IMP: Integrative Multi-species Prediction

Homo sapiens

6 genes annotated in human

positive regulation of multicellular organism growth

Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of multicellular organism growth"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of multicellular organism growth" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD3	SMAD family member 3	0.746	Worm
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.628
INSR	insulin receptor	0.441	Worm Fly
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.275
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.211
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.198
CBX3	chromobox homolog 3	0.172	Worm
H2AFX	H2A histone family, member X	0.172
TNRC6A	trinucleotide repeat containing 6A	0.170
TRIM28	tripartite motif containing 28	0.148
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.141
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.136
IGF1R	insulin-like growth factor 1 receptor	0.105	Worm Fly
IRS1	insulin receptor substrate 1	0.104	Fly
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.102	Worm
PDIA3	protein disulfide isomerase family A, member 3	0.092	Worm
RPL27	ribosomal protein L27	0.090
CREB1	cAMP responsive element binding protein 1	0.085	Mouse
MBNL1	muscleblind-like (Drosophila)	0.083
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.080
CREBBP	CREB binding protein	0.079
GH1	growth hormone 1	0.078
EGFR	epidermal growth factor receptor	0.075
RPL37A	ribosomal protein L37a	0.073
FKBP1A	FK506 binding protein 1A, 12kDa	0.062
SMAD2	SMAD family member 2	0.060	Worm
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.056
TUFM	Tu translation elongation factor, mitochondrial	0.054
RPL36A	ribosomal protein L36a	0.048
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.046
EP300	E1A binding protein p300	0.045
HNRNPR	heterogeneous nuclear ribonucleoprotein R	0.043
SP1	Sp1 transcription factor	0.043
MCM5	minichromosome maintenance complex component 5	0.043
RPL32	ribosomal protein L32	0.042
RPL34	ribosomal protein L34	0.041
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.041
MTA1	metastasis associated 1	0.039
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.039
PDIA4	protein disulfide isomerase family A, member 4	0.039	Worm
EIF3H	eukaryotic translation initiation factor 3, subunit H	0.036
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.035
ZFX	zinc finger protein, X-linked	0.035
ADNP	activity-dependent neuroprotector homeobox	0.035
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.034	Worm
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.034	Worm
RPL41	ribosomal protein L41	0.033
BAD	BCL2-associated agonist of cell death	0.033
PRDX4	peroxiredoxin 4	0.032	Worm
AR	androgen receptor	0.032
PRDX1	peroxiredoxin 1	0.031	Worm
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.031
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.028
NOP58	NOP58 ribonucleoprotein homolog (yeast)	0.028
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	0.028
ELP3	elongation protein 3 homolog (S. cerevisiae)	0.027
NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	0.026
NCOA6	nuclear receptor coactivator 6	0.026
RAN	RAN, member RAS oncogene family	0.026
HIPK2	homeodomain interacting protein kinase 2	0.026
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.025
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.025
TP53	tumor protein p53	0.024	Fly
MAPK1	mitogen-activated protein kinase 1	0.024
SMAD7	SMAD family member 7	0.024
RPS25	ribosomal protein S25	0.023
EIF4B	eukaryotic translation initiation factor 4B	0.022
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.022
SMAD4	SMAD family member 4	0.022	Worm
CTR9	Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.022
RPL30	ribosomal protein L30	0.021	Worm
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.020
EEF1B2	eukaryotic translation elongation factor 1 beta 2	0.020
PABPC1	poly(A) binding protein, cytoplasmic 1	0.020
PEX14	peroxisomal biogenesis factor 14	0.019
BCL2L1	BCL2-like 1	0.019
GRB10	growth factor receptor-bound protein 10	0.019
CNOT1	CCR4-NOT transcription complex, subunit 1	0.018
PAPOLA	poly(A) polymerase alpha	0.018
PAX3	paired box 3	0.018
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.018
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.017
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.017	Human
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.017
SKIL	SKI-like oncogene	0.016
MCM2	minichromosome maintenance complex component 2	0.016
SNIP1	Smad nuclear interacting protein 1	0.016
MANF	mesencephalic astrocyte-derived neurotrophic factor	0.016
SF1	splicing factor 1	0.016
CRH	corticotropin releasing hormone	0.015
ILF3	interleukin enhancer binding factor 3, 90kDa	0.015
TXN	thioredoxin	0.015
PGK1	phosphoglycerate kinase 1	0.015
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.015
MED15	mediator complex subunit 15	0.015
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.015
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.015
PTPRN	protein tyrosine phosphatase, receptor type, N	0.015
CARM1	coactivator-associated arginine methyltransferase 1	0.014
ADAM10	ADAM metallopeptidase domain 10	0.014
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.014
COL4A1	collagen, type IV, alpha 1	0.013
HIST1H3B	histone cluster 1, H3b	0.013
PRKCZ	protein kinase C, zeta	0.013
TGFB1	transforming growth factor, beta 1	0.013
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.012
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.012
SOX10	SRY (sex determining region Y)-box 10	0.012
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.012
ENOPH1	enolase-phosphatase 1	0.012
TRAPPC2L	trafficking protein particle complex 2-like	0.012
EBNA1BP2	EBNA1 binding protein 2	0.012
EIF2B4	eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa	0.011
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.011
SMAD1	SMAD family member 1	0.011	Worm
TIMM9	translocase of inner mitochondrial membrane 9 homolog (yeast)	0.011
CSH2	chorionic somatomammotropin hormone 2	0.011	Human
WAPAL	wings apart-like homolog (Drosophila)	0.010
CALCA	calcitonin-related polypeptide alpha	0.010
IRS2	insulin receptor substrate 2	0.010	Fly
NCBP2	nuclear cap binding protein subunit 2, 20kDa	0.010
PDIA6	protein disulfide isomerase family A, member 6	0.010
RPL24	ribosomal protein L24	0.010
RRAGC	Ras-related GTP binding C	0.010