IMP: Integrative Multi-species Prediction

Homo sapiens

28 genes annotated in human

Multi-species View

sterol homeostasis

GO:0055092

Any process involved in the maintenance of an internal steady state of sterol within an organism or cell.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "sterol homeostasis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "sterol homeostasis" (in gray)

Name	Description	Probability	Func Analog Organism
APOA1	apolipoprotein A-I	0.999
ALB	albumin	0.976
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.969
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.951
RXRA	retinoid X receptor, alpha	0.881
HP	haptoglobin	0.879
FGA	fibrinogen alpha chain	0.835
CREBBP	CREB binding protein	0.791
APOE	apolipoprotein E	0.762
NCOA1	nuclear receptor coactivator 1	0.756
APOA2	apolipoprotein A-II	0.751
ABCG8	ATP-binding cassette, sub-family G (WHITE), member 8	0.742
RRAGC	Ras-related GTP binding C	0.722
SMAD2	SMAD family member 2	0.646
RPL18A	ribosomal protein L18a	0.627
APOC1	apolipoprotein C-I	0.623
LDLR	low density lipoprotein receptor	0.600
HNF4A	hepatocyte nuclear factor 4, alpha	0.555	Mouse
RARA	retinoic acid receptor, alpha	0.538
CRP	C-reactive protein, pentraxin-related	0.510
A2M	alpha-2-macroglobulin	0.438
PROX1	prospero homeobox 1	0.383
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.380
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.379
LCAT	lecithin-cholesterol acyltransferase	0.344
LRP1	low density lipoprotein receptor-related protein 1	0.332	Human
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.274
APOC2	apolipoprotein C-II	0.272
SEC24D	SEC24 family, member D (S. cerevisiae)	0.266
APOB	apolipoprotein B (including Ag(x) antigen)	0.244
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.215
PTPRF	protein tyrosine phosphatase, receptor type, F	0.177
APOC3	apolipoprotein C-III	0.160
FGB	fibrinogen beta chain	0.153
ABCF3	ATP-binding cassette, sub-family F (GCN20), member 3	0.152
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.148
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.147
ANKFY1	ankyrin repeat and FYVE domain containing 1	0.102
CAPRIN2	caprin family member 2	0.101
EPS15	epidermal growth factor receptor pathway substrate 15	0.100
KAT2B	K(lysine) acetyltransferase 2B	0.093
ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	0.089
TTR	transthyretin	0.087
CAV2	caveolin 2	0.078
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.077
AR	androgen receptor	0.077
EP300	E1A binding protein p300	0.070
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.069
TRAF5	TNF receptor-associated factor 5	0.068
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.065	Human
MED25	mediator complex subunit 25	0.057
PPARA	peroxisome proliferator-activated receptor alpha	0.056
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.054
MASP2	mannan-binding lectin serine peptidase 2	0.053
SEC23A	Sec23 homolog A (S. cerevisiae)	0.052
MTAP	methylthioadenosine phosphorylase	0.051
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.049
EGFR	epidermal growth factor receptor	0.048
SREBF2	sterol regulatory element binding transcription factor 2	0.047	Mouse
AHSG	alpha-2-HS-glycoprotein	0.047
PCSK9	proprotein convertase subtilisin/kexin type 9	0.047
SREBF1	sterol regulatory element binding transcription factor 1	0.045
LRRK2	leucine-rich repeat kinase 2	0.045
MBL2	mannose-binding lectin (protein C) 2, soluble	0.044
EPS8	epidermal growth factor receptor pathway substrate 8	0.044
HIPK2	homeodomain interacting protein kinase 2	0.044
SKIL	SKI-like oncogene	0.042
HR	hairless homolog (mouse)	0.041
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.039
MAP2K3	mitogen-activated protein kinase kinase 3	0.038
SEC24B	SEC24 family, member B (S. cerevisiae)	0.037
STON2	stonin 2	0.037
F7	coagulation factor VII (serum prothrombin conversion accelerator)	0.037
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.037
ESR1	estrogen receptor 1	0.036
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.036
ITGB5	integrin, beta 5	0.035
MDK	midkine (neurite growth-promoting factor 2)	0.035
KNG1	kininogen 1	0.035
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.035
APP	amyloid beta (A4) precursor protein	0.034
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.034	Fly
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.033
GSK3B	glycogen synthase kinase 3 beta	0.033
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.033
MSTO1	misato homolog 1 (Drosophila)	0.031
STX12	syntaxin 12	0.031
AMBP	alpha-1-microglobulin/bikunin precursor	0.031
DHCR7	7-dehydrocholesterol reductase	0.030
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.028
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.026
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.026
LOXL4	lysyl oxidase-like 4	0.025
RUNX1	runt-related transcription factor 1	0.025
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.025	Fly
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.024
MICALL1	MICAL-like 1	0.023
APOA4	apolipoprotein A-IV	0.023
MAT1A	methionine adenosyltransferase I, alpha	0.023
NCOA3	nuclear receptor coactivator 3	0.023
ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	0.022
FOXO3	forkhead box O3	0.022
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.022
FGG	fibrinogen gamma chain	0.020	Human
AGFG1	ArfGAP with FG repeats 1	0.020
F2	coagulation factor II (thrombin)	0.020
AHNAK	AHNAK nucleoprotein	0.019
EDF1	endothelial differentiation-related factor 1	0.019
APCS	amyloid P component, serum	0.019
CLINT1	clathrin interactor 1	0.019
OSBPL9	oxysterol binding protein-like 9	0.019	Yeast
C14orf1	chromosome 14 open reading frame 1	0.018
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.018
EHD4	EH-domain containing 4	0.018
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.018
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.017
FAM83C	family with sequence similarity 83, member C	0.017
VAPA	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	0.017
ADH6	alcohol dehydrogenase 6 (class V)	0.017
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.017
HDAC3	histone deacetylase 3	0.017
LBP	lipopolysaccharide binding protein	0.017
FCHO2	FCH domain only 2	0.017
F11	coagulation factor XI	0.017
ANXA4	annexin A4	0.016
HPX	hemopexin	0.016
CDK9	cyclin-dependent kinase 9	0.016
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.016
CSTB	cystatin B (stefin B)	0.015
FGL1	fibrinogen-like 1	0.015
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.015
VTN	vitronectin	0.015
HPD	4-hydroxyphenylpyruvate dioxygenase	0.015
BHMT	betaine--homocysteine S-methyltransferase	0.015
THPO	thrombopoietin	0.014
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.014
LIPC	lipase, hepatic	0.014
PRKCA	protein kinase C, alpha	0.014
ITIH1	inter-alpha (globulin) inhibitor H1	0.014
CREB3L2	cAMP responsive element binding protein 3-like 2	0.014
APOA5	apolipoprotein A-V	0.014
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.013
SMAD4	SMAD family member 4	0.013
ITIH2	inter-alpha (globulin) inhibitor H2	0.013
NCOA6	nuclear receptor coactivator 6	0.013
BRI3	brain protein I3	0.013
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.013
ITGB4	integrin, beta 4	0.013
CTSB	cathepsin B	0.013
CA5A	carbonic anhydrase VA, mitochondrial	0.013
SCARB1	scavenger receptor class B, member 1	0.013	Mouse
HNF1A	HNF1 homeobox A	0.013
KRT16	keratin 16	0.013
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.013
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.012
TRIP13	thyroid hormone receptor interactor 13	0.012
PID1	phosphotyrosine interaction domain containing 1	0.012
TF	transferrin	0.012
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.012
GPNMB	glycoprotein (transmembrane) nmb	0.012
EPAS1	endothelial PAS domain protein 1	0.012
HABP2	hyaluronan binding protein 2	0.012
TSC22D1	TSC22 domain family, member 1	0.012
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	0.012
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.012
ALDOB	aldolase B, fructose-bisphosphate	0.012
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.012
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.012
AFP	alpha-fetoprotein	0.012
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.012
PON1	paraoxonase 1	0.012
PTRF	polymerase I and transcript release factor	0.012
USP25	ubiquitin specific peptidase 25	0.011
C1QA	complement component 1, q subcomponent, A chain	0.011
VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	0.011
MICAL1	microtubule associated monoxygenase, calponin and LIM domain containing 1	0.011
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.011
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.011
C8A	complement component 8, alpha polypeptide	0.011
TBL3	transducin (beta)-like 3	0.011
CXXC5	CXXC finger protein 5	0.011
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.011
LRPAP1	low density lipoprotein receptor-related protein associated protein 1	0.011
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.011
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.011
C8G	complement component 8, gamma polypeptide	0.011
PFAS	phosphoribosylformylglycinamidine synthase	0.011
MYLIP	myosin regulatory light chain interacting protein	0.011	Mouse
APOC4	apolipoprotein C-IV	0.011
EGF	epidermal growth factor	0.011	Human
RXRB	retinoid X receptor, beta	0.011
HRG	histidine-rich glycoprotein	0.011
GM2A	GM2 ganglioside activator	0.011
C4BPB	complement component 4 binding protein, beta	0.011
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.011	Fly
SAA4	serum amyloid A4, constitutive	0.011
SMAD3	SMAD family member 3	0.011
PLTP	phospholipid transfer protein	0.011
FLOT1	flotillin 1	0.010
HADH	hydroxyacyl-CoA dehydrogenase	0.010
OSBPL11	oxysterol binding protein-like 11	0.010	Yeast
RBP4	retinol binding protein 4, plasma	0.010
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.010
MTTP	microsomal triglyceride transfer protein	0.010
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.010
SP1	Sp1 transcription factor	0.010
WNT3A	wingless-type MMTV integration site family, member 3A	0.010
SCP2	sterol carrier protein 2	0.010
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.010
GRB10	growth factor receptor-bound protein 10	0.010
BMP2K	BMP2 inducible kinase	0.010