IMP
Process View
nucleotide excision repair
A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "nucleotide excision repair"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Msh2 | mutS homolog 2 (E. coli) | 0.859 | ||
| Trp53 | transformation related protein 53 | 0.746 | Human | |
| Timeless | timeless homolog (Drosophila) | 0.586 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.527 | ||
| Dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | 0.460 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.437 | ||
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.410 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.310 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.218 | ||
| Tomm70a | translocase of outer mitochondrial membrane 70 homolog A (yeast) | 0.208 | ||
| Rb1 | retinoblastoma 1 | 0.175 | ||
| Nf1 | neurofibromatosis 1 | 0.124 | ||
| Parp1 | poly (ADP-ribose) polymerase family, member 1 | 0.111 | ||
| Mcm2 | minichromosome maintenance deficient 2 mitotin (S. cerevisiae) | 0.096 | ||
| Cbx1 | chromobox homolog 1 (Drosophila HP1 beta) | 0.092 | ||
| Brca1 | breast cancer 1 | 0.087 | ||
| Anp32e | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.085 | ||
| Hmgb1 | high mobility group box 1 | 0.082 | ||
| Foxo3 | forkhead box O3 | 0.080 | ||
| Eftud2 | elongation factor Tu GTP binding domain containing 2 | 0.075 | ||
| Ormdl1 | ORM1-like 1 (S. cerevisiae) | 0.071 | ||
| Ewsr1 | Ewing sarcoma breakpoint region 1 | 0.070 | ||
| Nup85 | nucleoporin 85 | 0.070 | ||
| Dsg4 | desmoglein 4 | 0.068 | ||
| Ncl | nucleolin | 0.065 | ||
| Lsm3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.062 | ||
| Lsm2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.060 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.059 | ||
| E2f1 | E2F transcription factor 1 | 0.059 | ||
| Rnf7 | ring finger protein 7 | 0.058 | ||
| Prmt1 | protein arginine N-methyltransferase 1 | 0.054 | ||
| Xpc | xeroderma pigmentosum, complementation group C | 0.052 | ||
| Prpf40a | PRP40 pre-mRNA processing factor 40 homolog A (yeast) | 0.051 | ||
| Trim28 | tripartite motif-containing 28 | 0.048 | ||
| Actr6 | ARP6 actin-related protein 6 homolog (yeast) | 0.046 | ||
| Hdac2 | histone deacetylase 2 | 0.046 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.045 | ||
| Wwox | WW domain-containing oxidoreductase | 0.044 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.044 | ||
| Srsf9 | serine/arginine-rich splicing factor 9 | 0.043 | ||
| Dtymk | deoxythymidylate kinase | 0.043 | ||
| Pms2 | postmeiotic segregation increased 2 (S. cerevisiae) | 0.043 | ||
| Cry1 | cryptochrome 1 (photolyase-like) | 0.041 | ||
| Tbcb | tubulin folding cofactor B | 0.040 | ||
| Siva1 | SIVA1, apoptosis-inducing factor | 0.039 | ||
| Srsf4 | serine/arginine-rich splicing factor 4 | 0.039 | ||
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.039 | ||
| Stk11 | serine/threonine kinase 11 | 0.038 | ||
| Mcm4 | minichromosome maintenance deficient 4 homolog (S. cerevisiae) | 0.038 | ||
| Tsc1 | tuberous sclerosis 1 | 0.037 | ||
| Ppm1g | protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform | 0.037 | ||
| Nup188 | nucleoporin 188 | 0.036 | ||
| Rrm1 | ribonucleotide reductase M1 | 0.036 | ||
| Pole | polymerase (DNA directed), epsilon | 0.035 | Human Yeast | |
| Hist1h2bm | histone cluster 1, H2bm | 0.033 | ||
| Ints9 | integrator complex subunit 9 | 0.033 | ||
| Rttn | rotatin | 0.032 | ||
| Rev1 | REV1 homolog (S. cerevisiae) | 0.032 | ||
| Mapk14 | mitogen-activated protein kinase 14 | 0.032 | ||
| Wrn | Werner syndrome homolog (human) | 0.032 | ||
| Snrnp40 | small nuclear ribonucleoprotein 40 (U5) | 0.031 | ||
| Cad | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 0.030 | ||
| Nup133 | nucleoporin 133 | 0.030 | ||
| Ptch1 | patched homolog 1 | 0.029 | ||
| 2700029M09Rik | RIKEN cDNA 2700029M09 gene | 0.029 | ||
| Tipin | timeless interacting protein | 0.029 | ||
| Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | 0.029 | ||
| 2500003M10Rik | RIKEN cDNA 2500003M10 gene | 0.029 | ||
| Gtf2h2 | general transcription factor II H, polypeptide 2 | 0.028 | Yeast | |
| Dut | deoxyuridine triphosphatase | 0.028 | ||
| Rfc1 | replication factor C (activator 1) 1 | 0.028 | ||
| Nbn | nibrin | 0.027 | ||
| Cdk9 | cyclin-dependent kinase 9 (CDC2-related kinase) | 0.027 | ||
| Rnf8 | ring finger protein 8 | 0.026 | ||
| Terf1 | telomeric repeat binding factor 1 | 0.025 | ||
| Eif1ax | eukaryotic translation initiation factor 1A, X-linked | 0.025 | ||
| Ssrp1 | structure specific recognition protein 1 | 0.025 | ||
| Psmg2 | proteasome (prosome, macropain) assembly chaperone 2 | 0.025 | ||
| Pten | phosphatase and tensin homolog | 0.024 | ||
| Gins4 | GINS complex subunit 4 (Sld5 homolog) | 0.024 | ||
| Smn1 | survival motor neuron 1 | 0.024 | ||
| E130303B06Rik | RIKEN cDNA E130303B06 gene | 0.024 | ||
| Rpgrip1l | Rpgrip1-like | 0.024 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.024 | ||
| Naa50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | 0.023 | ||
| Gtl3 | gene trap locus 3 | 0.023 | ||
| Mcm3 | minichromosome maintenance deficient 3 (S. cerevisiae) | 0.023 | ||
| Fancd2 | Fanconi anemia, complementation group D2 | 0.023 | ||
| Sae1 | SUMO1 activating enzyme subunit 1 | 0.023 | ||
| Bmi1 | Bmi1 polycomb ring finger oncogene | 0.023 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.023 | ||
| Zfp444 | zinc finger protein 444 | 0.023 | ||
| Gmnn | geminin | 0.022 | ||
| Xrcc5 | X-ray repair complementing defective repair in Chinese hamster cells 5 | 0.022 | ||
| AI314976 | expressed sequence AI314976 | 0.022 | ||
| Ep300 | E1A binding protein p300 | 0.022 | ||
| Cdc123 | cell division cycle 123 homolog (S. cerevisiae) | 0.021 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.021 | ||
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.021 | ||
| Nup107 | nucleoporin 107 | 0.021 | ||
| Cdk4 | cyclin-dependent kinase 4 | 0.021 | ||
| Pcid2 | PCI domain containing 2 | 0.021 | ||
| Nf2 | neurofibromatosis 2 | 0.020 | ||
| Alms1 | Alstrom syndrome 1 homolog (human) | 0.020 | ||
| Rara | retinoic acid receptor, alpha | 0.020 | ||
| Anapc5 | anaphase-promoting complex subunit 5 | 0.020 | ||
| Nfatc3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.020 | ||
| Dkc1 | dyskeratosis congenita 1, dyskerin homolog (human) | 0.019 | ||
| Hnrnpab | heterogeneous nuclear ribonucleoprotein A/B | 0.019 | ||
| Psmb7 | proteasome (prosome, macropain) subunit, beta type 7 | 0.019 | ||
| Arl6ip6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.019 | ||
| Mrpl13 | mitochondrial ribosomal protein L13 | 0.019 | ||
| Fam96a | family with sequence similarity 96, member A | 0.019 | ||
| Miip | migration and invasion inhibitory protein | 0.019 | ||
| Apc | adenomatosis polyposis coli | 0.018 | ||
| Fen1 | flap structure specific endonuclease 1 | 0.018 | ||
| Mcm8 | minichromosome maintenance deficient 8 (S. cerevisiae) | 0.018 | ||
| Rtel1 | regulator of telomere elongation helicase 1 | 0.018 | ||
| Hnrnpd | heterogeneous nuclear ribonucleoprotein D | 0.018 | ||
| Xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 0.018 | ||
| Psme3 | proteaseome (prosome, macropain) 28 subunit, 3 | 0.017 | ||
| Asf1a | ASF1 anti-silencing function 1 homolog A (S. cerevisiae) | 0.017 | ||
| Ndnl2 | necdin-like 2 | 0.017 | ||
| Mrfap1 | Morf4 family associated protein 1 | 0.017 | ||
| Clspn | claspin homolog (Xenopus laevis) | 0.017 | ||
| Nae1 | NEDD8 activating enzyme E1 subunit 1 | 0.017 | ||
| Rpa1 | replication protein A1 | 0.017 | Human Yeast | |
| Brd2 | bromodomain containing 2 | 0.017 | ||
| H2afx | H2A histone family, member X | 0.017 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.017 | ||
| G3bp1 | Ras-GTPase-activating protein SH3-domain binding protein 1 | 0.017 | ||
| Prpf19 | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) | 0.016 | ||
| Tfam | transcription factor A, mitochondrial | 0.016 | ||
| Srrt | serrate RNA effector molecule homolog (Arabidopsis) | 0.016 | ||
| Refbp2 | RNA and export factor binding protein 2 | 0.016 | Yeast | |
| Hnrnpl | heterogeneous nuclear ribonucleoprotein L | 0.016 | ||
| Polr2b | polymerase (RNA) II (DNA directed) polypeptide B | 0.016 | ||
| Dmtf1 | cyclin D binding myb-like transcription factor 1 | 0.016 | ||
| 1500010J02Rik | RIKEN cDNA 1500010J02 gene | 0.016 | ||
| Paxip1 | PAX interacting (with transcription-activation domain) protein 1 | 0.016 | ||
| Vcp | valosin containing protein | 0.016 | ||
| Raf1 | v-raf-leukemia viral oncogene 1 | 0.015 | ||
| Psmd11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.015 | ||
| Lig1 | ligase I, DNA, ATP-dependent | 0.015 | ||
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.015 | ||
| Dpy30 | dpy-30 homolog (C. elegans) | 0.015 | ||
| Dicer1 | Dicer1, Dcr-1 homolog (Drosophila) | 0.015 | ||
| Polr2d | polymerase (RNA) II (DNA directed) polypeptide D | 0.015 | ||
| Cetn3 | centrin 3 | 0.015 | ||
| Ncapd2 | non-SMC condensin I complex, subunit D2 | 0.015 | ||
| Rbx1 | ring-box 1 | 0.015 | ||
| Ddx1 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 | 0.015 | ||
| Rbbp4 | retinoblastoma binding protein 4 | 0.015 | ||
| Commd1 | COMM domain containing 1 | 0.015 | ||
| Ppp1r7 | protein phosphatase 1, regulatory (inhibitor) subunit 7 | 0.014 | ||
| Mms22l | MMS22-like, DNA repair protein | 0.014 | ||
| Haus4 | HAUS augmin-like complex, subunit 4 | 0.014 | ||
| Lrrc40 | leucine rich repeat containing 40 | 0.014 | ||
| Cpsf1 | cleavage and polyadenylation specific factor 1 | 0.014 | ||
| 1110002B05Rik | RIKEN cDNA 1110002B05 gene | 0.014 | ||
| Cox4nb | COX4 neighbor | 0.014 | ||
| Ipo5 | importin 5 | 0.014 | ||
| Thrb | thyroid hormone receptor beta | 0.014 | ||
| Ash2l | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.014 | ||
| Bcap29 | B-cell receptor-associated protein 29 | 0.014 | ||
| Pold2 | polymerase (DNA directed), delta 2, regulatory subunit | 0.014 | ||
| Bub1b | budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) | 0.014 | ||
| Exosc7 | exosome component 7 | 0.014 | ||
| Hist2h4 | histone cluster 2, H4 | 0.014 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.014 | ||
| Atr | ataxia telangiectasia and Rad3 related | 0.014 | ||
| Sos2 | son of sevenless homolog 2 (Drosophila) | 0.014 | ||
| Gins1 | GINS complex subunit 1 (Psf1 homolog) | 0.014 | ||
| Puf60 | poly-U binding splicing factor 60 | 0.014 | ||
| Top3b | topoisomerase (DNA) III beta | 0.013 | ||
| Fkbp4 | FK506 binding protein 4 | 0.013 | ||
| Psmc2 | proteasome (prosome, macropain) 26S subunit, ATPase 2 | 0.013 | ||
| Ube2e1 | ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast) | 0.013 | ||
| Lig3 | ligase III, DNA, ATP-dependent | 0.013 | ||
| Rrn3 | RRN3 RNA polymerase I transcription factor homolog (yeast) | 0.013 | ||
| Nup37 | nucleoporin 37 | 0.013 | ||
| Psmc3 | proteasome (prosome, macropain) 26S subunit, ATPase 3 | 0.013 | ||
| Cops7b | COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana) | 0.013 | ||
| Trim23 | tripartite motif-containing 23 | 0.013 | ||
| Setdb1 | SET domain, bifurcated 1 | 0.013 | ||
| Farsa | phenylalanyl-tRNA synthetase, alpha subunit | 0.013 | ||
| Tonsl | tonsoku-like, DNA repair protein | 0.013 | ||
| Cul9 | cullin 9 | 0.012 | ||
| Strada | STE20-related kinase adaptor alpha | 0.012 | ||
| Srsf2 | serine/arginine-rich splicing factor 2 | 0.012 | ||
| Ruvbl2 | RuvB-like protein 2 | 0.012 | ||
| Prim1 | DNA primase, p49 subunit | 0.012 | ||
| Tubg1 | tubulin, gamma 1 | 0.012 | ||
| Dars | aspartyl-tRNA synthetase | 0.012 | ||
| Magoh | mago-nashi homolog, proliferation-associated (Drosophila) | 0.012 | ||
| Kdm5a | lysine (K)-specific demethylase 5A | 0.012 | ||
| C1d | C1D nuclear receptor co-repressor | 0.012 | ||
| Lig4 | ligase IV, DNA, ATP-dependent | 0.012 | Human | |
| Orc5 | origin recognition complex, subunit 5 | 0.012 | ||
| Parn | poly(A)-specific ribonuclease (deadenylation nuclease) | 0.012 | ||
| Asxl1 | additional sex combs like 1 (Drosophila) | 0.012 | ||
| Lrwd1 | leucine-rich repeats and WD repeat domain containing 1 | 0.012 | ||
| Rfc2 | replication factor C (activator 1) 2 | 0.012 | ||
| Pdpk1 | 3-phosphoinositide dependent protein kinase 1 | 0.012 | ||
| Ccdc90b | coiled-coil domain containing 90B | 0.012 | ||
| Ppie | peptidylprolyl isomerase E (cyclophilin E) | 0.012 | ||
| Zbtb48 | zinc finger and BTB domain containing 48 | 0.012 | ||
| Nde1 | nuclear distribution gene E homolog 1 (A nidulans) | 0.011 | ||
| Rqcd1 | rcd1 (required for cell differentiation) homolog 1 (S. pombe) | 0.011 | ||
| Tdp1 | tyrosyl-DNA phosphodiesterase 1 | 0.011 | ||
| Arid4a | AT rich interactive domain 4A (RBP1-like) | 0.011 | ||
| Arpp19 | cAMP-regulated phosphoprotein 19 | 0.011 | ||
| Siah1b | seven in absentia 1B | 0.011 | ||
| C2cd3 | C2 calcium-dependent domain containing 3 | 0.011 | ||
| Acyp1 | acylphosphatase 1, erythrocyte (common) type | 0.011 | ||
| Prmt3 | protein arginine N-methyltransferase 3 | 0.011 | ||
| Pabpn1 | poly(A) binding protein, nuclear 1 | 0.011 | ||
| Cdkn2d | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 0.011 | ||
| Ppih | peptidyl prolyl isomerase H | 0.011 | ||
| Odf2 | outer dense fiber of sperm tails 2 | 0.011 | ||
| Atad5 | ATPase family, AAA domain containing 5 | 0.011 | ||
| Hist2h3c2-ps | histone cluster 2, H3c2, pseudogene | 0.011 | ||
| Braf | Braf transforming gene | 0.010 | ||
| Hist1h2bc | histone cluster 1, H2bc | 0.010 | ||
| Zbtb45 | zinc finger and BTB domain containing 45 | 0.010 | ||
| Stk4 | serine/threonine kinase 4 | 0.010 | ||
| Nup93 | nucleoporin 93 | 0.010 | ||
| 5830433M19Rik | RIKEN cDNA 5830433M19 gene | 0.010 | ||
| Dclre1a | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) | 0.010 | ||
| Fbxo47 | F-box protein 47 | 0.010 | ||
| Acin1 | apoptotic chromatin condensation inducer 1 | 0.010 | ||
| Pcbp1 | poly(rC) binding protein 1 | 0.010 | ||
| Pdcd10 | programmed cell death 10 | 0.010 | ||
| Psma4 | proteasome (prosome, macropain) subunit, alpha type 4 | 0.010 | ||
| Med1 | mediator complex subunit 1 | 0.010 |