IMP: Integrative Multi-species Prediction

Homo sapiens

19 genes annotated in human

Multi-species View

negative regulation of gene expression epigenetic

GO:0045814

Any epigenetic process that stops, prevents or reduces the rate of gene expression.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of gene expression epigenetic"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of gene expression epigenetic" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	0.999	Human Fly
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.952
HDAC2	histone deacetylase 2	0.943
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.933	Yeast Mouse
CBX5	chromobox homolog 5	0.905	Fly
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.835
ACTL6A	actin-like 6A	0.700
RBBP4	retinoblastoma binding protein 4	0.519	Yeast Fly
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.496
RB1	retinoblastoma 1	0.459
PCNA	proliferating cell nuclear antigen	0.419
CHD4	chromodomain helicase DNA binding protein 4	0.371
YY1	YY1 transcription factor	0.368	Fly
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.328
MCM6	minichromosome maintenance complex component 6	0.310
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.306
HIST1H3B	histone cluster 1, H3b	0.263
MCM7	minichromosome maintenance complex component 7	0.251	Yeast
HCFC1	host cell factor C1 (VP16-accessory protein)	0.169
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.167
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.161
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.156
NBN	nibrin	0.149
DAXX	death-domain associated protein	0.146
PARP1	poly (ADP-ribose) polymerase 1	0.139
TMPO	thymopoietin	0.136
EED	embryonic ectoderm development	0.131	Fly
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.130	Yeast
BMI1	BMI1 polycomb ring finger oncogene	0.128	Fly
THOC4	THO complex 4	0.124
MED15	mediator complex subunit 15	0.120
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.109
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.109
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.107	Yeast Mouse
HIST1H2AI	histone cluster 1, H2ai	0.104	Yeast
BCOR	BCL6 corepressor	0.102
WDR5	WD repeat domain 5	0.100
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.099
MRFAP1	Morf4 family associated protein 1	0.094
HDAC3	histone deacetylase 3	0.093
KAT5	K(lysine) acetyltransferase 5	0.093	Yeast
BRCA1	breast cancer 1, early onset	0.090
MCM2	minichromosome maintenance complex component 2	0.089
ESR1	estrogen receptor 1	0.089
HIST1H2AM	histone cluster 1, H2am	0.089
CBX8	chromobox homolog 8	0.086
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.081
HIST1H3D	histone cluster 1, H3d	0.078	Yeast
RING1	ring finger protein 1	0.078	Fly
TP53	tumor protein p53	0.074
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.074
CHD8	chromodomain helicase DNA binding protein 8	0.074
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.073
PBRM1	polybromo 1	0.071	Fly
HIST1H4D	histone cluster 1, H4d	0.070	Yeast
HIST1H2BG	histone cluster 1, H2bg	0.069
ORC3	origin recognition complex, subunit 3	0.068
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.067
KDM1A	lysine (K)-specific demethylase 1A	0.066
CBX3	chromobox homolog 3	0.065	Fly
RUVBL1	RuvB-like 1 (E. coli)	0.064
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.060
DICER1	dicer 1, ribonuclease type III	0.058
RBBP7	retinoblastoma binding protein 7	0.055	Yeast Fly
HIST1H3A	histone cluster 1, H3a	0.055
HIST1H2AB	histone cluster 1, H2ab	0.054	Yeast
SP1	Sp1 transcription factor	0.052
CBX1	chromobox homolog 1	0.051	Fly
NCAPH	non-SMC condensin I complex, subunit H	0.050
RNF2	ring finger protein 2	0.048	Fly
USP11	ubiquitin specific peptidase 11	0.048
HIST1H2AE	histone cluster 1, H2ae	0.046	Yeast
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.045	Fly
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.044
MTA1	metastasis associated 1	0.044
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.043	Yeast
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.042
MCM4	minichromosome maintenance complex component 4	0.042
ARID4B	AT rich interactive domain 4B (RBP1-like)	0.041
CDC73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.040
SAP30	Sin3A-associated protein, 30kDa	0.040
HIST2H3C	histone cluster 2, H3c	0.040
MSH6	mutS homolog 6 (E. coli)	0.039
ADNP	activity-dependent neuroprotector homeobox	0.039
ING3	inhibitor of growth family, member 3	0.037
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.037
TRIM28	tripartite motif containing 28	0.037
MORF4L1	mortality factor 4 like 1	0.036	Fly
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.035	Yeast
MCM5	minichromosome maintenance complex component 5	0.035	Yeast
LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.034
TOP2B	topoisomerase (DNA) II beta 180kDa	0.033	Fly
EP300	E1A binding protein p300	0.033
TFDP1	transcription factor Dp-1	0.033
HIST1H2AJ	histone cluster 1, H2aj	0.032	Yeast
H2AFZ	H2A histone family, member Z	0.032	Yeast
HIST1H2AL	histone cluster 1, H2al	0.032	Yeast
MCM10	minichromosome maintenance complex component 10	0.032	Fly
MBD1	methyl-CpG binding domain protein 1	0.032
MORF4L2	mortality factor 4 like 2	0.031	Fly
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.031
ORC6	origin recognition complex, subunit 6	0.031
MYST1	MYST histone acetyltransferase 1	0.030
HIST1H4B	histone cluster 1, H4b	0.030	Yeast
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.029	Yeast
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.028	Yeast Mouse
RAD18	RAD18 homolog (S. cerevisiae)	0.028
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.028
E2F3	E2F transcription factor 3	0.028
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.027
HIST1H2BJ	histone cluster 1, H2bj	0.025
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.025
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.025
ORC2	origin recognition complex, subunit 2	0.024	Yeast
ENO1	enolase 1, (alpha)	0.024
TRIM39	tripartite motif containing 39	0.024	Human
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.023	Fly
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	0.023	Yeast
HIST1H4E	histone cluster 1, H4e	0.023	Yeast
SSRP1	structure specific recognition protein 1	0.023
NCBP1	nuclear cap binding protein subunit 1, 80kDa	0.022
MBD2	methyl-CpG binding domain protein 2	0.022
HIST1H4A	histone cluster 1, H4a	0.022	Yeast
ORC1	origin recognition complex, subunit 1	0.022
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.022
H2AFX	H2A histone family, member X	0.022	Yeast
LRIF1	ligand dependent nuclear receptor interacting factor 1	0.021
KIAA0101	KIAA0101	0.021
POLD3	polymerase (DNA-directed), delta 3, accessory subunit	0.021
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.021
MTA3	metastasis associated 1 family, member 3	0.021
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.021	Yeast
NIPBL	Nipped-B homolog (Drosophila)	0.021
HIST1H4H	histone cluster 1, H4h	0.021	Yeast
POGZ	pogo transposable element with ZNF domain	0.020
PCGF1	polycomb group ring finger 1	0.020
TRIM5	tripartite motif containing 5	0.019	Human
C20orf20	chromosome 20 open reading frame 20	0.019
MRFAP1L1	Morf4 family associated protein 1-like 1	0.019
SKP1	S-phase kinase-associated protein 1	0.019
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.019
RANBP2	RAN binding protein 2	0.019
HIST1H2BM	histone cluster 1, H2bm	0.019
CBX7	chromobox homolog 7	0.019
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.019
ARID1A	AT rich interactive domain 1A (SWI-like)	0.018	Mouse
ORC4	origin recognition complex, subunit 4	0.018	Yeast
SFPQ	splicing factor proline/glutamine-rich	0.018
NONO	non-POU domain containing, octamer-binding	0.018
WDR61	WD repeat domain 61	0.017
SMC4	structural maintenance of chromosomes 4	0.017
ORC5	origin recognition complex, subunit 5	0.017	Yeast
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.017
HIST1H2AK	histone cluster 1, H2ak	0.017	Yeast
CXXC1	CXXC finger protein 1	0.017
MTA2	metastasis associated 1 family, member 2	0.017
FOXD3	forkhead box D3	0.017
HIST1H4I	histone cluster 1, H4i	0.016	Yeast
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.016
SOX10	SRY (sex determining region Y)-box 10	0.016
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.016
RYBP	RING1 and YY1 binding protein	0.016
NCAPG	non-SMC condensin I complex, subunit G	0.016
LBR	lamin B receptor	0.016
PTMA	prothymosin, alpha	0.015
HIST1H4F	histone cluster 1, H4f	0.015	Yeast
RCOR1	REST corepressor 1	0.015
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.015
CDT1	chromatin licensing and DNA replication factor 1	0.015
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.015
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.015
CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.015	Yeast
PCGF2	polycomb group ring finger 2	0.015	Fly
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.015	Fly
HIST1H2BB	histone cluster 1, H2bb	0.014
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.014	Fly
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.014
GATAD2B	GATA zinc finger domain containing 2B	0.014
ZBTB8A	zinc finger and BTB domain containing 8A	0.014
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.014	Fly
TYMS	thymidylate synthetase	0.014
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.014
PHF10	PHD finger protein 10	0.014
TRRAP	transformation/transcription domain-associated protein	0.013
RNF20	ring finger protein 20	0.013
MEN1	multiple endocrine neoplasia I	0.013
THOC2	THO complex 2	0.013
BRWD1	bromodomain and WD repeat domain containing 1	0.013
CDYL	chromodomain protein, Y-like	0.013
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.013
PAX3	paired box 3	0.013
TRIM21	tripartite motif containing 21	0.013	Human
EPC2	enhancer of polycomb homolog 2 (Drosophila)	0.013	Human
HIST1H2BN	histone cluster 1, H2bn	0.012
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.012	Mouse
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.012
GATAD2A	GATA zinc finger domain containing 2A	0.012
HIST1H3G	histone cluster 1, H3g	0.012
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.012
RSF1	remodeling and spacing factor 1	0.012
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.012
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.012
BPTF	bromodomain PHD finger transcription factor	0.012
HIST1H4J	histone cluster 1, H4j	0.012	Yeast
RSBN1	round spermatid basic protein 1	0.011
HIST2H4A	histone cluster 2, H4a	0.011
SOX2	SRY (sex determining region Y)-box 2	0.011
HIST1H2BI	histone cluster 1, H2bi	0.011
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.011
ZNF512B	zinc finger protein 512B	0.011
TRIM34	tripartite motif containing 34	0.011
SET	SET nuclear oncogene	0.011
HIST1H2BO	histone cluster 1, H2bo	0.011
HIST1H2AG	histone cluster 1, H2ag	0.011	Yeast
FLNA	filamin A, alpha	0.011
SP100	SP100 nuclear antigen	0.011
MCM3	minichromosome maintenance complex component 3	0.011	Yeast
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.011
HIST4H4	histone cluster 4, H4	0.011	Yeast
PCGF6	polycomb group ring finger 6	0.011
SMC2	structural maintenance of chromosomes 2	0.011
UBXN7	UBX domain protein 7	0.011
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.011
ZNF263	zinc finger protein 263	0.011
DPY30	dpy-30 homolog (C. elegans)	0.011
HIST1H3H	histone cluster 1, H3h	0.011
ILF2	interleukin enhancer binding factor 2, 45kDa	0.011
MBD4	methyl-CpG binding domain protein 4	0.010
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.010
DTL	denticleless homolog (Drosophila)	0.010
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.010
PHF19	PHD finger protein 19	0.010
RNASEH2A	ribonuclease H2, subunit A	0.010