IMP
Process View
tricarboxylic acid cycle
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Loading network...
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "tricarboxylic acid cycle"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| HDAC1 | histone deacetylase 1 | 0.988 | Fly | |
| DLAT | dihydrolipoamide S-acetyltransferase | 0.818 | ||
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | 0.759 | ||
| PDHA1 | pyruvate dehydrogenase (lipoamide) alpha 1 | 0.737 | ||
| FH | fumarate hydratase | 0.706 | ||
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.604 | ||
| PDHX | pyruvate dehydrogenase complex, component X | 0.568 | ||
| ATP5B | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | 0.468 | ||
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 0.424 | ||
| PRKAR2A | protein kinase, cAMP-dependent, regulatory, type II, alpha | 0.420 | ||
| UQCRC1 | ubiquinol-cytochrome c reductase core protein I | 0.270 | ||
| GOT1 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 0.245 | ||
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | 0.244 | ||
| PFDN1 | prefoldin subunit 1 | 0.224 | ||
| ADRBK1 | adrenergic, beta, receptor kinase 1 | 0.169 | ||
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 0.167 | ||
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | 0.146 | ||
| AFG3L2 | AFG3 ATPase family gene 3-like 2 (S. cerevisiae) | 0.145 | ||
| IDH3A | isocitrate dehydrogenase 3 (NAD+) alpha | 0.144 | Rat | |
| AIFM1 | apoptosis-inducing factor, mitochondrion-associated, 1 | 0.142 | ||
| SUCLG1 | succinate-CoA ligase, alpha subunit | 0.126 | ||
| OXA1L | oxidase (cytochrome c) assembly 1-like | 0.122 | ||
| MDH2 | malate dehydrogenase 2, NAD (mitochondrial) | 0.109 | Fly | |
| HIGD2A | HIG1 hypoxia inducible domain family, member 2A | 0.105 | ||
| ACO2 | aconitase 2, mitochondrial | 0.098 | ||
| IDH3G | isocitrate dehydrogenase 3 (NAD+) gamma | 0.091 | Rat | |
| NCAPG | non-SMC condensin I complex, subunit G | 0.087 | ||
| SENP1 | SUMO1/sentrin specific peptidase 1 | 0.075 | ||
| HDAC2 | histone deacetylase 2 | 0.069 | Fly | |
| CYC1 | cytochrome c-1 | 0.066 | ||
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.060 | ||
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.057 | ||
| GPI | glucose-6-phosphate isomerase | 0.055 | ||
| C3orf15 | chromosome 3 open reading frame 15 | 0.054 | ||
| USPL1 | ubiquitin specific peptidase like 1 | 0.052 | ||
| PDHB | pyruvate dehydrogenase (lipoamide) beta | 0.052 | ||
| PRKCA | protein kinase C, alpha | 0.049 | ||
| ECHS1 | enoyl CoA hydratase, short chain, 1, mitochondrial | 0.046 | ||
| MDH1 | malate dehydrogenase 1, NAD (soluble) | 0.042 | ||
| HDAC3 | histone deacetylase 3 | 0.041 | ||
| TXN2 | thioredoxin 2 | 0.038 | ||
| DLD | dihydrolipoamide dehydrogenase | 0.035 | ||
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | 0.035 | Rat | |
| ANXA7 | annexin A7 | 0.034 | ||
| COQ9 | coenzyme Q9 homolog (S. cerevisiae) | 0.031 | ||
| SIRT2 | sirtuin 2 | 0.029 | ||
| GRHPR | glyoxylate reductase/hydroxypyruvate reductase | 0.028 | ||
| C21orf33 | chromosome 21 open reading frame 33 | 0.028 | ||
| APOO | apolipoprotein O | 0.028 | ||
| NDUFV1 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa | 0.028 | ||
| NFS1 | NFS1 nitrogen fixation 1 homolog (S. cerevisiae) | 0.025 | ||
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.024 | Rat | |
| BCKDHA | branched chain keto acid dehydrogenase E1, alpha polypeptide | 0.023 | ||
| HADH | hydroxyacyl-CoA dehydrogenase | 0.023 | ||
| SAMM50 | sorting and assembly machinery component 50 homolog (S. cerevisiae) | 0.021 | ||
| ALAS1 | aminolevulinate, delta-, synthase 1 | 0.020 | ||
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.020 | ||
| MECR | mitochondrial trans-2-enoyl-CoA reductase | 0.020 | ||
| CYLD | cylindromatosis (turban tumor syndrome) | 0.019 | ||
| SUCLA2 | succinate-CoA ligase, ADP-forming, beta subunit | 0.019 | ||
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 0.018 | ||
| TUBA1A | tubulin, alpha 1a | 0.017 | ||
| ECH1 | enoyl CoA hydratase 1, peroxisomal | 0.017 | ||
| ACAT1 | acetyl-CoA acetyltransferase 1 | 0.017 | ||
| ATP5SL | ATP5S-like | 0.016 | ||
| NCOR2 | nuclear receptor corepressor 2 | 0.015 | ||
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.015 | ||
| FDX1 | ferredoxin 1 | 0.014 | ||
| UBAC1 | UBA domain containing 1 | 0.014 | ||
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 0.014 | ||
| RCOR1 | REST corepressor 1 | 0.014 | ||
| PPARA | peroxisome proliferator-activated receptor alpha | 0.014 | ||
| PHB2 | prohibitin 2 | 0.014 | ||
| MIPEP | mitochondrial intermediate peptidase | 0.013 | ||
| NCAPH2 | non-SMC condensin II complex, subunit H2 | 0.013 | ||
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | 0.013 | ||
| HADHB | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | 0.013 | ||
| ASNA1 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) | 0.013 | ||
| ZMYM3 | zinc finger, MYM-type 3 | 0.013 | ||
| MFN2 | mitofusin 2 | 0.013 | ||
| CYCS | cytochrome c, somatic | 0.012 | ||
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.012 | ||
| CTTN | cortactin | 0.011 | ||
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.011 | ||
| LMNB1 | lamin B1 | 0.011 | ||
| CHCHD10 | coiled-coil-helix-coiled-coil-helix domain containing 10 | 0.011 | ||
| ECI2 | enoyl-CoA delta isomerase 2 | 0.010 | ||
| ACAD8 | acyl-CoA dehydrogenase family, member 8 | 0.010 | ||
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.010 | ||
| SUMO4 | SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) | 0.010 | ||
| CUX1 | cut-like homeobox 1 | 0.010 | ||
| MCCC1 | methylcrotonoyl-CoA carboxylase 1 (alpha) | 0.010 | ||
| RFK | riboflavin kinase | 0.010 | ||
| MYCBP | c-myc binding protein | 0.010 |