IMP: Integrative Multi-species Prediction

Homo sapiens

3 genes annotated in human

Multi-species View

hemoglobin metabolic process

GO:0020027

The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in humanInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hemoglobin metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "hemoglobin metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
JUN	jun proto-oncogene	0.866
IER2	immediate early response 2	0.795
KLF6	Kruppel-like factor 6	0.638	Human
DUSP1	dual specificity phosphatase 1	0.544
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.389
KLF4	Kruppel-like factor 4 (gut)	0.346
LMO4	LIM domain only 4	0.306
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.295
EGLN3	egl nine homolog 3 (C. elegans)	0.286
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.244
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.244
JUNB	jun B proto-oncogene	0.198
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.189
GAST	gastrin	0.174
CIAPIN1	cytokine induced apoptosis inhibitor 1	0.172
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.130
SH3BP4	SH3-domain binding protein 4	0.115
EGLN1	egl nine homolog 1 (C. elegans)	0.109
SP1	Sp1 transcription factor	0.087
FOSL2	FOS-like antigen 2	0.060
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.054
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.050
GADD45B	growth arrest and DNA-damage-inducible, beta	0.048
SMAD7	SMAD family member 7	0.048
ATF3	activating transcription factor 3	0.046
KAT2B	K(lysine) acetyltransferase 2B	0.046
RHOB	ras homolog gene family, member B	0.045
VHL	von Hippel-Lindau tumor suppressor	0.042
ARNT	aryl hydrocarbon receptor nuclear translocator	0.042
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.041
CTBP1	C-terminal binding protein 1	0.038
PGK1	phosphoglycerate kinase 1	0.035
CYR61	cysteine-rich, angiogenic inducer, 61	0.035
EMP1	epithelial membrane protein 1	0.034
RANBP9	RAN binding protein 9	0.034
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.033
SSX4	synovial sarcoma, X breakpoint 4	0.032
CSRNP1	cysteine-serine-rich nuclear protein 1	0.031
EPAS1	endothelial PAS domain protein 1	0.031
LDHA	lactate dehydrogenase A	0.031
HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	0.027
GSK3A	glycogen synthase kinase 3 alpha	0.027
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.026
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.025
GOLM1	golgi membrane protein 1	0.025
ING2	inhibitor of growth family, member 2	0.024
RUNX1	runt-related transcription factor 1	0.024
NFIL3	nuclear factor, interleukin 3 regulated	0.024
RLIM	ring finger protein, LIM domain interacting	0.024
TSC22D3	TSC22 domain family, member 3	0.023
SLC16A1	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)	0.023
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.023
FST	follistatin	0.023
JUND	jun D proto-oncogene	0.022
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.022
DUSP5	dual specificity phosphatase 5	0.022
CSNK1E	casein kinase 1, epsilon	0.022
RAB6A	RAB6A, member RAS oncogene family	0.022
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.021
RHOA	ras homolog gene family, member A	0.021
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.021
CP	ceruloplasmin (ferroxidase)	0.020
HBG2	hemoglobin, gamma G	0.020
TGIF1	TGFB-induced factor homeobox 1	0.020
IER5	immediate early response 5	0.020
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.019
STX7	syntaxin 7	0.019
HBA2	hemoglobin, alpha 2	0.018
EGR1	early growth response 1	0.018
PRKCQ	protein kinase C, theta	0.018
ZFAND5	zinc finger, AN1-type domain 5	0.018
HBB	hemoglobin, beta	0.018
HBD	hemoglobin, delta	0.018
MYO1G	myosin IG	0.018
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.017
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.017
EIF1	eukaryotic translation initiation factor 1	0.017
SAT1	spermidine/spermine N1-acetyltransferase 1	0.017
APC	adenomatous polyposis coli	0.017
ZFP36L2	zinc finger protein 36, C3H type-like 2	0.016
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.016
HEXDC	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing	0.016
MCC	mutated in colorectal cancers	0.016
FRS2	fibroblast growth factor receptor substrate 2	0.016
POU2F1	POU class 2 homeobox 1	0.016
GHITM	growth hormone inducible transmembrane protein	0.016
MXD1	MAX dimerization protein 1	0.015
HEBP1	heme binding protein 1	0.015
SUGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	0.015
TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	0.015
PRRC2B	proline-rich coiled-coil 2B	0.015
MYADM	myeloid-associated differentiation marker	0.014
IGFBP3	insulin-like growth factor binding protein 3	0.014
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.014
RND3	Rho family GTPase 3	0.014
ATXN3	ataxin 3	0.014
HFE	hemochromatosis	0.014
ACTR10	actin-related protein 10 homolog (S. cerevisiae)	0.014
FOXO3	forkhead box O3	0.014
APOM	apolipoprotein M	0.014
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.013
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.013
PNO1	partner of NOB1 homolog (S. cerevisiae)	0.013
ANXA1	annexin A1	0.013
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.013
NCOA4	nuclear receptor coactivator 4	0.013
SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	0.013
JOSD1	Josephin domain containing 1	0.013
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.013
NBR1	neighbor of BRCA1 gene 1	0.013
SMAD2	SMAD family member 2	0.013
PER1	period homolog 1 (Drosophila)	0.012
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.012
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.012
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.012
NCOA6	nuclear receptor coactivator 6	0.012
KLF7	Kruppel-like factor 7 (ubiquitous)	0.012	Human
FOXO1	forkhead box O1	0.012
RHAG	Rh-associated glycoprotein	0.012
CTGF	connective tissue growth factor	0.012
BTG2	BTG family, member 2	0.012
POLH	polymerase (DNA directed), eta	0.012
CREG1	cellular repressor of E1A-stimulated genes 1	0.012
PF4	platelet factor 4	0.012
HTT	huntingtin	0.012
TRIB1	tribbles homolog 1 (Drosophila)	0.011
FTH1	ferritin, heavy polypeptide 1	0.011
ALAS2	aminolevulinate, delta-, synthase 2	0.011	Mouse
ANK1	ankyrin 1, erythrocytic	0.011
LEPR	leptin receptor	0.011
ESR2	estrogen receptor 2 (ER beta)	0.011
KLF3	Kruppel-like factor 3 (basic)	0.011	Human
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.011
KLF1	Kruppel-like factor 1 (erythroid)	0.011	Human
HSPA1A	heat shock 70kDa protein 1A	0.011
HIPK2	homeodomain interacting protein kinase 2	0.011
HSPH1	heat shock 105kDa/110kDa protein 1	0.011
TDG	thymine-DNA glycosylase	0.011
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.011
VPS35	vacuolar protein sorting 35 homolog (S. cerevisiae)	0.011
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.011
HES1	hairy and enhancer of split 1, (Drosophila)	0.011
FAM110C	family with sequence similarity 110, member C	0.011
AXIN2	axin 2	0.011
EGLN2	egl nine homolog 2 (C. elegans)	0.011
SEC24D	SEC24 family, member D (S. cerevisiae)	0.010
CORO1C	coronin, actin binding protein, 1C	0.010
GLRX2	glutaredoxin 2	0.010
SGK1	serum/glucocorticoid regulated kinase 1	0.010
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.010
BHLHE40	basic helix-loop-helix family, member e40	0.010
PGM1	phosphoglucomutase 1	0.010
PCTP	phosphatidylcholine transfer protein	0.010
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.010
KLF10	Kruppel-like factor 10	0.010
HEMGN	hemogen	0.010
LCN2	lipocalin 2	0.010
HBEGF	heparin-binding EGF-like growth factor	0.010