IMP: Integrative Multi-species Prediction

Homo sapiens

33 genes annotated in human

Multi-species View

negative regulation of cell activation

GO:0050866

Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cell activation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
C1QA	complement component 1, q subcomponent, A chain	0.792	Human
SYK	spleen tyrosine kinase	0.775
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.690
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.648	Mouse
HLA-B	major histocompatibility complex, class I, B	0.551
CD80	CD80 molecule	0.533
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.509
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.474
B2M	beta-2-microglobulin	0.466
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.411	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.408
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.334	Human
HLA-G	major histocompatibility complex, class I, G	0.319
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.314
HLA-A	major histocompatibility complex, class I, A	0.286	Human
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.260
FASLG	Fas ligand (TNF superfamily, member 6)	0.241
CD86	CD86 molecule	0.220
CXCL9	chemokine (C-X-C motif) ligand 9	0.220
HLA-C	major histocompatibility complex, class I, C	0.203	Human
HLA-E	major histocompatibility complex, class I, E	0.202	Human
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.190
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.187
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.181
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.177
IL4R	interleukin 4 receptor	0.165	Mouse
IL2RG	interleukin 2 receptor, gamma	0.164
CCR5	chemokine (C-C motif) receptor 5	0.159
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.157
HLA-F	major histocompatibility complex, class I, F	0.150	Human
IL10RA	interleukin 10 receptor, alpha	0.147
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.122	Human
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.122	Human
XIAP	X-linked inhibitor of apoptosis	0.119
ICAM1	intercellular adhesion molecule 1	0.117
PILRA	paired immunoglobin-like type 2 receptor alpha	0.115
EPOR	erythropoietin receptor	0.115
PAX3	paired box 3	0.107
BMPR1A	bone morphogenetic protein receptor, type IA	0.106
HLA-DMB	major histocompatibility complex, class II, DM beta	0.096
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.090
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.086
IL10	interleukin 10	0.085
NRP1	neuropilin 1	0.084
DRD2	dopamine receptor D2	0.079
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.074
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.072
FSTL1	follistatin-like 1	0.071
A2M	alpha-2-macroglobulin	0.068
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.067
POU3F2	POU class 3 homeobox 2	0.063
GHR	growth hormone receptor	0.059
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.058	Mouse
TFF1	trefoil factor 1	0.056
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.055
CCL2	chemokine (C-C motif) ligand 2	0.053	Human
HK3	hexokinase 3 (white cell)	0.052
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.051
SIGLEC7	sialic acid binding Ig-like lectin 7	0.051
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.049
ADAM17	ADAM metallopeptidase domain 17	0.049
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.049	Mouse
PTPRB	protein tyrosine phosphatase, receptor type, B	0.048
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.048
BIRC3	baculoviral IAP repeat containing 3	0.046
CCR1	chemokine (C-C motif) receptor 1	0.044
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.044
CD14	CD14 molecule	0.044
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.044	Human Rat
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.043
CCL4	chemokine (C-C motif) ligand 4	0.042	Human
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.041
C1QC	complement component 1, q subcomponent, C chain	0.041	Human
CCL8	chemokine (C-C motif) ligand 8	0.041	Human
SLA	Src-like-adaptor	0.040
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.040	Human
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.040
IL22RA1	interleukin 22 receptor, alpha 1	0.040
CSK	c-src tyrosine kinase	0.040
CD163	CD163 molecule	0.039
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.038
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.038
APOC1	apolipoprotein C-I	0.038
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.038
CD33	CD33 molecule	0.036
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.036
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.036
HP	haptoglobin	0.035
LAT	linker for activation of T cells	0.035
ECSIT	ECSIT homolog (Drosophila)	0.034
APAF1	apoptotic peptidase activating factor 1	0.034
CXCL10	chemokine (C-X-C motif) ligand 10	0.033
GAB2	GRB2-associated binding protein 2	0.033
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.033
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.032
NCF4	neutrophil cytosolic factor 4, 40kDa	0.032
C19orf50	chromosome 19 open reading frame 50	0.032
PGF	placental growth factor	0.032	Human
BTN3A1	butyrophilin, subfamily 3, member A1	0.032
BTN3A3	butyrophilin, subfamily 3, member A3	0.032
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.031	Human
IL2RA	interleukin 2 receptor, alpha	0.031	Mouse
APP	amyloid beta (A4) precursor protein	0.031
PLK3	polo-like kinase 3	0.031
CCL5	chemokine (C-C motif) ligand 5	0.030	Human
GAS6	growth arrest-specific 6	0.030
MARCO	macrophage receptor with collagenous structure	0.030
C1QB	complement component 1, q subcomponent, B chain	0.030	Human
CDH5	cadherin 5, type 2 (vascular endothelium)	0.030
SLC15A3	solute carrier family 15, member 3	0.028
CCL11	chemokine (C-C motif) ligand 11	0.027	Human
RNF11	ring finger protein 11	0.027
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.027
IDE	insulin-degrading enzyme	0.027
LAPTM5	lysosomal protein transmembrane 5	0.027
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.027	Human
CCL13	chemokine (C-C motif) ligand 13	0.027	Human
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.026
CCR4	chemokine (C-C motif) receptor 4	0.026
SRGN	serglycin	0.026
PTAFR	platelet-activating factor receptor	0.026
TRAF5	TNF receptor-associated factor 5	0.026
BIN2	bridging integrator 2	0.026
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.025
IL4	interleukin 4	0.025	Mouse
VAV1	vav 1 guanine nucleotide exchange factor	0.025
IL6	interleukin 6 (interferon, beta 2)	0.025
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.024
FGL2	fibrinogen-like 2	0.024
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.024
AIF1	allograft inflammatory factor 1	0.024
CFLAR	CASP8 and FADD-like apoptosis regulator	0.024
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.024	Human
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.023
DPP4	dipeptidyl-peptidase 4	0.023
BTN3A2	butyrophilin, subfamily 3, member A2	0.023
LDLR	low density lipoprotein receptor	0.023
TYROBP	TYRO protein tyrosine kinase binding protein	0.022
NCF1	neutrophil cytosolic factor 1	0.022
IL8	interleukin 8	0.022
TYMP	thymidine phosphorylase	0.022
SLAMF1	signaling lymphocytic activation molecule family member 1	0.022
IRF8	interferon regulatory factor 8	0.022
CXCR4	chemokine (C-X-C motif) receptor 4	0.022
VEGFA	vascular endothelial growth factor A	0.022	Human
PRDM1	PR domain containing 1, with ZNF domain	0.022	Mouse
EGFR	epidermal growth factor receptor	0.022
IL22RA2	interleukin 22 receptor, alpha 2	0.022
SOD2	superoxide dismutase 2, mitochondrial	0.022
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.022
STAB1	stabilin 1	0.021
OPTN	optineurin	0.021
CDK6	cyclin-dependent kinase 6	0.021
CD2	CD2 molecule	0.021
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.021
CCL3	chemokine (C-C motif) ligand 3	0.020	Human
MYO1F	myosin IF	0.020
MICA	MHC class I polypeptide-related sequence A	0.020
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.020
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.020
HCST	hematopoietic cell signal transducer	0.020
CYBB	cytochrome b-245, beta polypeptide	0.020
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.020
SIRPB1	signal-regulatory protein beta 1	0.019
SCNM1	sodium channel modifier 1	0.019
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.019
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.019
CSF1	colony stimulating factor 1 (macrophage)	0.019
PINK1	PTEN induced putative kinase 1	0.019
C3	complement component 3	0.019
CXCL2	chemokine (C-X-C motif) ligand 2	0.019
CXCL3	chemokine (C-X-C motif) ligand 3	0.019
HDAC9	histone deacetylase 9	0.019
TNIP1	TNFAIP3 interacting protein 1	0.019
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.019
ZNF282	zinc finger protein 282	0.018
CTSS	cathepsin S	0.018
CLEC10A	C-type lectin domain family 10, member A	0.018
BLNK	B-cell linker	0.018
PTEN	phosphatase and tensin homolog	0.018
NUCB1	nucleobindin 1	0.018
CMKLR1	chemokine-like receptor 1	0.018
GBP4	guanylate binding protein 4	0.018
IL1B	interleukin 1, beta	0.018
STX11	syntaxin 11	0.017
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.017
SIRPA	signal-regulatory protein alpha	0.017
SLAMF8	SLAM family member 8	0.017
CYLD	cylindromatosis (turban tumor syndrome)	0.017	Mouse
SOS2	son of sevenless homolog 2 (Drosophila)	0.017
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.017	Human
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.017
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.017
CD68	CD68 molecule	0.017
MAP2	microtubule-associated protein 2	0.017
CD69	CD69 molecule	0.017
FPR3	formyl peptide receptor 3	0.016
CCDC85B	coiled-coil domain containing 85B	0.016
BMP2	bone morphogenetic protein 2	0.016	Human
BTN2A2	butyrophilin, subfamily 2, member A2	0.016	Mouse
C1orf38	chromosome 1 open reading frame 38	0.016
SOCS1	suppressor of cytokine signaling 1	0.016
COL6A1	collagen, type VI, alpha 1	0.016
NLRP3	NLR family, pyrin domain containing 3	0.016
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.016
CCL7	chemokine (C-C motif) ligand 7	0.016	Human
MAPK12	mitogen-activated protein kinase 12	0.016
IRF4	interferon regulatory factor 4	0.016
IFNG	interferon, gamma	0.016
APOA2	apolipoprotein A-II	0.016
EBI3	Epstein-Barr virus induced 3	0.016
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.015	Human
CYTH4	cytohesin 4	0.015
NCKAP1L	NCK-associated protein 1-like	0.015
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.015
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.015
IRF9	interferon regulatory factor 9	0.015
PML	promyelocytic leukemia	0.015
ATP2B1	ATPase, Ca++ transporting, plasma membrane 1	0.015
CCR7	chemokine (C-C motif) receptor 7	0.015
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.015
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.015
C5AR1	complement component 5a receptor 1	0.015
MAN2B1	mannosidase, alpha, class 2B, member 1	0.015
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.015
CCL19	chemokine (C-C motif) ligand 19	0.015	Human
LGALS9	lectin, galactoside-binding, soluble, 9	0.015
CH25H	cholesterol 25-hydroxylase	0.015
C2	complement component 2	0.015
RNF111	ring finger protein 111	0.015
POU5F1	POU class 5 homeobox 1	0.015
KRT8	keratin 8	0.015
CD300C	CD300c molecule	0.014	Human
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.014	Mouse
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.014
MARCKSL1	MARCKS-like 1	0.014
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.014
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.014
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.014
KITLG	KIT ligand	0.014
TBC1D10A	TBC1 domain family, member 10A	0.014
MSR1	macrophage scavenger receptor 1	0.014
IGF1R	insulin-like growth factor 1 receptor	0.014
VSIG4	V-set and immunoglobulin domain containing 4	0.014	Mouse
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.014
C3AR1	complement component 3a receptor 1	0.014
THOC5	THO complex 5	0.013
CXCL11	chemokine (C-X-C motif) ligand 11	0.013
CD72	CD72 molecule	0.013
SELPLG	selectin P ligand	0.013
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.013	Human
BCL2A1	BCL2-related protein A1	0.013
WNT2	wingless-type MMTV integration site family member 2	0.013
IL32	interleukin 32	0.013
HAS1	hyaluronan synthase 1	0.013
SOS1	son of sevenless homolog 1 (Drosophila)	0.013
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.013
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.013	Mouse
MPEG1	macrophage expressed 1	0.013
TAPBP	TAP binding protein (tapasin)	0.013
APBA3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.013
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.013
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.013
GAB1	GRB2-associated binding protein 1	0.013
TLR8	toll-like receptor 8	0.013
TREM1	triggering receptor expressed on myeloid cells 1	0.013
ADAP2	ArfGAP with dual PH domains 2	0.013
SELE	selectin E	0.013
RHOU	ras homolog gene family, member U	0.013
EPHB1	EPH receptor B1	0.012
ANKRD13A	ankyrin repeat domain 13A	0.012
PBK	PDZ binding kinase	0.012
PCDH9	protocadherin 9	0.012
LY86	lymphocyte antigen 86	0.012
MEOX2	mesenchyme homeobox 2	0.012
FTL	ferritin, light polypeptide	0.012
AXL	AXL receptor tyrosine kinase	0.012	Mouse
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.012
SIGLEC9	sialic acid binding Ig-like lectin 9	0.012
SMAD7	SMAD family member 7	0.012
CD28	CD28 molecule	0.012	Human
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.012
PPAP2B	phosphatidic acid phosphatase type 2B	0.012
BATF	basic leucine zipper transcription factor, ATF-like	0.012
BTN2A1	butyrophilin, subfamily 2, member A1	0.012	Mouse
VAV3	vav 3 guanine nucleotide exchange factor	0.012
INSR	insulin receptor	0.012
FLT4	fms-related tyrosine kinase 4	0.012	Human
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.012
TMEM173	transmembrane protein 173	0.012
AOAH	acyloxyacyl hydrolase (neutrophil)	0.012
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.012
ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	0.012
IL18RAP	interleukin 18 receptor accessory protein	0.012
BCL2L1	BCL2-like 1	0.012
CD48	CD48 molecule	0.012
CD300A	CD300a molecule	0.012
CCND3	cyclin D3	0.012
CCL22	chemokine (C-C motif) ligand 22	0.012	Human
EVI2A	ecotropic viral integration site 2A	0.012
PPARA	peroxisome proliferator-activated receptor alpha	0.012
IL2RB	interleukin 2 receptor, beta	0.012
GBP2	guanylate binding protein 2, interferon-inducible	0.012
SOX18	SRY (sex determining region Y)-box 18	0.012	Human
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.011
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.011	Human
RUNX3	runt-related transcription factor 3	0.011
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.011
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.011
CD40	CD40 molecule, TNF receptor superfamily member 5	0.011
TBX2	T-box 2	0.011
CCNL1	cyclin L1	0.011
ACVR1	activin A receptor, type I	0.011
STAT4	signal transducer and activator of transcription 4	0.011
CD247	CD247 molecule	0.011
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.011
CCND1	cyclin D1	0.011
RNASE6	ribonuclease, RNase A family, k6	0.011
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.011
CYBA	cytochrome b-245, alpha polypeptide	0.011
P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.011
MRC1	mannose receptor, C type 1	0.011
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.011
NKG7	natural killer cell group 7 sequence	0.011
IL24	interleukin 24	0.011	Human
CLEC7A	C-type lectin domain family 7, member A	0.011
TFG	TRK-fused gene	0.011
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.011
IFT20	intraflagellar transport 20 homolog (Chlamydomonas)	0.011
MSTO1	misato homolog 1 (Drosophila)	0.011
ND1	NADH dehydrogenase, subunit 1 (complex I)	0.011
PDGFC	platelet derived growth factor C	0.010
FTH1	ferritin, heavy polypeptide 1	0.010
ALPL	alkaline phosphatase, liver/bone/kidney	0.010
TAPBPL	TAP binding protein-like	0.010
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.010	Human
SOCS3	suppressor of cytokine signaling 3	0.010
S100A4	S100 calcium binding protein A4	0.010
TLR7	toll-like receptor 7	0.010
NAMPT	nicotinamide phosphoribosyltransferase	0.010
IL21R	interleukin 21 receptor	0.010
VEGFC	vascular endothelial growth factor C	0.010	Human
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.010
NGFR	nerve growth factor receptor	0.010
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.010
RUNX2	runt-related transcription factor 2	0.010
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.010
CCR3	chemokine (C-C motif) receptor 3	0.010
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.010
C1S	complement component 1, s subcomponent	0.010
LCAT	lecithin-cholesterol acyltransferase	0.010
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.010
FOLR2	folate receptor 2 (fetal)	0.010
CD83	CD83 molecule	0.010