IMP: Integrative Multi-species Prediction

Mus musculus

3 genes annotated in mouse

Multi-species View

positive regulation of rap gtpase activity

GO:0032854

Any process that activates or increases the activity of a GTPase of the Rap family.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of rap gtpase activity"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of rap gtpase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Pten	phosphatase and tensin homolog	0.842
Braf	Braf transforming gene	0.792
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.694	Worm
Apc	adenomatosis polyposis coli	0.641
Rb1	retinoblastoma 1	0.447
Trp53	transformation related protein 53	0.403
Raf1	v-raf-leukemia viral oncogene 1	0.215
Ctnnb1	catenin (cadherin associated protein), beta 1	0.200
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.196
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.188
Lepr	leptin receptor	0.160
Sept7	septin 7	0.115
Ptp4a2	protein tyrosine phosphatase 4a2	0.106
Nf1	neurofibromatosis 1	0.105
Mdm2	transformed mouse 3T3 cell double minute 2	0.098
Hif1a	hypoxia inducible factor 1, alpha subunit	0.098
Esr1	estrogen receptor 1 (alpha)	0.094
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.091
Msh2	mutS homolog 2 (E. coli)	0.091
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.086
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.076
Kit	kit oncogene	0.075
Kitl	kit ligand	0.070
Nf2	neurofibromatosis 2	0.069
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.066
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.055
Grb2	growth factor receptor bound protein 2	0.053
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.052
Sav1	salvador homolog 1 (Drosophila)	0.052
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.051
Epas1	endothelial PAS domain protein 1	0.047
Ptch1	patched homolog 1	0.045
Rictor	RPTOR independent companion of MTOR, complex 2	0.045
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.043
Sh3bgrl	SH3-binding domain glutamic acid-rich protein like	0.040
Egfr	epidermal growth factor receptor	0.038
Vbp1	von Hippel-Lindau binding protein 1	0.037
Rint1	RAD50 interactor 1	0.037
Itga6	integrin alpha 6	0.037
Cdc34	cell division cycle 34 homolog (S. cerevisiae)	0.036
Ptgs2	prostaglandin-endoperoxide synthase 2	0.036
Smad4	MAD homolog 4 (Drosophila)	0.035
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.033
Stk11	serine/threonine kinase 11	0.032
Rap2c	RAP2C, member of RAS oncogene family	0.031
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.029
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.029
Tsc1	tuberous sclerosis 1	0.029
Capza2	capping protein (actin filament) muscle Z-line, alpha 2	0.027
Pclo	piccolo (presynaptic cytomatrix protein)	0.026
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.026
Agfg1	ArfGAP with FG repeats 1	0.025
Cxcr5	chemokine (C-X-C motif) receptor 5	0.025
1110008P14Rik	RIKEN cDNA 1110008P14 gene	0.025
Fam49b	family with sequence similarity 49, member B	0.024
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.024
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.023
Foxp1	forkhead box P1	0.023
Vhl	von Hippel-Lindau tumor suppressor	0.023
Vav3	vav 3 oncogene	0.023
Csnk2b	casein kinase 2, beta polypeptide	0.022
Cyb5r4	cytochrome b5 reductase 4	0.022
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.022
Cbl	Casitas B-lineage lymphoma	0.021
Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	0.021
Capza1	capping protein (actin filament) muscle Z-line, alpha 1	0.021
Rfng	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.021
Vav2	vav 2 oncogene	0.021
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.021
Brca1	breast cancer 1	0.020
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.020
Hspbp1	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	0.020
Vamp3	vesicle-associated membrane protein 3	0.019
Notch2	Notch gene homolog 2 (Drosophila)	0.019
Rfwd2	ring finger and WD repeat domain 2	0.019
Rims2	regulating synaptic membrane exocytosis 2	0.018
Tgfbr1	transforming growth factor, beta receptor I	0.018
Rap1b	RAS related protein 1b	0.018
Sorl1	sortilin-related receptor, LDLR class A repeats-containing	0.018
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.018
Ltb	lymphotoxin B	0.018
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.018
Ar	androgen receptor	0.017
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.017
Mtpn	myotrophin	0.017
Ngef	neuronal guanine nucleotide exchange factor	0.017
Smad2	MAD homolog 2 (Drosophila)	0.016
Pparg	peroxisome proliferator activated receptor gamma	0.016
Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.016
Nras	neuroblastoma ras oncogene	0.016	Worm
Trim33	tripartite motif-containing 33	0.016
Ugcg	UDP-glucose ceramide glucosyltransferase	0.015
Cbfb	core binding factor beta	0.015
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.015
Sh3glb1	SH3-domain GRB2-like B1 (endophilin)	0.015
Rasal1	RAS protein activator like 1 (GAP1 like)	0.015
Flt1	FMS-like tyrosine kinase 1	0.015
Abca2	ATP-binding cassette, sub-family A (ABC1), member 2	0.015
Tomm40	translocase of outer mitochondrial membrane 40 homolog (yeast)	0.014
Mapre1	microtubule-associated protein, RP/EB family, member 1	0.014
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.014
Rims1	regulating synaptic membrane exocytosis 1	0.014
Dmtf1	cyclin D binding myb-like transcription factor 1	0.014
Hhex	hematopoietically expressed homeobox	0.014
Ppp1r1b	protein phosphatase 1, regulatory (inhibitor) subunit 1B	0.014
Ccl8	chemokine (C-C motif) ligand 8	0.014
Ap1s1	adaptor protein complex AP-1, sigma 1	0.014
Pgp	phosphoglycolate phosphatase	0.013
Npy	neuropeptide Y	0.013
Rasa2	RAS p21 protein activator 2	0.013
Shank3	SH3/ankyrin domain gene 3	0.013
Rhot2	ras homolog gene family, member T2	0.013
Pim2	proviral integration site 2	0.013
Notch1	Notch gene homolog 1 (Drosophila)	0.013
Hdac11	histone deacetylase 11	0.013
Nbn	nibrin	0.013
Actr2	ARP2 actin-related protein 2 homolog (yeast)	0.013
Egr1	early growth response 1	0.013
2810008M24Rik	RIKEN cDNA 2810008M24 gene	0.013
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.012
Meox2	mesenchyme homeobox 2	0.012
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.012
Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3	0.012
Adrb1	adrenergic receptor, beta 1	0.012
Strn	striatin, calmodulin binding protein	0.012
Txn2	thioredoxin 2	0.012
Npy1r	neuropeptide Y receptor Y1	0.012
Map2k2	mitogen-activated protein kinase kinase 2	0.012
Eps15	epidermal growth factor receptor pathway substrate 15	0.012
Osbpl8	oxysterol binding protein-like 8	0.012
Errfi1	ERBB receptor feedback inhibitor 1	0.012
Prkcz	protein kinase C, zeta	0.012
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.012
Nab1	Ngfi-A binding protein 1	0.011
Dock4	dedicator of cytokinesis 4	0.011
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.011
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
Rab15	RAB15, member RAS oncogene family	0.011
Ndufb2	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2	0.011
Kcnk2	potassium channel, subfamily K, member 2	0.011
Rbm7	RNA binding motif protein 7	0.011
Pde2a	phosphodiesterase 2A, cGMP-stimulated	0.011
Sos1	son of sevenless homolog 1 (Drosophila)	0.011
Mapk14	mitogen-activated protein kinase 14	0.011
Gnl1	guanine nucleotide binding protein-like 1	0.011
1190002H23Rik	RIKEN cDNA 1190002H23 gene	0.011
Xpa	xeroderma pigmentosum, complementation group A	0.011
Zcchc11	zinc finger, CCHC domain containing 11	0.010
Dync1i2	dynein cytoplasmic 1 intermediate chain 2	0.010
Trim46	tripartite motif-containing 46	0.010
Sept4	septin 4	0.010
Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	0.010
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.010
Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	0.010
Kcnk1	potassium channel, subfamily K, member 1	0.010
Bdp1	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	0.010
9030418K01Rik	RIKEN cDNA 9030418K01 gene	0.010
Adcy8	adenylate cyclase 8	0.010