IMP: Integrative Multi-species Prediction

Homo sapiens

16 genes annotated in human

negative regulation of jnk cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of jnk cascade"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of jnk cascade" (in gray)

Name	Description	Probability	Func Analog Organism
ZNF43	zinc finger protein 43	0.990
MAP2K4	mitogen-activated protein kinase kinase 4	0.948
MAPK8	mitogen-activated protein kinase 8	0.904	Fly
ZNF253	zinc finger protein 253	0.859
ZNF273	zinc finger protein 273	0.832	Human
GSK3B	glycogen synthase kinase 3 beta	0.684	Fly
MAPK14	mitogen-activated protein kinase 14	0.675
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.655
ZNF675	zinc finger protein 675	0.651
MAPK1	mitogen-activated protein kinase 1	0.559
NCOR1	nuclear receptor corepressor 1	0.458
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.423
ZNF746	zinc finger protein 746	0.356
ILK	integrin-linked kinase	0.315
MAP2K7	mitogen-activated protein kinase kinase 7	0.293
CHUK	conserved helix-loop-helix ubiquitous kinase	0.275
ZNF430	zinc finger protein 430	0.252	Human
ZNF91	zinc finger protein 91	0.231
PPARA	peroxisome proliferator-activated receptor alpha	0.184
ZNF708	zinc finger protein 708	0.183	Human
ZNF93	zinc finger protein 93	0.180
ZNF117	zinc finger protein 117	0.173	Human
AXIN1	axin 1	0.170
ARRB2	arrestin, beta 2	0.166
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.166
ZNF680	zinc finger protein 680	0.156	Human
CSNK1E	casein kinase 1, epsilon	0.140
ZNF85	zinc finger protein 85	0.139	Human
ATF2	activating transcription factor 2	0.135
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.117
ZNF254	zinc finger protein 254	0.117	Human
SMAD2	SMAD family member 2	0.114
CREBBP	CREB binding protein	0.114
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.097
CUL1	cullin 1	0.090
JUN	jun proto-oncogene	0.084
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.074	Rat
CREB1	cAMP responsive element binding protein 1	0.072
RALBP1	ralA binding protein 1	0.072
WWOX	WW domain containing oxidoreductase	0.069
ZNF107	zinc finger protein 107	0.069
TOX4	TOX high mobility group box family member 4	0.067
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.066	Fly
ARRB1	arrestin, beta 1	0.057
HDAC3	histone deacetylase 3	0.057
MAPK3	mitogen-activated protein kinase 3	0.054
DUSP1	dual specificity phosphatase 1	0.054
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.053
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.051
RANBP3	RAN binding protein 3	0.048
L3MBTL2	l(3)mbt-like 2 (Drosophila)	0.045
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.045
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.043
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.042	Fly
HSPA8	heat shock 70kDa protein 8	0.041
ZNF92	zinc finger protein 92	0.041	Human
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.035
APC	adenomatous polyposis coli	0.034
MAPK9	mitogen-activated protein kinase 9	0.032	Fly
RAB10	RAB10, member RAS oncogene family	0.031
CAV1	caveolin 1, caveolae protein, 22kDa	0.031
NCK2	NCK adaptor protein 2	0.030
LIMD1	LIM domains containing 1	0.030
ANXA7	annexin A7	0.030
MAGEA2	melanoma antigen family A, 2	0.027
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.027
ATF3	activating transcription factor 3	0.026
TRAF5	TNF receptor-associated factor 5	0.026
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.026
PKM2	pyruvate kinase, muscle	0.025
ZNF682	zinc finger protein 682	0.025	Human
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.023
FBXW11	F-box and WD repeat domain containing 11	0.023
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.022
CLIP1	CAP-GLY domain containing linker protein 1	0.022
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.022
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.021
CHD3	chromodomain helicase DNA binding protein 3	0.021
SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	0.021
ZCCHC17	zinc finger, CCHC domain containing 17	0.021
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.020
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.020
MAP2K3	mitogen-activated protein kinase kinase 3	0.020
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.020
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.019	Fly
SIRT1	sirtuin 1	0.018
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.017
SUGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	0.017
MSH5	mutS homolog 5 (E. coli)	0.017
ZNF320	zinc finger protein 320	0.017
BTRC	beta-transducin repeat containing	0.016
ATXN3	ataxin 3	0.016
NCOR2	nuclear receptor corepressor 2	0.016	Human
PEA15	phosphoprotein enriched in astrocytes 15	0.015
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.015
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.015
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.015
MDFI	MyoD family inhibitor	0.015
MTMR4	myotubularin related protein 4	0.015
RAB21	RAB21, member RAS oncogene family	0.015
ZNF260	zinc finger protein 260	0.015
BAG1	BCL2-associated athanogene	0.014
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.014
ZNF506	zinc finger protein 506	0.014	Human
SHOC2	soc-2 suppressor of clear homolog (C. elegans)	0.014
C14orf129	chromosome 14 open reading frame 129	0.014
MAP2K1	mitogen-activated protein kinase kinase 1	0.013
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.013
SIAH1	seven in absentia homolog 1 (Drosophila)	0.013
PPP4C	protein phosphatase 4, catalytic subunit	0.013
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.013
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.013
RAB1A	RAB1A, member RAS oncogene family	0.013
RCHY1	ring finger and CHY zinc finger domain containing 1	0.013
MCC	mutated in colorectal cancers	0.012
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.012
NIN	ninein (GSK3B interacting protein)	0.012
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.012
PPP6C	protein phosphatase 6, catalytic subunit	0.012
ERBB2IP	erbb2 interacting protein	0.012
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.012
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.012
LPXN	leupaxin	0.012
PDCD2	programmed cell death 2	0.012
INADL	InaD-like (Drosophila)	0.012
TRIM33	tripartite motif containing 33	0.012
MAP2K6	mitogen-activated protein kinase kinase 6	0.012
TRAF6	TNF receptor-associated factor 6	0.011
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.011
HSPH1	heat shock 105kDa/110kDa protein 1	0.011
ZMYND11	zinc finger, MYND-type containing 11	0.011
BMPR1A	bone morphogenetic protein receptor, type IA	0.011
EIF4E	eukaryotic translation initiation factor 4E	0.011
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.011
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.011
PARVB	parvin, beta	0.011
PINK1	PTEN induced putative kinase 1	0.011
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.011
CAV2	caveolin 2	0.011
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.010
C1D	C1D nuclear receptor corepressor	0.010
KAT2B	K(lysine) acetyltransferase 2B	0.010
PGR	progesterone receptor	0.010
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.010