synthetase	0.369
VAC14	Vac14 homolog (S. cerevisiae)	0.334
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.299
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.180
GCDH	glutaryl-CoA dehydrogenase	0.174
XIAP	X-linked inhibitor of apoptosis	0.154
EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	0.128
PHGDH	phosphoglycerate dehydrogenase	0.127
DLG2	discs, large homolog 2 (Drosophila)	0.122
CALCA	calcitonin-related polypeptide alpha	0.121
AARS	alanyl-tRNA synthetase	0.108
EPT1	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	0.088
TOM1L1	target of myb1 (chicken)-like 1	0.082
MARS	methionyl-tRNA synthetase	0.078
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.076
GLUD1	glutamate dehydrogenase 1	0.075
GLUD2	glutamate dehydrogenase 2	0.070
GLYAT	glycine-N-acyltransferase	0.070
HADH	hydroxyacyl-CoA dehydrogenase	0.070
ACADSB	acyl-CoA dehydrogenase, short/branched chain	0.064
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.061
MAP2K5	mitogen-activated protein kinase kinase 5	0.053
MASP2	mannan-binding lectin serine peptidase 2	0.048
LONP1	lon peptidase 1, mitochondrial	0.046
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.037
TMEM97	transmembrane protein 97	0.036
C21orf33	chromosome 21 open reading frame 33	0.034
APEH	N-acylaminoacyl-peptide hydrolase	0.033
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.032
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.032
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.031
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.030
PSAT1	phosphoserine aminotransferase 1	0.030
SUPV3L1	suppressor of var1, 3-like 1 (S. cerevisiae)	0.029
CA5A	carbonic anhydrase VA, mitochondrial	0.029
PAH	phenylalanine hydroxylase	0.028	Fly
ATF2	activating transcription factor 2	0.027
PLG	plasminogen	0.027
BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	0.025
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.024
GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	0.024
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.023
DLG1	discs, large homolog 1 (Drosophila)	0.023
PCYOX1	prenylcysteine oxidase 1	0.022
PTDSS1	phosphatidylserine synthase 1	0.022
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.022
SORD	sorbitol dehydrogenase	0.021
SARS	seryl-tRNA synthetase	0.020
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.020
PON1	paraoxonase 1	0.020
VDAC1	voltage-dependent anion channel 1	0.020
SARDH	sarcosine dehydrogenase	0.019	Fly
MLEC	malectin	0.019
AGXT	alanine-glyoxylate aminotransferase	0.019
KNG1	kininogen 1	0.019
SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	0.019
TIMM44	translocase of inner mitochondrial membrane 44 homolog (yeast)	0.019
NOS1AP	nitric oxide synthase 1 (neuronal) adaptor protein	0.019
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.019
SLC37A4	solute carrier family 37 (glucose-6-phosphate transporter), member 4	0.018
HNF4A	hepatocyte nuclear factor 4, alpha	0.018
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.018
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	0.018
OGFOD1	2-oxoglutarate and iron-dependent oxygenase domain containing 1	0.018
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.018
DHTKD1	dehydrogenase E1 and transketolase domain containing 1	0.018
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.018
ECI2	enoyl-CoA delta isomerase 2	0.017
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.017
HAX1	HCLS1 associated protein X-1	0.017
MBL2	mannose-binding lectin (protein C) 2, soluble	0.017
HABP2	hyaluronan binding protein 2	0.017
BDH1	3-hydroxybutyrate dehydrogenase, type 1	0.016
BHMT	betaine--homocysteine S-methyltransferase	0.016
MAT1A	methionine adenosyltransferase I, alpha	0.016
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.016
APOC2	apolipoprotein C-II	0.016
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.016
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.016
PKLR	pyruvate kinase, liver and RBC	0.016
ALDOA	aldolase A, fructose-bisphosphate	0.016
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.016
C8A	complement component 8, alpha polypeptide	0.015
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.015
ELAVL3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.015
APOA5	apolipoprotein A-V	0.015
ECHS1	enoyl CoA hydratase, short chain, 1, mitochondrial	0.015
CARS	cysteinyl-tRNA synthetase	0.015
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.015
C17orf28	chromosome 17 open reading frame 28	0.015
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.014
G6PC	glucose-6-phosphatase, catalytic subunit	0.014
OSBPL8	oxysterol binding protein-like 8	0.014
SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)	0.014
CTH	cystathionase (cystathionine gamma-lyase)	0.014
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.014
PIPOX	pipecolic acid oxidase	0.014
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.014
PCCB	propionyl CoA carboxylase, beta polypeptide	0.014
C9	complement component 9	0.014
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.014
ADH6	alcohol dehydrogenase 6 (class V)	0.014
LECT2	leukocyte cell-derived chemotaxin 2	0.014
PHYH	phytanoyl-CoA 2-hydroxylase	0.014
ALDH4A1	aldehyde dehydrogenase 4 family, member A1	0.014	Yeast
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.013	Yeast
DPYS	dihydropyrimidinase	0.013
ALDH6A1	aldehyde dehydrogenase 6 family, member A1	0.013
SUOX	sulfite oxidase	0.013
ASGR2	asialoglycoprotein receptor 2	0.013
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.013
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.013
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.013
CECR5	cat eye syndrome chromosome region, candidate 5	0.012
TRIB3	tribbles homolog 3 (Drosophila)	0.012
DPAGT1	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	0.012
PC	pyruvate carboxylase	0.012
CPT2	carnitine palmitoyltransferase 2	0.012
C4BPA	complement component 4 binding protein, alpha	0.012
MS4A2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	0.012
EPHX2	epoxide hydrolase 2, cytoplasmic	0.012
C8B	complement component 8, beta polypeptide	0.012
UPB1	ureidopropionase, beta	0.012
SEPT11	septin 11	0.012
PRODH2	proline dehydrogenase (oxidase) 2	0.012
APCS	amyloid P component, serum	0.012
ALAD	aminolevulinate dehydratase	0.012
ABCC6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.012
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.012
GHITM	growth hormone inducible transmembrane protein	0.012
CRAT	carnitine O-acetyltransferase	0.012
HGFAC	HGF activator	0.012
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.011
ALPI	alkaline phosphatase, intestinal	0.011
ARG1	arginase, liver	0.011	Rat
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.011
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.011
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.011
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.011
DCXR	dicarbonyl/L-xylulose reductase	0.011
HPN	hepsin	0.011
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.011
HAL	histidine ammonia-lyase	0.011
CDK17	cyclin-dependent kinase 17	0.011
CXCL10	chemokine (C-X-C motif) ligand 10	0.011
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.011
TRAP1	TNF receptor-associated protein 1	0.011
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.011
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.011
RGN	regucalcin (senescence marker protein-30)	0.011
METTL7A	methyltransferase like 7A	0.011
PFAS	phosphoribosylformylglycinamidine synthase	0.011
NAT8B	N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)	0.011
ITIH1	inter-alpha (globulin) inhibitor H1	0.011
HGD	homogentisate 1,2-dioxygenase	0.010
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.010
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.010
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.010
SELRC1	Sel1 repeat containing 1	0.010
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.010
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.010
PEBP1	phosphatidylethanolamine binding protein 1	0.010
APOE	apolipoprotein E	0.010
GCAT	glycine C-acetyltransferase	0.010
MTTP	microsomal triglyceride transfer protein	0.010
FABP1	fatty acid binding protein 1, liver	0.010
APOB	apolipoprotein B (including Ag(x) antigen)	0.010
AMBP	alpha-1-microglobulin/bikunin precursor	0.010
DHRS11	dehydrogenase/reductase (SDR family) member 11	0.010
CAT	catalase	0.010
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.010
PYCR1	pyrroline-5-carboxylate reductase 1	0.010