IMP: Integrative Multi-species Prediction

Mus musculus

18 genes annotated in mouse

Multi-species View

negative regulation of alpha beta t cell activation

GO:0046636

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of alpha beta t cell activation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of alpha beta t cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
Stat3	signal transducer and activator of transcription 3	0.989
Gli3	GLI-Kruppel family member GLI3	0.985
Tnf	tumor necrosis factor	0.919
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.852
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.830	Mouse
Myd88	myeloid differentiation primary response gene 88	0.735
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.695
Il6st	interleukin 6 signal transducer	0.562
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.559	Mouse
Rc3h1	RING CCCH (C3H) domains 1	0.520
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.448
Ifng	interferon gamma	0.414
Jak2	Janus kinase 2	0.355	Mouse
Lepr	leptin receptor	0.350
Cyld	cylindromatosis (turban tumor syndrome)	0.296
Lta	lymphotoxin A	0.277
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.250
Traf6	TNF receptor-associated factor 6	0.245
Fas	Fas (TNF receptor superfamily member 6)	0.240
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.231
Gli2	GLI-Kruppel family member GLI2	0.230	Mouse
Zeb1	zinc finger E-box binding homeobox 1	0.223
Il6	interleukin 6	0.211
Pten	phosphatase and tensin homolog	0.204
Pthlh	parathyroid hormone-like peptide	0.182
Socs1	suppressor of cytokine signaling 1	0.182	Mouse
Socs3	suppressor of cytokine signaling 3	0.179	Mouse
Cd40	CD40 antigen	0.170	Mouse
S1pr2	sphingosine-1-phosphate receptor 2	0.168
Fgf10	fibroblast growth factor 10	0.157
Igh	immunoglobulin heavy chain complex	0.133
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.133
Ikzf1	IKAROS family zinc finger 1	0.130
Ren1	renin 1 structural	0.118
Bcl3	B-cell leukemia/lymphoma 3	0.117
Il4	interleukin 4	0.112
Foxp3	forkhead box P3	0.111
Ctnnb1	catenin (cadherin associated protein), beta 1	0.104
Fgfr2	fibroblast growth factor receptor 2	0.099
Stat5a	signal transducer and activator of transcription 5A	0.098
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.090
Rnf11	ring finger protein 11	0.090
Kit	kit oncogene	0.090
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.085
Stat6	signal transducer and activator of transcription 6	0.084
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.079
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.077
Fgfr3	fibroblast growth factor receptor 3	0.076
Nos2	nitric oxide synthase 2, inducible	0.071
Egfr	epidermal growth factor receptor	0.064
Zbtb37	zinc finger and BTB domain containing 37	0.063
Ptch1	patched homolog 1	0.060
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.057
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.056
Il1r1	interleukin 1 receptor, type I	0.055
Fgf9	fibroblast growth factor 9	0.055
Ccl2	chemokine (C-C motif) ligand 2	0.055
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.054
Rac1	RAS-related C3 botulinum substrate 1	0.053
Il2rg	interleukin 2 receptor, gamma chain	0.052
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.049
Stat5b	signal transducer and activator of transcription 5B	0.049
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.048
Sh2b2	SH2B adaptor protein 2	0.048
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.046
Plcg1	phospholipase C, gamma 1	0.046
Foxn1	forkhead box N1	0.046
Traf2	TNF receptor-associated factor 2	0.044
Twist2	twist homolog 2 (Drosophila)	0.044
Sox9	SRY-box containing gene 9	0.041
Cul5	cullin 5	0.041
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.041
Smad6	MAD homolog 6 (Drosophila)	0.041
Atp11c	ATPase, class VI, type 11C	0.040
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.038
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.038
Shh	sonic hedgehog	0.037
Prdm1	PR domain containing 1, with ZNF domain	0.036
Rc3h2	ring finger and CCCH-type zinc finger domains 2	0.036	Mouse
Il2rb	interleukin 2 receptor, beta chain	0.036
Trp53	transformation related protein 53	0.034
Il10ra	interleukin 10 receptor, alpha	0.033
Rag1	recombination activating gene 1	0.033
Pim1	proviral integration site 1	0.032
Grb10	growth factor receptor bound protein 10	0.030
Il3ra	interleukin 3 receptor, alpha chain	0.030
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.029
Fes	feline sarcoma oncogene	0.029
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.028
Tmem64	transmembrane protein 64	0.027
Neurog3	neurogenin 3	0.027
Tcra	T-cell receptor alpha chain	0.026
Bdkrb2	bradykinin receptor, beta 2	0.026
Acvrl1	activin A receptor, type II-like 1	0.025
Rps6ka3	ribosomal protein S6 kinase polypeptide 3	0.025
Cd40lg	CD40 ligand	0.025
Bmp7	bone morphogenetic protein 7	0.025
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.025
Socs5	suppressor of cytokine signaling 5	0.024
Irf5	interferon regulatory factor 5	0.024
Runx2	runt related transcription factor 2	0.024
Il10	interleukin 10	0.023
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.023
Irf4	interferon regulatory factor 4	0.022
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.022
Cflar	CASP8 and FADD-like apoptosis regulator	0.022
Pitx1	paired-like homeodomain transcription factor 1	0.021
Inpp5d	inositol polyphosphate-5-phosphatase D	0.021
Gab2	growth factor receptor bound protein 2-associated protein 2	0.021
Bmp8b	bone morphogenetic protein 8b	0.021
Ptgir	prostaglandin I receptor (IP)	0.020
Creb1	cAMP responsive element binding protein 1	0.020
Lat	linker for activation of T cells	0.020
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.019
Ptges	prostaglandin E synthase	0.019
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.019
Trp53bp1	transformation related protein 53 binding protein 1	0.018
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.018
Grb2	growth factor receptor bound protein 2	0.018
Lcor	ligand dependent nuclear receptor corepressor	0.018
Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	0.018
Foxc1	forkhead box C1	0.018
Spsb2	splA/ryanodine receptor domain and SOCS box containing 2	0.018
Foxd2	forkhead box D2	0.018
Hnf1a	HNF1 homeobox A	0.017
Litaf	LPS-induced TN factor	0.017
Cd19	CD19 antigen	0.017
Ar	androgen receptor	0.017
Tlr4	toll-like receptor 4	0.017
Plxna1	plexin A1	0.017
Lag3	lymphocyte-activation gene 3	0.017
Elf3	E74-like factor 3	0.016
Bcl6b	B-cell CLL/lymphoma 6, member B	0.016	Mouse
Adcy4	adenylate cyclase 4	0.016
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.016
a	nonagouti	0.016
Bik	BCL2-interacting killer	0.015
Ephb2	Eph receptor B2	0.015
Sh2b1	SH2B adaptor protein 1	0.015
Zbtb7c	zinc finger and BTB domain containing 7C	0.015
Plekho2	pleckstrin homology domain containing, family O member 2	0.015
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.015	Mouse
Ugcg	UDP-glucose ceramide glucosyltransferase	0.015
Fyn	Fyn proto-oncogene	0.015
Il27ra	interleukin 27 receptor, alpha	0.015
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.015
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.015
Batf	basic leucine zipper transcription factor, ATF-like	0.014
Cd80	CD80 antigen	0.014
Csf1r	colony stimulating factor 1 receptor	0.014
Itgb3	integrin beta 3	0.014
Tbx21	T-box 21	0.014
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.014
Robo3	roundabout homolog 3 (Drosophila)	0.014
Icam1	intercellular adhesion molecule 1	0.014
Sct	secretin	0.014
Hmx3	H6 homeobox 3	0.014
Rel	reticuloendotheliosis oncogene	0.013
Ppard	peroxisome proliferator activator receptor delta	0.013
Aplnr	apelin receptor	0.013
S1pr3	sphingosine-1-phosphate receptor 3	0.013
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.013
Atxn1	ataxin 1	0.013
Nkd2	naked cuticle 2 homolog (Drosophila)	0.013
Amh	anti-Mullerian hormone	0.013
Map3k2	mitogen-activated protein kinase kinase kinase 2	0.013
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.013
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.013
Foxo1	forkhead box O1	0.013
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.013
Esr2	estrogen receptor 2 (beta)	0.013
Mb	myoglobin	0.013
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.013
Rim4	recombination induced mutation 4	0.013
Mmp9	matrix metallopeptidase 9	0.012
Fam83g	family with sequence similarity 83, member G	0.012
Mefv	Mediterranean fever	0.012
Lif	leukemia inhibitory factor	0.012
Bcl6	B-cell leukemia/lymphoma 6	0.012
Tead3	TEA domain family member 3	0.012
Ints6	integrator complex subunit 6	0.012
Ticam1	toll-like receptor adaptor molecule 1	0.012
Alx4	aristaless-like homeobox 4	0.012
Fut4	fucosyltransferase 4	0.012
Flt4	FMS-like tyrosine kinase 4	0.012
Drd4	dopamine receptor D4	0.011
Phospho1	phosphatase, orphan 1	0.011
Pvrl2	poliovirus receptor-related 2	0.011
Ltbp2	latent transforming growth factor beta binding protein 2	0.011
Shc1	src homology 2 domain-containing transforming protein C1	0.011
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.011
Sult5a1	sulfotransferase family 5A, member 1	0.011
Spp1	secreted phosphoprotein 1	0.011
Zfp790	zinc finger protein 790	0.011
Arhgef40	Rho guanine nucleotide exchange factor (GEF) 40	0.011
Foxa3	forkhead box A3	0.011
Chd7	chromodomain helicase DNA binding protein 7	0.011
Tnks1bp1	tankyrase 1 binding protein 1	0.011
Smad7	MAD homolog 7 (Drosophila)	0.011
Efna4	ephrin A4	0.011
Krt84	keratin 84	0.011
Hrh1	histamine receptor H1	0.011
Elk4	ELK4, member of ETS oncogene family	0.011
Il1r2	interleukin 1 receptor, type II	0.011
Zfp518b	zinc finger protein 518B	0.011
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.011
Col2a1	collagen, type II, alpha 1	0.011
Ptch2	patched homolog 2	0.011
Hoxa10	homeobox A10	0.011
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.011
Pkdcc	protein kinase domain containing, cytoplasmic	0.011
Tcf15	transcription factor 15	0.011
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.011
Zfp191	zinc finger protein 191	0.010
Csf1	colony stimulating factor 1 (macrophage)	0.010
Ifngr2	interferon gamma receptor 2	0.010
Foxn4	forkhead box N4	0.010
Ripk2	receptor (TNFRSF)-interacting serine-threonine kinase 2	0.010
Ptafr	platelet-activating factor receptor	0.010
Spry4	sprouty homolog 4 (Drosophila)	0.010
Spry2	sprouty homolog 2 (Drosophila)	0.010
Sfpi1	SFFV proviral integration 1	0.010
Zmym2	zinc finger, MYM-type 2	0.010
Tssk5	testis-specific serine kinase 5	0.010
Fzd7	frizzled homolog 7 (Drosophila)	0.010
Pdcd1	programmed cell death 1	0.010