IMP: Integrative Multi-species Prediction

Homo sapiens

39 genes annotated in human

macroautophagy

The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "macroautophagy"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "macroautophagy" (in gray)

Name	Description	Probability	Func Analog Organism
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	1.000
GABARAPL2	GABA(A) receptor-associated protein-like 2	1.000
ATG3	ATG3 autophagy related 3 homolog (S. cerevisiae)	1.000	Yeast
GABARAP	GABA(A) receptor-associated protein	1.000
ATG5	ATG5 autophagy related 5 homolog (S. cerevisiae)	0.999	Mouse Fly
ATG13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.997
SQSTM1	sequestosome 1	0.996
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.996	Fly
ULK1	unc-51-like kinase 1 (C. elegans)	0.993
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.985	Yeast Mouse Fly
RB1CC1	RB1-inducible coiled-coil 1	0.982	Mouse
NBR1	neighbor of BRCA1 gene 1	0.971
MAPK1	mitogen-activated protein kinase 1	0.947	Fly
GABARAPL1	GABA(A) receptor-associated protein like 1	0.947
SH3KBP1	SH3-domain kinase binding protein 1	0.782
CHMP1A	chromatin modifying protein 1A	0.759
MAP2K1	mitogen-activated protein kinase kinase 1	0.757
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.723	Rat
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.592
LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	0.533
SIRT1	sirtuin 1	0.464
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.447
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.440
ATG7	ATG7 autophagy related 7 homolog (S. cerevisiae)	0.435
RRAGA	Ras-related GTP binding A	0.433
SESN2	sestrin 2	0.427
OPTN	optineurin	0.367
NRBF2	nuclear receptor binding factor 2	0.344
GRB10	growth factor receptor-bound protein 10	0.327
TSC2	tuberous sclerosis 2	0.321
GOLGA2	golgin A2	0.318
IRS2	insulin receptor substrate 2	0.311
ATG16L1	ATG16 autophagy related 16-like 1 (S. cerevisiae)	0.307	Worm
GFM1	G elongation factor, mitochondrial 1	0.277
PDCD6	programmed cell death 6	0.267
CREBBP	CREB binding protein	0.264
EGFR	epidermal growth factor receptor	0.259
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.255
BCL2	B-cell CLL/lymphoma 2	0.241
AMBRA1	autophagy/beclin-1 regulator 1	0.239
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.218
RHEB	Ras homolog enriched in brain	0.211
COASY	CoA synthase	0.210
AR	androgen receptor	0.209
PDCD6IP	programmed cell death 6 interacting protein	0.190
COG7	component of oligomeric golgi complex 7	0.181
MAPK8	mitogen-activated protein kinase 8	0.166
STX7	syntaxin 7	0.154
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.154
KAT2B	K(lysine) acetyltransferase 2B	0.154
TTC15	tetratricopeptide repeat domain 15	0.150
USP8	ubiquitin specific peptidase 8	0.146
CLTB	clathrin, light chain B	0.146
BECN1	beclin 1, autophagy related	0.142	Mouse
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.138
UVRAG	UV radiation resistance associated gene	0.137
ZFYVE1	zinc finger, FYVE domain containing 1	0.137
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.136	Fly
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.134
NCOA2	nuclear receptor coactivator 2	0.131
PINK1	PTEN induced putative kinase 1	0.129
EEF1G	eukaryotic translation elongation factor 1 gamma	0.106
ATXN3	ataxin 3	0.102
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.093	Fly
MAP2K2	mitogen-activated protein kinase kinase 2	0.092
ANKRD27	ankyrin repeat domain 27 (VPS9 domain)	0.092
ATG9A	ATG9 autophagy related 9 homolog A (S. cerevisiae)	0.091
PIK3C3	phosphoinositide-3-kinase, class 3	0.090	Rat
DCTN1	dynactin 1	0.088
PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.087
RFK	riboflavin kinase	0.084
CHMP6	chromatin modifying protein 6	0.083
NCOA1	nuclear receptor coactivator 1	0.083
SUPT6H	suppressor of Ty 6 homolog (S. cerevisiae)	0.083
APC	adenomatous polyposis coli	0.081
PSEN2	presenilin 2 (Alzheimer disease 4)	0.081
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.076
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.076
IRS1	insulin receptor substrate 1	0.074
FUNDC2	FUN14 domain containing 2	0.073
SCHIP1	schwannomin interacting protein 1	0.073
NCOA6	nuclear receptor coactivator 6	0.072
RAB1A	RAB1A, member RAS oncogene family	0.070
RICTOR	RPTOR independent companion of MTOR, complex 2	0.070
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.068
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.068	Fly
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.065
MKRN1	makorin ring finger protein 1	0.063
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.062
PTK2	PTK2 protein tyrosine kinase 2	0.061
KIF5B	kinesin family member 5B	0.061
CTSA	cathepsin A	0.061
GAB2	GRB2-associated binding protein 2	0.060
SPAG9	sperm associated antigen 9	0.060
STX4	syntaxin 4	0.060
UBXN6	UBX domain protein 6	0.059
BAD	BCL2-associated agonist of cell death	0.058
KIAA1377	KIAA1377	0.058
EP300	E1A binding protein p300	0.058
RPS19BP1	ribosomal protein S19 binding protein 1	0.058
ARFGAP2	ADP-ribosylation factor GTPase activating protein 2	0.056
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.056
RAB5A	RAB5A, member RAS oncogene family	0.056
HDAC5	histone deacetylase 5	0.056
PEBP4	phosphatidylethanolamine-binding protein 4	0.056
C5orf41	chromosome 5 open reading frame 41	0.055
CMPK1	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic	0.055
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.055
TSG101	tumor susceptibility gene 101	0.055
SH3GL2	SH3-domain GRB2-like 2	0.054
DAPK1	death-associated protein kinase 1	0.054
CARM1	coactivator-associated arginine methyltransferase 1	0.054
PHAX	phosphorylated adaptor for RNA export	0.053
PIK3R4	phosphoinositide-3-kinase, regulatory subunit 4	0.052	Yeast
FOXO1	forkhead box O1	0.052	Fly
INSR	insulin receptor	0.051	Worm
RAB11A	RAB11A, member RAS oncogene family	0.050
BCL2L1	BCL2-like 1	0.048
FOXO3	forkhead box O3	0.048	Fly
KEAP1	kelch-like ECH-associated protein 1	0.047
VPS4A	vacuolar protein sorting 4 homolog A (S. cerevisiae)	0.047	Fly
C14orf129	chromosome 14 open reading frame 129	0.047
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.046
RPTOR	regulatory associated protein of MTOR, complex 1	0.045
APIP	APAF1 interacting protein	0.045
PKP4	plakophilin 4	0.044
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.044
MAPT	microtubule-associated protein tau	0.044
TMEM222	transmembrane protein 222	0.044
TRIM63	tripartite motif containing 63	0.044	Human
CLTA	clathrin, light chain A	0.043
GAK	cyclin G associated kinase	0.041
SCAND1	SCAN domain containing 1	0.041
SCFD1	sec1 family domain containing 1	0.040
BAG1	BCL2-associated athanogene	0.040
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.040
COG1	component of oligomeric golgi complex 1	0.040
FAM82A2	family with sequence similarity 82, member A2	0.040
ATG10	ATG10 autophagy related 10 homolog (S. cerevisiae)	0.039
PAF1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.038
IGF1R	insulin-like growth factor 1 receptor	0.038	Worm
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.038
FLNB	filamin B, beta	0.037
FAM48A	family with sequence similarity 48, member A	0.036
DUSP1	dual specificity phosphatase 1	0.036
PRPF6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	0.035
SIRT2	sirtuin 2	0.035
UBXN2A	UBX domain protein 2A	0.035
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.034
FAM134A	family with sequence similarity 134, member A	0.034
ADRBK1	adrenergic, beta, receptor kinase 1	0.034
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.034
RAB6A	RAB6A, member RAS oncogene family	0.034
SEC22B	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)	0.034
WASH1	WAS protein family homolog 1	0.034
TIMM50	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	0.033
PRKCE	protein kinase C, epsilon	0.032
KBTBD7	kelch repeat and BTB (POZ) domain containing 7	0.032
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.032
TMEM11	transmembrane protein 11	0.031
TMOD3	tropomodulin 3 (ubiquitous)	0.031
DEPTOR	DEP domain containing MTOR-interacting protein	0.031
OCRL	oculocerebrorenal syndrome of Lowe	0.031
IGSF21	immunoglobin superfamily, member 21	0.031
CNPPD1	cyclin Pas1/PHO80 domain containing 1	0.030
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.030
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.030
RAP1A	RAP1A, member of RAS oncogene family	0.030
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.030
ATG2A	ATG2 autophagy related 2 homolog A (S. cerevisiae)	0.030
CORO1C	coronin, actin binding protein, 1C	0.029
TBC1D15	TBC1 domain family, member 15	0.029
PXN	paxillin	0.029
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.029
FHL2	four and a half LIM domains 2	0.029
ULK2	unc-51-like kinase 2 (C. elegans)	0.029	Human
C12orf4	chromosome 12 open reading frame 4	0.029
DUSP3	dual specificity phosphatase 3	0.028
C12orf44	chromosome 12 open reading frame 44	0.028
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.028
UFD1L	ubiquitin fusion degradation 1 like (yeast)	0.028
BRMS1	breast cancer metastasis suppressor 1	0.028
MAPK3	mitogen-activated protein kinase 3	0.027	Fly
NRBP1	nuclear receptor binding protein 1	0.027
PEA15	phosphoprotein enriched in astrocytes 15	0.027
SAR1B	SAR1 homolog B (S. cerevisiae)	0.027
RRAGD	Ras-related GTP binding D	0.027
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.026
MOSPD1	motile sperm domain containing 1	0.026
CHMP2B	chromatin modifying protein 2B	0.026
RAB1B	RAB1B, member RAS oncogene family	0.026
GABBR1	gamma-aminobutyric acid (GABA) B receptor, 1	0.026
RAB7A	RAB7A, member RAS oncogene family	0.026
AKT1S1	AKT1 substrate 1 (proline-rich)	0.026
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.026
VCPIP1	valosin containing protein (p97)/p47 complex interacting protein 1	0.026
AIG1	androgen-induced 1	0.026
FHOD3	formin homology 2 domain containing 3	0.026
DPH3	DPH3, KTI11 homolog (S. cerevisiae)	0.025
WBP2	WW domain binding protein 2	0.025
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.025
CRTC2	CREB regulated transcription coactivator 2	0.025
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.025
ABCF3	ATP-binding cassette, sub-family F (GCN20), member 3	0.025
ARPC5L	actin related protein 2/3 complex, subunit 5-like	0.025
KSR1	kinase suppressor of ras 1	0.025
TBC1D17	TBC1 domain family, member 17	0.025
STK25	serine/threonine kinase 25	0.024
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.024
STX8	syntaxin 8	0.024
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.024
EIF1B	eukaryotic translation initiation factor 1B	0.024
CALU	calumenin	0.024
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.023
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.023
GNAI3	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	0.023
USP54	ubiquitin specific peptidase 54	0.023
ARL8B	ADP-ribosylation factor-like 8B	0.023
BCL7B	B-cell CLL/lymphoma 7B	0.023
CHMP7	CHMP family, member 7	0.023
HDAC4	histone deacetylase 4	0.023
CALCOCO2	calcium binding and coiled-coil domain 2	0.022
PABPN1	poly(A) binding protein, nuclear 1	0.022
SEC24C	SEC24 family, member C (S. cerevisiae)	0.022
TRAF6	TNF receptor-associated factor 6	0.022
BAG3	BCL2-associated athanogene 3	0.022
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.022
RALGDS	ral guanine nucleotide dissociation stimulator	0.021
RPS6KB2	ribosomal protein S6 kinase, 70kDa, polypeptide 2	0.021	Worm Fly
GDI1	GDP dissociation inhibitor 1	0.021
ISCA2	iron-sulfur cluster assembly 2 homolog (S. cerevisiae)	0.021
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.021
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.021
GTF3C1	general transcription factor IIIC, polypeptide 1, alpha 220kDa	0.021
ASCC2	activating signal cointegrator 1 complex subunit 2	0.021
ACTR10	actin-related protein 10 homolog (S. cerevisiae)	0.021
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.020
SNAP23	synaptosomal-associated protein, 23kDa	0.020
AMFR	autocrine motility factor receptor	0.020
ATP13A2	ATPase type 13A2	0.020
UBE4B	ubiquitination factor E4B (UFD2 homolog, yeast)	0.020
KRT18	keratin 18	0.020
PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	0.020
PTS	6-pyruvoyltetrahydropterin synthase	0.020
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.020
VIPAR	VPS33B interacting protein, apical-basolateral polarity regulator	0.020
STBD1	starch binding domain 1	0.020
APP	amyloid beta (A4) precursor protein	0.020
ADD1	adducin 1 (alpha)	0.020
ZNF219	zinc finger protein 219	0.020
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.019
ZDHHC17	zinc finger, DHHC-type containing 17	0.019
SELS	selenoprotein S	0.019
GORAB	golgin, RAB6-interacting	0.019
SH3GL1	SH3-domain GRB2-like 1	0.019
HTT	huntingtin	0.019
RUSC2	RUN and SH3 domain containing 2	0.019
DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40	0.019
STAT5A	signal transducer and activator of transcription 5A	0.019
TSSC4	tumor suppressing subtransferable candidate 4	0.019
FAM96B	family with sequence similarity 96, member B	0.019
PBK	PDZ binding kinase	0.019
ATP5A1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	0.019
RXRA	retinoid X receptor, alpha	0.019
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.018
ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1	0.018
PRKCI	protein kinase C, iota	0.018
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.018
CTTN	cortactin	0.018
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.018
CTNND1	catenin (cadherin-associated protein), delta 1	0.018
CREB1	cAMP responsive element binding protein 1	0.018
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.018
ELF2	E74-like factor 2 (ets domain transcription factor)	0.018
MYO18A	myosin XVIIIA	0.018
BRI3	brain protein I3	0.018
RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	0.018
GRAP2	GRB2-related adaptor protein 2	0.018
ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	0.017
VPS28	vacuolar protein sorting 28 homolog (S. cerevisiae)	0.017
GOLGA5	golgin A5	0.017
AAMP	angio-associated, migratory cell protein	0.017
RNF14	ring finger protein 14	0.017
GHR	growth hormone receptor	0.017
EDC4	enhancer of mRNA decapping 4	0.017
RNF11	ring finger protein 11	0.017
UBE2E3	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)	0.017
NF2	neurofibromin 2 (merlin)	0.017
DES	desmin	0.017
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.017
TUBB2A	tubulin, beta 2A	0.017
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.016
FYCO1	FYVE and coiled-coil domain containing 1	0.016
SH3GLB1	SH3-domain GRB2-like endophilin B1	0.016
SSNA1	Sjogren syndrome nuclear autoantigen 1	0.016
FAM89B	family with sequence similarity 89, member B	0.016
BTBD10	BTB (POZ) domain containing 10	0.016
MRPL41	mitochondrial ribosomal protein L41	0.016
C14orf1	chromosome 14 open reading frame 1	0.016
PYCARD	PYD and CARD domain containing	0.016
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.016
GRPEL1	GrpE-like 1, mitochondrial (E. coli)	0.016
ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	0.016
KIAA0930	KIAA0930	0.016
ARF1	ADP-ribosylation factor 1	0.016
EMD	emerin	0.016
FAM190B	family with sequence similarity 190, member B	0.016
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	0.016
EXOC1	exocyst complex component 1	0.016
EXOC4	exocyst complex component 4	0.016
ATG4A	ATG4 autophagy related 4 homolog A (S. cerevisiae)	0.016	Human
TBC1D25	TBC1 domain family, member 25	0.016
MAPK1IP1L	mitogen-activated protein kinase 1 interacting protein 1-like	0.016
RIN1	Ras and Rab interactor 1	0.015
MRPL28	mitochondrial ribosomal protein L28	0.015
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.015
RBM11	RNA binding motif protein 11	0.015
MARCH9	membrane-associated ring finger (C3HC4) 9	0.015
MAD2L1BP	MAD2L1 binding protein	0.015
C7orf59	chromosome 7 open reading frame 59	0.015
DNM2	dynamin 2	0.015
PEBP1	phosphatidylethanolamine binding protein 1	0.015
TOMM40L	translocase of outer mitochondrial membrane 40 homolog (yeast)-like	0.015
C18orf32	chromosome 18 open reading frame 32	0.015
BIK	BCL2-interacting killer (apoptosis-inducing)	0.015
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.015
KCTD2	potassium channel tetramerisation domain containing 2	0.015
UBE2E2	ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)	0.015
DR1	down-regulator of transcription 1, TBP-binding (negative cofactor 2)	0.015
RRP8	ribosomal RNA processing 8, methyltransferase, homolog (yeast)	0.015
HIGD1A	HIG1 hypoxia inducible domain family, member 1A	0.014
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.014
SNX3	sorting nexin 3	0.014
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.014
HK1	hexokinase 1	0.014
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.014
LDLR	low density lipoprotein receptor	0.014
NCOR2	nuclear receptor corepressor 2	0.014
WDFY3	WD repeat and FYVE domain containing 3	0.014
RAB9A	RAB9A, member RAS oncogene family	0.014
EDC3	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	0.014
RRAGB	Ras-related GTP binding B	0.014
CMIP	c-Maf-inducing protein	0.014
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.014
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
KIFC2	kinesin family member C2	0.014
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.014
COMMD8	COMM domain containing 8	0.014
TMEM59	transmembrane protein 59	0.014
DIXDC1	DIX domain containing 1	0.014
RPL27A	ribosomal protein L27a	0.014
VTI1B	vesicle transport through interaction with t-SNAREs homolog 1B (yeast)	0.014
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.014
PDPK1	3-phosphoinositide dependent protein kinase-1	0.014
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.014
RPLP1	ribosomal protein, large, P1	0.014
DEDD2	death effector domain containing 2	0.014
AP3S1	adaptor-related protein complex 3, sigma 1 subunit	0.014
AFTPH	aftiphilin	0.014
SRP19	signal recognition particle 19kDa	0.014
GPN2	GPN-loop GTPase 2	0.014
PGR	progesterone receptor	0.014
TRIB3	tribbles homolog 3 (Drosophila)	0.014
STK38	serine/threonine kinase 38	0.014
MAP2K4	mitogen-activated protein kinase kinase 4	0.013
ZNF32	zinc finger protein 32	0.013
PI4KB	phosphatidylinositol 4-kinase, catalytic, beta	0.013
SUPT4H1	suppressor of Ty 4 homolog 1 (S. cerevisiae)	0.013
NAT15	N-acetyltransferase 15 (GCN5-related, putative)	0.013
TOM1	target of myb1 (chicken)	0.013
FHOD1	formin homology 2 domain containing 1	0.013
GMFB	glia maturation factor, beta	0.013
FLNC	filamin C, gamma	0.013
ABHD16A	abhydrolase domain containing 16A	0.013
JKAMP	JNK1/MAPK8-associated membrane protein	0.013
EXOC8	exocyst complex component 8	0.013
ADRM1	adhesion regulating molecule 1	0.013
SH3GL3	SH3-domain GRB2-like 3	0.013
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.013
VAMP7	vesicle-associated membrane protein 7	0.013	Fly
WSB2	WD repeat and SOCS box containing 2	0.013
SLC25A46	solute carrier family 25, member 46	0.013
EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	0.013
LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	0.013
COBRA1	cofactor of BRCA1	0.013
TOLLIP	toll interacting protein	0.013
SEPT2	septin 2	0.013
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.013
CORO1B	coronin, actin binding protein, 1B	0.013
SREBF1	sterol regulatory element binding transcription factor 1	0.013
FER	fer (fps/fes related) tyrosine kinase	0.013
MAPKAP1	mitogen-activated protein kinase associated protein 1	0.013
EIF5A2	eukaryotic translation initiation factor 5A2	0.013
PNPLA6	patatin-like phospholipase domain containing 6	0.013
DCAF6	DDB1 and CUL4 associated factor 6	0.013
TPRG1L	tumor protein p63 regulated 1-like	0.013
MOSPD2	motile sperm domain containing 2	0.013
NAPG	N-ethylmaleimide-sensitive factor attachment protein, gamma	0.013
POLDIP2	polymerase (DNA-directed), delta interacting protein 2	0.013
MYOZ1	myozenin 1	0.013
ACTA1	actin, alpha 1, skeletal muscle	0.013
HDAC7	histone deacetylase 7	0.013
MTMR6	myotubularin related protein 6	0.013
LAMTOR2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	0.012
SMAP1	small ArfGAP 1	0.012
VPS18	vacuolar protein sorting 18 homolog (S. cerevisiae)	0.012
ARF6	ADP-ribosylation factor 6	0.012
KLC1	kinesin light chain 1	0.012
MARK3	MAP/microtubule affinity-regulating kinase 3	0.012
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.012
SREBF2	sterol regulatory element binding transcription factor 2	0.012
RNF20	ring finger protein 20	0.012
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.012
PDCD10	programmed cell death 10	0.012
STX12	syntaxin 12	0.012
FOXA1	forkhead box A1	0.012
OSBPL8	oxysterol binding protein-like 8	0.012
MLX	MAX-like protein X	0.012
FAM134C	family with sequence similarity 134, member C	0.012
KLF13	Kruppel-like factor 13	0.012
WDTC1	WD and tetratricopeptide repeats 1	0.012
PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	0.012
AP3S2	adaptor-related protein complex 3, sigma 2 subunit	0.012
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.012
RAD52	RAD52 homolog (S. cerevisiae)	0.012
SLC35A4	solute carrier family 35, member A4	0.012
RHOA	ras homolog gene family, member A	0.012
ZNRF1	zinc and ring finger 1	0.012
MAP1LC3C	microtubule-associated protein 1 light chain 3 gamma	0.012
KLHL12	kelch-like 12 (Drosophila)	0.012
PPARA	peroxisome proliferator-activated receptor alpha	0.012
IRAK2	interleukin-1 receptor-associated kinase 2	0.012
RLF	rearranged L-myc fusion	0.012
DYNLL1	dynein, light chain, LC8-type 1	0.011
TJP2	tight junction protein 2 (zona occludens 2)	0.011
ARCN1	archain 1	0.011
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.011
RNF6	ring finger protein (C3H2C3 type) 6	0.011
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.011
JOSD1	Josephin domain containing 1	0.011
RIC8A	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	0.011
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.011
HES1	hairy and enhancer of split 1, (Drosophila)	0.011
TRIP4	thyroid hormone receptor interactor 4	0.011
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.011
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.011
RNF167	ring finger protein 167	0.011
PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	0.011
NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	0.011
ANKRD13D	ankyrin repeat domain 13 family, member D	0.011
RAB5B	RAB5B, member RAS oncogene family	0.011
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.011
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.011
C20orf24	chromosome 20 open reading frame 24	0.011
HDHD2	haloacid dehalogenase-like hydrolase domain containing 2	0.011
NELF	nasal embryonic LHRH factor	0.011
WDR45	WD repeat domain 45	0.011
CHM	choroideremia (Rab escort protein 1)	0.011
TMEM141	transmembrane protein 141	0.011
RRM2B	ribonucleotide reductase M2 B (TP53 inducible)	0.011
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.011
CRELD1	cysteine-rich with EGF-like domains 1	0.011
GAB1	GRB2-associated binding protein 1	0.011
KIAA0415	KIAA0415	0.011
GSK3B	glycogen synthase kinase 3 beta	0.011
SMG5	Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.011
TYK2	tyrosine kinase 2	0.011
C16orf7	chromosome 16 open reading frame 7	0.011
FAM3A	family with sequence similarity 3, member A	0.011
MAPK14	mitogen-activated protein kinase 14	0.011
CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.011
WRB	tryptophan rich basic protein	0.011
SLC25A40	solute carrier family 25, member 40	0.011
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.011
SGK1	serum/glucocorticoid regulated kinase 1	0.011
SEC61B	Sec61 beta subunit	0.011
HEY2	hairy/enhancer-of-split related with YRPW motif 2	0.011
BABAM1	BRISC and BRCA1 A complex member 1	0.011
RADIL	Ras association and DIL domains	0.011
OSBPL3	oxysterol binding protein-like 3	0.011
RBM42	RNA binding motif protein 42	0.011
TTN	titin	0.011
SPTLC1	serine palmitoyltransferase, long chain base subunit 1	0.010
RLIM	ring finger protein, LIM domain interacting	0.010
DGKZ	diacylglycerol kinase, zeta	0.010
SCRN3	secernin 3	0.010
EPC1	enhancer of polycomb homolog 1 (Drosophila)	0.010
SAMD4B	sterile alpha motif domain containing 4B	0.010
TP53INP2	tumor protein p53 inducible nuclear protein 2	0.010
C4orf14	chromosome 4 open reading frame 14	0.010
OAT	ornithine aminotransferase	0.010
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.010
IKZF5	IKAROS family zinc finger 5 (Pegasus)	0.010
SRCAP	Snf2-related CREBBP activator protein	0.010
KIAA0232	KIAA0232	0.010
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.010
EEF2K	eukaryotic elongation factor-2 kinase	0.010
GBAS	glioblastoma amplified sequence	0.010
KLC4	kinesin light chain 4	0.010
FIG4	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	0.010
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.010
ZMYM3	zinc finger, MYM-type 3	0.010
STX3	syntaxin 3	0.010
ZMYM5	zinc finger, MYM-type 5	0.010
MXI1	MAX interactor 1	0.010
RNF10	ring finger protein 10	0.010
IL9R	interleukin 9 receptor	0.010
GSTP1	glutathione S-transferase pi 1	0.010
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.010	Fly
FGFR1	fibroblast growth factor receptor 1	0.010
RNF38	ring finger protein 38	0.010
CCDC6	coiled-coil domain containing 6	0.010
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.010
SPAG7	sperm associated antigen 7	0.010
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.010
STK4	serine/threonine kinase 4	0.010
FAM160A2	family with sequence similarity 160, member A2	0.010
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.010