IMP: Integrative Multi-species Prediction

Homo sapiens

24 genes annotated in human

Multi-species View

positive regulation of protein binding

GO:0032092

Any process that activates or increases the frequency, rate or extent of protein binding.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of protein binding"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of protein binding" (in gray)

Name	Description	Probability	Func Analog Organism
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.720
BMPR1A	bone morphogenetic protein receptor, type IA	0.572
ZNF260	zinc finger protein 260	0.540
CREBBP	CREB binding protein	0.337
IRAK2	interleukin-1 receptor-associated kinase 2	0.318
BIRC3	baculoviral IAP repeat containing 3	0.283
SPTB	spectrin, beta, erythrocytic	0.278
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.246
RIPK2	receptor-interacting serine-threonine kinase 2	0.234
TICAM2	toll-like receptor adaptor molecule 2	0.225
TRAF6	TNF receptor-associated factor 6	0.224	Human
IRAK1	interleukin-1 receptor-associated kinase 1	0.222
ZMYND11	zinc finger, MYND-type containing 11	0.209
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.207
STK3	serine/threonine kinase 3	0.148
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.143
GGA3	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	0.141
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.125
CD40	CD40 molecule, TNF receptor superfamily member 5	0.124
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.115
MYD88	myeloid differentiation primary response gene (88)	0.106
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.104
ZNF420	zinc finger protein 420	0.104
HOOK2	hook homolog 2 (Drosophila)	0.104
TCF4	transcription factor 4	0.101
DNAJB9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.101
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	0.099
MAPRE2	microtubule-associated protein, RP/EB family, member 2	0.093
SMAD3	SMAD family member 3	0.091
TGFB1	transforming growth factor, beta 1	0.090
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.090
LRP6	low density lipoprotein receptor-related protein 6	0.089
HDAC4	histone deacetylase 4	0.080
ZNF12	zinc finger protein 12	0.079
SMAD7	SMAD family member 7	0.072
SMAD1	SMAD family member 1	0.072
STK4	serine/threonine kinase 4	0.071
ACVR1B	activin A receptor, type IB	0.070
SELS	selenoprotein S	0.066
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.063	Rat
CASK	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.062
FZD1	frizzled homolog 1 (Drosophila)	0.059
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.057
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.057
ZNF83	zinc finger protein 83	0.056
TRAF3	TNF receptor-associated factor 3	0.054	Human
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.052
ZNF432	zinc finger protein 432	0.051
PELI3	pellino homolog 3 (Drosophila)	0.047
ANK1	ankyrin 1, erythrocytic	0.047
ZNF84	zinc finger protein 84	0.047
SPTBN1	spectrin, beta, non-erythrocytic 1	0.046
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.046	Human
HSPA8	heat shock 70kDa protein 8	0.044
ZNF571	zinc finger protein 571	0.042
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.042
TRADD	TNFRSF1A-associated via death domain	0.042
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.041
FSTL1	follistatin-like 1	0.041
MAVS	mitochondrial antiviral signaling protein	0.041
PSEN1	presenilin 1	0.040
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.040
ZNF585A	zinc finger protein 585A	0.038
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.038	Human
TGFBR1	transforming growth factor, beta receptor 1	0.035
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.034
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.032
BIRC2	baculoviral IAP repeat containing 2	0.031
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.031
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.031
RBM12B	RNA binding motif protein 12B	0.030
PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	0.030
ATF5	activating transcription factor 5	0.029
NUMBL	numb homolog (Drosophila)-like	0.029
SAV1	salvador homolog 1 (Drosophila)	0.027
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.027
ZNF569	zinc finger protein 569	0.026
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.026
ARRB2	arrestin, beta 2	0.026
ZNF529	zinc finger protein 529	0.025
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.025
LRP5	low density lipoprotein receptor-related protein 5	0.025
EP300	E1A binding protein p300	0.025	Mouse
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.024
SPAG9	sperm associated antigen 9	0.024
HDAC9	histone deacetylase 9	0.023
ING2	inhibitor of growth family, member 2	0.023
FAM65A	family with sequence similarity 65, member A	0.023
SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	0.023
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.023
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.023
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.023
RIN1	Ras and Rab interactor 1	0.022
ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	0.021
RAP1A	RAP1A, member of RAS oncogene family	0.021
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.021
ZFP30	zinc finger protein 30 homolog (mouse)	0.021
AR	androgen receptor	0.021
SOD1	superoxide dismutase 1, soluble	0.021
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.020
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.020
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.020
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.020
IRAK4	interleukin-1 receptor-associated kinase 4	0.019
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.019
ZNF512B	zinc finger protein 512B	0.019
HOOK3	hook homolog 3 (Drosophila)	0.019
HIC1	hypermethylated in cancer 1	0.019
GLRX	glutaredoxin (thioltransferase)	0.019
CADM1	cell adhesion molecule 1	0.019
SMAD2	SMAD family member 2	0.018
ZNF567	zinc finger protein 567	0.018
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.018
IRAK3	interleukin-1 receptor-associated kinase 3	0.018
STK38L	serine/threonine kinase 38 like	0.018
DZIP3	DAZ interacting protein 3, zinc finger	0.017
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.017
CFL1	cofilin 1 (non-muscle)	0.017
RUNX3	runt-related transcription factor 3	0.017
THBS2	thrombospondin 2	0.017
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.017
ZNF623	zinc finger protein 623	0.017
VCP	valosin containing protein	0.016
PIAS4	protein inhibitor of activated STAT, 4	0.016
CNOT4	CCR4-NOT transcription complex, subunit 4	0.016
NBN	nibrin	0.016
MAP1B	microtubule-associated protein 1B	0.016
PRKCZ	protein kinase C, zeta	0.015
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.015	Rat
FAM190B	family with sequence similarity 190, member B	0.015
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.015
TRAF1	TNF receptor-associated factor 1	0.015	Human
SDC2	syndecan 2	0.015
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.015
MAPK10	mitogen-activated protein kinase 10	0.015
GLIS2	GLIS family zinc finger 2	0.015
HSPH1	heat shock 105kDa/110kDa protein 1	0.015
CCL7	chemokine (C-C motif) ligand 7	0.014
DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.014
SLMAP	sarcolemma associated protein	0.014
CXXC1	CXXC finger protein 1	0.014
CABLES1	Cdk5 and Abl enzyme substrate 1	0.014
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.014
BTBD2	BTB (POZ) domain containing 2	0.014
ITGA6	integrin, alpha 6	0.014
TADA3	transcriptional adaptor 3	0.014
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.013
DCTN1	dynactin 1	0.013
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.013
IGF2R	insulin-like growth factor 2 receptor	0.013
SORBS3	sorbin and SH3 domain containing 3	0.013
TP53	tumor protein p53	0.013
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.013
MPHOSPH8	M-phase phosphoprotein 8	0.013
ZNF23	zinc finger protein 23 (KOX 16)	0.013
GATAD1	GATA zinc finger domain containing 1	0.013
CSNK2B	casein kinase 2, beta polypeptide	0.013
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.013
ZNF189	zinc finger protein 189	0.013
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.013
ATP8	ATP synthase F0 subunit 8	0.013
ZNF304	zinc finger protein 304	0.013
CCL20	chemokine (C-C motif) ligand 20	0.012
MMP13	matrix metallopeptidase 13 (collagenase 3)	0.012	Human
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.012	Human
INHBA	inhibin, beta A	0.012
TUBB	tubulin, beta	0.012
TANK	TRAF family member-associated NFKB activator	0.012
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.012
IRF7	interferon regulatory factor 7	0.012
MAPT	microtubule-associated protein tau	0.012
TRAF3IP2	TRAF3 interacting protein 2	0.012
LTBR	lymphotoxin beta receptor (TNFR superfamily, member 3)	0.012
FGFR1	fibroblast growth factor receptor 1	0.012
SESN2	sestrin 2	0.011
MEF2A	myocyte enhancer factor 2A	0.011
WDFY3	WD repeat and FYVE domain containing 3	0.011
HOOK1	hook homolog 1 (Drosophila)	0.011
TIFA	TRAF-interacting protein with forkhead-associated domain	0.011
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.010
EMD	emerin	0.010
RIPK3	receptor-interacting serine-threonine kinase 3	0.010
CLTC	clathrin, heavy chain (Hc)	0.010
NOG	noggin	0.010
TNIK	TRAF2 and NCK interacting kinase	0.010
PDIA3	protein disulfide isomerase family A, member 3	0.010
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.010
ZNF426	zinc finger protein 426	0.010
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.010
TNF	tumor necrosis factor	0.010