IMP: Integrative Multi-species Prediction

Homo sapiens

33 genes annotated in human

Multi-species View

negative regulation of response to dna damage stimulus

GO:2001021

Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in humanInclude functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of response to dna damage stimulus"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of response to dna damage stimulus" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2L1	BCL2-like 1	0.986
TP53	tumor protein p53	0.674
BCL2	B-cell CLL/lymphoma 2	0.447	Human
EP300	E1A binding protein p300	0.344
THOC4	THO complex 4	0.333
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.331
BAX	BCL2-associated X protein	0.317	Human
MSN	moesin	0.252
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.174
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.137
CDK2	cyclin-dependent kinase 2	0.112	Yeast
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.105
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.104
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.104
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.100
JMJD6	jumonji domain containing 6	0.094
SETD8	SET domain containing (lysine methyltransferase) 8	0.093
RB1	retinoblastoma 1	0.091
LAPTM5	lysosomal protein transmembrane 5	0.088
CREBBP	CREB binding protein	0.087
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.080
RUNX1	runt-related transcription factor 1	0.076
ESR1	estrogen receptor 1	0.074
H2AFX	H2A histone family, member X	0.073
HIPK2	homeodomain interacting protein kinase 2	0.072
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.065
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.065
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.064
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.062
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.056	Worm
BAD	BCL2-associated agonist of cell death	0.053
BAK1	BCL2-antagonist/killer 1	0.053	Human
KAT2B	K(lysine) acetyltransferase 2B	0.050
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.048
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.048
SF3B2	splicing factor 3b, subunit 2, 145kDa	0.045
E2F1	E2F transcription factor 1	0.045
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.042
PAIP2	poly(A) binding protein interacting protein 2	0.041
ATM	ataxia telangiectasia mutated	0.040
THOC2	THO complex 2	0.040
PRMT6	protein arginine methyltransferase 6	0.039
WRN	Werner syndrome, RecQ helicase-like	0.039
THOC5	THO complex 5	0.038
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.038
TP53BP2	tumor protein p53 binding protein, 2	0.038
EGR1	early growth response 1	0.038
ZRANB1	zinc finger, RAN-binding domain containing 1	0.037
LIN28B	lin-28 homolog B (C. elegans)	0.037
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.037
RIN1	Ras and Rab interactor 1	0.035
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.035
SF3B1	splicing factor 3b, subunit 1, 155kDa	0.035
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.033
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.033	Human
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.031
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.031
SARNP	SAP domain containing ribonucleoprotein	0.029
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.029
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.028
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.028
ATR	ataxia telangiectasia and Rad3 related	0.028
CXCR4	chemokine (C-X-C motif) receptor 4	0.027
CCNT1	cyclin T1	0.027
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.027	Mouse
SPRR2A	small proline-rich protein 2A	0.026
USP42	ubiquitin specific peptidase 42	0.026
JUB	jub, ajuba homolog (Xenopus laevis)	0.025
RHOA	ras homolog gene family, member A	0.025
YAP1	Yes-associated protein 1	0.025
PSEN2	presenilin 2 (Alzheimer disease 4)	0.024
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.023
BRCA1	breast cancer 1, early onset	0.023
SETD7	SET domain containing (lysine methyltransferase) 7	0.023
RBBP8	retinoblastoma binding protein 8	0.023
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.022
TK1	thymidine kinase 1, soluble	0.022
DCAF7	DDB1 and CUL4 associated factor 7	0.021
CUX1	cut-like homeobox 1	0.021
ADRM1	adhesion regulating molecule 1	0.021
RNR2	l-rRNA	0.020
UBXN1	UBX domain protein 1	0.020
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.020
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.020
SNRPD3	small nuclear ribonucleoprotein D3 polypeptide 18kDa	0.020
THOC1	THO complex 1	0.019
STRN4	striatin, calmodulin binding protein 4	0.019
GATA2	GATA binding protein 2	0.019
DBN1	drebrin 1	0.019
BTBD2	BTB (POZ) domain containing 2	0.019
U2AF1	U2 small nuclear RNA auxiliary factor 1	0.019
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.019
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.019	Fly
CLNS1A	chloride channel, nucleotide-sensitive, 1A	0.019
HDAC1	histone deacetylase 1	0.019
FANCD2	Fanconi anemia, complementation group D2	0.019
CDK4	cyclin-dependent kinase 4	0.019
SF3A1	splicing factor 3a, subunit 1, 120kDa	0.018
FBXW11	F-box and WD repeat domain containing 11	0.018
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.018
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.018
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.017
NBN	nibrin	0.017
VCAN	versican	0.017
POLH	polymerase (DNA directed), eta	0.017
DPP4	dipeptidyl-peptidase 4	0.017
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.017
ANKRD28	ankyrin repeat domain 28	0.017
TP53BP1	tumor protein p53 binding protein 1	0.016
CCNA2	cyclin A2	0.016
HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	0.016
AHR	aryl hydrocarbon receptor	0.016
ZNF830	zinc finger protein 830	0.016
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.016
SFN	stratifin	0.015
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.015
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.015
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.015
UBE3A	ubiquitin protein ligase E3A	0.015
RBM23	RNA binding motif protein 23	0.015
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.015
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.015
PDE9A	phosphodiesterase 9A	0.014
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.014
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.014
BCAR1	breast cancer anti-estrogen resistance 1	0.014
RNF20	ring finger protein 20	0.014
UBE2S	ubiquitin-conjugating enzyme E2S	0.014
MAGEA2	melanoma antigen family A, 2	0.014
DCN	decorin	0.014
RNF11	ring finger protein 11	0.014
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.014
E2F2	E2F transcription factor 2	0.014
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.014
RCC1	regulator of chromosome condensation 1	0.014
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.013
CCND1	cyclin D1	0.013
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.013
BIK	BCL2-interacting killer (apoptosis-inducing)	0.013
USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	0.013
RAD18	RAD18 homolog (S. cerevisiae)	0.013
MSH5	mutS homolog 5 (E. coli)	0.013
C17orf79	chromosome 17 open reading frame 79	0.013
EZR	ezrin	0.013
MESDC2	mesoderm development candidate 2	0.013
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.013
RPS5	ribosomal protein S5	0.013
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.012
TBC1D17	TBC1 domain family, member 17	0.012
ZFYVE1	zinc finger, FYVE domain containing 1	0.012
STX5	syntaxin 5	0.012
LZTS2	leucine zipper, putative tumor suppressor 2	0.012
PTK2	PTK2 protein tyrosine kinase 2	0.012
SRGN	serglycin	0.012
LMO2	LIM domain only 2 (rhombotin-like 1)	0.012
RNF144B	ring finger protein 144B	0.012
RPL39	ribosomal protein L39	0.012
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.012
MED1	mediator complex subunit 1	0.012
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.012
RAD52	RAD52 homolog (S. cerevisiae)	0.012
CHFR	checkpoint with forkhead and ring finger domains	0.012
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.012
PAAF1	proteasomal ATPase-associated factor 1	0.012
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.012
BID	BH3 interacting domain death agonist	0.012
RYBP	RING1 and YY1 binding protein	0.011
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.011
THOC3	THO complex 3	0.011
ARIH2	ariadne homolog 2 (Drosophila)	0.011
ABI2	abl-interactor 2	0.011
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.011
WDR26	WD repeat domain 26	0.011
ANKRD13B	ankyrin repeat domain 13B	0.011
EIF6	eukaryotic translation initiation factor 6	0.011
SNRNP200	small nuclear ribonucleoprotein 200kDa (U5)	0.011
CDK9	cyclin-dependent kinase 9	0.011
CSNK2B	casein kinase 2, beta polypeptide	0.011
RBL1	retinoblastoma-like 1 (p107)	0.011
CHTOP	chromatin target of PRMT1	0.011
SF3A2	splicing factor 3a, subunit 2, 66kDa	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.011
FAF2	Fas associated factor family member 2	0.011
SF3B4	splicing factor 3b, subunit 4, 49kDa	0.011
E2F4	E2F transcription factor 4, p107/p130-binding	0.011
DAD1	defender against cell death 1	0.011
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.011
THOC6	THO complex 6 homolog (Drosophila)	0.011
CDK6	cyclin-dependent kinase 6	0.011
ZNRF1	zinc and ring finger 1	0.010
RNF40	ring finger protein 40	0.010
PGAM1	phosphoglycerate mutase 1 (brain)	0.010
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.010
DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide	0.010
RNF168	ring finger protein 168	0.010	Human
MYST1	MYST histone acetyltransferase 1	0.010
CCND3	cyclin D3	0.010
ANXA1	annexin A1	0.010
HIST2H2AC	histone cluster 2, H2ac	0.010
FAP	fibroblast activation protein, alpha	0.010
RFWD2	ring finger and WD repeat domain 2	0.010