IMP
Process View
cholesterol biosynthetic process
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "cholesterol biosynthetic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Hmgcs1 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 | 0.998 | ||
| Dhcr7 | 7-dehydrocholesterol reductase | 0.980 | Human | |
| Ldlr | low density lipoprotein receptor | 0.980 | ||
| Sqle | squalene epoxidase | 0.975 | ||
| Lss | lanosterol synthase | 0.962 | Human | |
| Mvd | mevalonate (diphospho) decarboxylase | 0.959 | ||
| Dhcr24 | 24-dehydrocholesterol reductase | 0.888 | ||
| Cyp51 | cytochrome P450, family 51 | 0.867 | Rat | |
| Sc4mol | sterol-C4-methyl oxidase-like | 0.788 | ||
| Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.638 | ||
| Fasn | fatty acid synthase | 0.584 | ||
| Idi1 | isopentenyl-diphosphate delta isomerase | 0.455 | ||
| Apoa1 | apolipoprotein A-I | 0.440 | ||
| Aacs | acetoacetyl-CoA synthetase | 0.282 | ||
| Hsd17b7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.251 | ||
| Acat2 | acetyl-Coenzyme A acetyltransferase 2 | 0.221 | ||
| Lyz2 | lysozyme 2 | 0.217 | ||
| Npc1 | Niemann Pick type C1 | 0.206 | ||
| Apoe | apolipoprotein E | 0.201 | Human Mouse | |
| Sc5d | sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) | 0.176 | ||
| Fdps | farnesyl diphosphate synthetase | 0.158 | ||
| Nsdhl | NAD(P) dependent steroid dehydrogenase-like | 0.156 | ||
| Srebf2 | sterol regulatory element binding factor 2 | 0.147 | Mouse | |
| Stard4 | StAR-related lipid transfer (START) domain containing 4 | 0.124 | ||
| Slc25a1 | solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 | 0.119 | ||
| Tm7sf2 | transmembrane 7 superfamily member 2 | 0.115 | ||
| Scd1 | stearoyl-Coenzyme A desaturase 1 | 0.109 | ||
| Acly | ATP citrate lyase | 0.107 | ||
| Mvk | mevalonate kinase | 0.105 | Human | |
| Apob | apolipoprotein B | 0.094 | ||
| 0610007P14Rik | RIKEN cDNA 0610007P14 gene | 0.078 | ||
| Pcyt2 | phosphate cytidylyltransferase 2, ethanolamine | 0.065 | ||
| Insig1 | insulin induced gene 1 | 0.065 | ||
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.065 | ||
| Rdh11 | retinol dehydrogenase 11 | 0.063 | ||
| Ebag9 | estrogen receptor-binding fragment-associated gene 9 | 0.056 | ||
| Aldob | aldolase B, fructose-bisphosphate | 0.054 | ||
| Scd2 | stearoyl-Coenzyme A desaturase 2 | 0.053 | ||
| Elovl6 | ELOVL family member 6, elongation of long chain fatty acids (yeast) | 0.051 | ||
| Fads2 | fatty acid desaturase 2 | 0.044 | ||
| Lrp1 | low density lipoprotein receptor-related protein 1 | 0.043 | ||
| Hmgcr | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 0.042 | ||
| Scarb1 | scavenger receptor class B, member 1 | 0.036 | ||
| Srebf1 | sterol regulatory element binding transcription factor 1 | 0.033 | ||
| Slc9a3r1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.032 | ||
| Eif2ak3 | eukaryotic translation initiation factor 2 alpha kinase 3 | 0.028 | ||
| Hnf4a | hepatic nuclear factor 4, alpha | 0.028 | ||
| Pgd | phosphogluconate dehydrogenase | 0.027 | ||
| Fdft1 | farnesyl diphosphate farnesyl transferase 1 | 0.023 | ||
| Pmvk | phosphomevalonate kinase | 0.020 | ||
| Lepr | leptin receptor | 0.020 | ||
| Slc4a4 | solute carrier family 4 (anion exchanger), member 4 | 0.020 | ||
| Tmem97 | transmembrane protein 97 | 0.020 | ||
| Pparg | peroxisome proliferator activated receptor gamma | 0.019 | ||
| Abhd5 | abhydrolase domain containing 5 | 0.019 | ||
| Idh1 | isocitrate dehydrogenase 1 (NADP+), soluble | 0.019 | ||
| Reep6 | receptor accessory protein 6 | 0.019 | ||
| Fads1 | fatty acid desaturase 1 | 0.017 | ||
| Cyb5b | cytochrome b5 type B | 0.017 | ||
| Apoc3 | apolipoprotein C-III | 0.017 | ||
| Hsd17b2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.016 | ||
| Ormdl1 | ORM1-like 1 (S. cerevisiae) | 0.015 | ||
| Apom | apolipoprotein M | 0.015 | ||
| Srf | serum response factor | 0.015 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.014 | ||
| Mt1 | metallothionein 1 | 0.014 | ||
| Tkt | transketolase | 0.014 | ||
| C3 | complement component 3 | 0.013 | ||
| Pltp | phospholipid transfer protein | 0.013 | ||
| Azgp1 | alpha-2-glycoprotein 1, zinc | 0.013 | ||
| Apoa2 | apolipoprotein A-II | 0.013 | ||
| Angptl4 | angiopoietin-like 4 | 0.013 | ||
| Nr2f6 | nuclear receptor subfamily 2, group F, member 6 | 0.013 | ||
| Pklr | pyruvate kinase liver and red blood cell | 0.013 | ||
| Foxa2 | forkhead box A2 | 0.013 | ||
| Gcgr | glucagon receptor | 0.013 | ||
| Slc33a1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | 0.012 | ||
| Fgg | fibrinogen gamma chain | 0.012 | ||
| Mt2 | metallothionein 2 | 0.012 | ||
| Cdhr5 | cadherin-related family member 5 | 0.012 | ||
| Mertk | c-mer proto-oncogene tyrosine kinase | 0.012 | ||
| Otc | ornithine transcarbamylase | 0.011 | ||
| Sigmar1 | sigma non-opioid intracellular receptor 1 | 0.011 | ||
| Zg16 | zymogen granule protein 16 | 0.011 | ||
| Klf15 | Kruppel-like factor 15 | 0.011 | ||
| Bscl2 | Bernardinelli-Seip congenital lipodystrophy 2 homolog (human) | 0.011 | ||
| Apoa4 | apolipoprotein A-IV | 0.011 | Mouse | |
| Ahsg | alpha-2-HS-glycoprotein | 0.011 | ||
| Sar1b | SAR1 gene homolog B (S. cerevisiae) | 0.010 | ||
| Lgals2 | lectin, galactose-binding, soluble 2 | 0.010 | ||
| Kit | kit oncogene | 0.010 | ||
| Erf | Ets2 repressor factor | 0.010 | ||
| Men1 | multiple endocrine neoplasia 1 | 0.010 | ||
| Abcg1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.010 | ||
| Lcat | lecithin cholesterol acyltransferase | 0.010 |