IMP: Integrative Multi-species Prediction

Homo sapiens

1 genes annotated in human

Multi-species View

negative regulation of neural precursor cell proliferation

GO:2000178

Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of neural precursor cell proliferation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of neural precursor cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.999	Fly
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.982
TAL1	T-cell acute lymphocytic leukemia 1	0.922
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.863
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.671
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.652	Fly
TCP1	t-complex 1	0.619
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.443	Fly
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.410
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.409
BCOR	BCL6 corepressor	0.373
ETFA	electron-transfer-flavoprotein, alpha polypeptide	0.367
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.356
MED10	mediator complex subunit 10	0.322	Fly
IL1R1	interleukin 1 receptor, type I	0.264
NCK2	NCK adaptor protein 2	0.249
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.238
COX6C	cytochrome c oxidase subunit VIc	0.237
ARID1A	AT rich interactive domain 1A (SWI-like)	0.221
ATP5I	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E	0.216
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.208
MED28	mediator complex subunit 28	0.174
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.146
PARVA	parvin, alpha	0.145
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.142
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.128
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.126
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.124
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.119
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.115
ILK	integrin-linked kinase	0.112	Mouse
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.108
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.103	Fly
LPXN	leupaxin	0.102
CDK8	cyclin-dependent kinase 8	0.101
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.099
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.095
SKA3	spindle and kinetochore associated complex subunit 3	0.093
ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	0.086
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.079
NCOR1	nuclear receptor corepressor 1	0.077
TGFBR1	transforming growth factor, beta receptor 1	0.076
JUP	junction plakoglobin	0.075
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.073
IL1RAP	interleukin 1 receptor accessory protein	0.071
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.071
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.066
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.066
PPP4C	protein phosphatase 4, catalytic subunit	0.064
CREBBP	CREB binding protein	0.061
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.060
FSTL1	follistatin-like 1	0.059
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.057
PBRM1	polybromo 1	0.057
COX7C	cytochrome c oxidase subunit VIIc	0.056
HDAC6	histone deacetylase 6	0.054
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.054
PXN	paxillin	0.053
YY1	YY1 transcription factor	0.053
NAP1L1	nucleosome assembly protein 1-like 1	0.050
ZMYND11	zinc finger, MYND-type containing 11	0.050
COX5B	cytochrome c oxidase subunit Vb	0.048
MED27	mediator complex subunit 27	0.046
VDAC2	voltage-dependent anion channel 2	0.045
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.044
MED30	mediator complex subunit 30	0.043
SMAD2	SMAD family member 2	0.043
KLF13	Kruppel-like factor 13	0.043
SMAD1	SMAD family member 1	0.042
PSEN1	presenilin 1	0.040
RUNX1	runt-related transcription factor 1	0.040
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.040
APC	adenomatous polyposis coli	0.038
TBX5	T-box 5	0.037
IL8	interleukin 8	0.037
GATA2	GATA binding protein 2	0.034
SMAD7	SMAD family member 7	0.034
MED19	mediator complex subunit 19	0.034
BTRC	beta-transducin repeat containing	0.034
COX7B	cytochrome c oxidase subunit VIIb	0.033
PRKCZ	protein kinase C, zeta	0.033
CTNND1	catenin (cadherin-associated protein), delta 1	0.033
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.032
ZFPM1	zinc finger protein, multitype 1	0.031
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.031	Fly
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.031
HIPK2	homeodomain interacting protein kinase 2	0.031
CXCL2	chemokine (C-X-C motif) ligand 2	0.031
PARVB	parvin, beta	0.029
SERTAD4	SERTA domain containing 4	0.029
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.029
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.029
CTBP1	C-terminal binding protein 1	0.029
LIMS1	LIM and senescent cell antigen-like domains 1	0.029	Mouse
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.029
MED29	mediator complex subunit 29	0.028
CCNC	cyclin C	0.027
MYOD1	myogenic differentiation 1	0.027
IL1RN	interleukin 1 receptor antagonist	0.027
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.027	Human
NDUFA4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	0.027
CLSPN	claspin	0.027
AR	androgen receptor	0.027
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.026
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.026
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.026
RHOU	ras homolog gene family, member U	0.025
THBS1	thrombospondin 1	0.025
CCL20	chemokine (C-C motif) ligand 20	0.025
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.025
TCF12	transcription factor 12	0.024
RSU1	Ras suppressor protein 1	0.023
ACTN1	actinin, alpha 1	0.023
NDUFB1	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa	0.023
COX7A2	cytochrome c oxidase subunit VIIa polypeptide 2 (liver)	0.023
NDUFS4	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)	0.023
PEX14	peroxisomal biogenesis factor 14	0.022
CXCL3	chemokine (C-X-C motif) ligand 3	0.022
BTG1	B-cell translocation gene 1, anti-proliferative	0.022
TGFB3	transforming growth factor, beta 3	0.021
UQCR11	ubiquinol-cytochrome c reductase, complex III subunit XI	0.021
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.021
DOCK1	dedicator of cytokinesis 1	0.021
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.020
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.020
TCF4	transcription factor 4	0.020
MAX	MYC associated factor X	0.020
MED8	mediator complex subunit 8	0.020
PPME1	protein phosphatase methylesterase 1	0.020
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.020
UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1	0.020
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.019
HIC1	hypermethylated in cancer 1	0.019
PEBP1	phosphatidylethanolamine binding protein 1	0.019
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.019
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.019
DDR1	discoidin domain receptor tyrosine kinase 1	0.019
MYH9	myosin, heavy chain 9, non-muscle	0.019
MED18	mediator complex subunit 18	0.019
CKB	creatine kinase, brain	0.018
MED1	mediator complex subunit 1	0.018
ZNF746	zinc finger protein 746	0.018
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.018
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.018
CTNNBIP1	catenin, beta interacting protein 1	0.018
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.018	Fly
HIPK3	homeodomain interacting protein kinase 3	0.017
SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	0.017
PNRC1	proline-rich nuclear receptor coactivator 1	0.017
SMAD3	SMAD family member 3	0.017
RFWD2	ring finger and WD repeat domain 2	0.017
CNOT8	CCR4-NOT transcription complex, subunit 8	0.017
ECI1	enoyl-CoA delta isomerase 1	0.017
C22orf39	chromosome 22 open reading frame 39	0.017
COX4I1	cytochrome c oxidase subunit IV isoform 1	0.017	Fly
HAND2	heart and neural crest derivatives expressed 2	0.017
SMAD4	SMAD family member 4	0.017
CHCHD10	coiled-coil-helix-coiled-coil-helix domain containing 10	0.017
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.016
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.016
LHX2	LIM homeobox 2	0.016
APP	amyloid beta (A4) precursor protein	0.016
STAT5A	signal transducer and activator of transcription 5A	0.016
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.016
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.016
BMP2	bone morphogenetic protein 2	0.016
AXIN1	axin 1	0.016
MAPK8	mitogen-activated protein kinase 8	0.016
MED4	mediator complex subunit 4	0.016
LMO2	LIM domain only 2 (rhombotin-like 1)	0.016
BLVRB	biliverdin reductase B (flavin reductase (NADPH))	0.016
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.016
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.016
DMAP1	DNA methyltransferase 1 associated protein 1	0.015
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.015
DUSP1	dual specificity phosphatase 1	0.015
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.015
H3F3B	H3 histone, family 3B (H3.3B)	0.015
IER3	immediate early response 3	0.015
FLII	flightless I homolog (Drosophila)	0.015
RB1	retinoblastoma 1	0.015
POGZ	pogo transposable element with ZNF domain	0.015
EFNB2	ephrin-B2	0.015
SKP1	S-phase kinase-associated protein 1	0.015
HDAC3	histone deacetylase 3	0.015
MED26	mediator complex subunit 26	0.015
SNIP1	Smad nuclear interacting protein 1	0.015
MED14	mediator complex subunit 14	0.014
KAT2B	K(lysine) acetyltransferase 2B	0.014
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.014
IL6	interleukin 6 (interferon, beta 2)	0.014
TGFBR3	transforming growth factor, beta receptor III	0.014
GSK3B	glycogen synthase kinase 3 beta	0.014
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.014
TST	thiosulfate sulfurtransferase (rhodanese)	0.014
PAX5	paired box 5	0.014
ARRB2	arrestin, beta 2	0.014
MAK	male germ cell-associated kinase	0.014
SKIL	SKI-like oncogene	0.014
GATAD2B	GATA zinc finger domain containing 2B	0.013
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.013
EMD	emerin	0.013
CCL4	chemokine (C-C motif) ligand 4	0.013
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.013
SP1	Sp1 transcription factor	0.013
FBXW2	F-box and WD repeat domain containing 2	0.013
ACAA1	acetyl-CoA acyltransferase 1	0.013
KRT78	keratin 78	0.013
CDH5	cadherin 5, type 2 (vascular endothelium)	0.013
FBXW7	F-box and WD repeat domain containing 7	0.013
CSRP1	cysteine and glycine-rich protein 1	0.013
BRD3	bromodomain containing 3	0.013
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.013
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.013
MED17	mediator complex subunit 17	0.013
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.013
DHH	desert hedgehog	0.013
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.013
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.013
CNKSR1	connector enhancer of kinase suppressor of Ras 1	0.013
SURF1	surfeit 1	0.013
SAMM50	sorting and assembly machinery component 50 homolog (S. cerevisiae)	0.013
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.013
CYCS	cytochrome c, somatic	0.013
GLIS2	GLIS family zinc finger 2	0.013
ZNF579	zinc finger protein 579	0.013
INCENP	inner centromere protein antigens 135/155kDa	0.013
PRDX2	peroxiredoxin 2	0.013
CHD4	chromodomain helicase DNA binding protein 4	0.013
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.013
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.013
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.013
ALX4	ALX homeobox 4	0.013
SIX3	SIX homeobox 3	0.012
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.012
KIAA0802	KIAA0802	0.012
SATB1	SATB homeobox 1	0.012
SFRP5	secreted frizzled-related protein 5	0.012
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.012
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.012
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.012
ZFYVE9	zinc finger, FYVE domain containing 9	0.012
GATA3	GATA binding protein 3	0.012	Human
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.012
TBX2	T-box 2	0.012
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.012
WT1	Wilms tumor 1	0.012
LYL1	lymphoblastic leukemia derived sequence 1	0.012
COX6B1	cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)	0.012
ATP5L	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G	0.012
MGMT	O-6-methylguanine-DNA methyltransferase	0.012
CCL2	chemokine (C-C motif) ligand 2	0.012
SNW1	SNW domain containing 1	0.012
BIK	BCL2-interacting killer (apoptosis-inducing)	0.012
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.012
KRT1	keratin 1	0.012
ZBTB16	zinc finger and BTB domain containing 16	0.011
NDUFA5	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa	0.011
ANK1	ankyrin 1, erythrocytic	0.011
SMARCD2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	0.011
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.011
PEBP4	phosphatidylethanolamine-binding protein 4	0.011
PDPK1	3-phosphoinositide dependent protein kinase-1	0.011
BCL2L1	BCL2-like 1	0.011
CHD7	chromodomain helicase DNA binding protein 7	0.011
ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	0.011
HOXB9	homeobox B9	0.011
SPAG7	sperm associated antigen 7	0.011
CHMP2A	chromatin modifying protein 2A	0.011
MED9	mediator complex subunit 9	0.011
SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	0.011
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.011
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.011
DNAJC7	DnaJ (Hsp40) homolog, subfamily C, member 7	0.011
MED11	mediator complex subunit 11	0.011
NDUFA1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa	0.011
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.011
MSX1	msh homeobox 1	0.011
SOX2	SRY (sex determining region Y)-box 2	0.011
ZC3H12A	zinc finger CCCH-type containing 12A	0.011
COX7A2L	cytochrome c oxidase subunit VIIa polypeptide 2 like	0.011
CXCL5	chemokine (C-X-C motif) ligand 5	0.011
FST	follistatin	0.011
BANP	BTG3 associated nuclear protein	0.011
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.011
AMHR2	anti-Mullerian hormone receptor, type II	0.011
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.011
CALCOCO1	calcium binding and coiled-coil domain 1	0.011
DSP	desmoplakin	0.011
PABPN1	poly(A) binding protein, nuclear 1	0.011
PNKD	paroxysmal nonkinesigenic dyskinesia	0.011
SPINT1	serine peptidase inhibitor, Kunitz type 1	0.011
ANTXR2	anthrax toxin receptor 2	0.011
PIAS2	protein inhibitor of activated STAT, 2	0.011
ICAM4	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	0.011
CD83	CD83 molecule	0.011
KLF1	Kruppel-like factor 1 (erythroid)	0.011
SOD2	superoxide dismutase 2, mitochondrial	0.011
DOCK8	dedicator of cytokinesis 8	0.011
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
PF4	platelet factor 4	0.011
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.011
JPH3	junctophilin 3	0.011
C14orf2	chromosome 14 open reading frame 2	0.011
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.010
EGR1	early growth response 1	0.010
PKP3	plakophilin 3	0.010
RGS16	regulator of G-protein signaling 16	0.010
BAG1	BCL2-associated athanogene	0.010
C20orf94	chromosome 20 open reading frame 94	0.010
GSTZ1	glutathione transferase zeta 1	0.010
MEGF6	multiple EGF-like-domains 6	0.010
DACH1	dachshund homolog 1 (Drosophila)	0.010
TICAM2	toll-like receptor adaptor molecule 2	0.010
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.010
BAG2	BCL2-associated athanogene 2	0.010
AXIN2	axin 2	0.010
PML	promyelocytic leukemia	0.010
TGFB2	transforming growth factor, beta 2	0.010
POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	0.010
DUSP3	dual specificity phosphatase 3	0.010
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.010
SGOL1	shugoshin-like 1 (S. pombe)	0.010
GAB2	GRB2-associated binding protein 2	0.010
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.010
KLF2	Kruppel-like factor 2 (lung)	0.010
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.010
HES1	hairy and enhancer of split 1, (Drosophila)	0.010
TRRAP	transformation/transcription domain-associated protein	0.010
CDX2	caudal type homeobox 2	0.010
LIN54	lin-54 homolog (C. elegans)	0.010
SPINT2	serine peptidase inhibitor, Kunitz type, 2	0.010
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.010
MAP2K1	mitogen-activated protein kinase kinase 1	0.010
EDF1	endothelial differentiation-related factor 1	0.010
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.010