IMP: Integrative Multi-species Prediction

Homo sapiens

18 genes annotated in human

programmed necrotic cell death

A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "programmed necrotic cell death"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "programmed necrotic cell death" (in gray)

Name	Description	Probability	Func Analog Organism
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000	Mouse
BIRC3	baculoviral IAP repeat containing 3	1.000
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	1.000
FADD	Fas (TNFRSF6)-associated via death domain	1.000
FAS	Fas (TNF receptor superfamily, member 6)	0.994
TRAF1	TNF receptor-associated factor 1	0.994
CFLAR	CASP8 and FADD-like apoptosis regulator	0.993
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.993
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.985	Human
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.981	Human
BIRC2	baculoviral IAP repeat containing 2	0.974
TRADD	TNFRSF1A-associated via death domain	0.968
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.935	Human
TRAF2	TNF receptor-associated factor 2	0.922	Mouse
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.878	Human
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.703
RIPK2	receptor-interacting serine-threonine kinase 2	0.614	Human
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.599
TBK1	TANK-binding kinase 1	0.539
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.493
TANK	TRAF family member-associated NFKB activator	0.472
RNF31	ring finger protein 31	0.461
BBS10	Bardet-Biedl syndrome 10	0.385
NLRC4	NLR family, CARD domain containing 4	0.307
TRAF3	TNF receptor-associated factor 3	0.292
FASLG	Fas ligand (TNF superfamily, member 6)	0.285
RIPK3	receptor-interacting serine-threonine kinase 3	0.277
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.255
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.192
BAK1	BCL2-antagonist/killer 1	0.175
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.150
BID	BH3 interacting domain death agonist	0.148
TNF	tumor necrosis factor	0.146
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.120
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.117
CLTC	clathrin, heavy chain (Hc)	0.113
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.108
SMCR7	Smith-Magenis syndrome chromosome region, candidate 7	0.108
DAXX	death-domain associated protein	0.105
MAP2K4	mitogen-activated protein kinase kinase 4	0.098
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.092
TRAF6	TNF receptor-associated factor 6	0.090
CYLD	cylindromatosis (turban tumor syndrome)	0.088	Mouse
HDAC6	histone deacetylase 6	0.079
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.079
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.076
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.073
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.072
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.068
RNF144B	ring finger protein 144B	0.060
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.053
XIAP	X-linked inhibitor of apoptosis	0.050	Human
BCL2	B-cell CLL/lymphoma 2	0.050
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.050
ZBTB16	zinc finger and BTB domain containing 16	0.045
THOC3	THO complex 3	0.037
MAPK1	mitogen-activated protein kinase 1	0.036
EEF2	eukaryotic translation elongation factor 2	0.034
SHARPIN	SHANK-associated RH domain interactor	0.032
MAP2K7	mitogen-activated protein kinase kinase 7	0.030
FBXO33	F-box protein 33	0.030
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.029
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.028
TRIM21	tripartite motif containing 21	0.028
PPP6C	protein phosphatase 6, catalytic subunit	0.026
C1orf93	chromosome 1 open reading frame 93	0.026
NOD2	nucleotide-binding oligomerization domain containing 2	0.024
GRPEL1	GrpE-like 1, mitochondrial (E. coli)	0.024
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.024
MYH10	myosin, heavy chain 10, non-muscle	0.023
TRIM38	tripartite motif containing 38	0.023
USP15	ubiquitin specific peptidase 15	0.023
DIABLO	diablo, IAP-binding mitochondrial protein	0.023
MYH14	myosin, heavy chain 14, non-muscle	0.023
PYCARD	PYD and CARD domain containing	0.021
LMO4	LIM domain only 4	0.020
SOCS1	suppressor of cytokine signaling 1	0.020
HSPA1L	heat shock 70kDa protein 1-like	0.020
BECN1	beclin 1, autophagy related	0.019
TKT	transketolase	0.019
KIAA1377	KIAA1377	0.019
TRIM25	tripartite motif containing 25	0.018
MAPK8	mitogen-activated protein kinase 8	0.018	Mouse
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.017
EIF4A1	eukaryotic translation initiation factor 4A1	0.017
YBX1	Y box binding protein 1	0.016	Human
SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	0.016	Human
PABPC4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.015
ARRB2	arrestin, beta 2	0.015
NOD1	nucleotide-binding oligomerization domain containing 1	0.015
RNR2	l-rRNA	0.015
PRF1	perforin 1 (pore forming protein)	0.015
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.014	Mouse
TUBA3C	tubulin, alpha 3c	0.014
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.014
PITPNA	phosphatidylinositol transfer protein, alpha	0.014
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.014
NLK	nemo-like kinase	0.014
FKBP5	FK506 binding protein 5	0.014
OXA1L	oxidase (cytochrome c) assembly 1-like	0.013
JAK2	Janus kinase 2	0.013
MAVS	mitochondrial antiviral signaling protein	0.013
RIPK4	receptor-interacting serine-threonine kinase 4	0.013	Human
MIB1	mindbomb homolog 1 (Drosophila)	0.013
SMCR7L	Smith-Magenis syndrome chromosome region, candidate 7-like	0.012
RNF19A	ring finger protein 19A	0.012
LRRK2	leucine-rich repeat kinase 2	0.012
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.012
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.011
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.011	Mouse
ERP29	endoplasmic reticulum protein 29	0.011
ATM	ataxia telangiectasia mutated	0.011
PIAS4	protein inhibitor of activated STAT, 4	0.010
FOXO1	forkhead box O1	0.010
TMOD3	tropomodulin 3 (ubiquitous)	0.010
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.010
GRIP1	glutamate receptor interacting protein 1	0.010