IMP: Integrative Multi-species Prediction

Homo sapiens

14 genes annotated in human

Multi-species View

defense response to gram negative bacterium

GO:0050829

Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "defense response to gram negative bacterium"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "defense response to gram negative bacterium" (in gray)

Name	Description	Probability	Func Analog Organism
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.965
MAPK14	mitogen-activated protein kinase 14	0.877	Worm
ATF2	activating transcription factor 2	0.624
FGF1	fibroblast growth factor 1 (acidic)	0.580
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.550
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.409
NLRC4	NLR family, CARD domain containing 4	0.320
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.264
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.261
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.202
SMAD4	SMAD family member 4	0.122
CREBBP	CREB binding protein	0.116
RNASE4	ribonuclease, RNase A family, 4	0.101	Human
IRAK1	interleukin-1 receptor-associated kinase 1	0.098
DGCR8	DiGeorge syndrome critical region gene 8	0.097
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.096	Fly
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.088	Fly
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.068
HTT	huntingtin	0.067
ENG	endoglin	0.066
ANG	angiogenin, ribonuclease, RNase A family, 5	0.064	Human Zebrafish
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.064
CCL3	chemokine (C-C motif) ligand 3	0.056
IL23A	interleukin 23, alpha subunit p19	0.055
IL6	interleukin 6 (interferon, beta 2)	0.051
RIPK2	receptor-interacting serine-threonine kinase 2	0.051
MBD1	methyl-CpG binding domain protein 1	0.049
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.042
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.040	Fly
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.040
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.039
PLAU	plasminogen activator, urokinase	0.038
MAPK1	mitogen-activated protein kinase 1	0.037
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.035
LY96	lymphocyte antigen 96	0.035
TRAF6	TNF receptor-associated factor 6	0.034
IL6R	interleukin 6 receptor	0.032
TCF4	transcription factor 4	0.031
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.031
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.029
CSTF2	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	0.028
UBA1	ubiquitin-like modifier activating enzyme 1	0.027
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.027	Fly
CAT	catalase	0.026
MAPK8	mitogen-activated protein kinase 8	0.025
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.025
PYCARD	PYD and CARD domain containing	0.024
ELF4	E74-like factor 4 (ets domain transcription factor)	0.024
HSPB1	heat shock 27kDa protein 1	0.024
LRRK2	leucine-rich repeat kinase 2	0.023
TGFBR1	transforming growth factor, beta receptor 1	0.023
PLAUR	plasminogen activator, urokinase receptor	0.022
OSBPL9	oxysterol binding protein-like 9	0.020
TIMM9	translocase of inner mitochondrial membrane 9 homolog (yeast)	0.020
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.020
PLAT	plasminogen activator, tissue	0.020
CFLAR	CASP8 and FADD-like apoptosis regulator	0.020
HDAC7	histone deacetylase 7	0.020
CHD3	chromodomain helicase DNA binding protein 3	0.019
CPNE6	copine VI (neuronal)	0.019
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.019
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.019
THBS1	thrombospondin 1	0.018
FAS	Fas (TNF receptor superfamily, member 6)	0.018
IL22	interleukin 22	0.018
DUSP1	dual specificity phosphatase 1	0.018
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.018
MYD88	myeloid differentiation primary response gene (88)	0.018
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.018
SMAD5	SMAD family member 5	0.018
SMAD2	SMAD family member 2	0.017
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.017
PYDC2	pyrin domain containing 2	0.016
WRN	Werner syndrome, RecQ helicase-like	0.016
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.015
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.015
CD14	CD14 molecule	0.015
SMAD3	SMAD family member 3	0.014
TICAM2	toll-like receptor adaptor molecule 2	0.014
TP73	tumor protein p73	0.014
SEC23A	Sec23 homolog A (S. cerevisiae)	0.014
VTN	vitronectin	0.014
C4BPA	complement component 4 binding protein, alpha	0.013
BAG3	BCL2-associated athanogene 3	0.013
IRF3	interferon regulatory factor 3	0.013
CUL1	cullin 1	0.013
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.013
MEFV	Mediterranean fever	0.013
RIN1	Ras and Rab interactor 1	0.013
SOCS3	suppressor of cytokine signaling 3	0.013
DUSP9	dual specificity phosphatase 9	0.013
CP110	CP110 protein	0.013
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.013
SQSTM1	sequestosome 1	0.012
BCL3	B-cell CLL/lymphoma 3	0.012
UBQLN4	ubiquilin 4	0.012
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.012
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.012
CDK8	cyclin-dependent kinase 8	0.012
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.012
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.011	Fly
CUL3	cullin 3	0.011
ETFDH	electron-transferring-flavoprotein dehydrogenase	0.011
SP1	Sp1 transcription factor	0.011
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.011
TRAF5	TNF receptor-associated factor 5	0.011
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.011
SMAD9	SMAD family member 9	0.011
SMAD1	SMAD family member 1	0.011
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.011	Fly
EHD1	EH-domain containing 1	0.011
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.010
RCHY1	ring finger and CHY zinc finger domain containing 1	0.010
FGF2	fibroblast growth factor 2 (basic)	0.010
IGF2	insulin-like growth factor 2 (somatomedin A)	0.010
SMN1	survival of motor neuron 1, telomeric	0.010
FGF10	fibroblast growth factor 10	0.010
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.010	Fly