IMP: Integrative Multi-species Prediction

Homo sapiens

14 genes annotated in human

non recombinational repair

A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "non recombinational repair"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "non recombinational repair" (in gray)

Name	Description	Probability	Func Analog Organism
BRCA1	breast cancer 1, early onset	0.990
BLM	Bloom syndrome, RecQ helicase-like	0.985	Fly
RPA1	replication protein A1, 70kDa	0.980
H2AFX	H2A histone family, member X	0.980
WRN	Werner syndrome, RecQ helicase-like	0.861
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.850
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.834
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.801
PARP1	poly (ADP-ribose) polymerase 1	0.769
APLF	aprataxin and PNKP like factor	0.697
MDC1	mediator of DNA-damage checkpoint 1	0.680
MSH6	mutS homolog 6 (E. coli)	0.668
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.650
PSMA4	proteasome (prosome, macropain) subunit, alpha type, 4	0.621
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.596
NBN	nibrin	0.508
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.421
BRCA2	breast cancer 2, early onset	0.362
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.313
CDK2	cyclin-dependent kinase 2	0.281	Yeast
SMC1A	structural maintenance of chromosomes 1A	0.245
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.233
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.218
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.216
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.161
PNKP	polynucleotide kinase 3'-phosphatase	0.142
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.136
PCNA	proliferating cell nuclear antigen	0.128
TERF2	telomeric repeat binding factor 2	0.127
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.121
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.109
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.101
RAD50	RAD50 homolog (S. cerevisiae)	0.090
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.086
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.086
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.072
APTX	aprataxin	0.072
FANCD2	Fanconi anemia, complementation group D2	0.072
PSMB4	proteasome (prosome, macropain) subunit, beta type, 4	0.066
RBL1	retinoblastoma-like 1 (p107)	0.062
E2F1	E2F transcription factor 1	0.057
LIG4	ligase IV, DNA, ATP-dependent	0.057
RB1	retinoblastoma 1	0.055
EXO1	exonuclease 1	0.048
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	0.046
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.041
CCNA2	cyclin A2	0.040
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.038
PRMT6	protein arginine methyltransferase 6	0.038
RBM10	RNA binding motif protein 10	0.030
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.030
RPA2	replication protein A2, 32kDa	0.029
PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.028
MCM3	minichromosome maintenance complex component 3	0.027
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.026
BARD1	BRCA1 associated RING domain 1	0.026
TIMELESS	timeless homolog (Drosophila)	0.026
FEN1	flap structure-specific endonuclease 1	0.024	Yeast
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.024
CCNE1	cyclin E1	0.023
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.023
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.022
ATM	ataxia telangiectasia mutated	0.022
RPA3	replication protein A3, 14kDa	0.021
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.020
NEIL3	nei endonuclease VIII-like 3 (E. coli)	0.020
PLK1	polo-like kinase 1	0.019
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.019
POMP	proteasome maturation protein	0.018
PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	0.018
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.018
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.018
ORC1	origin recognition complex, subunit 1	0.017
PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	0.016
RAD52	RAD52 homolog (S. cerevisiae)	0.016	Yeast
CUX1	cut-like homeobox 1	0.016
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.016
MSH3	mutS homolog 3 (E. coli)	0.016
ADRM1	adhesion regulating molecule 1	0.015
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.015
TP53	tumor protein p53	0.015
RBBP4	retinoblastoma binding protein 4	0.015
ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	0.014
ANP32E	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.014
ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	0.014
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.014
NCAPD2	non-SMC condensin I complex, subunit D2	0.013
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.013
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.013
DDX11	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	0.013
RIF1	RAP1 interacting factor homolog (yeast)	0.012
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.012
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.012
TOPBP1	topoisomerase (DNA) II binding protein 1	0.012
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.012
SUGP1	SURP and G patch domain containing 1	0.012
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.012	Mouse
POLE	polymerase (DNA directed), epsilon	0.012	Yeast
PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2	0.012
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.011
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.011
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.011
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.011
CCNB2	cyclin B2	0.011
C20orf94	chromosome 20 open reading frame 94	0.010
SF3A1	splicing factor 3a, subunit 1, 120kDa	0.010
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.010
RAD18	RAD18 homolog (S. cerevisiae)	0.010
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.010