IMP: Integrative Multi-species Prediction

Mus musculus

21 genes annotated in mouse

tor signaling

GO:0031929

A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

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Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "tor signaling" (in gray)

Name	Description	Probability	Func Analog Organism
Mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.969	Human Yeast Worm
Apc	adenomatosis polyposis coli	0.894
Lepr	leptin receptor	0.822
Ctnnb1	catenin (cadherin associated protein), beta 1	0.812
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.795
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.770	Fly
Cbl	Casitas B-lineage lymphoma	0.755
Pten	phosphatase and tensin homolog	0.713
Mapkap1	mitogen-activated protein kinase associated protein 1	0.708
Vegfa	vascular endothelial growth factor A	0.632
Trp53	transformation related protein 53	0.535
Tgfb1	transforming growth factor, beta 1	0.520
Grap2	GRB2-related adaptor protein 2	0.432	Fly
Rictor	RPTOR independent companion of MTOR, complex 2	0.430	Human
Nf1	neurofibromatosis 1	0.384
Vhl	von Hippel-Lindau tumor suppressor	0.329
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.311
Nos3	nitric oxide synthase 3, endothelial cell	0.303
Grb2	growth factor receptor bound protein 2	0.295	Fly
Tsc2	tuberous sclerosis 2	0.271
Shc3	src homology 2 domain-containing transforming protein C3	0.227	Fly
Tsc1	tuberous sclerosis 1	0.223	Human Zebrafish Fly
Plcg1	phospholipase C, gamma 1	0.210
Mapk14	mitogen-activated protein kinase 14	0.208
Per1	period homolog 1 (Drosophila)	0.185
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.179
Mdm2	transformed mouse 3T3 cell double minute 2	0.171
Nf2	neurofibromatosis 2	0.157
Per2	period homolog 2 (Drosophila)	0.147
Clock	circadian locomotor output cycles kaput	0.146
Gata6	GATA binding protein 6	0.130	Mouse
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.129
Braf	Braf transforming gene	0.123
Raf1	v-raf-leukemia viral oncogene 1	0.122
Kitl	kit ligand	0.112
Gab2	growth factor receptor bound protein 2-associated protein 2	0.097
Tgfbr2	transforming growth factor, beta receptor II	0.096
Ghr	growth hormone receptor	0.095
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.094
Ptch1	patched homolog 1	0.092
Pparg	peroxisome proliferator activated receptor gamma	0.082
Shc1	src homology 2 domain-containing transforming protein C1	0.081	Fly
Tbc1d15	TBC1 domain family, member 15	0.081
Gata4	GATA binding protein 4	0.079	Mouse
Mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae)	0.078	Human Yeast Fly
Sim1	single-minded homolog 1 (Drosophila)	0.075	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.075
Insr	insulin receptor	0.073
Stat3	signal transducer and activator of transcription 3	0.072
Htt	huntingtin	0.071
Epor	erythropoietin receptor	0.070
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.067
Egfr	epidermal growth factor receptor	0.063
Cry1	cryptochrome 1 (photolyase-like)	0.062
Zfpm1	zinc finger protein, multitype 1	0.058
Jak2	Janus kinase 2	0.055
Fgfr2	fibroblast growth factor receptor 2	0.055
Axin1	axin 1	0.054
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.053
Kit	kit oncogene	0.052	Fly
Hif1a	hypoxia inducible factor 1, alpha subunit	0.051
Gab1	growth factor receptor bound protein 2-associated protein 1	0.049
Grb10	growth factor receptor bound protein 10	0.048
Rptor	regulatory associated protein of MTOR, complex 1	0.048	Human
Egln1	EGL nine homolog 1 (C. elegans)	0.047
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.047
Phc2	polyhomeotic-like 2 (Drosophila)	0.046
Fyn	Fyn proto-oncogene	0.043
Rpgrip1l	Rpgrip1-like	0.042
Csf1	colony stimulating factor 1 (macrophage)	0.040
Bmp4	bone morphogenetic protein 4	0.038
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.038
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.038
Flt1	FMS-like tyrosine kinase 1	0.036	Fly
Rxra	retinoid X receptor alpha	0.036
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.036
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.035
Foxa2	forkhead box A2	0.034
Zfpm2	zinc finger protein, multitype 2	0.033
Sos1	son of sevenless homolog 1 (Drosophila)	0.033
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.032
Rb1	retinoblastoma 1	0.032
Blnk	B-cell linker	0.032
Phc1	polyhomeotic-like 1 (Drosophila)	0.031
Ift88	intraflagellar transport 88 homolog (Chlamydomonas)	0.031
Nos1	nitric oxide synthase 1, neuronal	0.031
Stat5b	signal transducer and activator of transcription 5B	0.031
Flcn	folliculin	0.031
Cav1	caveolin 1, caveolae protein	0.031
Dab1	disabled homolog 1 (Drosophila)	0.030
Adam17	a disintegrin and metallopeptidase domain 17	0.029
Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	0.028
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.028
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.027
Cry2	cryptochrome 2 (photolyase-like)	0.027
Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.027
Tal1	T-cell acute lymphocytic leukemia 1	0.027
Rint1	RAD50 interactor 1	0.026
Epas1	endothelial PAS domain protein 1	0.026	Mouse
Kiss1r	KISS1 receptor	0.026
Myo6	myosin VI	0.026
Esr2	estrogen receptor 2 (beta)	0.026
Atf2	activating transcription factor 2	0.025
Pak2	p21 protein (Cdc42/Rac)-activated kinase 2	0.025
Gli3	GLI-Kruppel family member GLI3	0.025
Shc2	SHC (Src homology 2 domain containing) transforming protein 2	0.024	Fly
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.024
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.024
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.024
Src	Rous sarcoma oncogene	0.024
Fgf3	fibroblast growth factor 3	0.023
Aip	aryl-hydrocarbon receptor-interacting protein	0.023
Gna11	guanine nucleotide binding protein, alpha 11	0.023	Mouse
Fcho1	FCH domain only 1	0.023
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.023
Fgfr3	fibroblast growth factor receptor 3	0.023
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.022
Lhx3	LIM homeobox protein 3	0.022
Fbxo11	F-box protein 11	0.022
Tgfbr1	transforming growth factor, beta receptor I	0.022
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.022
Prkag1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.021
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.021
Twist2	twist homolog 2 (Drosophila)	0.021
Ank1	ankyrin 1, erythroid	0.020
Arnt	aryl hydrocarbon receptor nuclear translocator	0.020	Mouse
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.020
Vav2	vav 2 oncogene	0.019
Map4k1	mitogen-activated protein kinase kinase kinase kinase 1	0.019	Fly
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.019
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.019
Acvr1	activin A receptor, type 1	0.019
Foxf1a	forkhead box F1a	0.019
Irs2	insulin receptor substrate 2	0.018
Igf2	insulin-like growth factor 2	0.018
Ssr3	signal sequence receptor, gamma	0.018
Tek	endothelial-specific receptor tyrosine kinase	0.018
Mitf	microphthalmia-associated transcription factor	0.018
Smad4	MAD homolog 4 (Drosophila)	0.018
Pxn	paxillin	0.018
Lrrk1	leucine-rich repeat kinase 1	0.018
Kiss1	KiSS-1 metastasis-suppressor	0.017
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.017
Fcho2	FCH domain only 2	0.017
Sox4	SRY-box containing gene 4	0.017
Pdgfb	platelet derived growth factor, B polypeptide	0.017
Hand1	heart and neural crest derivatives expressed transcript 1	0.017
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.017
Tgfbr3	transforming growth factor, beta receptor III	0.017
Sh2b1	SH2B adaptor protein 1	0.017	Fly
Ncoa2	nuclear receptor coactivator 2	0.017
Fnip1	folliculin interacting protein 1	0.017
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.017
She	src homology 2 domain-containing transforming protein E	0.017
Adcy9	adenylate cyclase 9	0.017
Prkce	protein kinase C, epsilon	0.016
Ldlr	low density lipoprotein receptor	0.016
Hand2	heart and neural crest derivatives expressed transcript 2	0.016
Fbxl20	F-box and leucine-rich repeat protein 20	0.016
Klf1	Kruppel-like factor 1 (erythroid)	0.016
Pax8	paired box gene 8	0.016
Zfp639	zinc finger protein 639	0.016
Smad6	MAD homolog 6 (Drosophila)	0.016
Plxna1	plexin A1	0.016
Sh3kbp1	SH3-domain kinase binding protein 1	0.016
Npas2	neuronal PAS domain protein 2	0.016
Fzd4	frizzled homolog 4 (Drosophila)	0.016
Inpp5d	inositol polyphosphate-5-phosphatase D	0.015
Cep170	centrosomal protein 170	0.015
Cpeb4	cytoplasmic polyadenylation element binding protein 4	0.015
Jag1	jagged 1	0.015
Pcp2	Purkinje cell protein 2 (L7)	0.015
Thrb	thyroid hormone receptor beta	0.015
Col1a1	collagen, type I, alpha 1	0.015
Smad2	MAD homolog 2 (Drosophila)	0.015
Rps6kb1	ribosomal protein S6 kinase, polypeptide 1	0.015	Human
Lep	leptin	0.015
Ar	androgen receptor	0.015
Rgl2	ral guanine nucleotide dissociation stimulator-like 2	0.014
Fgf8	fibroblast growth factor 8	0.014
Fbxl3	F-box and leucine-rich repeat protein 3	0.014
Sav1	salvador homolog 1 (Drosophila)	0.014
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.014
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.014
Klf3	Kruppel-like factor 3 (basic)	0.014
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.014
Ubqln4	ubiquilin 4	0.014
Dcx	doublecortin	0.014
Foxc2	forkhead box C2	0.014
Duox2	dual oxidase 2	0.014
Aff1	AF4/FMR2 family, member 1	0.014
Ephb2	Eph receptor B2	0.014
Ptk2	PTK2 protein tyrosine kinase 2	0.014
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.014	Mouse
Rora	RAR-related orphan receptor alpha	0.014
Smad7	MAD homolog 7 (Drosophila)	0.014
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.014
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.014
Wdr26	WD repeat domain 26	0.014
Mapkapk2	MAP kinase-activated protein kinase 2	0.013	Mouse
Sap30l	SAP30-like	0.013
Irs1	insulin receptor substrate 1	0.013
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.013
Tbx3	T-box 3	0.013
Cd2ap	CD2-associated protein	0.013
Pgr	progesterone receptor	0.013
Gck	glucokinase	0.013
Telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.013	Human
Ppard	peroxisome proliferator activator receptor delta	0.013
Cops2	COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)	0.013
Csnk1e	casein kinase 1, epsilon	0.013
Epha1	Eph receptor A1	0.013
Nae1	NEDD8 activating enzyme E1 subunit 1	0.013
Plac1	placental specific protein 1	0.013
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.013
Otp	orthopedia homolog (Drosophila)	0.013
Pnpla2	patatin-like phospholipase domain containing 2	0.012
Hoxb4	homeobox B4	0.012
Gja1	gap junction protein, alpha 1	0.012
Fto	fat mass and obesity associated	0.012
Tac2	tachykinin 2	0.012
Pdcd6ip	programmed cell death 6 interacting protein	0.012
Zfp276	zinc finger protein (C2H2 type) 276	0.012
Tmem204	transmembrane protein 204	0.012
Chuk	conserved helix-loop-helix ubiquitous kinase	0.012
Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	0.012
Ncoa3	nuclear receptor coactivator 3	0.012
Tbx2	T-box 2	0.012
Alkbh1	alkB, alkylation repair homolog 1 (E. coli)	0.012
Ren1	renin 1 structural	0.012
Il6st	interleukin 6 signal transducer	0.012
Ltbp4	latent transforming growth factor beta binding protein 4	0.012
Gtpbp4	GTP binding protein 4	0.012
Atp8a1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	0.012
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.012
Meox2	mesenchyme homeobox 2	0.012
Morc3	microrchidia 3	0.012
Esr1	estrogen receptor 1 (alpha)	0.012
Kif5b	kinesin family member 5B	0.012
Prkcc	protein kinase C, gamma	0.012
Tgfb2	transforming growth factor, beta 2	0.012
Frs2	fibroblast growth factor receptor substrate 2	0.012
Asb6	ankyrin repeat and SOCS box-containing 6	0.011
Mib1	mindbomb homolog 1 (Drosophila)	0.011
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.011
Gtf3c1	general transcription factor III C 1	0.011
Rasip1	Ras interacting protein 1	0.011
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.011
Jag2	jagged 2	0.011
Akt1	thymoma viral proto-oncogene 1	0.011
Socs1	suppressor of cytokine signaling 1	0.011
Cux2	cut-like homeobox 2	0.011
Sorbs1	sorbin and SH3 domain containing 1	0.011
Vapa	vesicle-associated membrane protein, associated protein A	0.011
Nrp1	neuropilin 1	0.011
Nras	neuroblastoma ras oncogene	0.011	Fly
Rps6	ribosomal protein S6	0.011	Human
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.011
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.011
Eif3c	eukaryotic translation initiation factor 3, subunit C	0.011
Tgfa	transforming growth factor alpha	0.011
Ednrb	endothelin receptor type B	0.011
Pdlim7	PDZ and LIM domain 7	0.011
Vegfc	vascular endothelial growth factor C	0.011
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.011
Ddx3x	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked	0.011
Met	met proto-oncogene	0.011
Sh2d3c	SH2 domain containing 3C	0.011
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011
Lats1	large tumor suppressor	0.011
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.011
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.010
Apaf1	apoptotic peptidase activating factor 1	0.010
Sipa1	signal-induced proliferation associated gene 1	0.010
Hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.010
Tert	telomerase reverse transcriptase	0.010
Trap1a	tumor rejection antigen P1A	0.010
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.010
Sgpl1	sphingosine phosphate lyase 1	0.010
Ulk1	Unc-51 like kinase 1 (C. elegans)	0.010
Atn1	atrophin 1	0.010
Flii	flightless I homolog (Drosophila)	0.010