IMP: Integrative Multi-species Prediction

Homo sapiens

3 genes annotated in human

Multi-species View

regulation of cd4 positive alpha beta t cell differentiation

GO:0043370

Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in humanInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of cd4 positive alpha beta t cell differentiation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "regulation of cd4 positive alpha beta t cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
IL4R	interleukin 4 receptor	0.991	Mouse
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.945
IL2RG	interleukin 2 receptor, gamma	0.737	Mouse
NCOR2	nuclear receptor corepressor 2	0.727
LIN9	lin-9 homolog (C. elegans)	0.723
IL4	interleukin 4	0.717	Mouse
LIN54	lin-54 homolog (C. elegans)	0.533
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.319
TRAF3	TNF receptor-associated factor 3	0.248
IL6R	interleukin 6 receptor	0.246
CREBBP	CREB binding protein	0.195
TRAF1	TNF receptor-associated factor 1	0.172
BIRC3	baculoviral IAP repeat containing 3	0.147
MED25	mediator complex subunit 25	0.145
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.127
PPARA	peroxisome proliferator-activated receptor alpha	0.114
E2F1	E2F transcription factor 1	0.111
NCOA1	nuclear receptor coactivator 1	0.111
ZNF71	zinc finger protein 71	0.101
NOD1	nucleotide-binding oligomerization domain containing 1	0.084
SIRT1	sirtuin 1	0.083
CD40	CD40 molecule, TNF receptor superfamily member 5	0.082
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.061
IL7R	interleukin 7 receptor	0.059
IL8	interleukin 8	0.057
CCR7	chemokine (C-C motif) receptor 7	0.055
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.054
NLK	nemo-like kinase	0.054
RARA	retinoic acid receptor, alpha	0.053
RUNX1	runt-related transcription factor 1	0.049
PPAP2B	phosphatidic acid phosphatase type 2B	0.046
HDAC5	histone deacetylase 5	0.046
NUMB	numb homolog (Drosophila)	0.045
PGR	progesterone receptor	0.043
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.043
ESR1	estrogen receptor 1	0.042
SPOP	speckle-type POZ protein	0.039
E2F3	E2F transcription factor 3	0.037
PCDH9	protocadherin 9	0.036
NOD2	nucleotide-binding oligomerization domain containing 2	0.036
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.033
RAD54L	RAD54-like (S. cerevisiae)	0.033
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.032
RXRB	retinoid X receptor, beta	0.032
SOCS3	suppressor of cytokine signaling 3	0.030
SPIN1	spindlin 1	0.030
HDAC7	histone deacetylase 7	0.030
HDAC10	histone deacetylase 10	0.030
IL1B	interleukin 1, beta	0.028
RXRG	retinoid X receptor, gamma	0.028
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.027
HIPK2	homeodomain interacting protein kinase 2	0.026
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.026
CCDC115	coiled-coil domain containing 115	0.026
PML	promyelocytic leukemia	0.026
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.026
E2F4	E2F transcription factor 4, p107/p130-binding	0.025
EP300	E1A binding protein p300	0.025
CCL4	chemokine (C-C motif) ligand 4	0.025
KLHL24	kelch-like 24 (Drosophila)	0.024
HDAC9	histone deacetylase 9	0.024
EPOR	erythropoietin receptor	0.023
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.023
HCFC1	host cell factor C1 (VP16-accessory protein)	0.023
VHL	von Hippel-Lindau tumor suppressor	0.022
SLAMF1	signaling lymphocytic activation molecule family member 1	0.021
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.021
CXCL13	chemokine (C-X-C motif) ligand 13	0.021
NLRC4	NLR family, CARD domain containing 4	0.020
PRKD2	protein kinase D2	0.020
TRAF3IP3	TRAF3 interacting protein 3	0.020
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.019
MAPK7	mitogen-activated protein kinase 7	0.018
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.018
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.018
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.017
TAL1	T-cell acute lymphocytic leukemia 1	0.017
BIRC2	baculoviral IAP repeat containing 2	0.017
CXCL9	chemokine (C-X-C motif) ligand 9	0.016
TNF	tumor necrosis factor	0.016
CD48	CD48 molecule	0.016
PDPK1	3-phosphoinositide dependent protein kinase-1	0.016
IL2RB	interleukin 2 receptor, beta	0.016
DDX6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.016
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.016
IRF4	interferon regulatory factor 4	0.015
GINS4	GINS complex subunit 4 (Sld5 homolog)	0.015
GPSM3	G-protein signaling modulator 3	0.015
NAMPT	nicotinamide phosphoribosyltransferase	0.015
MED1	mediator complex subunit 1	0.015
RIPK4	receptor-interacting serine-threonine kinase 4	0.014
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.014
BAD	BCL2-associated agonist of cell death	0.014
SIRT6	sirtuin 6	0.014
SLA	Src-like-adaptor	0.014
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.014
PLEK	pleckstrin	0.014
CCNE1	cyclin E1	0.014
SELL	selectin L	0.014
RUNX3	runt-related transcription factor 3	0.014
IL10	interleukin 10	0.014
CCL20	chemokine (C-C motif) ligand 20	0.014
ICAM1	intercellular adhesion molecule 1	0.013
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.013
CD247	CD247 molecule	0.013
IKZF4	IKAROS family zinc finger 4 (Eos)	0.013
SELE	selectin E	0.013
GRAP2	GRB2-related adaptor protein 2	0.013
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.013
ARHGAP12	Rho GTPase activating protein 12	0.013
IL13	interleukin 13	0.013
CD69	CD69 molecule	0.013
GTSE1	G-2 and S-phase expressed 1	0.013
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.012
HRH1	histamine receptor H1	0.012
LY86	lymphocyte antigen 86	0.012
RUNX2	runt-related transcription factor 2	0.012
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.012
FAM64A	family with sequence similarity 64, member A	0.012
TFDP1	transcription factor Dp-1	0.012
ORC1	origin recognition complex, subunit 1	0.012
EBF1	early B-cell factor 1	0.012
CCL22	chemokine (C-C motif) ligand 22	0.012
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.012
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.012
SOD2	superoxide dismutase 2, mitochondrial	0.012
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.012
DENND1C	DENN/MADD domain containing 1C	0.012
CDK6	cyclin-dependent kinase 6	0.012
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.012
BATF	basic leucine zipper transcription factor, ATF-like	0.012
CRABP2	cellular retinoic acid binding protein 2	0.011
ITK	IL2-inducible T-cell kinase	0.011
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.011
IL2RA	interleukin 2 receptor, alpha	0.011
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.011
GRB7	growth factor receptor-bound protein 7	0.011
PIM2	pim-2 oncogene	0.011
CXCL3	chemokine (C-X-C motif) ligand 3	0.011
F11R	F11 receptor	0.011
TGIF1	TGFB-induced factor homeobox 1	0.011
CD80	CD80 molecule	0.011
CRY1	cryptochrome 1 (photolyase-like)	0.011
SPHK1	sphingosine kinase 1	0.011
IL1RN	interleukin 1 receptor antagonist	0.011
TBX21	T-box 21	0.011
IL24	interleukin 24	0.011
TMEM173	transmembrane protein 173	0.011
ZBTB16	zinc finger and BTB domain containing 16	0.011
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.011
SAP30	Sin3A-associated protein, 30kDa	0.011
RARG	retinoic acid receptor, gamma	0.011	Human
MED10	mediator complex subunit 10	0.011
IL3RA	interleukin 3 receptor, alpha (low affinity)	0.011
SH3BP1	SH3-domain binding protein 1	0.011
CD33	CD33 molecule	0.010
CXCR3	chemokine (C-X-C motif) receptor 3	0.010
CCL5	chemokine (C-C motif) ligand 5	0.010
ERC2	ELKS/RAB6-interacting/CAST family member 2	0.010
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.010
ORC6	origin recognition complex, subunit 6	0.010
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.010
IRF5	interferon regulatory factor 5	0.010
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.010
CSF1	colony stimulating factor 1 (macrophage)	0.010
RBL1	retinoblastoma-like 1 (p107)	0.010
MYBL1	v-myb myeloblastosis viral oncogene homolog (avian)-like 1	0.010	Human
NNMT	nicotinamide N-methyltransferase	0.010
STAT5A	signal transducer and activator of transcription 5A	0.010
BANP	BTG3 associated nuclear protein	0.010