IMP: Integrative Multi-species Prediction

Homo sapiens

26 genes annotated in human

Multi-species View

pyruvate metabolic process

GO:0006090

The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pyruvate metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "pyruvate metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
ALDOA	aldolase A, fructose-bisphosphate	0.999
LDHA	lactate dehydrogenase A	0.993
TPI1	triosephosphate isomerase 1	0.975	Fly
GPI	glucose-6-phosphate isomerase	0.969	Mouse
ENO1	enolase 1, (alpha)	0.966	Mouse
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.964	Fly
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	0.859
PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.856
NCOR2	nuclear receptor corepressor 2	0.832	Human
PKM2	pyruvate kinase, muscle	0.802
PGK1	phosphoglycerate kinase 1	0.794	Mouse
HNF4A	hepatocyte nuclear factor 4, alpha	0.790
PDHX	pyruvate dehydrogenase complex, component X	0.749
NCOR1	nuclear receptor corepressor 1	0.714
PPARA	peroxisome proliferator-activated receptor alpha	0.582
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.368
TUBGCP4	tubulin, gamma complex associated protein 4	0.340
INSR	insulin receptor	0.268
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.229
IRS1	insulin receptor substrate 1	0.224
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.200	Yeast
IGF1R	insulin-like growth factor 1 receptor	0.180	Human
ALDH1A1	aldehyde dehydrogenase 1 family, member A1	0.179	Yeast
ITGB1BP3	integrin beta 1 binding protein 3	0.157
MGEA5	meningioma expressed antigen 5 (hyaluronidase)	0.152
PGAM1	phosphoglycerate mutase 1 (brain)	0.152
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.124
VDAC1	voltage-dependent anion channel 1	0.112
GRB10	growth factor receptor-bound protein 10	0.104
GYS1	glycogen synthase 1 (muscle)	0.099
BBS1	Bardet-Biedl syndrome 1	0.095
RXRA	retinoid X receptor, alpha	0.086
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.086
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.080	Human
PFKP	phosphofructokinase, platelet	0.077	Human
EGLN1	egl nine homolog 1 (C. elegans)	0.074
HK1	hexokinase 1	0.074	Yeast
EGFR	epidermal growth factor receptor	0.072
ALDOC	aldolase C, fructose-bisphosphate	0.070	Human Fly
AGXT2	alanine--glyoxylate aminotransferase 2	0.068
GHR	growth hormone receptor	0.066
BCL6	B-cell CLL/lymphoma 6	0.066
TKT	transketolase	0.065
FAF1	Fas (TNFRSF6) associated factor 1	0.060
HDAC4	histone deacetylase 4	0.060	Mouse
HDAC3	histone deacetylase 3	0.058
VEGFA	vascular endothelial growth factor A	0.057
PDHB	pyruvate dehydrogenase (lipoamide) beta	0.054
IRS2	insulin receptor substrate 2	0.053
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.052
MEF2A	myocyte enhancer factor 2A	0.050
PTPRZ1	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	0.048
ESR1	estrogen receptor 1	0.044
PTN	pleiotrophin	0.041
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.040	Mouse
HR	hairless homolog (mouse)	0.040
PGR	progesterone receptor	0.037
BTRC	beta-transducin repeat containing	0.037
IGF2R	insulin-like growth factor 2 receptor	0.037
BCKDK	branched chain ketoacid dehydrogenase kinase	0.037
SLC16A3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)	0.036
FBP2	fructose-1,6-bisphosphatase 2	0.036	Human
TXNIP	thioredoxin interacting protein	0.036
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.035
ING2	inhibitor of growth family, member 2	0.034
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.034
ESRRG	estrogen-related receptor gamma	0.032
ILVBL	ilvB (bacterial acetolactate synthase)-like	0.031
TUBA4A	tubulin, alpha 4a	0.031
MARS	methionyl-tRNA synthetase	0.031
NCOA1	nuclear receptor coactivator 1	0.029
PGM1	phosphoglucomutase 1	0.029
MAP4	microtubule-associated protein 4	0.028
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.028
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.028
EGLN3	egl nine homolog 3 (C. elegans)	0.028
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.028
PFDN1	prefoldin subunit 1	0.027
MEF2C	myocyte enhancer factor 2C	0.027
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.027	Human Mouse
ENO2	enolase 2 (gamma, neuronal)	0.027	Rat
ST3GAL2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.027
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.026
MDH2	malate dehydrogenase 2, NAD (mitochondrial)	0.026
STAT5A	signal transducer and activator of transcription 5A	0.026
GCKR	glucokinase (hexokinase 4) regulator	0.024
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.024	Rat
CARS	cysteinyl-tRNA synthetase	0.023
STAT5B	signal transducer and activator of transcription 5B	0.023
ALDOB	aldolase B, fructose-bisphosphate	0.022
JAK2	Janus kinase 2	0.022
MLX	MAX-like protein X	0.022
EPAS1	endothelial PAS domain protein 1	0.022
GAPDHS	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.020	Fly
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.020
PGAM2	phosphoglycerate mutase 2 (muscle)	0.020
PFKL	phosphofructokinase, liver	0.019
SRSF5	serine/arginine-rich splicing factor 5	0.019
HDAC5	histone deacetylase 5	0.018
EPOR	erythropoietin receptor	0.018
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.018
LONP1	lon peptidase 1, mitochondrial	0.018
AQP7	aquaporin 7	0.018
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.017
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.017	Human
SIGIRR	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	0.017
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.017
IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	0.017
HTT	huntingtin	0.017	Mouse
PPP1R1A	protein phosphatase 1, regulatory (inhibitor) subunit 1A	0.017
GLYAT	glycine-N-acyltransferase	0.017
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.017
SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	0.017
MIF4GD	MIF4G domain containing	0.016
TF	transferrin	0.016
BBS4	Bardet-Biedl syndrome 4	0.016
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.016	Rat
POU2F1	POU class 2 homeobox 1	0.015
LAT	linker for activation of T cells	0.015
CLEC4G	C-type lectin domain family 4, member G	0.015
CDHR2	cadherin-related family member 2	0.015
FH	fumarate hydratase	0.015
NCOA6	nuclear receptor coactivator 6	0.015
C7orf68	chromosome 7 open reading frame 68	0.015
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.015
ATXN3	ataxin 3	0.015
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.015
RBP4	retinol binding protein 4, plasma	0.014
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.014
PSEN2	presenilin 2 (Alzheimer disease 4)	0.014
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.014
CFL1	cofilin 1 (non-muscle)	0.014
BHLHE40	basic helix-loop-helix family, member e40	0.014
PHGDH	phosphoglycerate dehydrogenase	0.014
C2orf18	chromosome 2 open reading frame 18	0.014
PLOD1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.013
BCAT2	branched chain amino-acid transaminase 2, mitochondrial	0.013
PPARG	peroxisome proliferator-activated receptor gamma	0.013	Human
ASL	argininosuccinate lyase	0.013
SP1	Sp1 transcription factor	0.013
APOC2	apolipoprotein C-II	0.013
STAT1	signal transducer and activator of transcription 1, 91kDa	0.013
NCOA2	nuclear receptor coactivator 2	0.013
MUC20	mucin 20, cell surface associated	0.013
AK4	adenylate kinase 4	0.013
FDX1	ferredoxin 1	0.013
HDAC7	histone deacetylase 7	0.013
SHBG	sex hormone-binding globulin	0.013
ERO1L	ERO1-like (S. cerevisiae)	0.013
TAT	tyrosine aminotransferase	0.013
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.013
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.013
GHITM	growth hormone inducible transmembrane protein	0.012
SESN2	sestrin 2	0.012
ENSA	endosulfine alpha	0.012
PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.012
EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1	0.012
SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	0.012
ACAD8	acyl-CoA dehydrogenase family, member 8	0.012
CHD9	chromodomain helicase DNA binding protein 9	0.012
NDRG1	N-myc downstream regulated 1	0.012
BBS2	Bardet-Biedl syndrome 2	0.012
EP300	E1A binding protein p300	0.012
ENO3	enolase 3 (beta, muscle)	0.012	Yeast
ANGPTL4	angiopoietin-like 4	0.012
DDB1	damage-specific DNA binding protein 1, 127kDa	0.012
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.011	Human
IGFBP1	insulin-like growth factor binding protein 1	0.011
SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	0.011
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.011
CAPNS1	calpain, small subunit 1	0.011
IGFBP3	insulin-like growth factor binding protein 3	0.011
HDAC9	histone deacetylase 9	0.011
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.011
PPM1E	protein phosphatase, Mg2+/Mn2+ dependent, 1E	0.011
CD4	CD4 molecule	0.011
ARNT	aryl hydrocarbon receptor nuclear translocator	0.011
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.011
TRIB3	tribbles homolog 3 (Drosophila)	0.011
PDPK1	3-phosphoinositide dependent protein kinase-1	0.011
AR	androgen receptor	0.011
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.011
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.011
G6PD	glucose-6-phosphate dehydrogenase	0.010
ADM	adrenomedullin	0.010
FABP1	fatty acid binding protein 1, liver	0.010
BCAR1	breast cancer anti-estrogen resistance 1	0.010
ACAT1	acetyl-CoA acetyltransferase 1	0.010
FAM162A	family with sequence similarity 162, member A	0.010
CDHR5	cadherin-related family member 5	0.010
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.010
HIPK2	homeodomain interacting protein kinase 2	0.010
HABP4	hyaluronan binding protein 4	0.010
SAP30	Sin3A-associated protein, 30kDa	0.010
TRIM32	tripartite motif containing 32	0.010
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.010
LDHC	lactate dehydrogenase C	0.010
DCAF11	DDB1 and CUL4 associated factor 11	0.010
ISOC2	isochorismatase domain containing 2	0.010
CAPN1	calpain 1, (mu/I) large subunit	0.010
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.010