IMP: Integrative Multi-species Prediction

Homo sapiens

27 genes annotated in human

regulation of microtubule polymerization or depolymerization

Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of microtubule polymerization or depolymerization"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "regulation of microtubule polymerization or depolymerization" (in gray)

Name	Description	Probability	Func Analog Organism
MAPT	microtubule-associated protein tau	0.941
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.927
SKA2	spindle and kinetochore associated complex subunit 2	0.867
RACGAP1	Rac GTPase activating protein 1	0.860
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.828
SKA1	spindle and kinetochore associated complex subunit 1	0.796
FYN	FYN oncogene related to SRC, FGR, YES	0.752
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.714
KIF1B	kinesin family member 1B	0.687
CENPJ	centromere protein J	0.675
CDK2	cyclin-dependent kinase 2	0.662
TBCD	tubulin folding cofactor D	0.657
ARL2	ADP-ribosylation factor-like 2	0.623
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.595
ZNF746	zinc finger protein 746	0.582
BIRC5	baculoviral IAP repeat containing 5	0.580
KIF5B	kinesin family member 5B	0.577
ITGB4	integrin, beta 4	0.498
GLIS2	GLIS family zinc finger 2	0.438
CENPE	centromere protein E, 312kDa	0.435
APC	adenomatous polyposis coli	0.418
PSEN2	presenilin 2 (Alzheimer disease 4)	0.391
CDCA8	cell division cycle associated 8	0.328
SASS6	spindle assembly 6 homolog (C. elegans)	0.309
KIF23	kinesin family member 23	0.289
TUBA4A	tubulin, alpha 4a	0.286
KIF20A	kinesin family member 20A	0.278
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.245
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.242
MAPRE2	microtubule-associated protein, RP/EB family, member 2	0.238	Human
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.232	Human
EXOC1	exocyst complex component 1	0.227
XPO1	exportin 1 (CRM1 homolog, yeast)	0.218
CDK1	cyclin-dependent kinase 1	0.217
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.204
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.199
NEK6	NIMA (never in mitosis gene a)-related kinase 6	0.188
CKAP5	cytoskeleton associated protein 5	0.182	Fly
GSK3B	glycogen synthase kinase 3 beta	0.170
MARK2	MAP/microtubule affinity-regulating kinase 2	0.166
TEX11	testis expressed 11	0.162
CENPF	centromere protein F, 350/400kDa (mitosin)	0.153
SMAD9	SMAD family member 9	0.141
STIL	SCL/TAL1 interrupting locus	0.140
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.131
ACD	adrenocortical dysplasia homolog (mouse)	0.130
LMO2	LIM domain only 2 (rhombotin-like 1)	0.129
CCNE1	cyclin E1	0.125
JUN	jun proto-oncogene	0.103
CDKN3	cyclin-dependent kinase inhibitor 3	0.103
EXOC2	exocyst complex component 2	0.101
KIF2C	kinesin family member 2C	0.100
CCNB2	cyclin B2	0.099	Human
GPSM2	G-protein signaling modulator 2	0.097
EXOC7	exocyst complex component 7	0.094
MPHOSPH9	M-phase phosphoprotein 9	0.092
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.092
ARL3	ADP-ribosylation factor-like 3	0.088
SKA3	spindle and kinetochore associated complex subunit 3	0.080
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.079
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.079
SPTBN1	spectrin, beta, non-erythrocytic 1	0.077
AURKB	aurora kinase B	0.077
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.076
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.070
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.070
SNCAIP	synuclein, alpha interacting protein	0.069
DISC1	disrupted in schizophrenia 1	0.066
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.064
SPRR2A	small proline-rich protein 2A	0.062
CKS2	CDC28 protein kinase regulatory subunit 2	0.060
JUP	junction plakoglobin	0.060
PPP5C	protein phosphatase 5, catalytic subunit	0.059
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.059
FOXM1	forkhead box M1	0.057
STAG1	stromal antigen 1	0.057
CCNA2	cyclin A2	0.057
ZRANB1	zinc finger, RAN-binding domain containing 1	0.056
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.056
FYB	FYN binding protein	0.054
CCND1	cyclin D1	0.052
ATF7IP	activating transcription factor 7 interacting protein	0.049
SMC4	structural maintenance of chromosomes 4	0.049
VPS29	vacuolar protein sorting 29 homolog (S. cerevisiae)	0.048
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.048
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.048
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.047
FLNB	filamin B, beta	0.047
CCDC85A	coiled-coil domain containing 85A	0.045
NCAPD2	non-SMC condensin I complex, subunit D2	0.045
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.045
AURKA	aurora kinase A	0.045
KIF14	kinesin family member 14	0.044
KIF4A	kinesin family member 4A	0.043
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.042
KIF20B	kinesin family member 20B	0.040
TACC1	transforming, acidic coiled-coil containing protein 1	0.040
ACOT7	acyl-CoA thioesterase 7	0.040
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.039
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.039
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.039
LMNA	lamin A/C	0.037
CCNB1	cyclin B1	0.037
TNIK	TRAF2 and NCK interacting kinase	0.036
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.035
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.034
BBS10	Bardet-Biedl syndrome 10	0.034
MACF1	microtubule-actin crosslinking factor 1	0.034	Fly
CCND3	cyclin D3	0.033
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.032
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.032
CYLD	cylindromatosis (turban tumor syndrome)	0.032
PTTG1	pituitary tumor-transforming 1	0.031
TUBGCP5	tubulin, gamma complex associated protein 5	0.030
LBR	lamin B receptor	0.030
PBK	PDZ binding kinase	0.030
ZNF775	zinc finger protein 775	0.030
DCTN1	dynactin 1	0.030
PDE4DIP	phosphodiesterase 4D interacting protein	0.029
NCAPG	non-SMC condensin I complex, subunit G	0.028
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.028
FLNA	filamin A, alpha	0.028
UBE2C	ubiquitin-conjugating enzyme E2C	0.028
MZT1	mitotic spindle organizing protein 1	0.028
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.027
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.027
SUFU	suppressor of fused homolog (Drosophila)	0.027
RIN3	Ras and Rab interactor 3	0.027
INCENP	inner centromere protein antigens 135/155kDa	0.027
TRIM37	tripartite motif containing 37	0.027
MARK1	MAP/microtubule affinity-regulating kinase 1	0.027
EZR	ezrin	0.027
SEPT2	septin 2	0.026
COL17A1	collagen, type XVII, alpha 1	0.026
LRRK2	leucine-rich repeat kinase 2	0.026
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.025
CP110	CP110 protein	0.025
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.025
H2AFV	H2A histone family, member V	0.025
RABAC1	Rab acceptor 1 (prenylated)	0.024
DST	dystonin	0.024	Mouse Fly
TACC3	transforming, acidic coiled-coil containing protein 3	0.024
FNBP1	formin binding protein 1	0.023
PDPK1	3-phosphoinositide dependent protein kinase-1	0.023
ADRBK1	adrenergic, beta, receptor kinase 1	0.023
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.023
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.023
MAP2K4	mitogen-activated protein kinase kinase 4	0.023
DTNBP1	dystrobrevin binding protein 1	0.022
LARP1	La ribonucleoprotein domain family, member 1	0.021
GIGYF2	GRB10 interacting GYF protein 2	0.021
REEP5	receptor accessory protein 5	0.021
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.021
CTTN	cortactin	0.020
GAS2L3	growth arrest-specific 2 like 3	0.020	Human
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.019
FHL1	four and a half LIM domains 1	0.019
TOP3A	topoisomerase (DNA) III alpha	0.019
USP24	ubiquitin specific peptidase 24	0.019
TMPO	thymopoietin	0.019
ANKRD28	ankyrin repeat domain 28	0.018
PRC1	protein regulator of cytokinesis 1	0.018	Worm Fly
BICD1	bicaudal D homolog 1 (Drosophila)	0.018
GRAP2	GRB2-related adaptor protein 2	0.018
KIF11	kinesin family member 11	0.018	Fly
ANKRD17	ankyrin repeat domain 17	0.017
MAPK14	mitogen-activated protein kinase 14	0.017
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.017
MARK4	MAP/microtubule affinity-regulating kinase 4	0.017
ZFP106	zinc finger protein 106 homolog (mouse)	0.016
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.016
HSPA1B	heat shock 70kDa protein 1B	0.016
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.016
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.016
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.016
SLC9A6	solute carrier family 9 (sodium/hydrogen exchanger), member 6	0.015
ANK2	ankyrin 2, neuronal	0.015
SYN1	synapsin I	0.015
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.015
RAD21	RAD21 homolog (S. pombe)	0.015
ARIH2	ariadne homolog 2 (Drosophila)	0.015
TERF2	telomeric repeat binding factor 2	0.015	Human
CDK5	cyclin-dependent kinase 5	0.015
CCND2	cyclin D2	0.015
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.015
PLXND1	plexin D1	0.015
MAP1B	microtubule-associated protein 1B	0.015
TOPBP1	topoisomerase (DNA) II binding protein 1	0.015
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.015
TPPP	tubulin polymerization promoting protein	0.014
HSPA1A	heat shock 70kDa protein 1A	0.014
SPAG5	sperm associated antigen 5	0.014
BIN1	bridging integrator 1	0.014
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.014
TRIM63	tripartite motif containing 63	0.014
SIRT2	sirtuin 2	0.014
MAPK9	mitogen-activated protein kinase 9	0.014
SYNE1	spectrin repeat containing, nuclear envelope 1	0.013
APOBEC3B	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	0.013
ARHGAP19	Rho GTPase activating protein 19	0.013
HMGB2	high mobility group box 2	0.013
PTK2	PTK2 protein tyrosine kinase 2	0.013
CEP55	centrosomal protein 55kDa	0.013
SAC3D1	SAC3 domain containing 1	0.013
CBX1	chromobox homolog 1	0.013
SRSF8	serine/arginine-rich splicing factor 8	0.013
UNC45A	unc-45 homolog A (C. elegans)	0.012
CITED1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0.012
EVC2	Ellis van Creveld syndrome 2	0.012
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.012
SCRIB	scribbled homolog (Drosophila)	0.012
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.012
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.012
TRIO	triple functional domain (PTPRF interacting)	0.012
ATF2	activating transcription factor 2	0.012
ANLN	anillin, actin binding protein	0.012
ORC2	origin recognition complex, subunit 2	0.011
DOCK7	dedicator of cytokinesis 7	0.011
MYO9B	myosin IXB	0.011
ARL2BP	ADP-ribosylation factor-like 2 binding protein	0.011
LRP6	low density lipoprotein receptor-related protein 6	0.011
RASAL2	RAS protein activator like 2	0.011
FRZB	frizzled-related protein	0.011
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	0.011
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.011
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.011
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.011
PKP4	plakophilin 4	0.011
ECSIT	ECSIT homolog (Drosophila)	0.011
CLIP1	CAP-GLY domain containing linker protein 1	0.011
DCK	deoxycytidine kinase	0.011
RANBP2	RAN binding protein 2	0.011
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.011
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.010
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.010
RGS2	regulator of G-protein signaling 2, 24kDa	0.010	Rat
NIN	ninein (GSK3B interacting protein)	0.010
CDK6	cyclin-dependent kinase 6	0.010
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.010
AIP	aryl hydrocarbon receptor interacting protein	0.010
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.010
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.010
ATM	ataxia telangiectasia mutated	0.010
PHTF2	putative homeodomain transcription factor 2	0.010