IMP: Integrative Multi-species Prediction

Homo sapiens

23 genes annotated in human

triglyceride metabolic process

The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "triglyceride metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "triglyceride metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
SC4MOL	sterol-C4-methyl oxidase-like	0.916
CDK2	cyclin-dependent kinase 2	0.889	Yeast
HP	haptoglobin	0.622
LDLR	low density lipoprotein receptor	0.575	Mouse
ALB	albumin	0.575
CCNE1	cyclin E1	0.559
APOC1	apolipoprotein C-I	0.554
CREBBP	CREB binding protein	0.481
APOE	apolipoprotein E	0.391
SREBF2	sterol regulatory element binding transcription factor 2	0.339
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.301
A2M	alpha-2-macroglobulin	0.235	Human
PPARA	peroxisome proliferator-activated receptor alpha	0.221
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.207
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.185
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.181	Mouse
RXRA	retinoid X receptor, alpha	0.170
LCAT	lecithin-cholesterol acyltransferase	0.161
IDI1	isopentenyl-diphosphate delta isomerase 1	0.157
DHCR7	7-dehydrocholesterol reductase	0.147
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.142
KAT2B	K(lysine) acetyltransferase 2B	0.140
MED15	mediator complex subunit 15	0.139
TTR	transthyretin	0.129
AR	androgen receptor	0.120
NCOA1	nuclear receptor coactivator 1	0.116
APOA2	apolipoprotein A-II	0.112
CTDNEP1	CTD nuclear envelope phosphatase 1	0.096
TMEM188	transmembrane protein 188	0.096
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.095
JAK1	Janus kinase 1	0.092
SQLE	squalene epoxidase	0.086
INSIG1	insulin induced gene 1	0.082	Mouse
FRS2	fibroblast growth factor receptor substrate 2	0.077
CAV2	caveolin 2	0.072
APOA1	apolipoprotein A-I	0.072	Human
TSC22D1	TSC22 domain family, member 1	0.069
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.068
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	0.068
UBXN2A	UBX domain protein 2A	0.065
MSTO1	misato homolog 1 (Drosophila)	0.062
RPL18A	ribosomal protein L18a	0.060
CFI	complement factor I	0.060
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.058
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.054
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.053
CLEC4G	C-type lectin domain family 4, member G	0.052
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.050
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.050
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.049
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.047
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.046
IL6R	interleukin 6 receptor	0.046
APOB	apolipoprotein B (including Ag(x) antigen)	0.046	Mouse
APOC3	apolipoprotein C-III	0.041
GAB1	GRB2-associated binding protein 1	0.041
AGXT2	alanine--glyoxylate aminotransferase 2	0.036
TNIK	TRAF2 and NCK interacting kinase	0.035
RBP4	retinol binding protein 4, plasma	0.034
CFB	complement factor B	0.033
ACSL1	acyl-CoA synthetase long-chain family member 1	0.031	Rat
CAT	catalase	0.030	Mouse
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.029
MBNL2	muscleblind-like 2 (Drosophila)	0.028
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.028
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.027
MPZL1	myelin protein zero-like 1	0.027
LAMC3	laminin, gamma 3	0.027
LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	0.026
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.026
ALDOB	aldolase B, fructose-bisphosphate	0.026
OTC	ornithine carbamoyltransferase	0.025
PPARG	peroxisome proliferator-activated receptor gamma	0.025
FOXO3	forkhead box O3	0.025
FOXO1	forkhead box O1	0.024
SOD2	superoxide dismutase 2, mitochondrial	0.023
MDK	midkine (neurite growth-promoting factor 2)	0.023
FADS1	fatty acid desaturase 1	0.023
RPL36	ribosomal protein L36	0.023
DUSP23	dual specificity phosphatase 23	0.023
LIPE	lipase, hormone-sensitive	0.023
TBL1X	transducin (beta)-like 1X-linked	0.022
TRIM11	tripartite motif containing 11	0.022
CA5A	carbonic anhydrase VA, mitochondrial	0.022
AQP7	aquaporin 7	0.022
LPA	lipoprotein, Lp(a)	0.022
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.021	Mouse
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.021
HDAC3	histone deacetylase 3	0.021
HLTF	helicase-like transcription factor	0.021
HNF4A	hepatocyte nuclear factor 4, alpha	0.020
ECSIT	ECSIT homolog (Drosophila)	0.020
DSE	dermatan sulfate epimerase	0.019
ACACA	acetyl-CoA carboxylase alpha	0.019
STARD4	StAR-related lipid transfer (START) domain containing 4	0.019
GLIS2	GLIS family zinc finger 2	0.019
NCOA2	nuclear receptor coactivator 2	0.019
PTEN	phosphatase and tensin homolog	0.019
FABP4	fatty acid binding protein 4, adipocyte	0.018
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.018
CP	ceruloplasmin (ferroxidase)	0.017
PTPRF	protein tyrosine phosphatase, receptor type, F	0.017
CCNB2	cyclin B2	0.017
CYB5A	cytochrome b5 type A (microsomal)	0.017
ZG16	zymogen granule protein 16 homolog (rat)	0.017
CPB2	carboxypeptidase B2 (plasma)	0.017
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.017
IRS1	insulin receptor substrate 1	0.017
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.017
PC	pyruvate carboxylase	0.017
STAG2	stromal antigen 2	0.017
THRSP	thyroid hormone responsive	0.016
LIFR	leukemia inhibitory factor receptor alpha	0.016
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.016
G6PC	glucose-6-phosphatase, catalytic subunit	0.016
CIDEC	cell death-inducing DFFA-like effector c	0.016
FABP1	fatty acid binding protein 1, liver	0.015
FASN	fatty acid synthase	0.015
GSK3B	glycogen synthase kinase 3 beta	0.015
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.015
SEPT8	septin 8	0.015
SKP2	S-phase kinase-associated protein 2 (p45)	0.014
CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1	0.014
PLG	plasminogen	0.014
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.014
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.014
AQR	aquarius homolog (mouse)	0.014
ABHD5	abhydrolase domain containing 5	0.014
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.014
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.014
RARRES2	retinoic acid receptor responder (tazarotene induced) 2	0.014
APOC2	apolipoprotein C-II	0.014
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.014
CREB1	cAMP responsive element binding protein 1	0.014
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.014
CNTF	ciliary neurotrophic factor	0.013
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.013
GLYAT	glycine-N-acyltransferase	0.013
EDF1	endothelial differentiation-related factor 1	0.013
LEPR	leptin receptor	0.013
FOXM1	forkhead box M1	0.013
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.013	Rat
MVK	mevalonate kinase	0.013
INSR	insulin receptor	0.013
APP	amyloid beta (A4) precursor protein	0.013
PLTP	phospholipid transfer protein	0.013
LIPC	lipase, hepatic	0.013
PHTF2	putative homeodomain transcription factor 2	0.013
AIP	aryl hydrocarbon receptor interacting protein	0.013
MTTP	microsomal triglyceride transfer protein	0.013
PBK	PDZ binding kinase	0.013
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.013
PLIN1	perilipin 1	0.013
FADS2	fatty acid desaturase 2	0.012
TXNRD1	thioredoxin reductase 1	0.012
F2R	coagulation factor II (thrombin) receptor	0.012
PDK4	pyruvate dehydrogenase kinase, isozyme 4	0.012
EED	embryonic ectoderm development	0.012
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.012
MVD	mevalonate (diphospho) decarboxylase	0.012
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.012
PLIN4	perilipin 4	0.012
OPLAH	5-oxoprolinase (ATP-hydrolysing)	0.012
PON1	paraoxonase 1	0.012
HIC1	hypermethylated in cancer 1	0.012
PSEN1	presenilin 1	0.012
FDPS	farnesyl diphosphate synthase	0.012
ADIPOQ	adiponectin, C1Q and collagen domain containing	0.012
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.012
ADH6	alcohol dehydrogenase 6 (class V)	0.012
GAB2	GRB2-associated binding protein 2	0.012
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.012
CPD	carboxypeptidase D	0.012
PAH	phenylalanine hydroxylase	0.012
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.012
CCNG2	cyclin G2	0.012
IGF1R	insulin-like growth factor 1 receptor	0.011
ACAA2	acetyl-CoA acyltransferase 2	0.011
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
MGST1	microsomal glutathione S-transferase 1	0.011
DHCR24	24-dehydrocholesterol reductase	0.011
CD36	CD36 molecule (thrombospondin receptor)	0.011	Rat
SDPR	serum deprivation response	0.011
BHMT	betaine--homocysteine S-methyltransferase	0.011
SCCPDH	saccharopine dehydrogenase (putative)	0.011
GRB10	growth factor receptor-bound protein 10	0.011
C14orf1	chromosome 14 open reading frame 1	0.011
HPD	4-hydroxyphenylpyruvate dioxygenase	0.011
SLC38A2	solute carrier family 38, member 2	0.011
APOC4	apolipoprotein C-IV	0.011
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	0.011
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.011
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.010
C8B	complement component 8, beta polypeptide	0.010
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	0.010
ACSM5	acyl-CoA synthetase medium-chain family member 5	0.010
CDK1	cyclin-dependent kinase 1	0.010	Yeast