IMP
Process View
base excision repair
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "base excision repair"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Timeless | timeless homolog (Drosophila) | 0.883 | ||
| Pold1 | polymerase (DNA directed), delta 1, catalytic subunit | 0.818 | ||
| Arid1b | AT rich interactive domain 1B (SWI-like) | 0.621 | ||
| Mcm2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | 0.611 | ||
| Mcm4 | minichromosome maintenance deficient 4 homolog (S. cerevisiae) | 0.589 | ||
| Gmnn | geminin | 0.576 | ||
| Cdt1 | chromatin licensing and DNA replication factor 1 | 0.483 | ||
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.405 | ||
| Dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | 0.367 | ||
| Mcm3 | minichromosome maintenance deficient 3 (S. cerevisiae) | 0.296 | ||
| Dnmt1 | DNA methyltransferase (cytosine-5) 1 | 0.195 | ||
| Trp53 | transformation related protein 53 | 0.156 | ||
| Ezh2 | enhancer of zeste homolog 2 (Drosophila) | 0.143 | ||
| Nup85 | nucleoporin 85 | 0.137 | ||
| E2f1 | E2F transcription factor 1 | 0.131 | ||
| Eftud2 | elongation factor Tu GTP binding domain containing 2 | 0.122 | ||
| Smarcc1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.109 | ||
| Nbn | nibrin | 0.102 | ||
| Tipin | timeless interacting protein | 0.099 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.094 | ||
| Rb1 | retinoblastoma 1 | 0.089 | ||
| Rfc1 | replication factor C (activator 1) 1 | 0.087 | ||
| Ube2t | ubiquitin-conjugating enzyme E2T (putative) | 0.087 | ||
| Prim1 | DNA primase, p49 subunit | 0.085 | ||
| Topbp1 | topoisomerase (DNA) II binding protein 1 | 0.084 | ||
| Cdk4 | cyclin-dependent kinase 4 | 0.075 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.075 | ||
| Ppp1cc | protein phosphatase 1, catalytic subunit, gamma isoform | 0.073 | ||
| Rpa1 | replication protein A1 | 0.071 | Human | |
| Slbp | stem-loop binding protein | 0.070 | ||
| Rfc2 | replication factor C (activator 1) 2 | 0.070 | ||
| Gm5806 | predicted gene 5806 | 0.067 | ||
| Hdac1 | histone deacetylase 1 | 0.067 | ||
| Brca1 | breast cancer 1 | 0.066 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.065 | ||
| Ncapd2 | non-SMC condensin I complex, subunit D2 | 0.065 | ||
| Rfc3 | replication factor C (activator 1) 3 | 0.064 | ||
| Orc6 | origin recognition complex, subunit 6 | 0.062 | ||
| H2afz | H2A histone family, member Z | 0.057 | ||
| Lig1 | ligase I, DNA, ATP-dependent | 0.057 | ||
| Cad | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 0.057 | ||
| Mcm5 | minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 0.056 | ||
| Nup107 | nucleoporin 107 | 0.053 | ||
| Parp1 | poly (ADP-ribose) polymerase family, member 1 | 0.052 | ||
| Fen1 | flap structure specific endonuclease 1 | 0.050 | Yeast | |
| Lrwd1 | leucine-rich repeats and WD repeat domain containing 1 | 0.049 | ||
| Pcna | proliferating cell nuclear antigen | 0.049 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.049 | ||
| Lbr | lamin B receptor | 0.046 | ||
| Smarcd3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | 0.046 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.045 | ||
| Actl6a | actin-like 6A | 0.043 | ||
| Brca2 | breast cancer 2 | 0.043 | ||
| Hmgb1 | high mobility group box 1 | 0.042 | ||
| Smarca4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.040 | Yeast | |
| Haus5 | HAUS augmin-like complex, subunit 5 | 0.040 | ||
| Dtymk | deoxythymidylate kinase | 0.038 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.037 | ||
| Rfc4 | replication factor C (activator 1) 4 | 0.037 | ||
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.036 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.036 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.035 | ||
| Cks1b | CDC28 protein kinase 1b | 0.035 | ||
| Cdca7 | cell division cycle associated 7 | 0.034 | ||
| Ssrp1 | structure specific recognition protein 1 | 0.032 | ||
| Srrt | serrate RNA effector molecule homolog (Arabidopsis) | 0.032 | ||
| Cpsf3 | cleavage and polyadenylation specificity factor 3 | 0.032 | ||
| Uba2 | ubiquitin-like modifier activating enzyme 2 | 0.031 | ||
| Anapc5 | anaphase-promoting complex subunit 5 | 0.031 | ||
| H2afx | H2A histone family, member X | 0.030 | ||
| Smc2 | structural maintenance of chromosomes 2 | 0.028 | ||
| Igh | immunoglobulin heavy chain complex | 0.027 | ||
| Smarcc2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.027 | ||
| Siva1 | SIVA1, apoptosis-inducing factor | 0.027 | ||
| Hspa14 | heat shock protein 14 | 0.027 | ||
| Rfwd3 | ring finger and WD repeat domain 3 | 0.025 | ||
| Impdh2 | inosine 5'-phosphate dehydrogenase 2 | 0.025 | ||
| Smc4 | structural maintenance of chromosomes 4 | 0.024 | ||
| Smarcb1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 0.022 | ||
| Xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.022 | ||
| Trim28 | tripartite motif-containing 28 | 0.022 | ||
| Cdca5 | cell division cycle associated 5 | 0.021 | ||
| Hmgb3 | high mobility group box 3 | 0.021 | ||
| Cdc6 | cell division cycle 6 homolog (S. cerevisiae) | 0.019 | ||
| Psmg2 | proteasome (prosome, macropain) assembly chaperone 2 | 0.019 | ||
| Acd | adrenocortical dysplasia | 0.019 | ||
| Nde1 | nuclear distribution gene E homolog 1 (A nidulans) | 0.018 | ||
| 2700029M09Rik | RIKEN cDNA 2700029M09 gene | 0.018 | ||
| Ung | uracil DNA glycosylase | 0.018 | Worm | |
| Noc4l | nucleolar complex associated 4 homolog (S. cerevisiae) | 0.017 | ||
| Cpsf1 | cleavage and polyadenylation specific factor 1 | 0.016 | ||
| Uhrf1 | ubiquitin-like, containing PHD and RING finger domains, 1 | 0.016 | ||
| Mms22l | MMS22-like, DNA repair protein | 0.016 | ||
| Rpa2 | replication protein A2 | 0.016 | Human | |
| Hmgn1 | high mobility group nucleosomal binding domain 1 | 0.016 | ||
| Racgap1 | Rac GTPase-activating protein 1 | 0.016 | ||
| Hat1 | histone aminotransferase 1 | 0.016 | ||
| Rad50 | RAD50 homolog (S. cerevisiae) | 0.015 | ||
| Pold2 | polymerase (DNA directed), delta 2, regulatory subunit | 0.015 | ||
| Chtf18 | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) | 0.015 | ||
| Smarce1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | 0.015 | ||
| Azi1 | 5-azacytidine induced gene 1 | 0.015 | ||
| Pole | polymerase (DNA directed), epsilon | 0.015 | Human Yeast | |
| Wdr90 | WD repeat domain 90 | 0.014 | ||
| Kif22 | kinesin family member 22 | 0.014 | ||
| Ints9 | integrator complex subunit 9 | 0.014 | ||
| Ddx39b | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.014 | ||
| Kpna2 | karyopherin (importin) alpha 2 | 0.013 | ||
| Ints7 | integrator complex subunit 7 | 0.013 | ||
| Tk1 | thymidine kinase 1 | 0.013 | ||
| 2700094K13Rik | RIKEN cDNA 2700094K13 gene | 0.013 | ||
| Nasp | nuclear autoantigenic sperm protein (histone-binding) | 0.012 | ||
| Rnps1 | ribonucleic acid binding protein S1 | 0.012 | ||
| Dazap1 | DAZ associated protein 1 | 0.012 | ||
| Dck | deoxycytidine kinase | 0.012 | ||
| 2610039C10Rik | RIKEN cDNA 2610039C10 gene | 0.011 | ||
| Mutyh | mutY homolog (E. coli) | 0.011 | ||
| Taf3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor | 0.011 | ||
| Hells | helicase, lymphoid specific | 0.011 | ||
| Tcof1 | Treacher Collins Franceschetti syndrome 1, homolog | 0.011 | ||
| Tdp2 | tyrosyl-DNA phosphodiesterase 2 | 0.011 | ||
| Ncaph | non-SMC condensin I complex, subunit H | 0.011 | ||
| Mpp5 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) | 0.011 | ||
| Prpf19 | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) | 0.011 | ||
| Sin3a | transcriptional regulator, SIN3A (yeast) | 0.011 | ||
| Aurkb | aurora kinase B | 0.011 | ||
| Phf5a | PHD finger protein 5A | 0.011 | ||
| Nudt1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.011 |