IMP: Integrative Multi-species Prediction

Homo sapiens

36 genes annotated in human

regulation of cell cycle arrest

Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.

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Known genes in the process in humanInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of cell cycle arrest"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "regulation of cell cycle arrest" (in gray)

Name	Description	Probability	Func Analog Organism
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	1.000
FGFR2	fibroblast growth factor receptor 2	1.000
STK4	serine/threonine kinase 4	1.000
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	1.000	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.999
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.999	Human
STK3	serine/threonine kinase 3	0.998
RB1	retinoblastoma 1	0.994
CDK6	cyclin-dependent kinase 6	0.993	Human
CCNE1	cyclin E1	0.989
CCND1	cyclin D1	0.975
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.962	Human
FGF1	fibroblast growth factor 1 (acidic)	0.946	Human
XIAP	X-linked inhibitor of apoptosis	0.945
CDK2	cyclin-dependent kinase 2	0.944
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.942
CCND3	cyclin D3	0.923	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.916
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.888
PAX3	paired box 3	0.817
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.807	Human
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.782
CDK4	cyclin-dependent kinase 4	0.745
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.717
TP53	tumor protein p53	0.715
APAF1	apoptotic peptidase activating factor 1	0.683
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.656	Human
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.653	Human
SMAD7	SMAD family member 7	0.629
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.621
RARA	retinoic acid receptor, alpha	0.619
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.618
FAS	Fas (TNF receptor superfamily, member 6)	0.617
DAXX	death-domain associated protein	0.613
IER3	immediate early response 3	0.605
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.594
POU3F2	POU class 3 homeobox 2	0.551
FGF10	fibroblast growth factor 10	0.540
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.537
RXRA	retinoid X receptor, alpha	0.534
ZNF260	zinc finger protein 260	0.532
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.510
RBL1	retinoblastoma-like 1 (p107)	0.477
NLRC4	NLR family, CARD domain containing 4	0.475
SAV1	salvador homolog 1 (Drosophila)	0.458
RIN3	Ras and Rab interactor 3	0.453
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.446
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.443
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.425
POU5F1	POU class 5 homeobox 1	0.425
SNX9	sorting nexin 9	0.405
CFLAR	CASP8 and FADD-like apoptosis regulator	0.397
BCL2	B-cell CLL/lymphoma 2	0.394
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.381	Human
ZNF420	zinc finger protein 420	0.355
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.354	Human
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.354
ZNF84	zinc finger protein 84	0.352
FGFR1	fibroblast growth factor receptor 1	0.349
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.332	Human
HDAC1	histone deacetylase 1	0.315
LRDD	leucine-rich repeats and death domain containing	0.277
RUNX1	runt-related transcription factor 1	0.277
CDK5	cyclin-dependent kinase 5	0.268
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.263
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.254
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.253
SLMAP	sarcolemma associated protein	0.251
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.244
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.239
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.222
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.210	Human
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.203
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.197
YAP1	Yes-associated protein 1	0.194
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.155
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.153
CCND2	cyclin D2	0.151	Human
CDT1	chromatin licensing and DNA replication factor 1	0.145
CABLES1	Cdk5 and Abl enzyme substrate 1	0.140
DNM1	dynamin 1	0.130
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.126
SKP2	S-phase kinase-associated protein 2 (p45)	0.123
EP300	E1A binding protein p300	0.119
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.118
FASLG	Fas ligand (TNF superfamily, member 6)	0.116
SYNJ1	synaptojanin 1	0.107
KCNRG	potassium channel regulator	0.106
ZNF304	zinc finger protein 304	0.103
CDCA4	cell division cycle associated 4	0.098
AKIP1	A kinase (PRKA) interacting protein 1	0.098
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.098
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.095
PCGF2	polycomb group ring finger 2	0.095
DOCK7	dedicator of cytokinesis 7	0.094
KRT5	keratin 5	0.093
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.093
MEOX2	mesenchyme homeobox 2	0.090
CDK9	cyclin-dependent kinase 9	0.089
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.087
ENG	endoglin	0.085
FOXD3	forkhead box D3	0.083
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.083
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.082
SMAD1	SMAD family member 1	0.081
ZNF189	zinc finger protein 189	0.078
BIRC2	baculoviral IAP repeat containing 2	0.078
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.078
SATB2	SATB homeobox 2	0.078
MYOD1	myogenic differentiation 1	0.073
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.071
SMAD4	SMAD family member 4	0.071
PML	promyelocytic leukemia	0.069	Mouse
NUCB2	nucleobindin 2	0.069
PRMT6	protein arginine methyltransferase 6	0.067
E2F1	E2F transcription factor 1	0.066
NMI	N-myc (and STAT) interactor	0.064
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.064
RYR2	ryanodine receptor 2 (cardiac)	0.063
FGF7	fibroblast growth factor 7	0.062	Human
TGFBR1	transforming growth factor, beta receptor 1	0.062
ARRB2	arrestin, beta 2	0.061
SOCS1	suppressor of cytokine signaling 1	0.058
ZNF432	zinc finger protein 432	0.057
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.055	Human
FADD	Fas (TNFRSF6)-associated via death domain	0.054
H3F3C	H3 histone, family 3C	0.054
FBXW7	F-box and WD repeat domain containing 7	0.053
HMGA2	high mobility group AT-hook 2	0.052
AXIN1	axin 1	0.051
CUX1	cut-like homeobox 1	0.047
ELF4	E74-like factor 4 (ets domain transcription factor)	0.047
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.047
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.046
ZNF12	zinc finger protein 12	0.043
GBP2	guanylate binding protein 2, interferon-inducible	0.043
SMAD3	SMAD family member 3	0.042
CCNDBP1	cyclin D-type binding-protein 1	0.041
SH3GL2	SH3-domain GRB2-like 2	0.040
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.040
RIPK2	receptor-interacting serine-threonine kinase 2	0.040
RPL11	ribosomal protein L11	0.039
CCNB2	cyclin B2	0.039
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.039
ZNF140	zinc finger protein 140	0.039	Human
DOCK8	dedicator of cytokinesis 8	0.039
ZNF83	zinc finger protein 83	0.039
FOXM1	forkhead box M1	0.038
FAM179B	family with sequence similarity 179, member B	0.038
PHF19	PHD finger protein 19	0.038
CCNT1	cyclin T1	0.038
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.037
MARCKSL1	MARCKS-like 1	0.037
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.036
FSTL1	follistatin-like 1	0.036
ZFPM1	zinc finger protein, multitype 1	0.036
FGF2	fibroblast growth factor 2 (basic)	0.035	Human
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.035	Human
SMAD5	SMAD family member 5	0.035
SRCIN1	SRC kinase signaling inhibitor 1	0.034
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.033
CDKN2D	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.033
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.033
WWOX	WW domain containing oxidoreductase	0.032
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.032
SALL2	sal-like 2 (Drosophila)	0.031
NOSTRIN	nitric oxide synthase trafficker	0.031
NOD1	nucleotide-binding oligomerization domain containing 1	0.031
FGF8	fibroblast growth factor 8 (androgen-induced)	0.031
GORAB	golgin, RAB6-interacting	0.030
DZIP1	DAZ interacting protein 1	0.030
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.029
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.028	Human
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.028
BTRC	beta-transducin repeat containing	0.027
CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.027
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.027
PLK1	polo-like kinase 1	0.026
IFI16	interferon, gamma-inducible protein 16	0.026
RBL2	retinoblastoma-like 2 (p130)	0.026
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.025
ZNF585A	zinc finger protein 585A	0.025
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.025
TRAP1	TNF receptor-associated protein 1	0.024
ZKSCAN5	zinc finger with KRAB and SCAN domains 5	0.024
MED1	mediator complex subunit 1	0.024
NOD2	nucleotide-binding oligomerization domain containing 2	0.024
CSNK1A1	casein kinase 1, alpha 1	0.023
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.023
ZNF419	zinc finger protein 419	0.022
FGFR3	fibroblast growth factor receptor 3	0.022
SOX11	SRY (sex determining region Y)-box 11	0.022	Human
ZNF266	zinc finger protein 266	0.022
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.022
KRT6C	keratin 6C	0.022
STX11	syntaxin 11	0.021
ABI2	abl-interactor 2	0.021
CXXC5	CXXC finger protein 5	0.021
MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	0.021
HNRNPCL1	heterogeneous nuclear ribonucleoprotein C-like 1	0.021
PLCG1	phospholipase C, gamma 1	0.021
E2F3	E2F transcription factor 3	0.021
ZNF180	zinc finger protein 180	0.020
KIAA1712	KIAA1712	0.020
NOTCH1	notch 1	0.020
TP73	tumor protein p73	0.020	Human
MAP1S	microtubule-associated protein 1S	0.020
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.020
TSC22D4	TSC22 domain family, member 4	0.020
DIABLO	diablo, IAP-binding mitochondrial protein	0.020
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.020	Human
SETD7	SET domain containing (lysine methyltransferase) 7	0.020
DLGAP4	discs, large (Drosophila) homolog-associated protein 4	0.020
MLX	MAX-like protein X	0.019
MSH5	mutS homolog 5 (E. coli)	0.019
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.019
NCOA1	nuclear receptor coactivator 1	0.019
PIM1	pim-1 oncogene	0.019
PPP5C	protein phosphatase 5, catalytic subunit	0.019
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.019
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.019
PAX6	paired box 6	0.019
ZBTB8A	zinc finger and BTB domain containing 8A	0.018
NRIP1	nuclear receptor interacting protein 1	0.018
FOXG1	forkhead box G1	0.018
HDAC3	histone deacetylase 3	0.018
MAX	MYC associated factor X	0.018
CARD16	caspase recruitment domain family, member 16	0.018
ZNF623	zinc finger protein 623	0.018
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.018
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.018
THBS1	thrombospondin 1	0.017
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.017
RAI1	retinoic acid induced 1	0.017
ZNF548	zinc finger protein 548	0.017
ATE1	arginyltransferase 1	0.017
FKBP6	FK506 binding protein 6, 36kDa	0.017
PKM2	pyruvate kinase, muscle	0.017
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.016	Human Rat
IFT74	intraflagellar transport 74 homolog (Chlamydomonas)	0.016
C8orf74	chromosome 8 open reading frame 74	0.016
RIPK4	receptor-interacting serine-threonine kinase 4	0.016
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.016
MAGED1	melanoma antigen family D, 1	0.016
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.016
ZNF426	zinc finger protein 426	0.015
TRIM43	tripartite motif containing 43	0.015
WASF1	WAS protein family, member 1	0.015
CCNA1	cyclin A1	0.015
ZNF23	zinc finger protein 23 (KOX 16)	0.015
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.015
ZNF673	zinc finger family member 673	0.015
TGFB3	transforming growth factor, beta 3	0.015
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.015
KLHDC4	kelch domain containing 4	0.015
GSTCD	glutathione S-transferase, C-terminal domain containing	0.015
SOX5	SRY (sex determining region Y)-box 5	0.015
ZNF571	zinc finger protein 571	0.014
ZNF295	zinc finger protein 295	0.014
SNAI1	snail homolog 1 (Drosophila)	0.014
C11orf61	chromosome 11 open reading frame 61	0.014
SOX9	SRY (sex determining region Y)-box 9	0.014	Human
OLIG2	oligodendrocyte lineage transcription factor 2	0.014
SOX8	SRY (sex determining region Y)-box 8	0.014	Human
ZNF559	zinc finger protein 559	0.014
PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	0.014
CCR2	chemokine (C-C motif) receptor 2	0.014
BRD3	bromodomain containing 3	0.014
SPRR2A	small proline-rich protein 2A	0.014
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.014
SORBS3	sorbin and SH3 domain containing 3	0.014
CTGF	connective tissue growth factor	0.014
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.014
PURA	purine-rich element binding protein A	0.014
PHC1	polyhomeotic homolog 1 (Drosophila)	0.014
CDK14	cyclin-dependent kinase 14	0.013
ZNF302	zinc finger protein 302	0.013	Human
C12orf35	chromosome 12 open reading frame 35	0.013
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.013
ZNF529	zinc finger protein 529	0.013
CASP8AP2	caspase 8 associated protein 2	0.013
USP2	ubiquitin specific peptidase 2	0.013
FRS2	fibroblast growth factor receptor substrate 2	0.013
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	0.013
ZNF337	zinc finger protein 337	0.013
MMP16	matrix metallopeptidase 16 (membrane-inserted)	0.013
PATZ1	POZ (BTB) and AT hook containing zinc finger 1	0.013
EPM2AIP1	EPM2A (laforin) interacting protein 1	0.013
STK38L	serine/threonine kinase 38 like	0.013
NCOR1	nuclear receptor corepressor 1	0.013
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.013
FKBP3	FK506 binding protein 3, 25kDa	0.012
FGF19	fibroblast growth factor 19	0.012
IL15	interleukin 15	0.012
SIX3	SIX homeobox 3	0.012
LMO2	LIM domain only 2 (rhombotin-like 1)	0.012
SH3BP4	SH3-domain binding protein 4	0.012
RBM12B	RNA binding motif protein 12B	0.012
MAP1B	microtubule-associated protein 1B	0.012
ZNF10	zinc finger protein 10	0.012
ZNF43	zinc finger protein 43	0.012
SP1	Sp1 transcription factor	0.012
ZNF184	zinc finger protein 184	0.012
CCDC85B	coiled-coil domain containing 85B	0.012
PLSCR4	phospholipid scramblase 4	0.012
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.012
SRM	spermidine synthase	0.012
WT1	Wilms tumor 1	0.012
COL2A1	collagen, type II, alpha 1	0.012
TRAF3	TNF receptor-associated factor 3	0.012
ZNF676	zinc finger protein 676	0.012
WASF2	WAS protein family, member 2	0.012
ACVR1B	activin A receptor, type IB	0.012
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.012
WNT1	wingless-type MMTV integration site family, member 1	0.012
ZNF222	zinc finger protein 222	0.012
HOXD1	homeobox D1	0.012
PAX5	paired box 5	0.012
MPP3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	0.012
ZNF558	zinc finger protein 558	0.012	Human
RGS2	regulator of G-protein signaling 2, 24kDa	0.012
CLSPN	claspin	0.011
ZBTB16	zinc finger and BTB domain containing 16	0.011
CCNE2	cyclin E2	0.011
POU2F1	POU class 2 homeobox 1	0.011
KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.011
E2F2	E2F transcription factor 2	0.011
S100B	S100 calcium binding protein B	0.011
TGFB2	transforming growth factor, beta 2	0.011
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.011
OTP	orthopedia homeobox	0.011
SORBS1	sorbin and SH3 domain containing 1	0.011
ZFP112	zinc finger protein 112 homolog (mouse)	0.011
ARRB1	arrestin, beta 1	0.011
KLHL20	kelch-like 20 (Drosophila)	0.011
SALL3	sal-like 3 (Drosophila)	0.011
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.011
ZNF350	zinc finger protein 350	0.011
ZNF230	zinc finger protein 230	0.011
GALR1	galanin receptor 1	0.011
IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	0.011
SMAD6	SMAD family member 6	0.011
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.011
MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	0.011
PDE4DIP	phosphodiesterase 4D interacting protein	0.011
SIM2	single-minded homolog 2 (Drosophila)	0.011
SMAD9	SMAD family member 9	0.010
S100A2	S100 calcium binding protein A2	0.010
RXRB	retinoid X receptor, beta	0.010
SHB	Src homology 2 domain containing adaptor protein B	0.010
ZNF133	zinc finger protein 133	0.010
SERGEF	secretion regulating guanine nucleotide exchange factor	0.010
HIPK2	homeodomain interacting protein kinase 2	0.010
EFHC1	EF-hand domain (C-terminal) containing 1	0.010
C5orf28	chromosome 5 open reading frame 28	0.010
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.010
E2F4	E2F transcription factor 4, p107/p130-binding	0.010
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.010	Human
BMP7	bone morphogenetic protein 7	0.010
RSPO2	R-spondin 2 homolog (Xenopus laevis)	0.010
ZNF320	zinc finger protein 320	0.010
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.010
TNP2	transition protein 2 (during histone to protamine replacement)	0.010
ZNF329	zinc finger protein 329	0.010	Human
FNBP1	formin binding protein 1	0.010
POU4F2	POU class 4 homeobox 2	0.010
ZNF274	zinc finger protein 274	0.010
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.010
REV3L	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	0.010
SOX4	SRY (sex determining region Y)-box 4	0.010