IMP: Integrative Multi-species Prediction

Homo sapiens

35 genes annotated in human

negative regulation of proteolysis involved in cellular protein catabolic process

GO:1903051

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of proteolysis involved in cellular protein catabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of proteolysis involved in cellular protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.938	Fly
ANAPC4	anaphase promoting complex subunit 4	0.653
ANAPC7	anaphase promoting complex subunit 7	0.423
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.392
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.363	Fly
RB1	retinoblastoma 1	0.299
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.227	Worm Fly
ANAPC5	anaphase promoting complex subunit 5	0.196
CDK2	cyclin-dependent kinase 2	0.162
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.152
DAXX	death-domain associated protein	0.141
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.127
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.126
TP53	tumor protein p53	0.121
BRCA2	breast cancer 2, early onset	0.119
CCNA2	cyclin A2	0.112
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.106
CD2BP2	CD2 (cytoplasmic tail) binding protein 2	0.104
ZNF263	zinc finger protein 263	0.086
PSEN1	presenilin 1	0.078	Mouse
TRIM39	tripartite motif containing 39	0.075
ASF1A	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.072
HIPK2	homeodomain interacting protein kinase 2	0.072
GABARAPL1	GABA(A) receptor-associated protein like 1	0.069
SMAD2	SMAD family member 2	0.061
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.060
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.059
TPBG	trophoblast glycoprotein	0.058
CCNB1	cyclin B1	0.058
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.053
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.052
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.051
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.051	Yeast
FXR2	fragile X mental retardation, autosomal homolog 2	0.049
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.049	Human
MED15	mediator complex subunit 15	0.046
TRAF6	TNF receptor-associated factor 6	0.046
NBR1	neighbor of BRCA1 gene 1	0.045
ARIH2	ariadne homolog 2 (Drosophila)	0.044
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.044
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.043
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.042	Human
BAG2	BCL2-associated athanogene 2	0.042
C19orf39	chromosome 19 open reading frame 39	0.042
GFI1B	growth factor independent 1B transcription repressor	0.041
CBX1	chromobox homolog 1	0.041
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.039
CASC5	cancer susceptibility candidate 5	0.039
CREBBP	CREB binding protein	0.039
PLK1	polo-like kinase 1	0.039
SQSTM1	sequestosome 1	0.038
SKP2	S-phase kinase-associated protein 2 (p45)	0.038
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.037
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.036
ZNF207	zinc finger protein 207	0.034
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.034
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.034
STX5	syntaxin 5	0.034
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.032
VCP	valosin containing protein	0.032
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.032
CCND1	cyclin D1	0.032
TOR1A	torsin family 1, member A (torsin A)	0.032
ANAPC11	anaphase promoting complex subunit 11	0.031
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.031
MED1	mediator complex subunit 1	0.030
COPS8	COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)	0.030
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.030
MDC1	mediator of DNA-damage checkpoint 1	0.029
GABARAP	GABA(A) receptor-associated protein	0.029
HUWE1	HECT, UBA and WWE domain containing 1	0.029
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.028
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.028
TP53BP1	tumor protein p53 binding protein 1	0.028
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.028
BIRC5	baculoviral IAP repeat containing 5	0.027
TOR1AIP2	torsin A interacting protein 2	0.027
TYRP1	tyrosinase-related protein 1	0.027
FLNB	filamin B, beta	0.026
SP100	SP100 nuclear antigen	0.026
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.026
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.026
MYST1	MYST histone acetyltransferase 1	0.026
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.025	Yeast
CBX5	chromobox homolog 5	0.025
FAS	Fas (TNF receptor superfamily, member 6)	0.025
SRI	sorcin	0.024
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.024
LMNA	lamin A/C	0.024
ATMIN	ATM interactor	0.024
PSEN2	presenilin 2 (Alzheimer disease 4)	0.024	Mouse
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.024
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.024
BTBD2	BTB (POZ) domain containing 2	0.023
UBC	ubiquitin C	0.023
BCL2L1	BCL2-like 1	0.023
FANCD2	Fanconi anemia, complementation group D2	0.023
TRIM32	tripartite motif containing 32	0.023
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.023
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.022
TRIM34	tripartite motif containing 34	0.022
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.022
AMFR	autocrine motility factor receptor	0.022
PKP4	plakophilin 4	0.022
NCSTN	nicastrin	0.022
PRNP	prion protein	0.022
CCND3	cyclin D3	0.022
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.021
MAD2L1BP	MAD2L1 binding protein	0.021
SNX9	sorting nexin 9	0.021
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.021
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.021
HERC2	hect domain and RLD 2	0.021
TBP	TATA box binding protein	0.021
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.021
GSK3B	glycogen synthase kinase 3 beta	0.021
MASTL	microtubule associated serine/threonine kinase-like	0.020
GLI1	GLI family zinc finger 1	0.020
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.020
CCNB2	cyclin B2	0.020
DLG1	discs, large homolog 1 (Drosophila)	0.019
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.019
ATAD2	ATPase family, AAA domain containing 2	0.019
PTK2	PTK2 protein tyrosine kinase 2	0.019
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.019
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.019
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.019
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.019
PRC1	protein regulator of cytokinesis 1	0.019
TRIM8	tripartite motif containing 8	0.019
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.018
CDK6	cyclin-dependent kinase 6	0.018
RYBP	RING1 and YY1 binding protein	0.018
USP1	ubiquitin specific peptidase 1	0.018
COPS5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.018	Fly
ZWINT	ZW10 interactor	0.018
HSPA8	heat shock 70kDa protein 8	0.018
TLK2	tousled-like kinase 2	0.018
RFWD2	ring finger and WD repeat domain 2	0.018
RANBP9	RAN binding protein 9	0.017
SIAH1	seven in absentia homolog 1 (Drosophila)	0.017
TRIM37	tripartite motif containing 37	0.017
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.017
DMAP1	DNA methyltransferase 1 associated protein 1	0.017
TP53BP2	tumor protein p53 binding protein, 2	0.017
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.017
HDAC1	histone deacetylase 1	0.017
PARP3	poly (ADP-ribose) polymerase family, member 3	0.017
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.017
SOD1	superoxide dismutase 1, soluble	0.017
AXIN1	axin 1	0.016
KIF18A	kinesin family member 18A	0.016
SHCBP1	SHC SH2-domain binding protein 1	0.016
RAD51C	RAD51 homolog C (S. cerevisiae)	0.016
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.016
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.016
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.016
SPCS1	signal peptidase complex subunit 1 homolog (S. cerevisiae)	0.016
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.016
RAD23A	RAD23 homolog A (S. cerevisiae)	0.016
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.016
ZNF473	zinc finger protein 473	0.016
CDKN3	cyclin-dependent kinase inhibitor 3	0.016
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.016
TDGF1	teratocarcinoma-derived growth factor 1	0.016
BAG3	BCL2-associated athanogene 3	0.015
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.015
CCDC99	coiled-coil domain containing 99	0.015
CLSPN	claspin	0.015
CDYL	chromodomain protein, Y-like	0.015
BLM	Bloom syndrome, RecQ helicase-like	0.015
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.015
TRIM43	tripartite motif containing 43	0.015
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.015
TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	0.015
PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.015
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.015
SMC4	structural maintenance of chromosomes 4	0.015
SKP1	S-phase kinase-associated protein 1	0.015
COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	0.015
RAD52	RAD52 homolog (S. cerevisiae)	0.015
CENPF	centromere protein F, 350/400kDa (mitosin)	0.014
HIST1H1B	histone cluster 1, H1b	0.014
VTA1	Vps20-associated 1 homolog (S. cerevisiae)	0.014
EVI5	ecotropic viral integration site 5	0.014
CUL3	cullin 3	0.014
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.014
PLK4	polo-like kinase 4	0.014
VRK1	vaccinia related kinase 1	0.014
AXIN2	axin 2	0.014
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.014
PEX26	peroxisomal biogenesis factor 26	0.014
AIRE	autoimmune regulator	0.014
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.014
KIF2A	kinesin heavy chain member 2A	0.014
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.014
IFI16	interferon, gamma-inducible protein 16	0.014
MTPAP	mitochondrial poly(A) polymerase	0.014
FBXO7	F-box protein 7	0.014
CIB1	calcium and integrin binding 1 (calmyrin)	0.014
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.014
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.014	Human
EP300	E1A binding protein p300	0.014
USP44	ubiquitin specific peptidase 44	0.013
ZSWIM7	zinc finger, SWIM-type containing 7	0.013
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.013
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.013
FADD	Fas (TNFRSF6)-associated via death domain	0.013
CCDC101	coiled-coil domain containing 101	0.013
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.013
RNF20	ring finger protein 20	0.013
HIST1H1E	histone cluster 1, H1e	0.013
C13orf34	chromosome 13 open reading frame 34	0.013
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	0.013
APP	amyloid beta (A4) precursor protein	0.013
CENPE	centromere protein E, 312kDa	0.013	Mouse
PARP1	poly (ADP-ribose) polymerase 1	0.013
TERF2	telomeric repeat binding factor 2	0.013	Human
TRIM17	tripartite motif containing 17	0.013	Human
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.013
CSE1L	CSE1 chromosome segregation 1-like (yeast)	0.013
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.013
KLHL13	kelch-like 13 (Drosophila)	0.013
DEPDC1	DEP domain containing 1	0.013
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.013
VHL	von Hippel-Lindau tumor suppressor	0.013
ANKRD52	ankyrin repeat domain 52	0.013
MKRN1	makorin ring finger protein 1	0.013
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.012
USP49	ubiquitin specific peptidase 49	0.012	Human
GPS2	G protein pathway suppressor 2	0.012
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.012
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.012
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.012
BRD7	bromodomain containing 7	0.012
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.012
CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.012
BEND7	BEN domain containing 7	0.012
KIF5B	kinesin family member 5B	0.012
SMAD3	SMAD family member 3	0.012
LGALS7	lectin, galactoside-binding, soluble, 7	0.012
PPME1	protein phosphatase methylesterase 1	0.012
SESN2	sestrin 2	0.012
SERTAD4	SERTA domain containing 4	0.012
HIST4H4	histone cluster 4, H4	0.012
C11orf10	chromosome 11 open reading frame 10	0.012
KIF11	kinesin family member 11	0.012
SGOL2	shugoshin-like 2 (S. pombe)	0.012
ZNF764	zinc finger protein 764	0.012
NRD1	nardilysin (N-arginine dibasic convertase)	0.012
ZNF295	zinc finger protein 295	0.012
NUP98	nucleoporin 98kDa	0.012
UBR4	ubiquitin protein ligase E3 component n-recognin 4	0.012
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.011
RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	0.011
TRADD	TNFRSF1A-associated via death domain	0.011
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.011
USP42	ubiquitin specific peptidase 42	0.011	Human
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.011
PML	promyelocytic leukemia	0.011
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.011
CARM1	coactivator-associated arginine methyltransferase 1	0.011
ANKRD17	ankyrin repeat domain 17	0.011
SPOP	speckle-type POZ protein	0.011
SNAI1	snail homolog 1 (Drosophila)	0.011
TOP3A	topoisomerase (DNA) III alpha	0.011
MCM10	minichromosome maintenance complex component 10	0.011
PIAS2	protein inhibitor of activated STAT, 2	0.011
SETD7	SET domain containing (lysine methyltransferase) 7	0.011
RNF31	ring finger protein 31	0.011
KDM4A	lysine (K)-specific demethylase 4A	0.011
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.011
BCR	breakpoint cluster region	0.011
UBE2C	ubiquitin-conjugating enzyme E2C	0.011
PRKCA	protein kinase C, alpha	0.011
TACC2	transforming, acidic coiled-coil containing protein 2	0.011
H2AFX	H2A histone family, member X	0.011
HAUS6	HAUS augmin-like complex, subunit 6	0.011
AKAP10	A kinase (PRKA) anchor protein 10	0.011
KIF14	kinesin family member 14	0.011
ATM	ataxia telangiectasia mutated	0.011
TXNL1	thioredoxin-like 1	0.011
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.011
ATXN1	ataxin 1	0.011
MAGEA2	melanoma antigen family A, 2	0.011
HIST1H4F	histone cluster 1, H4f	0.011
KDM5A	lysine (K)-specific demethylase 5A	0.011
MT1A	metallothionein 1A	0.011
CDT1	chromatin licensing and DNA replication factor 1	0.011
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.011
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.011
MAPK8	mitogen-activated protein kinase 8	0.011
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.011
FOXM1	forkhead box M1	0.011
RAD51AP1	RAD51 associated protein 1	0.010
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.010
EIF2D	eukaryotic translation initiation factor 2D	0.010
PRDX2	peroxiredoxin 2	0.010
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.010
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.010
MCOLN1	mucolipin 1	0.010
CDAN1	congenital dyserythropoietic anemia, type I	0.010
ING4	inhibitor of growth family, member 4	0.010
AURKB	aurora kinase B	0.010
ZNF828	zinc finger protein 828	0.010
AMZ2	archaelysin family metallopeptidase 2	0.010
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.010
ANAPC13	anaphase promoting complex subunit 13	0.010
KDM5C	lysine (K)-specific demethylase 5C	0.010
NOMO1	NODAL modulator 1	0.010
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.010
EXOSC9	exosome component 9	0.010
BANP	BTG3 associated nuclear protein	0.010
KAT5	K(lysine) acetyltransferase 5	0.010
TAF5L	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	0.010
IRF9	interferon regulatory factor 9	0.010