IMP: Integrative Multi-species Prediction

Homo sapiens

17 genes annotated in human

Multi-species View

negative regulation of mitotic sister chromatid separation

GO:2000816

Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of mitotic sister chromatid separation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of mitotic sister chromatid separation" (in gray)

Name	Description	Probability	Func Analog Organism
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.997	Fly
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.991
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.929	Yeast
ANAPC4	anaphase promoting complex subunit 4	0.893
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.613
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.556	Fly
CDK2	cyclin-dependent kinase 2	0.523
ANAPC7	anaphase promoting complex subunit 7	0.430
CCNA2	cyclin A2	0.407
CCNB1	cyclin B1	0.364
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.352	Worm Fly
ANAPC5	anaphase promoting complex subunit 5	0.244
ANAPC1	anaphase promoting complex subunit 1	0.192
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.160
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.148
ANAPC11	anaphase promoting complex subunit 11	0.124
BRCA2	breast cancer 2, early onset	0.100
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.081
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.076
CBX5	chromobox homolog 5	0.069
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.066
ZWINT	ZW10 interactor	0.065
CASC5	cancer susceptibility candidate 5	0.059
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.054
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.050
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.048
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.046
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.045
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.041
MYST1	MYST histone acetyltransferase 1	0.039
SKA3	spindle and kinetochore associated complex subunit 3	0.039
SKA1	spindle and kinetochore associated complex subunit 1	0.038
PTTG1	pituitary tumor-transforming 1	0.037
CENPE	centromere protein E, 312kDa	0.036	Mouse
SKA2	spindle and kinetochore associated complex subunit 2	0.034
CDKN3	cyclin-dependent kinase inhibitor 3	0.034
AURKB	aurora kinase B	0.033
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.033
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.031
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.030
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.030
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.029
ORC2	origin recognition complex, subunit 2	0.026
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.025
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.024
ZNF207	zinc finger protein 207	0.024
PRNP	prion protein	0.023
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.023
SKP2	S-phase kinase-associated protein 2 (p45)	0.022
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.022
FBXO5	F-box protein 5	0.022
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.021
CCDC99	coiled-coil domain containing 99	0.020
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.020
CCNE1	cyclin E1	0.020	Fly
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.020
CCNB2	cyclin B2	0.019
C19orf39	chromosome 19 open reading frame 39	0.019
HERC2	hect domain and RLD 2	0.019
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.018
SMC3	structural maintenance of chromosomes 3	0.018
FXR2	fragile X mental retardation, autosomal homolog 2	0.018
H2AFX	H2A histone family, member X	0.018
KIF18A	kinesin family member 18A	0.018
TCP1	t-complex 1	0.018
PTEN	phosphatase and tensin homolog	0.017
CDT1	chromatin licensing and DNA replication factor 1	0.017
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.017
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.016
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.016
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.016
HIST1H4A	histone cluster 1, H4a	0.016
SMC4	structural maintenance of chromosomes 4	0.015
UBE2C	ubiquitin-conjugating enzyme E2C	0.015
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.015
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.015
ATMIN	ATM interactor	0.015
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.015
PPP6R2	protein phosphatase 6, regulatory subunit 2	0.015
RAD52	RAD52 homolog (S. cerevisiae)	0.015
PPME1	protein phosphatase methylesterase 1	0.015
FANCD2	Fanconi anemia, complementation group D2	0.014
PARP3	poly (ADP-ribose) polymerase family, member 3	0.014
MDC1	mediator of DNA-damage checkpoint 1	0.013
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.013
HIST1H1E	histone cluster 1, H1e	0.013
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.012
USP44	ubiquitin specific peptidase 44	0.012
C13orf34	chromosome 13 open reading frame 34	0.012
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.012
BRCA1	breast cancer 1, early onset	0.011
TTK	TTK protein kinase	0.011	Yeast
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.011
CBX1	chromobox homolog 1	0.011
MAD2L1BP	MAD2L1 binding protein	0.011
ANKRD52	ankyrin repeat domain 52	0.011
RAD51AP1	RAD51 associated protein 1	0.011
USP49	ubiquitin specific peptidase 49	0.011	Human
TP53BP1	tumor protein p53 binding protein 1	0.011
CCNE2	cyclin E2	0.010	Fly
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.010
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.010
PLK4	polo-like kinase 4	0.010