IMP: Integrative Multi-species Prediction

Homo sapiens

5 genes annotated in human

Multi-species View

cell cell signaling involved in cell fate commitment

GO:0045168

Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell cell signaling involved in cell fate commitment"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cell cell signaling involved in cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
COPS6	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	0.971	Fly
NOTCH1	notch 1	0.956	Worm Fly
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.872
FGFR2	fibroblast growth factor receptor 2	0.854
CSNK1E	casein kinase 1, epsilon	0.745
BMPR1A	bone morphogenetic protein receptor, type IA	0.713
FGFR1	fibroblast growth factor receptor 1	0.690	Mouse
CDK2	cyclin-dependent kinase 2	0.666
RFC5	replication factor C (activator 1) 5, 36.5kDa	0.607	Fly
JAG1	jagged 1	0.532	Fly
FGF1	fibroblast growth factor 1 (acidic)	0.433
RFC2	replication factor C (activator 1) 2, 40kDa	0.410
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.357
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.354	Fly
COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	0.293	Fly
MCM3	minichromosome maintenance complex component 3	0.259
TP53	tumor protein p53	0.236
RFC1	replication factor C (activator 1) 1, 145kDa	0.232	Fly
BBS10	Bardet-Biedl syndrome 10	0.210
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.210	Mouse Fly
PAX3	paired box 3	0.209
MCM5	minichromosome maintenance complex component 5	0.183
NOTCH3	notch 3	0.176	Worm Fly
FOXD3	forkhead box D3	0.174
MCM7	minichromosome maintenance complex component 7	0.163
CSNK2B	casein kinase 2, beta polypeptide	0.143
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.134
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.130	Fly
LRP6	low density lipoprotein receptor-related protein 6	0.130
LRRK2	leucine-rich repeat kinase 2	0.124
RFC4	replication factor C (activator 1) 4, 37kDa	0.121	Fly
ENO2	enolase 2 (gamma, neuronal)	0.112
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.111
GRB2	growth factor receptor-bound protein 2	0.097
SMAD4	SMAD family member 4	0.093
MCM2	minichromosome maintenance complex component 2	0.089
PSEN2	presenilin 2 (Alzheimer disease 4)	0.086
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.081
POU5F1	POU class 5 homeobox 1	0.080
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.079	Fly
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	0.077
CUL2	cullin 2	0.077
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.076	Fly
CUL1	cullin 1	0.073
WEE1	WEE1 homolog (S. pombe)	0.066
WNT3A	wingless-type MMTV integration site family, member 3A	0.059
RBX1	ring-box 1, E3 ubiquitin protein ligase	0.059
GINS2	GINS complex subunit 2 (Psf2 homolog)	0.059
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.058
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.058	Fly
MED10	mediator complex subunit 10	0.056
COPS7A	COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)	0.055	Fly
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.053
NCF2	neutrophil cytosolic factor 2	0.050
FZD1	frizzled homolog 1 (Drosophila)	0.047	Human
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.041	Fly
SOX2	SRY (sex determining region Y)-box 2	0.036	Mouse
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.035
TSC1	tuberous sclerosis 1	0.033
BABAM1	BRISC and BRCA1 A complex member 1	0.033
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.033
SH3KBP1	SH3-domain kinase binding protein 1	0.032	Fly
RFC3	replication factor C (activator 1) 3, 38kDa	0.031
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.030
MCM4	minichromosome maintenance complex component 4	0.030
SP1	Sp1 transcription factor	0.029
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.027	Fly
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.026
GFER	growth factor, augmenter of liver regeneration	0.026
POP4	processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)	0.026
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.024
ATN1	atrophin 1	0.024
FBLN1	fibulin 1	0.023
NAA15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	0.023
FGF2	fibroblast growth factor 2 (basic)	0.022	Mouse
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.021
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.021
PKP4	plakophilin 4	0.020
PFN1	profilin 1	0.019
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.019
EP300	E1A binding protein p300	0.018
MCM10	minichromosome maintenance complex component 10	0.018
CDK11B	cyclin-dependent kinase 11B	0.017
GFI1B	growth factor independent 1B transcription repressor	0.017
DBF4	DBF4 homolog (S. cerevisiae)	0.017
SKP2	S-phase kinase-associated protein 2 (p45)	0.017
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.017
TNRC6B	trinucleotide repeat containing 6B	0.016
PAX8	paired box 8	0.016
SORBS3	sorbin and SH3 domain containing 3	0.016
CLSPN	claspin	0.015
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.015
SMAD1	SMAD family member 1	0.015
JAG2	jagged 2	0.014	Fly
COPS2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	0.014
WNT5A	wingless-type MMTV integration site family, member 5A	0.014	Human
NOTCH2	notch 2	0.014	Fly
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.014
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.013
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.013	Fly
CDK8	cyclin-dependent kinase 8	0.013
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.013
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.013
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.012
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.012
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.012
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.012
CTNNBIP1	catenin, beta interacting protein 1	0.012
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.012
GJA1	gap junction protein, alpha 1, 43kDa	0.011
SOX11	SRY (sex determining region Y)-box 11	0.011
DCAF7	DDB1 and CUL4 associated factor 7	0.011
SOX10	SRY (sex determining region Y)-box 10	0.011
PRKCI	protein kinase C, iota	0.011
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.011
TGFB2	transforming growth factor, beta 2	0.011
MRPS22	mitochondrial ribosomal protein S22	0.011