IMP: Integrative Multi-species Prediction

Mus musculus

11 genes annotated in mouse

Multi-species View

determination of adult lifespan

GO:0008340

The control of viability and duration in the adult phase of the life-cycle.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "determination of adult lifespan"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "determination of adult lifespan" (in gray)

Name	Description	Probability	Func Analog Organism
Pten	phosphatase and tensin homolog	0.951	Worm
Trp53	transformation related protein 53	0.573
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.561
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.480	Fly
Rpgrip1l	Rpgrip1-like	0.447
Mapk14	mitogen-activated protein kinase 14	0.371	Fly
Hif1a	hypoxia inducible factor 1, alpha subunit	0.313	Worm
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.235	Worm
Mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.207	Worm Fly
Atf2	activating transcription factor 2	0.193
Insr	insulin receptor	0.168	Worm Fly
Akt1	thymoma viral proto-oncogene 1	0.153	Worm
Psma1	proteasome (prosome, macropain) subunit, alpha type 1	0.152	Worm
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.151	Worm
Tsc1	tuberous sclerosis 1	0.137	Fly
Pparg	peroxisome proliferator activated receptor gamma	0.123
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.121
Vegfa	vascular endothelial growth factor A	0.114
Hdac2	histone deacetylase 2	0.098	Fly
Shc1	src homology 2 domain-containing transforming protein C1	0.092
Tgfb1	transforming growth factor, beta 1	0.090	Fly
Nf2	neurofibromatosis 2	0.087
Aldoa	aldolase A, fructose-bisphosphate	0.085
Eif4g1	eukaryotic translation initiation factor 4, gamma 1	0.083
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.080	Worm
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.078	Worm
Epas1	endothelial PAS domain protein 1	0.076	Worm
Hbb-b1	hemoglobin, beta adult major chain	0.073
Mdh2	malate dehydrogenase 2, NAD (mitochondrial)	0.072
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.066
Pou5f1	POU domain, class 5, transcription factor 1	0.064	Mouse
Tgfbr1	transforming growth factor, beta receptor I	0.064	Fly
Braf	Braf transforming gene	0.063	Worm
Mta2	metastasis-associated gene family, member 2	0.060	Worm
Iqcb1	IQ calmodulin-binding motif containing 1	0.059
Pabpn1	poly(A) binding protein, nuclear 1	0.059
Cyld	cylindromatosis (turban tumor syndrome)	0.054	Fly
Foxa2	forkhead box A2	0.053	Worm
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.053	Worm
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.053
Msh2	mutS homolog 2 (E. coli)	0.051
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.051
Cox5b	cytochrome c oxidase, subunit Vb	0.050
Rxra	retinoid X receptor alpha	0.049	Worm
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.049
Ndufs3	NADH dehydrogenase (ubiquinone) Fe-S protein 3	0.049	Worm
Skp1a	S-phase kinase-associated protein 1A	0.049
Esrrb	estrogen related receptor, beta	0.049
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.049	Worm
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.048
Lmna	lamin A	0.047	Worm
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.047	Worm
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.046
Wdr5	WD repeat domain 5	0.046	Worm
Ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	0.045
Inpp5d	inositol polyphosphate-5-phosphatase D	0.045
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.044
Lepr	leptin receptor	0.043
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.043	Worm
Bcl2	B-cell leukemia/lymphoma 2	0.042
Smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.041	Worm
Lyst	lysosomal trafficking regulator	0.040
Nos3	nitric oxide synthase 3, endothelial cell	0.040
Gab2	growth factor receptor bound protein 2-associated protein 2	0.040
Psmd14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.039
Foxo1	forkhead box O1	0.039	Worm Fly
Uqcrc1	ubiquinol-cytochrome c reductase core protein 1	0.039
Rbbp4	retinoblastoma binding protein 4	0.038
Pgls	6-phosphogluconolactonase	0.038
Nos1	nitric oxide synthase 1, neuronal	0.038
Rictor	RPTOR independent companion of MTOR, complex 2	0.038	Worm
Hr	hairless	0.037
Tlr4	toll-like receptor 4	0.037
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.036	Worm
Nanog	Nanog homeobox	0.035
Nfib	nuclear factor I/B	0.035	Worm
Becn1	beclin 1, autophagy related	0.033	Worm
Rb1	retinoblastoma 1	0.033
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.032
Atp5o	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	0.032
Dnm1l	dynamin 1-like	0.031	Worm
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.030
Blnk	B-cell linker	0.030
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.030	Worm
Cacybp	calcyclin binding protein	0.030
Grpel1	GrpE-like 1, mitochondrial	0.029
Smad3	MAD homolog 3 (Drosophila)	0.029
Rara	retinoic acid receptor, alpha	0.029
Eed	embryonic ectoderm development	0.029
Psma7	proteasome (prosome, macropain) subunit, alpha type 7	0.028
Vdac3	voltage-dependent anion channel 3	0.028
Atp5d	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit	0.028
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.028
Lims1	LIM and senescent cell antigen-like domains 1	0.028
Prkce	protein kinase C, epsilon	0.027
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.027	Worm
Ctnnb1	catenin (cadherin associated protein), beta 1	0.027
Notch2	Notch gene homolog 2 (Drosophila)	0.027	Worm Fly
Tpi1	triosephosphate isomerase 1	0.027	Worm Fly
Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1	0.026	Worm
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.026	Fly
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.025
Rnf2	ring finger protein 2	0.025
Sqstm1	sequestosome 1	0.025
Mcm7	minichromosome maintenance deficient 7 (S. cerevisiae)	0.024
Vhl	von Hippel-Lindau tumor suppressor	0.024	Worm
Dctn1	dynactin 1	0.024
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.023	Worm
Atg12	autophagy-related 12 (yeast)	0.023
Kit	kit oncogene	0.023
Pbx1	pre B-cell leukemia transcription factor 1	0.023
Notch1	Notch gene homolog 1 (Drosophila)	0.023	Worm Fly
Pdx1	pancreatic and duodenal homeobox 1	0.023
Fasn	fatty acid synthase	0.023	Worm
Hsd3b4	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4	0.023
Cav1	caveolin 1, caveolae protein	0.023
Sox2	SRY-box containing gene 2	0.023
Tardbp	TAR DNA binding protein	0.023
Myh9	myosin, heavy polypeptide 9, non-muscle	0.022
Cxcr4	chemokine (C-X-C motif) receptor 4	0.022
Bcl6	B-cell leukemia/lymphoma 6	0.022
Hdac1	histone deacetylase 1	0.022	Fly
Hoxa9	homeobox A9	0.022
Srsf1	serine/arginine-rich splicing factor 1	0.022
Cs	citrate synthase	0.021
Spna2	spectrin alpha 2	0.021
Rbbp5	retinoblastoma binding protein 5	0.021
Sav1	salvador homolog 1 (Drosophila)	0.021
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.021	Worm Fly
Raf1	v-raf-leukemia viral oncogene 1	0.021	Worm
Gaa	glucosidase, alpha, acid	0.020
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.020
Prlr	prolactin receptor	0.020
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.020	Fly
Lep	leptin	0.020
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.020
Pycard	PYD and CARD domain containing	0.020
Cdx2	caudal type homeobox 2	0.020
Acly	ATP citrate lyase	0.019
Gspt1	G1 to S phase transition 1	0.019
Sp1	trans-acting transcription factor 1	0.019
Eif4a1	eukaryotic translation initiation factor 4A1	0.019	Worm
Vdr	vitamin D receptor	0.019
Apoe	apolipoprotein E	0.019
Psma3	proteasome (prosome, macropain) subunit, alpha type 3	0.019
Pkd2	polycystic kidney disease 2	0.019
Prpf4b	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.019
Cul3	cullin 3	0.019	Worm
Foxf1a	forkhead box F1a	0.019
Fh1	fumarate hydratase 1	0.019
Gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.019	Worm
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.019	Worm
Dkc1	dyskeratosis congenita 1, dyskerin homolog (human)	0.019
Psmb5	proteasome (prosome, macropain) subunit, beta type 5	0.018
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.018
Col1a1	collagen, type I, alpha 1	0.018
Irs2	insulin receptor substrate 2	0.018	Fly
Ndufa4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4	0.018
Kitl	kit ligand	0.018
Smn1	survival motor neuron 1	0.018	Worm
Scd1	stearoyl-Coenzyme A desaturase 1	0.017	Worm
Gpi1	glucose phosphate isomerase 1	0.017	Worm
Ndufs2	NADH dehydrogenase (ubiquinone) Fe-S protein 2	0.017
Apc	adenomatosis polyposis coli	0.017
Hoxa13	homeobox A13	0.017
Sall4	sal-like 4 (Drosophila)	0.017
Esr1	estrogen receptor 1 (alpha)	0.017
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.017
Sall1	sal-like 1 (Drosophila)	0.017
Egfr	epidermal growth factor receptor	0.017
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.017
Aifm1	apoptosis-inducing factor, mitochondrion-associated 1	0.017
Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.016
Hspa9	heat shock protein 9	0.016
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.016
Ncoa3	nuclear receptor coactivator 3	0.016
Krt14	keratin 14	0.016
Ptk2	PTK2 protein tyrosine kinase 2	0.016
Hspd1	heat shock protein 1 (chaperonin)	0.016
Qk	quaking	0.016	Worm
Gmnn	geminin	0.016
Sf3b1	splicing factor 3b, subunit 1	0.016
Pklr	pyruvate kinase liver and red blood cell	0.016	Worm
Tsc2	tuberous sclerosis 2	0.016	Fly
Stk4	serine/threonine kinase 4	0.016	Worm
Slc4a4	solute carrier family 4 (anion exchanger), member 4	0.016
Hspa8	heat shock protein 8	0.015
Ttn	titin	0.015
Pgk1	phosphoglycerate kinase 1	0.015
Cbl	Casitas B-lineage lymphoma	0.015
Gdf11	growth differentiation factor 11	0.015
Ghr	growth hormone receptor	0.015
Gna11	guanine nucleotide binding protein, alpha 11	0.015	Worm
Timm17a	translocase of inner mitochondrial membrane 17a	0.015
Tdp2	tyrosyl-DNA phosphodiesterase 2	0.015
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.015
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.015
Il6st	interleukin 6 signal transducer	0.015
Dsg4	desmoglein 4	0.015
Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.015
Cidea	cell death-inducing DNA fragmentation factor, alpha subunit-like effector A	0.015
Psmd12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.015
Chd2	chromodomain helicase DNA binding protein 2	0.015
Foxo3	forkhead box O3	0.015	Worm Fly
Tgfbr2	transforming growth factor, beta receptor II	0.015
Ndufa8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8	0.014
Hgd	homogentisate 1, 2-dioxygenase	0.014
Wdr1	WD repeat domain 1	0.014	Worm
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.014
Plin4	perilipin 4	0.014
Rtn2	reticulon 2 (Z-band associated protein)	0.014
Mdk	midkine	0.014
Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.014
Barx1	BarH-like homeobox 1	0.014
Sdhd	succinate dehydrogenase complex, subunit D, integral membrane protein	0.014	Worm
Hrc	histidine rich calcium binding protein	0.014
Trp73	transformation related protein 73	0.014	Mouse Worm Fly
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.014
Rps6	ribosomal protein S6	0.013	Worm
Vasp	vasodilator-stimulated phosphoprotein	0.013
Plcg1	phospholipase C, gamma 1	0.013
Lamp1	lysosomal-associated membrane protein 1	0.013
Dhcr7	7-dehydrocholesterol reductase	0.013
Meis1	Meis homeobox 1	0.013	Worm
Psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.013
Ptgs2	prostaglandin-endoperoxide synthase 2	0.013
Psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.013
Soat1	sterol O-acyltransferase 1	0.013	Worm
Cdt1	chromatin licensing and DNA replication factor 1	0.013	Worm
Ndufv1	NADH dehydrogenase (ubiquinone) flavoprotein 1	0.013
Tenc1	tensin like C1 domain-containing phosphatase	0.013
Glrx3	glutaredoxin 3	0.013
Psmb6	proteasome (prosome, macropain) subunit, beta type 6	0.013
Adam17	a disintegrin and metallopeptidase domain 17	0.013
Emx1	empty spiracles homolog 1 (Drosophila)	0.013
Pcx	pyruvate carboxylase	0.013
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.013
Nphp1	nephronophthisis 1 (juvenile) homolog (human)	0.012	Worm
Gtf2a1	general transcription factor II A, 1	0.012
Ep300	E1A binding protein p300	0.012	Worm
Ghitm	growth hormone inducible transmembrane protein	0.012
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.012
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.012
Ndufb6	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6	0.012
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.012
Atp5g3	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)	0.012
Klf5	Kruppel-like factor 5	0.012
Hnrnpm	heterogeneous nuclear ribonucleoprotein M	0.012
Stat6	signal transducer and activator of transcription 6	0.012
Gab1	growth factor receptor bound protein 2-associated protein 1	0.012
Tgfbr3	transforming growth factor, beta receptor III	0.012
Thra	thyroid hormone receptor alpha	0.012
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.011
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.011
Gm5506	predicted gene 5506	0.011
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.011
Vim	vimentin	0.011
Ate1	arginyltransferase 1	0.011
Ppara	peroxisome proliferator activated receptor alpha	0.011
Hnrnpa3	heterogeneous nuclear ribonucleoprotein A3	0.011	Worm
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.011
Slc2a5	solute carrier family 2 (facilitated glucose transporter), member 5	0.011
Bhlha15	basic helix-loop-helix family, member a15	0.011
Tlx3	T-cell leukemia, homeobox 3	0.011
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.011
Ihh	Indian hedgehog	0.011
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.011
Fbxl20	F-box and leucine-rich repeat protein 20	0.011
Ldha	lactate dehydrogenase A	0.011
Psme4	proteasome (prosome, macropain) activator subunit 4	0.011
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.011
Sall3	sal-like 3 (Drosophila)	0.011
Mrpl16	mitochondrial ribosomal protein L16	0.011
Mks1	Meckel syndrome, type 1	0.011
Jup	junction plakoglobin	0.011
Cltc	clathrin, heavy polypeptide (Hc)	0.011
Lmnb1	lamin B1	0.011	Worm
Hoxc9	homeobox C9	0.010
Fgfr1	fibroblast growth factor receptor 1	0.010
Smtn	smoothelin	0.010
Stag1	stromal antigen 1	0.010
Ina	internexin neuronal intermediate filament protein, alpha	0.010
Egln3	EGL nine homolog 3 (C. elegans)	0.010	Worm
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.010
Psmc1	protease (prosome, macropain) 26S subunit, ATPase 1	0.010	Worm
Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	0.010
Acin1	apoptotic chromatin condensation inducer 1	0.010