IMP: Integrative Multi-species Prediction

Homo sapiens

30 genes annotated in human

dna duplex unwinding

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dna duplex unwinding"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "dna duplex unwinding" (in gray)

Name	Description	Probability	Func Analog Organism
RPA1	replication protein A1, 70kDa	0.984	Yeast
RPA2	replication protein A2, 32kDa	0.955	Yeast
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.889
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.888
NBN	nibrin	0.814
H2AFX	H2A histone family, member X	0.805
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.796
BRCA1	breast cancer 1, early onset	0.783
MCM2	minichromosome maintenance complex component 2	0.733	Yeast Mouse
RAD50	RAD50 homolog (S. cerevisiae)	0.697
NCAPD2	non-SMC condensin I complex, subunit D2	0.681
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.667
MCM6	minichromosome maintenance complex component 6	0.660
PARP1	poly (ADP-ribose) polymerase 1	0.615
MCM5	minichromosome maintenance complex component 5	0.578	Yeast Fly
MCM7	minichromosome maintenance complex component 7	0.527
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.497
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.488	Fly
MDC1	mediator of DNA-damage checkpoint 1	0.455
RUVBL1	RuvB-like 1 (E. coli)	0.442
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.386
GINS2	GINS complex subunit 2 (Psf2 homolog)	0.342
MCM3	minichromosome maintenance complex component 3	0.339	Yeast Fly
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.305
RPA3	replication protein A3, 14kDa	0.274
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.264
ORC1	origin recognition complex, subunit 1	0.263
PPARA	peroxisome proliferator-activated receptor alpha	0.199
ATR	ataxia telangiectasia and Rad3 related	0.176
FANCD2	Fanconi anemia, complementation group D2	0.172
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.158
BRCA2	breast cancer 2, early onset	0.152
CHD8	chromodomain helicase DNA binding protein 8	0.150
ORC3	origin recognition complex, subunit 3	0.144
BLM	Bloom syndrome, RecQ helicase-like	0.127
MCM10	minichromosome maintenance complex component 10	0.124
E2F1	E2F transcription factor 1	0.116
UNG	uracil-DNA glycosylase	0.115
CHD7	chromodomain helicase DNA binding protein 7	0.114	Human
GINS4	GINS complex subunit 4 (Sld5 homolog)	0.105
CUX1	cut-like homeobox 1	0.103
YY1	YY1 transcription factor	0.102
WRN	Werner syndrome, RecQ helicase-like	0.095
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.090	Yeast
RAD52	RAD52 homolog (S. cerevisiae)	0.089
ATM	ataxia telangiectasia mutated	0.078
MCM4	minichromosome maintenance complex component 4	0.076
TERF2	telomeric repeat binding factor 2	0.076
ACD	adrenocortical dysplasia homolog (mouse)	0.073
MCM8	minichromosome maintenance complex component 8	0.060
RAD54L	RAD54-like (S. cerevisiae)	0.058
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.055
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.048
EXO1	exonuclease 1	0.047
PALB2	partner and localizer of BRCA2	0.047
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.047
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.043
NCAPD3	non-SMC condensin II complex, subunit D3	0.042
CENPM	centromere protein M	0.041
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.039
MNAT1	menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)	0.038
ORC6	origin recognition complex, subunit 6	0.035
CTCF	CCCTC-binding factor (zinc finger protein)	0.035
NCAPG	non-SMC condensin I complex, subunit G	0.035
CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.034
RPS4Y1	ribosomal protein S4, Y-linked 1	0.034
SMC1A	structural maintenance of chromosomes 1A	0.032
RECQL4	RecQ protein-like 4	0.032
AURKB	aurora kinase B	0.032
DDX23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	0.031
SMC2	structural maintenance of chromosomes 2	0.030
TK1	thymidine kinase 1, soluble	0.029
SSRP1	structure specific recognition protein 1	0.029
ACTL6A	actin-like 6A	0.029
MSH6	mutS homolog 6 (E. coli)	0.028
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.027
MATR3	matrin 3	0.027
NCAPH2	non-SMC condensin II complex, subunit H2	0.027
RBBP8	retinoblastoma binding protein 8	0.026
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.025
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.025
TROAP	trophinin associated protein (tastin)	0.024
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.024
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.024
UBE2C	ubiquitin-conjugating enzyme E2C	0.024
MCMBP	minichromosome maintenance complex binding protein	0.024
RIF1	RAP1 interacting factor homolog (yeast)	0.024
DTL	denticleless homolog (Drosophila)	0.023
EIF1AY	eukaryotic translation initiation factor 1A, Y-linked	0.023
GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	0.023
CENPA	centromere protein A	0.023
CCNH	cyclin H	0.022
E2F3	E2F transcription factor 3	0.022
BNIPL	BCL2/adenovirus E1B 19kD interacting protein like	0.021
AHR	aryl hydrocarbon receptor	0.021
GTSE1	G-2 and S-phase expressed 1	0.021
E2F2	E2F transcription factor 2	0.021
ILF2	interleukin enhancer binding factor 2, 45kDa	0.020
C12orf11	chromosome 12 open reading frame 11	0.020
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.020
PAQR4	progestin and adipoQ receptor family member IV	0.020
C16orf59	chromosome 16 open reading frame 59	0.020
DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9	0.020
OTUD6B	OTU domain containing 6B	0.019
RMI1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)	0.019
LMNB1	lamin B1	0.019
USP9Y	ubiquitin specific peptidase 9, Y-linked	0.019
KDM5D	lysine (K)-specific demethylase 5D	0.019
TELO2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.018
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.018
TNRC6B	trinucleotide repeat containing 6B	0.018
FANCG	Fanconi anemia, complementation group G	0.017
RUVBL2	RuvB-like 2 (E. coli)	0.017
DPCD	deleted in primary ciliary dyskinesia homolog (mouse)	0.017
FAM64A	family with sequence similarity 64, member A	0.016
RAD21	RAD21 homolog (S. pombe)	0.016
APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	0.016
DMAP1	DNA methyltransferase 1 associated protein 1	0.016
XPC	xeroderma pigmentosum, complementation group C	0.016
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.016
PLK1	polo-like kinase 1	0.016
NAP1L1	nucleosome assembly protein 1-like 1	0.015
UTY	ubiquitously transcribed tetratricopeptide repeat gene, Y-linked	0.015
CLSPN	claspin	0.015
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.014
C20orf20	chromosome 20 open reading frame 20	0.014
HLTF	helicase-like transcription factor	0.014	Yeast
POC1A	POC1 centriolar protein homolog A (Chlamydomonas)	0.014
XPA	xeroderma pigmentosum, complementation group A	0.014
TCOF1	Treacher Collins-Franceschetti syndrome 1	0.014
PSMC3IP	PSMC3 interacting protein	0.014
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.014
POLQ	polymerase (DNA directed), theta	0.014
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.013
SRBD1	S1 RNA binding domain 1	0.013
FOXM1	forkhead box M1	0.013
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.013
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.013
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.013
TRAIP	TRAF interacting protein	0.013
GSG2	germ cell associated 2 (haspin)	0.012
SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	0.012
RB1	retinoblastoma 1	0.012
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.012
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.011
SLC25A10	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0.011
FANCA	Fanconi anemia, complementation group A	0.011
KIFC1	kinesin family member C1	0.011
RFC1	replication factor C (activator 1) 1, 145kDa	0.011
RARS	arginyl-tRNA synthetase	0.011
TIA1	TIA1 cytotoxic granule-associated RNA binding protein	0.011
TACC3	transforming, acidic coiled-coil containing protein 3	0.011
RNF8	ring finger protein 8	0.011
SEPT7	septin 7	0.010
MSH3	mutS homolog 3 (E. coli)	0.010
POLE	polymerase (DNA directed), epsilon	0.010
TOP3A	topoisomerase (DNA) III alpha	0.010