IMP: Integrative Multi-species Prediction

Homo sapiens

23 genes annotated in human

cardiac ventricle development

The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac ventricle development"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cardiac ventricle development" (in gray)

Name	Description	Probability	Func Analog Organism
TNNC1	troponin C type 1 (slow)	0.973
TNNI1	troponin I type 1 (skeletal, slow)	0.932	Human Mouse
TPM1	tropomyosin 1 (alpha)	0.931
JAG1	jagged 1	0.928	Mouse
NOTCH1	notch 1	0.887
TRIM63	tripartite motif containing 63	0.878
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.850
EP300	E1A binding protein p300	0.810
ACTA1	actin, alpha 1, skeletal muscle	0.632
DSP	desmoplakin	0.575	Mouse
TBX5	T-box 5	0.563	Mouse
EPAS1	endothelial PAS domain protein 1	0.558
TNNT2	troponin T type 2 (cardiac)	0.533
GATA4	GATA binding protein 4	0.514	Zebrafish Mouse
NOTCH3	notch 3	0.473	Human
SMYD1	SET and MYND domain containing 1	0.444
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.415
TPM2	tropomyosin 2 (beta)	0.371	Human
TNNT3	troponin T type 3 (skeletal, fast)	0.369	Human
GSK3B	glycogen synthase kinase 3 beta	0.339
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.339
HNF4A	hepatocyte nuclear factor 4, alpha	0.309
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.304
HAP1	huntingtin-associated protein 1	0.303
SMAD9	SMAD family member 9	0.303
CTGF	connective tissue growth factor	0.284
MYH9	myosin, heavy chain 9, non-muscle	0.252
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	0.226	Human
ARNT	aryl hydrocarbon receptor nuclear translocator	0.226
COX6A2	cytochrome c oxidase subunit VIa polypeptide 2	0.222
FGF1	fibroblast growth factor 1 (acidic)	0.211
SMAD3	SMAD family member 3	0.186
AXIN1	axin 1	0.171
SETD8	SET domain containing (lysine methyltransferase) 8	0.164
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.154
ACTN3	actinin, alpha 3	0.153
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.153
ACVR1B	activin A receptor, type IB	0.149
HDAC4	histone deacetylase 4	0.142
CKM	creatine kinase, muscle	0.130
SFN	stratifin	0.123
FGF10	fibroblast growth factor 10	0.120
PSEN1	presenilin 1	0.119
MYOD1	myogenic differentiation 1	0.112
KRT14	keratin 14	0.108
TNNI2	troponin I type 2 (skeletal, fast)	0.106	Human
CXXC5	CXXC finger protein 5	0.101
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.099
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.099
GATA2	GATA binding protein 2	0.097
MYBPC2	myosin binding protein C, fast type	0.097
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.091
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.089
MAML1	mastermind-like 1 (Drosophila)	0.088
ACTN1	actinin, alpha 1	0.087
KAT2B	K(lysine) acetyltransferase 2B	0.086
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.081	Human
PDX1	pancreatic and duodenal homeobox 1	0.080
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.080
SIRT1	sirtuin 1	0.077
JUP	junction plakoglobin	0.075
DLL1	delta-like 1 (Drosophila)	0.075
EGLN3	egl nine homolog 3 (C. elegans)	0.069
PKP4	plakophilin 4	0.065	Human
CTBP2	C-terminal binding protein 2	0.063
MYH2	myosin, heavy chain 2, skeletal muscle, adult	0.062	Human
TRIM29	tripartite motif containing 29	0.061
NCOR2	nuclear receptor corepressor 2	0.060
TNNT1	troponin T type 1 (skeletal, slow)	0.054	Human
JUB	jub, ajuba homolog (Xenopus laevis)	0.053
LAD1	ladinin 1	0.052
KRT8	keratin 8	0.050
MYH1	myosin, heavy chain 1, skeletal muscle, adult	0.050	Human
LDB3	LIM domain binding 3	0.048
WNT3A	wingless-type MMTV integration site family, member 3A	0.047
STK3	serine/threonine kinase 3	0.047
PKP2	plakophilin 2	0.046
PTCH1	patched 1	0.046
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.045
DBN1	drebrin 1	0.044
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.042	Mouse
COL4A1	collagen, type IV, alpha 1	0.042
SMAD6	SMAD family member 6	0.042
FZD1	frizzled homolog 1 (Drosophila)	0.041	Mouse
TGFB1	transforming growth factor, beta 1	0.040
SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	0.038
RARA	retinoic acid receptor, alpha	0.037
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.036
CNN1	calponin 1, basic, smooth muscle	0.035
DES	desmin	0.035
PDLIM7	PDZ and LIM domain 7 (enigma)	0.034
MYL3	myosin, light chain 3, alkali; ventricular, skeletal, slow	0.033
TGFBR1	transforming growth factor, beta receptor 1	0.032
PAX8	paired box 8	0.032
SMAD1	SMAD family member 1	0.031
TAGLN	transgelin	0.031
SP1	Sp1 transcription factor	0.031
MYL1	myosin, light chain 1, alkali; skeletal, fast	0.030	Human
HOXD12	homeobox D12	0.030
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.029	Mouse
ESR1	estrogen receptor 1	0.029
ACTC1	actin, alpha, cardiac muscle 1	0.029
KRT18	keratin 18	0.029
MYL12B	myosin, light chain 12B, regulatory	0.028	Human
SMAD7	SMAD family member 7	0.028	Mouse
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.027
SOX11	SRY (sex determining region Y)-box 11	0.027	Mouse
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.027
HIC1	hypermethylated in cancer 1	0.026
MYH6	myosin, heavy chain 6, cardiac muscle, alpha	0.026
SOX7	SRY (sex determining region Y)-box 7	0.026
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	0.026	Human
RPL36AL	ribosomal protein L36a-like	0.026
HAND2	heart and neural crest derivatives expressed 2	0.025	Human Mouse
GRIP1	glutamate receptor interacting protein 1	0.025
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.025
HDAC1	histone deacetylase 1	0.025
ESR2	estrogen receptor 2 (ER beta)	0.024
MYOG	myogenin (myogenic factor 4)	0.024
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.024
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.024	Human
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.023
FOXG1	forkhead box G1	0.023
RUNX1	runt-related transcription factor 1	0.023
DSG2	desmoglein 2	0.023
LHX5	LIM homeobox 5	0.023
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.023
HIPK2	homeodomain interacting protein kinase 2	0.022
ACTB	actin, beta	0.022
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.022
PHOX2A	paired-like homeobox 2a	0.022
JAG2	jagged 2	0.022
TTN	titin	0.022
WNT5A	wingless-type MMTV integration site family, member 5A	0.021	Mouse
SIX6	SIX homeobox 6	0.021
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.021
TNNC2	troponin C type 2 (fast)	0.020	Human
HOXD13	homeobox D13	0.020
CNN2	calponin 2	0.020
FRMD5	FERM domain containing 5	0.020
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.020
ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	0.020
CSNK1E	casein kinase 1, epsilon	0.020
DRD4	dopamine receptor D4	0.020
KRT17	keratin 17	0.020
ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0.019
FOXF2	forkhead box F2	0.019	Human
NOTCH2	notch 2	0.019	Human
GJB3	gap junction protein, beta 3, 31kDa	0.019	Human
TINAGL1	tubulointerstitial nephritis antigen-like 1	0.019
MYLK2	myosin light chain kinase 2	0.019
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.019
SOX9	SRY (sex determining region Y)-box 9	0.019
SOX17	SRY (sex determining region Y)-box 17	0.018
SFRP5	secreted frizzled-related protein 5	0.018	Human
MED10	mediator complex subunit 10	0.018
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.018
FOXC1	forkhead box C1	0.018	Mouse
TPM4	tropomyosin 4	0.018	Human
BTF3	basic transcription factor 3	0.018
NOTCH2NL	notch 2 N-terminal like	0.018
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.018
FLNA	filamin A, alpha	0.018
TAGLN2	transgelin 2	0.018
C19orf50	chromosome 19 open reading frame 50	0.017
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.017	Human
MYH8	myosin, heavy chain 8, skeletal muscle, perinatal	0.017	Human
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.017
MARK3	MAP/microtubule affinity-regulating kinase 3	0.017
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.017
EFNB2	ephrin-B2	0.017
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.017
LRRN2	leucine rich repeat neuronal 2	0.017
TNNI3	troponin I type 3 (cardiac)	0.017
FGF3	fibroblast growth factor 3	0.017
PYY	peptide YY	0.016
CDH15	cadherin 15, type 1, M-cadherin (myotubule)	0.016
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.016
MYBPC1	myosin binding protein C, slow type	0.016
SNW1	SNW domain containing 1	0.016
RPL3L	ribosomal protein L3-like	0.016
NAP1L1	nucleosome assembly protein 1-like 1	0.016
LDB1	LIM domain binding 1	0.016
DSG3	desmoglein 3	0.016
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.016
HOXA10	homeobox A10	0.015
APOBEC2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	0.015
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.015
FUNDC2	FUN14 domain containing 2	0.015
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.015
KRT5	keratin 5	0.015
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.015
CASQ2	calsequestrin 2 (cardiac muscle)	0.015
TBX1	T-box 1	0.015
CCK	cholecystokinin	0.015
POU3F2	POU class 3 homeobox 2	0.015
MB	myoglobin	0.015
ACTA2	actin, alpha 2, smooth muscle, aorta	0.015
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.015
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.014
TAL1	T-cell acute lymphocytic leukemia 1	0.014	Human
SRPK3	SRSF protein kinase 3	0.014
GJB5	gap junction protein, beta 5, 31.1kDa	0.014	Human
NEUROG1	neurogenin 1	0.014	Human
TBX2	T-box 2	0.014
FGFR1	fibroblast growth factor receptor 1	0.014
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.014	Mouse
PFDN5	prefoldin subunit 5	0.014
MYBPH	myosin binding protein H	0.014
NPPB	natriuretic peptide B	0.014
NPAS1	neuronal PAS domain protein 1	0.014
MYL7	myosin, light chain 7, regulatory	0.014	Human
SOX13	SRY (sex determining region Y)-box 13	0.014
COL17A1	collagen, type XVII, alpha 1	0.013
VHL	von Hippel-Lindau tumor suppressor	0.013
TNS4	tensin 4	0.013
POU3F4	POU class 3 homeobox 4	0.013
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.013
LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	0.013
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.013
AKAP6	A kinase (PRKA) anchor protein 6	0.013
INHBB	inhibin, beta B	0.013
CALCA	calcitonin-related polypeptide alpha	0.013
SOX18	SRY (sex determining region Y)-box 18	0.013
SSX4	synovial sarcoma, X breakpoint 4	0.013
GAB1	GRB2-associated binding protein 1	0.013
MYH4	myosin, heavy chain 4, skeletal muscle	0.013	Human
MED25	mediator complex subunit 25	0.013
ZFPM1	zinc finger protein, multitype 1	0.013	Human Mouse
FOXA2	forkhead box A2	0.013
ASCC2	activating signal cointegrator 1 complex subunit 2	0.013
SIM2	single-minded homolog 2 (Drosophila)	0.013
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.012
NR2F2	nuclear receptor subfamily 2, group F, member 2	0.012
AMOTL2	angiomotin like 2	0.012
HOXB13	homeobox B13	0.012
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
POU4F2	POU class 4 homeobox 2	0.012
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.012	Mouse
TXNIP	thioredoxin interacting protein	0.012
POU4F1	POU class 4 homeobox 1	0.012	Mouse
PKD2L1	polycystic kidney disease 2-like 1	0.012
THBS1	thrombospondin 1	0.012
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.012
MYLK	myosin light chain kinase	0.012
RB1	retinoblastoma 1	0.012
USP6	ubiquitin specific peptidase 6 (Tre-2 oncogene)	0.012
OCLN	occludin	0.012
SLN	sarcolipin	0.012
HAND1	heart and neural crest derivatives expressed 1	0.012
RBBP4	retinoblastoma binding protein 4	0.012
SYNPO2L	synaptopodin 2-like	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.011
NEUROD1	neurogenic differentiation 1	0.011	Human
CDX2	caudal type homeobox 2	0.011
HOXA11	homeobox A11	0.011
AXIN2	axin 2	0.011
LBX1	ladybird homeobox 1	0.011
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.011
FGF7	fibroblast growth factor 7	0.011
ZNF830	zinc finger protein 830	0.011
PPL	periplakin	0.011
SMPX	small muscle protein, X-linked	0.011
TCF15	transcription factor 15 (basic helix-loop-helix)	0.011	Human
DEFA1	defensin, alpha 1	0.011
NRIP1	nuclear receptor interacting protein 1	0.011
HMGA2	high mobility group AT-hook 2	0.011
GRB7	growth factor receptor-bound protein 7	0.011
NPY	neuropeptide Y	0.011
FZD10	frizzled homolog 10 (Drosophila)	0.011
CAV1	caveolin 1, caveolae protein, 22kDa	0.011
ATXN3	ataxin 3	0.011
FLNB	filamin B, beta	0.011
PBX1	pre-B-cell leukemia homeobox 1	0.011
FZD7	frizzled homolog 7 (Drosophila)	0.011
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.011
CALD1	caldesmon 1	0.011
MNX1	motor neuron and pancreas homeobox 1	0.011
WNT2	wingless-type MMTV integration site family member 2	0.011
PTRF	polymerase I and transcript release factor	0.011
TP73	tumor protein p73	0.010
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.010
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.010
FEV	FEV (ETS oncogene family)	0.010
TAC1	tachykinin, precursor 1	0.010
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.010
FOXF1	forkhead box F1	0.010
PTF1A	pancreas specific transcription factor, 1a	0.010	Human
COL2A1	collagen, type II, alpha 1	0.010
PITX2	paired-like homeodomain 2	0.010	Mouse
MPZL1	myelin protein zero-like 1	0.010
NEUROD2	neurogenic differentiation 2	0.010	Human
NCOA7	nuclear receptor coactivator 7	0.010
LMO2	LIM domain only 2 (rhombotin-like 1)	0.010
SHOX2	short stature homeobox 2	0.010
AQP5	aquaporin 5	0.010
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.010
RHOD	ras homolog gene family, member D	0.010
FHL2	four and a half LIM domains 2	0.010
SKIL	SKI-like oncogene	0.010