IMP
Process View
endoplasmic reticulum unfolded protein response
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "endoplasmic reticulum unfolded protein response"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | 1.000 | Fly | |
| PDIA3 | protein disulfide isomerase family A, member 3 | 1.000 | ||
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.999 | Mouse Worm | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.993 | Human | |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.991 | ||
| BCL2L1 | BCL2-like 1 | 0.983 | Human | |
| VCP | valosin containing protein | 0.959 | Worm | |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.953 | Mouse | |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.936 | Worm | |
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.928 | Human | |
| SELS | selenoprotein S | 0.908 | ||
| DERL1 | Der1-like domain family, member 1 | 0.884 | ||
| CANX | calnexin | 0.849 | Worm | |
| BAX | BCL2-associated X protein | 0.806 | ||
| HSPA8 | heat shock 70kDa protein 8 | 0.774 | ||
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.745 | Worm | |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) | 0.740 | ||
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.691 | ||
| BAD | BCL2-associated agonist of cell death | 0.631 | ||
| ATF3 | activating transcription factor 3 | 0.630 | ||
| GHR | growth hormone receptor | 0.624 | ||
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.621 | Worm | |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 0.455 | ||
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.443 | Worm | |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.430 | ||
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.349 | ||
| BAK1 | BCL2-antagonist/killer 1 | 0.306 | ||
| VDAC1 | voltage-dependent anion channel 1 | 0.275 | ||
| ERO1L | ERO1-like (S. cerevisiae) | 0.262 | Mouse | |
| GRB2 | growth factor receptor-bound protein 2 | 0.245 | ||
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.230 | ||
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.212 | ||
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.187 | ||
| MAFG | v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) | 0.170 | ||
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.114 | ||
| CALR | calreticulin | 0.109 | Worm | |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.109 | ||
| CCND3 | cyclin D3 | 0.097 | ||
| DNAJB11 | DnaJ (Hsp40) homolog, subfamily B, member 11 | 0.086 | ||
| ATF2 | activating transcription factor 2 | 0.076 | ||
| C4orf14 | chromosome 4 open reading frame 14 | 0.070 | ||
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.067 | ||
| DBP | D site of albumin promoter (albumin D-box) binding protein | 0.064 | ||
| AMFR | autocrine motility factor receptor | 0.062 | ||
| BAG1 | BCL2-associated athanogene | 0.061 | ||
| ENO1 | enolase 1, (alpha) | 0.057 | ||
| SSR1 | signal sequence receptor, alpha | 0.055 | ||
| STON2 | stonin 2 | 0.055 | ||
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.051 | ||
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.050 | ||
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.050 | ||
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.049 | ||
| RPN1 | ribophorin I | 0.048 | ||
| CDK6 | cyclin-dependent kinase 6 | 0.046 | ||
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.045 | ||
| RABAC1 | Rab acceptor 1 (prenylated) | 0.041 | ||
| TUFM | Tu translation elongation factor, mitochondrial | 0.039 | ||
| RNF144B | ring finger protein 144B | 0.039 | ||
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.039 | ||
| FKBP4 | FK506 binding protein 4, 59kDa | 0.038 | ||
| NUCB2 | nucleobindin 2 | 0.037 | ||
| HYOU1 | hypoxia up-regulated 1 | 0.037 | ||
| ATXN3 | ataxin 3 | 0.037 | ||
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.032 | ||
| LDHA | lactate dehydrogenase A | 0.031 | ||
| CDK4 | cyclin-dependent kinase 4 | 0.030 | ||
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.028 | ||
| CYCS | cytochrome c, somatic | 0.027 | ||
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.027 | ||
| STX8 | syntaxin 8 | 0.027 | ||
| ERO1LB | ERO1-like beta (S. cerevisiae) | 0.027 | ||
| BACH1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | 0.026 | ||
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 0.025 | ||
| BAG2 | BCL2-associated athanogene 2 | 0.025 | ||
| BID | BH3 interacting domain death agonist | 0.024 | ||
| RNR2 | l-rRNA | 0.023 | ||
| NSFL1C | NSFL1 (p97) cofactor (p47) | 0.023 | ||
| C19orf10 | chromosome 19 open reading frame 10 | 0.023 | ||
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.022 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.022 | ||
| HM13 | histocompatibility (minor) 13 | 0.022 | ||
| DERL2 | Der1-like domain family, member 2 | 0.021 | ||
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.021 | ||
| EIF1 | eukaryotic translation initiation factor 1 | 0.020 | ||
| LDLR | low density lipoprotein receptor | 0.020 | ||
| RPN2 | ribophorin II | 0.020 | ||
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | 0.019 | ||
| GANAB | glucosidase, alpha; neutral AB | 0.019 | ||
| EMD | emerin | 0.019 | ||
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.018 | Worm | |
| SERP1 | stress-associated endoplasmic reticulum protein 1 | 0.018 | Mouse | |
| USP46 | ubiquitin specific peptidase 46 | 0.017 | ||
| ANKRD12 | ankyrin repeat domain 12 | 0.017 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.017 | ||
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 0.017 | ||
| DNM1 | dynamin 1 | 0.017 | ||
| TRAP1 | TNF receptor-associated protein 1 | 0.016 | Worm | |
| HSPA13 | heat shock protein 70kDa family, member 13 | 0.016 | ||
| KEAP1 | kelch-like ECH-associated protein 1 | 0.016 | ||
| MOV10 | Mov10, Moloney leukemia virus 10, homolog (mouse) | 0.016 | ||
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.015 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.015 | ||
| GRB10 | growth factor receptor-bound protein 10 | 0.015 | ||
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.014 | ||
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.014 | Human | |
| NCL | nucleolin | 0.014 | ||
| PRDX4 | peroxiredoxin 4 | 0.014 | ||
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 0.013 | ||
| HSPA1B | heat shock 70kDa protein 1B | 0.013 | ||
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.013 | ||
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.013 | ||
| CALU | calumenin | 0.013 | ||
| SURF4 | surfeit 4 | 0.013 | ||
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.013 | ||
| SLU7 | SLU7 splicing factor homolog (S. cerevisiae) | 0.012 | ||
| VCPIP1 | valosin containing protein (p97)/p47 complex interacting protein 1 | 0.012 | ||
| ATF4 | activating transcription factor 4 (tax-responsive enhancer element B67) | 0.012 | ||
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.012 | ||
| TRIB3 | tribbles homolog 3 (Drosophila) | 0.012 | ||
| PRKRA | protein kinase, interferon-inducible double stranded RNA dependent activator | 0.011 | ||
| AP2A1 | adaptor-related protein complex 2, alpha 1 subunit | 0.011 | ||
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.011 | ||
| XBP1 | X-box binding protein 1 | 0.011 | ||
| TRIP10 | thyroid hormone receptor interactor 10 | 0.011 | ||
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.010 | ||
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.010 | ||
| EIF3CL | eukaryotic translation initiation factor 3, subunit C-like | 0.010 | ||
| EPRS | glutamyl-prolyl-tRNA synthetase | 0.010 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.010 | ||
| KDM6B | lysine (K)-specific demethylase 6B | 0.010 |