IMP: Integrative Multi-species Prediction

Homo sapiens

32 genes annotated in human

Multi-species View

regulation of mrna splicing via spliceosome

GO:0048024

Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of mrna splicing via spliceosome"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "regulation of mrna splicing via spliceosome" (in gray)

Name	Description	Probability	Func Analog Organism
U2AF2	U2 small nuclear RNA auxiliary factor 2	1.000
RNPS1	RNA binding protein S1, serine-rich domain	1.000
SRPK2	SRSF protein kinase 2	1.000
SF3A2	splicing factor 3a, subunit 2, 66kDa	0.999
PTBP1	polypyrimidine tract binding protein 1	0.998
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.996
SF1	splicing factor 1	0.995
RBM10	RNA binding motif protein 10	0.993	Human Mouse
PNN	pinin, desmosome associated protein	0.992
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.992	Fly
RBM39	RNA binding motif protein 39	0.981	Fly
SRSF1	serine/arginine-rich splicing factor 1	0.980	Human
EIF4A3	eukaryotic translation initiation factor 4A3	0.973	Mouse
SRSF3	serine/arginine-rich splicing factor 3	0.971	Human
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.958	Fly
EED	embryonic ectoderm development	0.946
ILF3	interleukin enhancer binding factor 3, 90kDa	0.945
SRRM1	serine/arginine repetitive matrix 1	0.942
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.931	Fly
SNRPA	small nuclear ribonucleoprotein polypeptide A	0.909
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.905
LUC7L3	LUC7-like 3 (S. cerevisiae)	0.904
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.903
SRSF7	serine/arginine-rich splicing factor 7	0.885
SRPK1	SRSF protein kinase 1	0.883
QKI	quaking homolog, KH domain RNA binding (mouse)	0.882	Worm Fly
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.837	Mouse
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.833	Mouse
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.815
SNW1	SNW domain containing 1	0.797
SF3B4	splicing factor 3b, subunit 4, 49kDa	0.784	Mouse
RBM4	RNA binding motif protein 4	0.761
TARDBP	TAR DNA binding protein	0.745
TRA2B	transformer 2 beta homolog (Drosophila)	0.701
CHERP	calcium homeostasis endoplasmic reticulum protein	0.697
ATXN1	ataxin 1	0.672
MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)	0.660
ELAVL1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.619	Worm
PTBP2	polypyrimidine tract binding protein 2	0.609	Human
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.605
SRRT	serrate RNA effector molecule homolog (Arabidopsis)	0.589
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.586
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.553
SFPQ	splicing factor proline/glutamine-rich	0.538
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.535	Mouse Fly
SRSF2	serine/arginine-rich splicing factor 2	0.528	Mouse Fly
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.516
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.497
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.479
ARGLU1	arginine and glutamate rich 1	0.475
TCERG1	transcription elongation regulator 1	0.462
SRSF10	serine/arginine-rich splicing factor 10	0.450
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.448
SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	0.425
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.424
FUS	fused in sarcoma	0.403
PRPF38A	PRP38 pre-mRNA processing factor 38 (yeast) domain containing A	0.388
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.387
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.386	Fly
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.368
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.367
SAFB	scaffold attachment factor B	0.347	Fly
SRSF4	serine/arginine-rich splicing factor 4	0.312
SF3B1	splicing factor 3b, subunit 1, 155kDa	0.311
NXF1	nuclear RNA export factor 1	0.293
SREK1	splicing regulatory glutamine/lysine-rich protein 1	0.289	Fly
FUBP1	far upstream element (FUSE) binding protein 1	0.281	Fly
THOC4	THO complex 4	0.266
PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.248
YTHDC1	YTH domain containing 1	0.244
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.238	Fly
SRSF9	serine/arginine-rich splicing factor 9	0.236
SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)	0.231	Mouse Fly
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.228
PRPF19	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)	0.216	Mouse
SAFB2	scaffold attachment factor B2	0.213	Fly
SNRPA1	small nuclear ribonucleoprotein polypeptide A'	0.208
HNRNPR	heterogeneous nuclear ribonucleoprotein R	0.207
CELF1	CUGBP, Elav-like family member 1	0.202	Human Fly
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.202
SNIP1	Smad nuclear interacting protein 1	0.198
HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	0.189	Fly
DHX15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.177
SRSF6	serine/arginine-rich splicing factor 6	0.176
SRSF5	serine/arginine-rich splicing factor 5	0.170	Human Fly
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.164
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.161
LUC7L	LUC7-like (S. cerevisiae)	0.156
EIF3B	eukaryotic translation initiation factor 3, subunit B	0.145
SF3B2	splicing factor 3b, subunit 2, 145kDa	0.142
SON	SON DNA binding protein	0.141
PUF60	poly-U binding splicing factor 60KDa	0.132	Fly
RALY	RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))	0.115
SNRPB	small nuclear ribonucleoprotein polypeptides B and B1	0.112
EWSR1	Ewing sarcoma breakpoint region 1	0.112
CDAN1	congenital dyserythropoietic anemia, type I	0.112
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.109
SUGP1	SURP and G patch domain containing 1	0.104
U2SURP	U2 snRNP-associated SURP domain containing	0.094
SAP30BP	SAP30 binding protein	0.093
PCBP2	poly(rC) binding protein 2	0.087
YBX1	Y box binding protein 1	0.086	Zebrafish
CHTOP	chromatin target of PRMT1	0.086
GCN1L1	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	0.084
RBM23	RNA binding motif protein 23	0.083	Fly
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.083
CAND1	cullin-associated and neddylation-dissociated 1	0.077
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.077
SART1	squamous cell carcinoma antigen recognized by T cells	0.075
SF3B3	splicing factor 3b, subunit 3, 130kDa	0.075
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.075
NAA38	N(alpha)-acetyltransferase 38, NatC auxiliary subunit	0.072
SRSF11	serine/arginine-rich splicing factor 11	0.071	Fly
PABPC1	poly(A) binding protein, cytoplasmic 1	0.069
RBM14	RNA binding motif protein 14	0.069
PRPF38B	PRP38 pre-mRNA processing factor 38 (yeast) domain containing B	0.067
WDR83	WD repeat domain 83	0.067
ACIN1	apoptotic chromatin condensation inducer 1	0.067
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.066
KHSRP	KH-type splicing regulatory protein	0.065	Fly
CTNNBL1	catenin, beta like 1	0.062
BCLAF1	BCL2-associated transcription factor 1	0.061
PRPF6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	0.056
PABPN1	poly(A) binding protein, nuclear 1	0.055
SRRM2	serine/arginine repetitive matrix 2	0.054
MBNL1	muscleblind-like (Drosophila)	0.052	Mouse
SFRS18	splicing factor, arginine/serine-rich 18	0.051
CPSF7	cleavage and polyadenylation specific factor 7, 59kDa	0.050	Fly
ZNF207	zinc finger protein 207	0.049
SNRPD1	small nuclear ribonucleoprotein D1 polypeptide 16kDa	0.049
METTL3	methyltransferase like 3	0.047
PRCC	papillary renal cell carcinoma (translocation-associated)	0.047
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.046	Human Fly
RHOXF2	Rhox homeobox family, member 2	0.045
RBMX	RNA binding motif protein, X-linked	0.044
LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.042
PPWD1	peptidylprolyl isomerase domain and WD repeat containing 1	0.041
FNBP4	formin binding protein 4	0.040
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.040
PRRC2C	proline-rich coiled-coil 2C	0.039
TOP1	topoisomerase (DNA) I	0.039
LSM6	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.039
PRPF31	PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)	0.038
CTCF	CCCTC-binding factor (zinc finger protein)	0.037
PAPD7	PAP associated domain containing 7	0.037
PLDN	pallidin homolog (mouse)	0.037
SNRPF	small nuclear ribonucleoprotein polypeptide F	0.034
PRPF8	PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)	0.033
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.032
SF3A3	splicing factor 3a, subunit 3, 60kDa	0.031
RBM5	RNA binding motif protein 5	0.030
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.029
RBM17	RNA binding motif protein 17	0.029
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.029
LSM7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.028
BMI1	BMI1 polycomb ring finger oncogene	0.028
HMG20A	high mobility group 20A	0.028
SNRPC	small nuclear ribonucleoprotein polypeptide C	0.027	Zebrafish
RAE1	RAE1 RNA export 1 homolog (S. pombe)	0.027
SF3A1	splicing factor 3a, subunit 1, 120kDa	0.026	Fly
DDX42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	0.026
SART3	squamous cell carcinoma antigen recognized by T cells 3	0.025
CLK2	CDC-like kinase 2	0.025
THOC1	THO complex 1	0.024
CCNL1	cyclin L1	0.024
XPO1	exportin 1 (CRM1 homolog, yeast)	0.024
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.023
TUBA1B	tubulin, alpha 1b	0.023
WSB1	WD repeat and SOCS box containing 1	0.022
MMS22L	MMS22-like, DNA repair protein	0.020
SNRNP40	small nuclear ribonucleoprotein 40kDa (U5)	0.020
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.020
RBM22	RNA binding motif protein 22	0.020	Fly
CCAR1	cell division cycle and apoptosis regulator 1	0.020
RSRC2	arginine/serine-rich coiled-coil 2	0.020
DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	0.020	Fly
PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.020
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.020
TTC14	tetratricopeptide repeat domain 14	0.020
DAZAP1	DAZ associated protein 1	0.019	Mouse Fly
RNF126	ring finger protein 126	0.018
SMU1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	0.018	Worm
C1orf63	chromosome 1 open reading frame 63	0.018
C19orf43	chromosome 19 open reading frame 43	0.018
ILF2	interleukin enhancer binding factor 2, 45kDa	0.018
RBPMS	RNA binding protein with multiple splicing	0.018
UBAP2L	ubiquitin associated protein 2-like	0.018
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.017
PRPF4	PRP4 pre-mRNA processing factor 4 homolog (yeast)	0.017
DDX39A	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A	0.017	Fly
TOMM40	translocase of outer mitochondrial membrane 40 homolog (yeast)	0.017
CUL4A	cullin 4A	0.017
RBBP6	retinoblastoma binding protein 6	0.016
SARNP	SAP domain containing ribonucleoprotein	0.016
TOE1	target of EGR1, member 1 (nuclear)	0.016
SNRPD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa	0.016
RBM6	RNA binding motif protein 6	0.016	Human
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.016
MAT2A	methionine adenosyltransferase II, alpha	0.016
UBE2S	ubiquitin-conjugating enzyme E2S	0.016
AQR	aquarius homolog (mouse)	0.016
RNF2	ring finger protein 2	0.015
DCAF7	DDB1 and CUL4 associated factor 7	0.015
CIRBP	cold inducible RNA binding protein	0.015
ZNF830	zinc finger protein 830	0.015
C17orf85	chromosome 17 open reading frame 85	0.014
NKTR	natural killer-tumor recognition sequence	0.014
AATF	apoptosis antagonizing transcription factor	0.014
CD2BP2	CD2 (cytoplasmic tail) binding protein 2	0.014
THOC5	THO complex 5	0.014
IPO4	importin 4	0.014
LARP1	La ribonucleoprotein domain family, member 1	0.014
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.013
NUMBL	numb homolog (Drosophila)-like	0.013
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.013	Fly
NFATC2IP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	0.013
NCBP1	nuclear cap binding protein subunit 1, 80kDa	0.013
KIAA0907	KIAA0907	0.013
SMAD5	SMAD family member 5	0.013
CDK7	cyclin-dependent kinase 7	0.013
DNMT1	DNA (cytosine-5-)-methyltransferase 1	0.013
TLK1	tousled-like kinase 1	0.013
DDX56	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	0.013
MTF2	metal response element binding transcription factor 2	0.013
ANKRD10	ankyrin repeat domain 10	0.013
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.013
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.013
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.013
SOBP	sine oculis binding protein homolog (Drosophila)	0.013
PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.012
THOC6	THO complex 6 homolog (Drosophila)	0.012
CUL3	cullin 3	0.012
BRD4	bromodomain containing 4	0.012
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.012
DHX38	DEAH (Asp-Glu-Ala-His) box polypeptide 38	0.012
RBM25	RNA binding motif protein 25	0.012
DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.012
PUS1	pseudouridylate synthase 1	0.012
ILKAP	integrin-linked kinase-associated serine/threonine phosphatase	0.012
GTF2B	general transcription factor IIB	0.011
RBM8A	RNA binding motif protein 8A	0.011
NFYA	nuclear transcription factor Y, alpha	0.011
PABPC4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.011
FBXO33	F-box protein 33	0.011
RBM7	RNA binding motif protein 7	0.011	Human
FAM76B	family with sequence similarity 76, member B	0.011
WBP11	WW domain binding protein 11	0.011
BRD2	bromodomain containing 2	0.011
EIF4A1	eukaryotic translation initiation factor 4A1	0.011	Fly
SUGP2	SURP and G patch domain containing 2	0.011
UPF3A	UPF3 regulator of nonsense transcripts homolog A (yeast)	0.011
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.011
MAML1	mastermind-like 1 (Drosophila)	0.011
H3F3B	H3 histone, family 3B (H3.3B)	0.011
GNA13	guanine nucleotide binding protein (G protein), alpha 13	0.010
SFSWAP	splicing factor, suppressor of white-apricot homolog (Drosophila)	0.010
NOC4L	nucleolar complex associated 4 homolog (S. cerevisiae)	0.010
CBFB	core-binding factor, beta subunit	0.010
SMYD1	SET and MYND domain containing 1	0.010
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.010	Human
HMGB2	high mobility group box 2	0.010
PES1	pescadillo homolog 1, containing BRCT domain (zebrafish)	0.010
SF3B14	splicing factor 3B, 14 kDa subunit	0.010
CUL1	cullin 1	0.010
ZCCHC8	zinc finger, CCHC domain containing 8	0.010
CDK6	cyclin-dependent kinase 6	0.010
CEP192	centrosomal protein 192kDa	0.010
GPKOW	G patch domain and KOW motifs	0.010
ATF2	activating transcription factor 2	0.010
SCAF4	SR-related CTD-associated factor 4	0.010