IMP: Integrative Multi-species Prediction

Homo sapiens

15 genes annotated in human

regulation of stem cell proliferation

GO:0072091

Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of stem cell proliferation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "regulation of stem cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.772	Mouse
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.702
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.608	Human
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.455	Fly
BMPR1A	bone morphogenetic protein receptor, type IA	0.438	Mouse
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.428	Human
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.418
FSTL1	follistatin-like 1	0.400
SMAD7	SMAD family member 7	0.366
POU3F2	POU class 3 homeobox 2	0.364
CXCL3	chemokine (C-X-C motif) ligand 3	0.308	Mouse
BMP2	bone morphogenetic protein 2	0.300	Human
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.254
IL8	interleukin 8	0.244
CXCL2	chemokine (C-X-C motif) ligand 2	0.230	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.230
YAP1	Yes-associated protein 1	0.230	Mouse
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.224
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.221	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.206	Mouse
CTBP1	C-terminal binding protein 1	0.202
VEGFA	vascular endothelial growth factor A	0.201	Mouse
SOS1	son of sevenless homolog 1 (Drosophila)	0.183
NOTCH3	notch 3	0.180
JUP	junction plakoglobin	0.178
INSR	insulin receptor	0.175
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.174	Fly
FBLN5	fibulin 5	0.165	Human
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.160
NRP1	neuropilin 1	0.152
TCP1	t-complex 1	0.149
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.139
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.133
CDH5	cadherin 5, type 2 (vascular endothelium)	0.128
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.126
IGF1R	insulin-like growth factor 1 receptor	0.120
FBXW11	F-box and WD repeat domain containing 11	0.112
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.107	Mouse
MED10	mediator complex subunit 10	0.102	Fly
LRP6	low density lipoprotein receptor-related protein 6	0.088	Human Mouse
MED28	mediator complex subunit 28	0.086
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.086
ZMYND11	zinc finger, MYND-type containing 11	0.085
ENG	endoglin	0.083
LTBP4	latent transforming growth factor beta binding protein 4	0.081	Human
EGFR	epidermal growth factor receptor	0.079
APP	amyloid beta (A4) precursor protein	0.071
GRB10	growth factor receptor-bound protein 10	0.069
FGF1	fibroblast growth factor 1 (acidic)	0.067
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.065
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.064
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.063
NCOR1	nuclear receptor corepressor 1	0.062
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.060
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.059
BMP1	bone morphogenetic protein 1	0.056
APC	adenomatous polyposis coli	0.054
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.053
PAX3	paired box 3	0.053
ETFA	electron-transfer-flavoprotein, alpha polypeptide	0.052
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.050
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.050	Fly
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.049
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.046
TNRC6A	trinucleotide repeat containing 6A	0.046
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.045	Mouse
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.042
CDK8	cyclin-dependent kinase 8	0.042
IRS1	insulin receptor substrate 1	0.039	Mouse
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.038	Fly
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.037
JAG1	jagged 1	0.036
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.036
GRB2	growth factor receptor-bound protein 2	0.035
NFYC	nuclear transcription factor Y, gamma	0.034
LOXL1	lysyl oxidase-like 1	0.034
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.034
PRKCZ	protein kinase C, zeta	0.034
CHD4	chromodomain helicase DNA binding protein 4	0.032
ADORA2A	adenosine A2a receptor	0.032
TNIP2	TNFAIP3 interacting protein 2	0.031
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.030
IER3	immediate early response 3	0.029
JAG2	jagged 2	0.029
HOXD9	homeobox D9	0.029
CTBP2	C-terminal binding protein 2	0.028
HIC1	hypermethylated in cancer 1	0.028
SIRT1	sirtuin 1	0.028
GSK3B	glycogen synthase kinase 3 beta	0.028
NID1	nidogen 1	0.028
DNM1	dynamin 1	0.028
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.028
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.026
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.026
FZD1	frizzled homolog 1 (Drosophila)	0.026
AR	androgen receptor	0.026
ESR1	estrogen receptor 1	0.026
PGF	placental growth factor	0.025
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.025
MAX	MYC associated factor X	0.025
SKIL	SKI-like oncogene	0.024
SMAD4	SMAD family member 4	0.024
KRT5	keratin 5	0.023
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.023
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.023
HDAC4	histone deacetylase 4	0.023
DDR2	discoidin domain receptor tyrosine kinase 2	0.023
LOX	lysyl oxidase	0.023
TGFB2	transforming growth factor, beta 2	0.022
ELN	elastin	0.022
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.022
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.021
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.021
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.021
PLCG1	phospholipase C, gamma 1	0.021
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.021
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.021
AXL	AXL receptor tyrosine kinase	0.020
ATN1	atrophin 1	0.020
FGF7	fibroblast growth factor 7	0.020
CARM1	coactivator-associated arginine methyltransferase 1	0.019
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.019
FZD8	frizzled homolog 8 (Drosophila)	0.019
FERMT2	fermitin family member 2	0.019
COL2A1	collagen, type II, alpha 1	0.018
FGF10	fibroblast growth factor 10	0.018
BMP4	bone morphogenetic protein 4	0.018
LRRK2	leucine-rich repeat kinase 2	0.018
MARCKSL1	MARCKS-like 1	0.018
PSEN1	presenilin 1	0.018
SALL2	sal-like 2 (Drosophila)	0.018
HTT	huntingtin	0.018
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.017
COL6A2	collagen, type VI, alpha 2	0.017
MAP1A	microtubule-associated protein 1A	0.017
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.017
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.017
SNAP25	synaptosomal-associated protein, 25kDa	0.017
FBLN1	fibulin 1	0.017	Human
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.017
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.016
SFRP1	secreted frizzled-related protein 1	0.016
EMD	emerin	0.016
COL6A1	collagen, type VI, alpha 1	0.016
LTBP2	latent transforming growth factor beta binding protein 2	0.016	Human
TP53	tumor protein p53	0.016	Mouse
TCF4	transcription factor 4	0.016
IL6	interleukin 6 (interferon, beta 2)	0.016
MAML1	mastermind-like 1 (Drosophila)	0.015
BTRC	beta-transducin repeat containing	0.015
EPAS1	endothelial PAS domain protein 1	0.015
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.015
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.015
COX7C	cytochrome c oxidase subunit VIIc	0.015
PTPRB	protein tyrosine phosphatase, receptor type, B	0.015
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.015
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.015
GLIS2	GLIS family zinc finger 2	0.015
IPO8	importin 8	0.015
TNIP1	TNFAIP3 interacting protein 1	0.015
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.015
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.015
SMAD2	SMAD family member 2	0.015
PABPC1	poly(A) binding protein, cytoplasmic 1	0.015
ZBTB20	zinc finger and BTB domain containing 20	0.014
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.014
MED29	mediator complex subunit 29	0.014
TBX2	T-box 2	0.014
GATAD2B	GATA zinc finger domain containing 2B	0.014
IGFBP5	insulin-like growth factor binding protein 5	0.014
EP300	E1A binding protein p300	0.014
SATB2	SATB homeobox 2	0.014
MEIS2	Meis homeobox 2	0.014
TGFB3	transforming growth factor, beta 3	0.013
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.013
HMGA2	high mobility group AT-hook 2	0.013
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.013
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.013
SKA3	spindle and kinetochore associated complex subunit 3	0.013
BCL3	B-cell CLL/lymphoma 3	0.013
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.013
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.013
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.013
MED27	mediator complex subunit 27	0.013
APPBP2	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	0.013
DICER1	dicer 1, ribonuclease type III	0.013
TGIF1	TGFB-induced factor homeobox 1	0.012	Zebrafish
TRIP6	thyroid hormone receptor interactor 6	0.012
WNT3A	wingless-type MMTV integration site family, member 3A	0.012	Human
WWTR1	WW domain containing transcription regulator 1	0.012
AMOTL2	angiomotin like 2	0.012
CCL20	chemokine (C-C motif) ligand 20	0.012
PRMT6	protein arginine methyltransferase 6	0.012
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.012
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.012
AHR	aryl hydrocarbon receptor	0.012
MED30	mediator complex subunit 30	0.012
PRKCI	protein kinase C, iota	0.012
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.012
AES	amino-terminal enhancer of split	0.012
GABARAP	GABA(A) receptor-associated protein	0.012
FOXC1	forkhead box C1	0.012
FGF2	fibroblast growth factor 2 (basic)	0.012
IL1B	interleukin 1, beta	0.012
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.012	Fly
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.012
FOXD3	forkhead box D3	0.012
CD22	CD22 molecule	0.012
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.012
TCF7L1	transcription factor 7-like 1 (T-cell specific, HMG-box)	0.012
FBN1	fibrillin 1	0.011
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.011
JAM2	junctional adhesion molecule 2	0.011
SOX11	SRY (sex determining region Y)-box 11	0.011
STRN3	striatin, calmodulin binding protein 3	0.011
INHBB	inhibin, beta B	0.011
CTGF	connective tissue growth factor	0.011
KAT2B	K(lysine) acetyltransferase 2B	0.011
NFIA	nuclear factor I/A	0.011
ZC3H12A	zinc finger CCCH-type containing 12A	0.011
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.011
MEGF11	multiple EGF-like-domains 11	0.011
PDGFC	platelet derived growth factor C	0.011
MEOX2	mesenchyme homeobox 2	0.011
LAMB1	laminin, beta 1	0.011
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.011	Fly
NFYB	nuclear transcription factor Y, beta	0.011
LENG8	leukocyte receptor cluster (LRC) member 8	0.010
CCDC85B	coiled-coil domain containing 85B	0.010
MAP2K6	mitogen-activated protein kinase kinase 6	0.010
FRS2	fibroblast growth factor receptor substrate 2	0.010
MSX1	msh homeobox 1	0.010
SYNE1	spectrin repeat containing, nuclear envelope 1	0.010
COX6C	cytochrome c oxidase subunit VIc	0.010
MAP1B	microtubule-associated protein 1B	0.010
CABLES1	Cdk5 and Abl enzyme substrate 1	0.010
CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.010
AXIN1	axin 1	0.010
SOX9	SRY (sex determining region Y)-box 9	0.010	Human Mouse
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.010