IMP: Integrative Multi-species Prediction

Mus musculus

25 genes annotated in mouse

protein ubiquitination involved in ubiquitin dependent protein catabolic process

The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein ubiquitination involved in ubiquitin dependent protein catabolic process"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "protein ubiquitination involved in ubiquitin dependent protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.988
Ctnnb1	catenin (cadherin associated protein), beta 1	0.952
Gsk3b	glycogen synthase kinase 3 beta	0.694
Psen1	presenilin 1	0.670
Axin1	axin 1	0.616
Smad7	MAD homolog 7 (Drosophila)	0.514
Smad6	MAD homolog 6 (Drosophila)	0.413
Wnt3a	wingless-related MMTV integration site 3A	0.341	Mouse
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.285
Notch1	Notch gene homolog 1 (Drosophila)	0.276
Skil	SKI-like	0.217
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.214
Mdm2	transformed mouse 3T3 cell double minute 2	0.210	Human
Rnf11	ring finger protein 11	0.187	Human
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.186
Rnf111	ring finger 111	0.184
Apc	adenomatosis polyposis coli	0.173
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.172
Ncoa3	nuclear receptor coactivator 3	0.171
Tbx3	T-box 3	0.166
Pax2	paired box gene 2	0.164
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.159
Mdm4	transformed mouse 3T3 cell double minute 4	0.157
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.149
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.142
Traf6	TNF receptor-associated factor 6	0.140
Lrp6	low density lipoprotein receptor-related protein 6	0.137	Mouse
Cldn1	claudin 1	0.135
Dlg1	discs, large homolog 1 (Drosophila)	0.129
Lhx1	LIM homeobox protein 1	0.117
Cyld	cylindromatosis (turban tumor syndrome)	0.113
Notch2	Notch gene homolog 2 (Drosophila)	0.111
Setdb1	SET domain, bifurcated 1	0.108
Atf4	activating transcription factor 4	0.108
Mapk8	mitogen-activated protein kinase 8	0.105
F11r	F11 receptor	0.105
Eif2c1	eukaryotic translation initiation factor 2C, 1	0.104
Pick1	protein interacting with C kinase 1	0.102
En1	engrailed 1	0.097
Lrp5	low density lipoprotein receptor-related protein 5	0.095	Mouse
Ncstn	nicastrin	0.084
Otx1	orthodenticle homolog 1 (Drosophila)	0.082
Kcnj15	potassium inwardly-rectifying channel, subfamily J, member 15	0.082
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.080
Sap18	Sin3-associated polypeptide 18	0.072
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.070
Pias1	protein inhibitor of activated STAT 1	0.064
Map2k4	mitogen-activated protein kinase kinase 4	0.063
Prnp	prion protein	0.063
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.062
Cul3	cullin 3	0.060
Shh	sonic hedgehog	0.060
Rac1	RAS-related C3 botulinum substrate 1	0.059
Pax8	paired box gene 8	0.059
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.058
T	brachyury	0.056
Lama5	laminin, alpha 5	0.051
Daxx	Fas death domain-associated protein	0.051
Csde1	cold shock domain containing E1, RNA binding	0.051
Ranbp9	RAN binding protein 9	0.050
Sertad2	SERTA domain containing 2	0.050
Ptch1	patched homolog 1	0.049
Bcar1	breast cancer anti-estrogen resistance 1	0.049
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.049
Rc3h2	ring finger and CCCH-type zinc finger domains 2	0.049
Numb	numb gene homolog (Drosophila)	0.048
Bcl2	B-cell leukemia/lymphoma 2	0.047
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.047
Wnt4	wingless-related MMTV integration site 4	0.046	Mouse
Ube2d3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.046
Zfand5	zinc finger, AN1-type domain 5	0.046
Stat3	signal transducer and activator of transcription 3	0.044
Hist1h2ao	histone cluster 1, H2ao	0.044
Rnf19a	ring finger protein 19A	0.044
Gli3	GLI-Kruppel family member GLI3	0.042
Cxadr	coxsackie virus and adenovirus receptor	0.042
Fam103a1	family with sequence similarity 103, member A1	0.042
Wnt10b	wingless related MMTV integration site 10b	0.042	Mouse
Trp73	transformation related protein 73	0.040
Rfwd2	ring finger and WD repeat domain 2	0.039
Lef1	lymphoid enhancer binding factor 1	0.037
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.037
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.036
Fgf8	fibroblast growth factor 8	0.035
Rab10	RAB10, member RAS oncogene family	0.035
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.035
Ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.034
Porcn	porcupine homolog (Drosophila)	0.034
Pou3f3	POU domain, class 3, transcription factor 3	0.033
Irf7	interferon regulatory factor 7	0.033
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.033
Hoxa4	homeobox A4	0.033
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.031
Tgfa	transforming growth factor alpha	0.031
Nploc4	nuclear protein localization 4 homolog (S. cerevisiae)	0.030
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.030
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.030
Amhr2	anti-Mullerian hormone type 2 receptor	0.030
Smo	smoothened homolog (Drosophila)	0.030
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.030
Nog	noggin	0.029
Bcl6	B-cell leukemia/lymphoma 6	0.029
Senp6	SUMO/sentrin specific peptidase 6	0.029
Atxn3	ataxin 3	0.029
Wdr26	WD repeat domain 26	0.029
Src	Rous sarcoma oncogene	0.028
Myl12b	myosin, light chain 12B, regulatory	0.028
A930001N09Rik	RIKEN cDNA A930001N09 gene	0.028
Tnks1bp1	tankyrase 1 binding protein 1	0.028
Smad3	MAD homolog 3 (Drosophila)	0.026
App	amyloid beta (A4) precursor protein	0.026
Gli2	GLI-Kruppel family member GLI2	0.026
Zfx	zinc finger protein X-linked	0.026
Gli1	GLI-Kruppel family member GLI1	0.026
Zfp219	zinc finger protein 219	0.025
Tmem64	transmembrane protein 64	0.025
Hdac6	histone deacetylase 6	0.025
Nkd2	naked cuticle 2 homolog (Drosophila)	0.025
Brd1	bromodomain containing 1	0.025
Agrn	agrin	0.025
C77080	expressed sequence C77080	0.024
Gdnf	glial cell line derived neurotrophic factor	0.024
Prkce	protein kinase C, epsilon	0.024
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.024
Fzd8	frizzled homolog 8 (Drosophila)	0.024
Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isoform	0.023
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.023	Human Mouse Fly
Grb10	growth factor receptor bound protein 10	0.023
Pgr	progesterone receptor	0.022
Nodal	nodal	0.022
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.022
Map4k5	mitogen-activated protein kinase kinase kinase kinase 5	0.022
Pofut1	protein O-fucosyltransferase 1	0.022
Aff4	AF4/FMR2 family, member 4	0.022
Hoxc9	homeobox C9	0.022
Hoxa13	homeobox A13	0.022
Itga3	integrin alpha 3	0.021
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.021
Tjp1	tight junction protein 1	0.021
Htt	huntingtin	0.021
Kpna1	karyopherin (importin) alpha 1	0.021
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.021
Epha1	Eph receptor A1	0.021
Notch4	Notch gene homolog 4 (Drosophila)	0.021
Braf	Braf transforming gene	0.021
Ccdc117	coiled-coil domain containing 117	0.021
Eif1b	eukaryotic translation initiation factor 1B	0.021
A630007B06Rik	RIKEN cDNA A630007B06 gene	0.020
Ptk2	PTK2 protein tyrosine kinase 2	0.020
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.020
Fgfr1	fibroblast growth factor receptor 1	0.020
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.020
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.020
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.020
Nf2	neurofibromatosis 2	0.019
Rab18	RAB18, member RAS oncogene family	0.019
Slc34a2	solute carrier family 34 (sodium phosphate), member 2	0.019
Emx2	empty spiracles homolog 2 (Drosophila)	0.019
Ube2l3	ubiquitin-conjugating enzyme E2L 3	0.019
Sec16a	SEC16 homolog A (S. cerevisiae)	0.019
Fzd7	frizzled homolog 7 (Drosophila)	0.019
Psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.019
Fzd10	frizzled homolog 10 (Drosophila)	0.019
Ccng1	cyclin G1	0.019
Pafah1b1	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1	0.019
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.018
Crnkl1	Crn, crooked neck-like 1 (Drosophila)	0.018
Ufd1l	ubiquitin fusion degradation 1 like	0.018
Serinc1	serine incorporator 1	0.018
1110004F10Rik	RIKEN cDNA 1110004F10 gene	0.018
Acvr2a	activin receptor IIA	0.018
Stk11	serine/threonine kinase 11	0.018
Rarb	retinoic acid receptor, beta	0.018
Otx2	orthodenticle homolog 2 (Drosophila)	0.018
Spop	speckle-type POZ protein	0.018
Foxc1	forkhead box C1	0.018
Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.018
Csnk1d	casein kinase 1, delta	0.018
Arf1	ADP-ribosylation factor 1	0.018
Sec61a2	Sec61, alpha subunit 2 (S. cerevisiae)	0.018
Smad2	MAD homolog 2 (Drosophila)	0.018
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.018
Eea1	early endosome antigen 1	0.018
Lin7c	lin-7 homolog C (C. elegans)	0.018
Ubc	ubiquitin C	0.017
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.017
Fgfr3	fibroblast growth factor receptor 3	0.017
Kif2a	kinesin family member 2A	0.017
Rara	retinoic acid receptor, alpha	0.017
Optn	optineurin	0.017
Traf3	TNF receptor-associated factor 3	0.017
Pum2	pumilio 2 (Drosophila)	0.017
Cldn3	claudin 3	0.017
Hipk1	homeodomain interacting protein kinase 1	0.017
Stat1	signal transducer and activator of transcription 1	0.017
Efna4	ephrin A4	0.017
Npc1	Niemann Pick type C1	0.017
Ube2e3	ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeast)	0.017
Tbx2	T-box 2	0.017
Cdh1	cadherin 1	0.017
Mmp15	matrix metallopeptidase 15	0.016
Wbp4	WW domain binding protein 4	0.016
Axin2	axin2	0.016	Mouse
Hist1h2bl	histone cluster 1, H2bl	0.016
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.016
Ralbp1	ralA binding protein 1	0.016
Spint1	serine protease inhibitor, Kunitz type 1	0.016
Trp53bp1	transformation related protein 53 binding protein 1	0.016
Cflar	CASP8 and FADD-like apoptosis regulator	0.016
Akap1	A kinase (PRKA) anchor protein 1	0.016
Itch	itchy, E3 ubiquitin protein ligase	0.016
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.016
Irf1	interferon regulatory factor 1	0.015
Camsap1	calmodulin regulated spectrin-associated protein 1	0.015
Ppp4r2	protein phosphatase 4, regulatory subunit 2	0.015
Mfn2	mitofusin 2	0.015
Atp2c1	ATPase, Ca++-sequestering	0.015
Lmx1b	LIM homeobox transcription factor 1 beta	0.015
Fgf5	fibroblast growth factor 5	0.015
Rarg	retinoic acid receptor, gamma	0.015
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.014
Selk	selenoprotein K	0.014
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.014
Arih1	ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)	0.014	Fly
Erlin2	ER lipid raft associated 2	0.014
Psen2	presenilin 2	0.014
Rab21	RAB21, member RAS oncogene family	0.014
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.014
Fbxl3	F-box and leucine-rich repeat protein 3	0.014
Foxa2	forkhead box A2	0.014
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.014
Xpa	xeroderma pigmentosum, complementation group A	0.014
Pdcd7	programmed cell death 7	0.014
Cdh16	cadherin 16	0.014
Lmx1a	LIM homeobox transcription factor 1 alpha	0.014
Ret	ret proto-oncogene	0.014
Ldlr	low density lipoprotein receptor	0.014
Hoxb6	homeobox B6	0.014
Ccnj	cyclin J	0.014
Wnt3	wingless-related MMTV integration site 3	0.014	Mouse
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.014
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.014
Becn1	beclin 1, autophagy related	0.014
Rnf146	ring finger protein 146	0.014	Human
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.014
Col13a1	collagen, type XIII, alpha 1	0.014
L1cam	L1 cell adhesion molecule	0.014
Kctd9	potassium channel tetramerisation domain containing 9	0.013
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.013
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.013
Aars	alanyl-tRNA synthetase	0.013
Rbl1	retinoblastoma-like 1 (p107)	0.013
Dab1	disabled homolog 1 (Drosophila)	0.013
Tsc1	tuberous sclerosis 1	0.013
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.013
Otud4	OTU domain containing 4	0.013
Gal3st1	galactose-3-O-sulfotransferase 1	0.013
Fbxo28	F-box protein 28	0.013
Ulk2	Unc-51 like kinase 2 (C. elegans)	0.013
Dnm1l	dynamin 1-like	0.013
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.013
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.013
Gja3	gap junction protein, alpha 3	0.013
Ctnna1	catenin (cadherin associated protein), alpha 1	0.013
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.013
Ube2v1	ubiquitin-conjugating enzyme E2 variant 1	0.013
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.013
Rbm18	RNA binding motif protein 18	0.013
Ptprf	protein tyrosine phosphatase, receptor type, F	0.013
Clk4	CDC like kinase 4	0.013
Rbbp6	retinoblastoma binding protein 6	0.012	Human
Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	0.012
Dcun1d1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.012
Grb7	growth factor receptor bound protein 7	0.012
Senp2	SUMO/sentrin specific peptidase 2	0.012
Amfr	autocrine motility factor receptor	0.012
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.012
Nrip1	nuclear receptor interacting protein 1	0.012
Ikbkg	inhibitor of kappaB kinase gamma	0.012
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.012
Trh	thyrotropin releasing hormone	0.012
Adcy9	adenylate cyclase 9	0.012
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.012
Dcaf12	DDB1 and CUL4 associated factor 12	0.012
Msl1	male-specific lethal 1 homolog (Drosophila)	0.012
Slc12a1	solute carrier family 12, member 1	0.012
Stat6	signal transducer and activator of transcription 6	0.012
Syvn1	synovial apoptosis inhibitor 1, synoviolin	0.012
Msl2	male-specific lethal 2 homolog (Drosophila)	0.012
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.012
Ubap1	ubiquitin-associated protein 1	0.012
Ryk	receptor-like tyrosine kinase	0.012
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.012
Qrich1	glutamine-rich 1	0.012
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.012
Fgf3	fibroblast growth factor 3	0.012
Mapk1	mitogen-activated protein kinase 1	0.012
Katnb1	katanin p80 (WD40-containing) subunit B 1	0.011
Wbp2	WW domain binding protein 2	0.011
1810013L24Rik	RIKEN cDNA 1810013L24 gene	0.011
Fzd6	frizzled homolog 6 (Drosophila)	0.011
Tab3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.011
Mobkl3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.011
Fosl2	fos-like antigen 2	0.011
Exoc8	exocyst complex component 8	0.011
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.011
Nkx2-1	NK2 homeobox 1	0.011
Ube2n	ubiquitin-conjugating enzyme E2N	0.011
Apoe	apolipoprotein E	0.011
Atoh8	atonal homolog 8 (Drosophila)	0.011
Pja2	praja 2, RING-H2 motif containing	0.011
Ctnnd1	catenin (cadherin associated protein), delta 1	0.011
Zfp771	zinc finger protein 771	0.011
Scn5a	sodium channel, voltage-gated, type V, alpha	0.011
Ube2c	ubiquitin-conjugating enzyme E2C	0.011
Gm505	predicted gene 505	0.011
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.011
Cfl2	cofilin 2, muscle	0.011
Fscn3	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	0.011
Ikbkb	inhibitor of kappaB kinase beta	0.011
Atp11c	ATPase, class VI, type 11C	0.011
Kl	klotho	0.011
Egr1	early growth response 1	0.011
Siah1a	seven in absentia 1A	0.011
Bmp15	bone morphogenetic protein 15	0.011
Scoc	short coiled-coil protein	0.011
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.011
Trip12	thyroid hormone receptor interactor 12	0.011	Human
Chuk	conserved helix-loop-helix ubiquitous kinase	0.011
Zranb1	zinc finger, RAN-binding domain containing 1	0.011
Prdx6	peroxiredoxin 6	0.010
Fgf18	fibroblast growth factor 18	0.010
Rb1cc1	RB1-inducible coiled-coil 1	0.010
Usp43	ubiquitin specific peptidase 43	0.010
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.010
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.010
Chst8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	0.010
Cpeb2	cytoplasmic polyadenylation element binding protein 2	0.010
Usp15	ubiquitin specific peptidase 15	0.010
Arpp19	cAMP-regulated phosphoprotein 19	0.010
Igtp	interferon gamma induced GTPase	0.010
Actn4	actinin alpha 4	0.010
Arf2	ADP-ribosylation factor 2	0.010
Add1	adducin 1 (alpha)	0.010
Fyn	Fyn proto-oncogene	0.010
Cpeb4	cytoplasmic polyadenylation element binding protein 4	0.010
Nudcd3	NudC domain containing 3	0.010
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.010
Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	0.010
Asb10	ankyrin repeat and SOCS box-containing 10	0.010
Tsc22d2	TSC22 domain family, member 2	0.010
BC024139	cDNA sequence BC024139	0.010
Pou3f1	POU domain, class 3, transcription factor 1	0.010
H2afx	H2A histone family, member X	0.010
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.010
Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	0.010
Scrib	scribbled homolog (Drosophila)	0.010
Vangl1	vang-like 1 (van gogh, Drosophila)	0.010
Hoxd3	homeobox D3	0.010
Chac1	ChaC, cation transport regulator-like 1 (E. coli)	0.010
Mbd3	methyl-CpG binding domain protein 3	0.010
Slmap	sarcolemma associated protein	0.010
Mesdc2	mesoderm development candidate 2	0.010
Ube2d1	ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog (yeast)	0.010
Wnt9a	wingless-type MMTV integration site 9A	0.010	Mouse
Irf9	interferon regulatory factor 9	0.010
Polm	polymerase (DNA directed), mu	0.010
Nf1	neurofibromatosis 1	0.010
Pias2	protein inhibitor of activated STAT 2	0.010
Gripap1	GRIP1 associated protein 1	0.010