IMP: Integrative Multi-species Prediction

Homo sapiens

27 genes annotated in human

Multi-species View

neutral lipid metabolic process

GO:0006638

The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neutral lipid metabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "neutral lipid metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
APOE	apolipoprotein E	0.981
ALB	albumin	0.962
APOA1	apolipoprotein A-I	0.950	Human
RNASE4	ribonuclease, RNase A family, 4	0.889	Human
HP	haptoglobin	0.833
APP	amyloid beta (A4) precursor protein	0.725
CREBBP	CREB binding protein	0.645
CCNE1	cyclin E1	0.610
ANG	angiogenin, ribonuclease, RNase A family, 5	0.592
SKP2	S-phase kinase-associated protein 2 (p45)	0.546
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.534
APOC1	apolipoprotein C-I	0.495
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.456
LCAT	lecithin-cholesterol acyltransferase	0.384
LDLR	low density lipoprotein receptor	0.317	Mouse
APOC3	apolipoprotein C-III	0.314
FRS2	fibroblast growth factor receptor substrate 2	0.314
GAB1	GRB2-associated binding protein 1	0.277
NCOA1	nuclear receptor coactivator 1	0.276
DUSP23	dual specificity phosphatase 23	0.274
APOB	apolipoprotein B (including Ag(x) antigen)	0.264	Mouse
SREBF2	sterol regulatory element binding transcription factor 2	0.230
AR	androgen receptor	0.225
CFH	complement factor H	0.217
MPZL1	myelin protein zero-like 1	0.216
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.155	Mouse
RXRA	retinoid X receptor, alpha	0.143
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.141
PPARA	peroxisome proliferator-activated receptor alpha	0.131
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.126
CDK2	cyclin-dependent kinase 2	0.117	Yeast
CCDC6	coiled-coil domain containing 6	0.117
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.112
IL6R	interleukin 6 receptor	0.111
FOXM1	forkhead box M1	0.111
APOC2	apolipoprotein C-II	0.107
APOA2	apolipoprotein A-II	0.098
IRS1	insulin receptor substrate 1	0.095
IGF1R	insulin-like growth factor 1 receptor	0.094
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.091
MAPT	microtubule-associated protein tau	0.091
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.086
SKP1	S-phase kinase-associated protein 1	0.084
MSTO1	misato homolog 1 (Drosophila)	0.078
CAV2	caveolin 2	0.073
ECSIT	ECSIT homolog (Drosophila)	0.072
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.071
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.068
RNH1	ribonuclease/angiogenin inhibitor 1	0.067
INSIG1	insulin induced gene 1	0.067	Mouse
LEPR	leptin receptor	0.065
ACSL1	acyl-CoA synthetase long-chain family member 1	0.062	Rat
CFI	complement factor I	0.059
ALDOB	aldolase B, fructose-bisphosphate	0.058
JAK2	Janus kinase 2	0.057
UBXN2A	UBX domain protein 2A	0.055
RARA	retinoic acid receptor, alpha	0.054
CFB	complement factor B	0.054
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.054
C2	complement component 2	0.054
TNIK	TRAF2 and NCK interacting kinase	0.051
PECAM1	platelet/endothelial cell adhesion molecule	0.050
FABP4	fatty acid binding protein 4, adipocyte	0.050
PPARG	peroxisome proliferator-activated receptor gamma	0.050
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.047
A2M	alpha-2-macroglobulin	0.047	Human
LAMC3	laminin, gamma 3	0.045
WBP11	WW domain binding protein 11	0.042
TTR	transthyretin	0.041
INSR	insulin receptor	0.041
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.040
RPL18A	ribosomal protein L18a	0.040
VSIG4	V-set and immunoglobulin domain containing 4	0.039
AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.038
PCSK9	proprotein convertase subtilisin/kexin type 9	0.038
FOXO3	forkhead box O3	0.038
CLEC4G	C-type lectin domain family 4, member G	0.038
JAK1	Janus kinase 1	0.038
MED15	mediator complex subunit 15	0.037
TRIM11	tripartite motif containing 11	0.033
GAB2	GRB2-associated binding protein 2	0.033
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.032
PLTP	phospholipid transfer protein	0.030
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.030
HNF4A	hepatocyte nuclear factor 4, alpha	0.030
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.030
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.029
TBL1X	transducin (beta)-like 1X-linked	0.029
APOA4	apolipoprotein A-IV	0.028
THRSP	thyroid hormone responsive	0.028
MDK	midkine (neurite growth-promoting factor 2)	0.028
SNCAIP	synuclein, alpha interacting protein	0.028
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.027
RBP4	retinol binding protein 4, plasma	0.027
IDH3G	isocitrate dehydrogenase 3 (NAD+) gamma	0.026
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.026
HTT	huntingtin	0.026
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.025
EDF1	endothelial differentiation-related factor 1	0.024
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.024
ACAA2	acetyl-CoA acyltransferase 2	0.024
KAT2B	K(lysine) acetyltransferase 2B	0.024
MED13L	mediator complex subunit 13-like	0.024
PSEN1	presenilin 1	0.024
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.024	Mouse
LIPE	lipase, hormone-sensitive	0.024
SMN1	survival of motor neuron 1, telomeric	0.023
DHCR7	7-dehydrocholesterol reductase	0.023
CYB5A	cytochrome b5 type A (microsomal)	0.023
LPA	lipoprotein, Lp(a)	0.023
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.023
TPPP	tubulin polymerization promoting protein	0.023
MED25	mediator complex subunit 25	0.022
FBXW11	F-box and WD repeat domain containing 11	0.022
PDK4	pyruvate dehydrogenase kinase, isozyme 4	0.022
IDI1	isopentenyl-diphosphate delta isomerase 1	0.021
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.021
GLIS2	GLIS family zinc finger 2	0.021
SCARB1	scavenger receptor class B, member 1	0.021	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.021
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.020
CA5A	carbonic anhydrase VA, mitochondrial	0.020
SPTBN1	spectrin, beta, non-erythrocytic 1	0.020
LIPC	lipase, hepatic	0.020
ANXA4	annexin A4	0.020
DSE	dermatan sulfate epimerase	0.020
CAT	catalase	0.019	Mouse
CCNB2	cyclin B2	0.019
CIDEC	cell death-inducing DFFA-like effector c	0.019
ALAS1	aminolevulinate, delta-, synthase 1	0.019
ABHD5	abhydrolase domain containing 5	0.019
AQP7	aquaporin 7	0.018
CTNNBIP1	catenin, beta interacting protein 1	0.018
PTPRF	protein tyrosine phosphatase, receptor type, F	0.018
CFD	complement factor D (adipsin)	0.018
CLEC3B	C-type lectin domain family 3, member B	0.018
NSFL1C	NSFL1 (p97) cofactor (p47)	0.018
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.018
PTEN	phosphatase and tensin homolog	0.017
PLIN4	perilipin 4	0.017
GSK3B	glycogen synthase kinase 3 beta	0.017
KNG1	kininogen 1	0.017
TCF4	transcription factor 4	0.016
MBNL2	muscleblind-like 2 (Drosophila)	0.016
APOC4	apolipoprotein C-IV	0.016
CLDN5	claudin 5	0.016
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.016
MTTP	microsomal triglyceride transfer protein	0.016
LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	0.016
PDE4DIP	phosphodiesterase 4D interacting protein	0.016
APCS	amyloid P component, serum	0.015
AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.015
SQLE	squalene epoxidase	0.015
FADS1	fatty acid desaturase 1	0.015
PC	pyruvate carboxylase	0.015
HPD	4-hydroxyphenylpyruvate dioxygenase	0.015
F2R	coagulation factor II (thrombin) receptor	0.015
AGXT2	alanine--glyoxylate aminotransferase 2	0.015
FASN	fatty acid synthase	0.015
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.015
TXNRD1	thioredoxin reductase 1	0.015
NIPSNAP1	nipsnap homolog 1 (C. elegans)	0.015
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	0.015
PKLR	pyruvate kinase, liver and RBC	0.015
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.015
PAH	phenylalanine hydroxylase	0.014
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.014
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.014
CP	ceruloplasmin (ferroxidase)	0.014
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.014
CPD	carboxypeptidase D	0.014
TSC22D1	TSC22 domain family, member 1	0.014
AGXT	alanine-glyoxylate aminotransferase	0.014
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.014
ASGR2	asialoglycoprotein receptor 2	0.014
CD302	CD302 molecule	0.014
ORM1	orosomucoid 1	0.014
LIFR	leukemia inhibitory factor receptor alpha	0.014
CPB2	carboxypeptidase B2 (plasma)	0.014
CNTF	ciliary neurotrophic factor	0.013
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.013
PINK1	PTEN induced putative kinase 1	0.013
SEPP1	selenoprotein P, plasma, 1	0.013
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.013
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.013
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.013
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.013
C4BPB	complement component 4 binding protein, beta	0.013
CRP	C-reactive protein, pentraxin-related	0.013
ALDH1A1	aldehyde dehydrogenase 1 family, member A1	0.013
GGPS1	geranylgeranyl diphosphate synthase 1	0.013
A1BG	alpha-1-B glycoprotein	0.013
GRB10	growth factor receptor-bound protein 10	0.013
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.013
CIDEA	cell death-inducing DFFA-like effector a	0.013
STARD4	StAR-related lipid transfer (START) domain containing 4	0.013
FABP1	fatty acid binding protein 1, liver	0.013
HIC1	hypermethylated in cancer 1	0.013
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.013
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.013
HNMT	histamine N-methyltransferase	0.012
GPX3	glutathione peroxidase 3 (plasma)	0.012
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.012
DOCK7	dedicator of cytokinesis 7	0.012
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.012
SEPT8	septin 8	0.012
LRP1	low density lipoprotein receptor-related protein 1	0.012
GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.012
CD36	CD36 molecule (thrombospondin receptor)	0.012	Rat
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	0.012
RYK	RYK receptor-like tyrosine kinase	0.012
ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	0.012
USE1	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	0.012
BHLHE40	basic helix-loop-helix family, member e40	0.012
FGA	fibrinogen alpha chain	0.012
MEF2C	myocyte enhancer factor 2C	0.012
ACADS	acyl-CoA dehydrogenase, C-2 to C-3 short chain	0.012
NR1H3	nuclear receptor subfamily 1, group H, member 3	0.012
RUNX1	runt-related transcription factor 1	0.012
HDAC3	histone deacetylase 3	0.011
FAM83C	family with sequence similarity 83, member C	0.011
ASGR1	asialoglycoprotein receptor 1	0.011
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.011	Rat
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011
DECR1	2,4-dienoyl CoA reductase 1, mitochondrial	0.011
SDPR	serum deprivation response	0.011
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.011
G6PC	glucose-6-phosphatase, catalytic subunit	0.011
SELENBP1	selenium binding protein 1	0.011
PON1	paraoxonase 1	0.011
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	0.011
EIF3G	eukaryotic translation initiation factor 3, subunit G	0.011
CDK19	cyclin-dependent kinase 19	0.011
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.011
MAT1A	methionine adenosyltransferase I, alpha	0.011
PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	0.011
MGST1	microsomal glutathione S-transferase 1	0.011
TST	thiosulfate sulfurtransferase (rhodanese)	0.011
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.011	Rat
C7orf60	chromosome 7 open reading frame 60	0.011
FAM114A1	family with sequence similarity 114, member A1	0.011
SUGP1	SURP and G patch domain containing 1	0.011
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.011
GLYAT	glycine-N-acyltransferase	0.011
CTBP1	C-terminal binding protein 1	0.011
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.011
MPO	myeloperoxidase	0.010
AOX1	aldehyde oxidase 1	0.010
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.010
HAL	histidine ammonia-lyase	0.010
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.010
CRYAB	crystallin, alpha B	0.010
EDNRB	endothelin receptor type B	0.010
C8B	complement component 8, beta polypeptide	0.010
SLC38A2	solute carrier family 38, member 2	0.010
CRAT	carnitine O-acetyltransferase	0.010
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.010
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.010
FOXO1	forkhead box O1	0.010
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.010