IMP: Integrative Multi-species Prediction

Homo sapiens

23 genes annotated in human

Multi-species View

establishment of vesicle localization

GO:0051650

The directed movement of a vesicle to a specific location.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment of vesicle localization"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "establishment of vesicle localization" (in gray)

Name	Description	Probability	Func Analog Organism
ITSN1	intersectin 1 (SH3 domain protein)	0.999	Fly
DNM1	dynamin 1	0.996	Fly
SNAP25	synaptosomal-associated protein, 25kDa	0.989	Fly
DNM2	dynamin 2	0.977	Fly
LRRK2	leucine-rich repeat kinase 2	0.956
DTNBP1	dystrobrevin binding protein 1	0.899
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.880
AP2M1	adaptor-related protein complex 2, mu 1 subunit	0.853
MAP2K4	mitogen-activated protein kinase kinase 4	0.828
SH3GL3	SH3-domain GRB2-like 3	0.725	Fly
APP	amyloid beta (A4) precursor protein	0.669
NUMB	numb homolog (Drosophila)	0.625
AMPH	amphiphysin	0.618	Mouse
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.501
HTT	huntingtin	0.484
MAPT	microtubule-associated protein tau	0.470
GSK3B	glycogen synthase kinase 3 beta	0.414
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.402
KIAA1377	KIAA1377	0.397
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.394
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.393
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.393
SH3KBP1	SH3-domain kinase binding protein 1	0.391
SNX9	sorting nexin 9	0.316
PLDN	pallidin homolog (mouse)	0.306
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.304	Mouse
SH3GL2	SH3-domain GRB2-like 2	0.297	Mouse Fly
DAAM1	dishevelled associated activator of morphogenesis 1	0.287
EPS15	epidermal growth factor receptor pathway substrate 15	0.272	Worm Fly
FASLG	Fas ligand (TNF superfamily, member 6)	0.259
SOS1	son of sevenless homolog 1 (Drosophila)	0.248
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.216	Mouse Worm
APC	adenomatous polyposis coli	0.191
SH3GL1	SH3-domain GRB2-like 1	0.171	Fly
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.169	Rat
MUTED	muted homolog (mouse)	0.168
RAB1A	RAB1A, member RAS oncogene family	0.166
STX4	syntaxin 4	0.166	Rat
SEC24D	SEC24 family, member D (S. cerevisiae)	0.165
KIF5B	kinesin family member 5B	0.158	Mouse Rat Worm
ARRB2	arrestin, beta 2	0.151
EGFR	epidermal growth factor receptor	0.150
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.141
HSPA1B	heat shock 70kDa protein 1B	0.141
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.136
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.135	Fly
ARF6	ADP-ribosylation factor 6	0.135
STX5	syntaxin 5	0.132
WNK4	WNK lysine deficient protein kinase 4	0.128
PRKCZ	protein kinase C, zeta	0.127	Rat
TMED2	transmembrane emp24 domain trafficking protein 2	0.123
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.118
JUN	jun proto-oncogene	0.116
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.110
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.110
MAPK14	mitogen-activated protein kinase 14	0.106
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	0.105
GRB2	growth factor receptor-bound protein 2	0.104
OCRL	oculocerebrorenal syndrome of Lowe	0.103
ARF4	ADP-ribosylation factor 4	0.102
COPS4	COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)	0.100
DAPK1	death-associated protein kinase 1	0.099
RAB7A	RAB7A, member RAS oncogene family	0.099
MAP2K7	mitogen-activated protein kinase kinase 7	0.094
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.092	Mouse
RAP1GAP	RAP1 GTPase activating protein	0.091
TOR1A	torsin family 1, member A (torsin A)	0.090
DPYSL4	dihydropyrimidinase-like 4	0.090
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.090
WASL	Wiskott-Aldrich syndrome-like	0.089	Rat
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.089
FGF1	fibroblast growth factor 1 (acidic)	0.087
SYNJ1	synaptojanin 1	0.086	Mouse Fly
BTBD10	BTB (POZ) domain containing 10	0.085
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.083
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.083
CSNK1A1	casein kinase 1, alpha 1	0.082
HIP1	huntingtin interacting protein 1	0.082
EPS8	epidermal growth factor receptor pathway substrate 8	0.081
MAP4	microtubule-associated protein 4	0.081
EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	0.079
GORASP2	golgi reassembly stacking protein 2, 55kDa	0.071
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.069
MTF1	metal-regulatory transcription factor 1	0.066
COPB2	coatomer protein complex, subunit beta 2 (beta prime)	0.061
PACSIN1	protein kinase C and casein kinase substrate in neurons 1	0.059	Mouse
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.059
MAPK1	mitogen-activated protein kinase 1	0.059
OPTN	optineurin	0.055
RPN2	ribophorin II	0.055
TJP2	tight junction protein 2 (zona occludens 2)	0.054
FGF10	fibroblast growth factor 10	0.051
CLASP1	cytoplasmic linker associated protein 1	0.051
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.050
CTTN	cortactin	0.049
MAPK8	mitogen-activated protein kinase 8	0.049	Worm
PSEN1	presenilin 1	0.048	Mouse
STON2	stonin 2	0.047
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.047
FAM190B	family with sequence similarity 190, member B	0.046
ANXA7	annexin A7	0.045
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.041
MLPH	melanophilin	0.040
VIM	vimentin	0.040
BBS1	Bardet-Biedl syndrome 1	0.039
SNAPIN	SNAP-associated protein	0.038
TOR1AIP2	torsin A interacting protein 2	0.038
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.037
NCF1	neutrophil cytosolic factor 1	0.037
PABPC1	poly(A) binding protein, cytoplasmic 1	0.037
STX1A	syntaxin 1A (brain)	0.036	Mouse Rat Fly
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.036
MAPK3	mitogen-activated protein kinase 3	0.036
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.035
BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	0.035
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.035
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.035
UPF3A	UPF3 regulator of nonsense transcripts homolog A (yeast)	0.035
GOLGA2	golgin A2	0.034
CPEB4	cytoplasmic polyadenylation element binding protein 4	0.033
DCTN1	dynactin 1	0.033	Mouse
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.033
DUSP3	dual specificity phosphatase 3	0.033
IQGAP1	IQ motif containing GTPase activating protein 1	0.032
SQSTM1	sequestosome 1	0.032
FBXW11	F-box and WD repeat domain containing 11	0.032
SYT1	synaptotagmin I	0.031	Mouse Fly
ARRB1	arrestin, beta 1	0.030
MAPK6	mitogen-activated protein kinase 6	0.029
AGFG1	ArfGAP with FG repeats 1	0.029
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.029	Fly
RBM8A	RNA binding motif protein 8A	0.029
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.028
SNAP23	synaptosomal-associated protein, 23kDa	0.028	Fly
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.027
PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	0.027
DPP3	dipeptidyl-peptidase 3	0.027
RAB6A	RAB6A, member RAS oncogene family	0.026
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.026
MAST1	microtubule associated serine/threonine kinase 1	0.026
PEBP4	phosphatidylethanolamine-binding protein 4	0.026
RAB5A	RAB5A, member RAS oncogene family	0.026
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.025
FXR2	fragile X mental retardation, autosomal homolog 2	0.025
CADM4	cell adhesion molecule 4	0.025
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.024
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.024
MED31	mediator complex subunit 31	0.024
CTNND1	catenin (cadherin-associated protein), delta 1	0.024
PINK1	PTEN induced putative kinase 1	0.024
CLIP1	CAP-GLY domain containing linker protein 1	0.024
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.024
CRMP1	collapsin response mediator protein 1	0.024
RABIF	RAB interacting factor	0.024
ERC2	ELKS/RAB6-interacting/CAST family member 2	0.023
TRIP6	thyroid hormone receptor interactor 6	0.023
SMG7	Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.023
RAB10	RAB10, member RAS oncogene family	0.023
KLC1	kinesin light chain 1	0.023	Worm
MAP1B	microtubule-associated protein 1B	0.022
DPPA4	developmental pluripotency associated 4	0.022
RUSC2	RUN and SH3 domain containing 2	0.022
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.021
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.021
LIN7A	lin-7 homolog A (C. elegans)	0.021	Mouse
F11R	F11 receptor	0.021
TOR1B	torsin family 1, member B (torsin B)	0.021	Human
SEPT8	septin 8	0.020
LDOC1	leucine zipper, down-regulated in cancer 1	0.020
MBIP	MAP3K12 binding inhibitory protein 1	0.020
ZDHHC17	zinc finger, DHHC-type containing 17	0.019
ARCN1	archain 1	0.019
PRRC2C	proline-rich coiled-coil 2C	0.019
NPTN	neuroplastin	0.019
STX12	syntaxin 12	0.019
RAB14	RAB14, member RAS oncogene family	0.019
PICALM	phosphatidylinositol binding clathrin assembly protein	0.019	Mouse Worm Fly
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.019
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.019
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.019
MYO5A	myosin VA (heavy chain 12, myoxin)	0.019
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.018
PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.018
KBTBD7	kelch repeat and BTB (POZ) domain containing 7	0.018
RALGDS	ral guanine nucleotide dissociation stimulator	0.018
TSC2	tuberous sclerosis 2	0.018
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.017
DLG4	discs, large homolog 4 (Drosophila)	0.017	Mouse
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.017	Fly
LRP6	low density lipoprotein receptor-related protein 6	0.017
PRKCA	protein kinase C, alpha	0.017
NIN	ninein (GSK3B interacting protein)	0.017
PTPRO	protein tyrosine phosphatase, receptor type, O	0.017
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.017
APLP1	amyloid beta (A4) precursor-like protein 1	0.017
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.016	Fly
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.016
SPOP	speckle-type POZ protein	0.016
AP3B1	adaptor-related protein complex 3, beta 1 subunit	0.016	Mouse
SSFA2	sperm specific antigen 2	0.016
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.016
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.016
FGF7	fibroblast growth factor 7	0.016
ALAS1	aminolevulinate, delta-, synthase 1	0.016
PFN2	profilin 2	0.016	Mouse
GPKOW	G patch domain and KOW motifs	0.016
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.016
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.015
WDFY3	WD repeat and FYVE domain containing 3	0.015
YAP1	Yes-associated protein 1	0.015
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.015
RAB27A	RAB27A, member RAS oncogene family	0.015	Mouse Worm
RFWD2	ring finger and WD repeat domain 2	0.015
CEP170	centrosomal protein 170kDa	0.015
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.014
MYO16	myosin XVI	0.014
NSF	N-ethylmaleimide-sensitive factor	0.014	Fly
BSN	bassoon (presynaptic cytomatrix protein)	0.014
ARL8B	ADP-ribosylation factor-like 8B	0.014
WDYHV1	WDYHV motif containing 1	0.014
MAP2K1	mitogen-activated protein kinase kinase 1	0.014	Rat
CORO1C	coronin, actin binding protein, 1C	0.014
PLEKHB2	pleckstrin homology domain containing, family B (evectins) member 2	0.014
STRN3	striatin, calmodulin binding protein 3	0.014
JUP	junction plakoglobin	0.014
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.014	Mouse
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.014	Mouse
MARK1	MAP/microtubule affinity-regulating kinase 1	0.014
RABAC1	Rab acceptor 1 (prenylated)	0.014
MYO1E	myosin IE	0.014
RAB3A	RAB3A, member RAS oncogene family	0.014	Mouse Rat
EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.014
ARHGAP31	Rho GTPase activating protein 31	0.014
SEC24C	SEC24 family, member C (S. cerevisiae)	0.014
ZBTB43	zinc finger and BTB domain containing 43	0.014
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.014
PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	0.014
RAP2C	RAP2C, member of RAS oncogene family	0.013
PIP5K1C	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	0.013
PRKCI	protein kinase C, iota	0.013
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.013
BAD	BCL2-associated agonist of cell death	0.013
GDI1	GDP dissociation inhibitor 1	0.013
RAB2A	RAB2A, member RAS oncogene family	0.013
ATF2	activating transcription factor 2	0.013
ABI1	abl-interactor 1	0.013
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.013
CPLX1	complexin 1	0.013
CCDC88A	coiled-coil domain containing 88A	0.013
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.013
PDE4DIP	phosphodiesterase 4D interacting protein	0.013
VAMP4	vesicle-associated membrane protein 4	0.013
TAOK1	TAO kinase 1	0.013
FNDC3B	fibronectin type III domain containing 3B	0.013
PKP4	plakophilin 4	0.013
KIAA1549	KIAA1549	0.013
RECQL5	RecQ protein-like 5	0.013
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.013
SEC24A	SEC24 family, member A (S. cerevisiae)	0.012
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.012
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.012
ADAM10	ADAM metallopeptidase domain 10	0.012
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.012
TNK2	tyrosine kinase, non-receptor, 2	0.012
AATF	apoptosis antagonizing transcription factor	0.012
NCSTN	nicastrin	0.012
CLPTM1	cleft lip and palate associated transmembrane protein 1	0.012
RACGAP1	Rac GTPase activating protein 1	0.012
RUNDC3A	RUN domain containing 3A	0.012
EMD	emerin	0.012
DOCK7	dedicator of cytokinesis 7	0.012
CNTF	ciliary neurotrophic factor	0.012
DSP	desmoplakin	0.012
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.011
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.011
ADAM9	ADAM metallopeptidase domain 9	0.011
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.011
SDF4	stromal cell derived factor 4	0.011
SEC23A	Sec23 homolog A (S. cerevisiae)	0.011	Yeast
CDC25B	cell division cycle 25 homolog B (S. pombe)	0.011
ACTL6B	actin-like 6B	0.011
AP1B1	adaptor-related protein complex 1, beta 1 subunit	0.011
EXOC7	exocyst complex component 7	0.011
RPH3A	rabphilin 3A homolog (mouse)	0.011
DYNC1LI2	dynein, cytoplasmic 1, light intermediate chain 2	0.011
SDC2	syndecan 2	0.011
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.011
SH3BP4	SH3-domain binding protein 4	0.011
AGTPBP1	ATP/GTP binding protein 1	0.011
REEP5	receptor accessory protein 5	0.011
NADK	NAD kinase	0.011
MARK2	MAP/microtubule affinity-regulating kinase 2	0.011
ABLIM1	actin binding LIM protein 1	0.011
CABLES1	Cdk5 and Abl enzyme substrate 1	0.011
PRMT6	protein arginine methyltransferase 6	0.011
RUNDC3B	RUN domain containing 3B	0.010
DCX	doublecortin	0.010
SIGMAR1	sigma non-opioid intracellular receptor 1	0.010
CSNK1E	casein kinase 1, epsilon	0.010
MAP3K10	mitogen-activated protein kinase kinase kinase 10	0.010
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.010
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.010
ARF5	ADP-ribosylation factor 5	0.010
MARK3	MAP/microtubule affinity-regulating kinase 3	0.010
EXOC8	exocyst complex component 8	0.010
GAPVD1	GTPase activating protein and VPS9 domains 1	0.010
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.010
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.010
CAB39	calcium binding protein 39	0.010
NEFL	neurofilament, light polypeptide	0.010
SRPK2	SRSF protein kinase 2	0.010