IMP: Integrative Multi-species Prediction

Mus musculus

2 genes annotated in mouse

Multi-species View

negative regulation of nlrp3 inflammasome complex assembly

GO:1900226

Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of nlrp3 inflammasome complex assembly"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of nlrp3 inflammasome complex assembly" (in gray)

Name	Description	Probability	Func Analog Organism
Stat1	signal transducer and activator of transcription 1	0.974
Irf9	interferon regulatory factor 9	0.851
Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.842
Parp14	poly (ADP-ribose) polymerase family, member 14	0.829
Gbp7	guanylate binding protein 7	0.819
Trim12a	tripartite motif-containing 12A	0.793	Mouse
Ifi203	interferon activated gene 203	0.756
Ifi44	interferon-induced protein 44	0.654
Trim21	tripartite motif-containing 21	0.599	Mouse
Oas1b	2'-5' oligoadenylate synthetase 1B	0.570
Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.544
Trim12c	tripartite motif-containing 12C	0.461	Mouse
Herc6	hect domain and RLD 6	0.423
Trim30d	tripartite motif-containing 30D	0.406	Mouse
Trim34a	tripartite motif-containing 34A	0.403	Mouse
Iigp1	interferon inducible GTPase 1	0.379
Trim30a	tripartite motif-containing 30A	0.373
Clk2	CDC-like kinase 2	0.324
Rtp4	receptor transporter protein 4	0.320
Parp9	poly (ADP-ribose) polymerase family, member 9	0.310
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.309
Samd9l	sterile alpha motif domain containing 9-like	0.307
Epsti1	epithelial stromal interaction 1 (breast)	0.294
Akap8l	A kinase (PRKA) anchor protein 8-like	0.280
Trim5	tripartite motif-containing 5	0.271	Mouse
Stat2	signal transducer and activator of transcription 2	0.249
Sp100	nuclear antigen Sp100	0.241
Irgm1	immunity-related GTPase family M member 1	0.214
Cd274	CD274 antigen	0.177
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.176
Oas3	2'-5' oligoadenylate synthetase 3	0.166
Irgm2	immunity-related GTPase family M member 2	0.163
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.162
Pprc1	peroxisome proliferative activated receptor, gamma, coactivator-related 1	0.159
Mx1	myxovirus (influenza virus) resistance 1	0.147
Dhx30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.145
Gbp3	guanylate binding protein 3	0.140
Aldh2	aldehyde dehydrogenase 2, mitochondrial	0.137
Kel	Kell blood group	0.121
E4f1	E4F transcription factor 1	0.118
Trim11	tripartite motif-containing 11	0.115	Mouse
Mndal	myeloid nuclear differentiation antigen like	0.113
Fam193b	family with sequence similarity 193, member B	0.103
Gm12185	predicted gene 12185	0.092
Sfi1	Sfi1 homolog, spindle assembly associated (yeast)	0.092
Man2c1	mannosidase, alpha, class 2C, member 1	0.084
Dtx3l	deltex 3-like (Drosophila)	0.082
Csprs	component of Sp100-rs	0.079
Xaf1	XIAP associated factor 1	0.079
BC006779	cDNA sequence BC006779	0.078
Mnda	myeloid cell nuclear differentiation antigen	0.077
Ifih1	interferon induced with helicase C domain 1	0.076
Dync1h1	dynein cytoplasmic 1 heavy chain 1	0.073
Gpa33	glycoprotein A33 (transmembrane)	0.070
Zc3hav1	zinc finger CCCH type, antiviral 1	0.070
Tom1	target of myb1 homolog (chicken)	0.070
Apbb3	amyloid beta (A4) precursor protein-binding, family B, member 3	0.066
Coq9	coenzyme Q9 homolog (yeast)	0.065
Pydc4	pyrin domain containing 4	0.062
Ap3d1	adaptor-related protein complex 3, delta 1 subunit	0.061
Zbp1	Z-DNA binding protein 1	0.061
Tex264	testis expressed gene 264	0.060
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.060
D14Ertd668e	DNA segment, Chr 14, ERATO Doi 668, expressed	0.059
Tlr3	toll-like receptor 3	0.057
Lrrc45	leucine rich repeat containing 45	0.056
Trmt2a	TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)	0.056
H2-M3	histocompatibility 2, M region locus 3	0.054
Trim60	tripartite motif-containing 60	0.053	Mouse
Samhd1	SAM domain and HD domain, 1	0.052
Nisch	nischarin	0.052
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.051
Prr14	proline rich 14	0.049
Gvin1	GTPase, very large interferon inducible 1	0.047
Stx5a	syntaxin 5A	0.047
Szt2	seizure threshold 2	0.046
Clk3	CDC-like kinase 3	0.046
Anks3	ankyrin repeat and sterile alpha motif domain containing 3	0.045
Pan2	PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)	0.045
Mbd6	methyl-CpG binding domain protein 6	0.044
Taf1a	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A	0.044
Dnajc4	DnaJ (Hsp40) homolog, subfamily C, member 4	0.043
Vwa5a	von Willebrand factor A domain containing 5A	0.043
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.042
Rabac1	Rab acceptor 1 (prenylated)	0.041
Nlrc5	NLR family, CARD domain containing 5	0.041
Rnf167	ring finger protein 167	0.040
Ppp1r14d	protein phosphatase 1, regulatory (inhibitor) subunit 14D	0.040
Slfn8	schlafen 8	0.039
Olig3	oligodendrocyte transcription factor 3	0.039
Oas2	2'-5' oligoadenylate synthetase 2	0.039
Ell	elongation factor RNA polymerase II	0.038
Adar	adenosine deaminase, RNA-specific	0.038
Sqstm1	sequestosome 1	0.036
Flcn	folliculin	0.036
Ahsp	alpha hemoglobin stabilizing protein	0.036
Slc5a9	solute carrier family 5 (sodium/glucose cotransporter), member 9	0.036
Ermap	erythroblast membrane-associated protein	0.036
Chkb	choline kinase beta	0.035
Kif3b	kinesin family member 3B	0.035
Ms4a10	membrane-spanning 4-domains, subfamily A, member 10	0.034
Uba7	ubiquitin-like modifier activating enzyme 7	0.034
Clec2h	C-type lectin domain family 2, member h	0.033
Tor3a	torsin family 3, member A	0.033
Exoc7	exocyst complex component 7	0.032
8030411F24Rik	RIKEN cDNA 8030411F24 gene	0.032
Il15	interleukin 15	0.031
Mlxip	MLX interacting protein	0.031
Lrwd1	leucine-rich repeats and WD repeat domain containing 1	0.031
Rbm14	RNA binding motif protein 14	0.031
Sirt7	sirtuin 7 (silent mating type information regulation 2, homolog) 7 (S. cerevisiae)	0.030
Ankrd16	ankyrin repeat domain 16	0.030
Sell	selectin, lymphocyte	0.030
Tpra1	transmembrane protein, adipocyte asscociated 1	0.029
Gtpbp2	GTP binding protein 2	0.029
Tcta	T-cell leukemia translocation altered gene	0.029
Zufsp	zinc finger with UFM1-specific peptidase domain	0.029
Gimap8	GTPase, IMAP family member 8	0.029
Zfp692	zinc finger protein 692	0.028
Slc5a4a	solute carrier family 5, member 4a	0.028
Pyhin1	pyrin and HIN domain family, member 1	0.027
Fbxl12	F-box and leucine-rich repeat protein 12	0.026
Serpinb9c	serine (or cysteine) peptidase inhibitor, clade B, member 9c	0.026
Hps4	Hermansky-Pudlak syndrome 4 homolog (human)	0.026
Atp6v0d1	ATPase, H+ transporting, lysosomal V0 subunit D1	0.026
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.025
Asb17	ankyrin repeat and SOCS box-containing 17	0.025
Chchd10	coiled-coil-helix-coiled-coil-helix domain containing 10	0.025
Rrnad1	ribosomal RNA adenine dimethylase domain containing 1	0.025
Ctso	cathepsin O	0.025
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.025
Surf1	surfeit gene 1	0.024
Cts6	cathepsin 6	0.024
H2-T24	histocompatibility 2, T region locus 24	0.024
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.024
2310061I04Rik	RIKEN cDNA 2310061I04 gene	0.024
H2-Q6	histocompatibility 2, Q region locus 6	0.024
Naip5	NLR family, apoptosis inhibitory protein 5	0.024
Arhgap30	Rho GTPase activating protein 30	0.024
Nxf1	nuclear RNA export factor 1 homolog (S. cerevisiae)	0.023
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.023
P2ry4	pyrimidinergic receptor P2Y, G-protein coupled, 4	0.023
Zfyve26	zinc finger, FYVE domain containing 26	0.023
Trim56	tripartite motif-containing 56	0.023
Wbp7	WW domain binding protein 7	0.022
Ly6i	lymphocyte antigen 6 complex, locus I	0.022
Ubp1	upstream binding protein 1	0.022
Vsx1	visual system homeobox 1 homolog (zebrafish)	0.022
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.021
Sp110	Sp110 nuclear body protein	0.021
Gbp8	guanylate-binding protein 8	0.021
Epb4.2	erythrocyte protein band 4.2	0.021
Oas1c	2'-5' oligoadenylate synthetase 1C	0.021
Hsh2d	hematopoietic SH2 domain containing	0.020
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.020
Naip6	NLR family, apoptosis inhibitory protein 6	0.020
2210407C18Rik	RIKEN cDNA 2210407C18 gene	0.020
Tmc2	transmembrane channel-like gene family 2	0.020
Zfp42	zinc finger protein 42	0.020
Lime1	Lck interacting transmembrane adaptor 1	0.020
Bysl	bystin-like	0.019
Olah	oleoyl-ACP hydrolase	0.019
Rsph3b	radial spoke 3B homolog (Chlamydomonas)	0.019
Mapk1ip1	mitogen-activated protein kinase 1 interacting protein 1	0.019
Pion	pigeon homolog (Drosophila)	0.019
Ifit2	interferon-induced protein with tetratricopeptide repeats 2	0.019
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.019
Gbp2	guanylate binding protein 2	0.019
Erap1	endoplasmic reticulum aminopeptidase 1	0.019
Cyp2d34	cytochrome P450, family 2, subfamily d, polypeptide 34	0.018
Zfp429	zinc finger protein 429	0.018
Sectm1b	secreted and transmembrane 1B	0.017
Parp11	poly (ADP-ribose) polymerase family, member 11	0.017
Pga5	pepsinogen 5, group I	0.017
Zfp653	zinc finger protein 653	0.017
Trim39	tripartite motif-containing 39	0.017	Mouse
Ppm1g	protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	0.017
Pank4	pantothenate kinase 4	0.017
Ky	kyphoscoliosis peptidase	0.017
Gjd4	gap junction protein, delta 4	0.017
Ift172	intraflagellar transport 172 homolog (Chlamydomonas)	0.017
Asz1	ankyrin repeat, SAM and basic leucine zipper domain containing 1	0.017
Nprl2	nitrogen permease regulator-like 2 (S. cerevisiae)	0.017
Clec2d	C-type lectin domain family 2, member d	0.017
Supt5h	suppressor of Ty 5 homolog (S. cerevisiae)	0.016
Ccnl2	cyclin L2	0.016
Tex13	testis expressed gene 13	0.016
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.016
Tnk1	tyrosine kinase, non-receptor, 1	0.016
Pml	promyelocytic leukemia	0.016
Zcchc7	zinc finger, CCHC domain containing 7	0.016
Dnajb2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.016
Gbp6	guanylate binding protein 6	0.016
1810049H13Rik	RIKEN cDNA 1810049H13 gene	0.016
Oas1e	2'-5' oligoadenylate synthetase 1E	0.016
6330590E21Rik	RIKEN cDNA 6330590E21 gene	0.016
Rnasel	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	0.016
Sec16a	SEC16 homolog A (S. cerevisiae)	0.016
Prss41	protease, serine, 41	0.015
Ms4a6b	membrane-spanning 4-domains, subfamily A, member 6B	0.015
Zcchc6	zinc finger, CCHC domain containing 6	0.015
Chchd7	coiled-coil-helix-coiled-coil-helix domain containing 7	0.015
Cyp11b2	cytochrome P450, family 11, subfamily b, polypeptide 2	0.015
Dhx16	DEAH (Asp-Glu-Ala-His) box polypeptide 16	0.015
Dkk4	dickkopf homolog 4 (Xenopus laevis)	0.015
Prl3a1	prolactin family 3, subfamily a, member 1	0.015
Igfbpl1	insulin-like growth factor binding protein-like 1	0.015
Msgn1	mesogenin 1	0.015
Aup1	ancient ubiquitous protein 1	0.015
Fyco1	FYVE and coiled-coil domain containing 1	0.015
Rnf181	ring finger protein 181	0.015
Ankrd10	ankyrin repeat domain 10	0.015
Icam4	intercellular adhesion molecule 4, Landsteiner-Wiener blood group	0.015
Tmem71	transmembrane protein 71	0.015
Ifi47	interferon gamma inducible protein 47	0.015
Ctse	cathepsin E	0.014
Hagh	hydroxyacyl glutathione hydrolase	0.014
Etv3	ets variant gene 3	0.014
Pigo	phosphatidylinositol glycan anchor biosynthesis, class O	0.014
Olfr749	olfactory receptor 749	0.014
Ctsr	cathepsin R	0.014
Serpina3a	serine (or cysteine) peptidase inhibitor, clade A, member 3A	0.014
Gcnt3	glucosaminyl (N-acetyl) transferase 3, mucin type	0.014
Slc13a2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.014
Cherp	calcium homeostasis endoplasmic reticulum protein	0.014
Gm12942	predicted gene 12942	0.014
Rhd	Rh blood group, D antigen	0.014
Dapp1	dual adaptor for phosphotyrosine and 3-phosphoinositides 1	0.014
Slc25a28	solute carrier family 25, member 28	0.014
Atg13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.014
Lgals8	lectin, galactose binding, soluble 8	0.014
Casp8	caspase 8	0.014
Cysltr1	cysteinyl leukotriene receptor 1	0.014
Top3b	topoisomerase (DNA) III beta	0.014
LOC100503923	hypothetical protein LOC100503923	0.014
AW112010	expressed sequence AW112010	0.014
Allc	allantoicase	0.013
Reg2	regenerating islet-derived 2	0.013
Hes7	hairy and enhancer of split 7 (Drosophila)	0.013
Parp10	poly (ADP-ribose) polymerase family, member 10	0.013
Rbm43	RNA binding motif protein 43	0.013
Defb13	defensin beta 13	0.013
Ly96	lymphocyte antigen 96	0.013
Sectm1a	secreted and transmembrane 1A	0.013
Rmnd1	required for meiotic nuclear division 1 homolog (S. cerevisiae)	0.013
Gprin1	G protein-regulated inducer of neurite outgrowth 1	0.013
Spag1	sperm associated antigen 1	0.013
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.013
Cldn13	claudin 13	0.013
Plg	plasminogen	0.013
Hsd17b6	hydroxysteroid (17-beta) dehydrogenase 6	0.013
H2afb1	H2A histone family, member B1	0.013
Trim41	tripartite motif-containing 41	0.013	Mouse
Cdh17	cadherin 17	0.013
Slc18a1	solute carrier family 18 (vesicular monoamine), member 1	0.013
Cxcl11	chemokine (C-X-C motif) ligand 11	0.012
Tlr8	toll-like receptor 8	0.012
Cml3	camello-like 3	0.012
Sntg1	syntrophin, gamma 1	0.012
Fars2	phenylalanine-tRNA synthetase 2 (mitochondrial)	0.012
Neu3	neuraminidase 3	0.012
Kdm6b	KDM1 lysine (K)-specific demethylase 6B	0.012
Ech1	enoyl coenzyme A hydratase 1, peroxisomal	0.012
Apobec3	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3	0.012
Gon4l	gon-4-like (C.elegans)	0.012
2510039O18Rik	RIKEN cDNA 2510039O18 gene	0.012
Zfp455	zinc finger protein 455	0.012
Rnf135	ring finger protein 135	0.012
Bbs2	Bardet-Biedl syndrome 2 (human)	0.012
G6pc2	glucose-6-phosphatase, catalytic, 2	0.012
Slc7a13	solute carrier family 7, (cationic amino acid transporter, y+ system) member 13	0.012
Pklr	pyruvate kinase liver and red blood cell	0.012
A630033H20Rik	RIKEN cDNA A630033H20 gene	0.012
Muc13	mucin 13, epithelial transmembrane	0.012
Olfr480	olfactory receptor 480	0.012
Ankfy1	ankyrin repeat and FYVE domain containing 1	0.012
Slc35b3	solute carrier family 35, member B3	0.012
Spp2	secreted phosphoprotein 2	0.012
Adam18	a disintegrin and metallopeptidase domain 18	0.012
Gm3402	predicted gene 3402	0.012
Hemgn	hemogen	0.012
Slc6a14	solute carrier family 6 (neurotransmitter transporter), member 14	0.012
Defa-rs1	defensin, alpha, related sequence 1	0.012
Msl1	male-specific lethal 1 homolog (Drosophila)	0.012
Tesk1	testis specific protein kinase 1	0.012
Gimap4	GTPase, IMAP family member 4	0.012
Gm7609	predicted pseudogene 7609	0.012
Samsn1	SAM domain, SH3 domain and nuclear localization signals, 1	0.012
Gbp10	guanylate-binding protein 10	0.012
Mmp1a	matrix metallopeptidase 1a (interstitial collagenase)	0.012
Tal1	T-cell acute lymphocytic leukemia 1	0.011
Tex19.2	testis expressed gene 19.2	0.011
Nmi	N-myc (and STAT) interactor	0.011
Irak4	interleukin-1 receptor-associated kinase 4	0.011
Psg18	pregnancy specific glycoprotein 18	0.011
Rbp3	retinol binding protein 3, interstitial	0.011
Etv2	ets variant gene 2	0.011
Cd69	CD69 antigen	0.011
Fam120b	family with sequence similarity 120, member B	0.011
Lrrc18	leucine rich repeat containing 18	0.011
Usp26	ubiquitin specific peptidase 26	0.011
Wbp2	WW domain binding protein 2	0.011
Tpbpb	trophoblast specific protein beta	0.011
Syvn1	synovial apoptosis inhibitor 1, synoviolin	0.011
Tmem59	transmembrane protein 59	0.011
Med12	mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)	0.011
Reg4	regenerating islet-derived family, member 4	0.011
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.011
Rere	arginine glutamic acid dipeptide (RE) repeats	0.011
Ifi205	interferon activated gene 205	0.011
Inpp5e	inositol polyphosphate-5-phosphatase E	0.011
Zfp957	zinc finger protein 957	0.011
Lace1	lactation elevated 1	0.011
Card6	caspase recruitment domain family, member 6	0.011
Phyh	phytanoyl-CoA hydroxylase	0.011
Gimap6	GTPase, IMAP family member 6	0.011
Sp5	trans-acting transcription factor 5	0.011
Gpr110	G protein-coupled receptor 110	0.011
Zfp595	zinc finger protein 595	0.011
2010002M12Rik	RIKEN cDNA 2010002M12 gene	0.011
Fkbp11	FK506 binding protein 11	0.011
Bmf	BCL2 modifying factor	0.011
Btnl2	butyrophilin-like 2	0.011
Arhgef18	rho/rac guanine nucleotide exchange factor (GEF) 18	0.011
Irf2	interferon regulatory factor 2	0.011
Tmem218	transmembrane protein 218	0.011
Il15ra	interleukin 15 receptor, alpha chain	0.011
2610015P09Rik	RIKEN cDNA 2610015P09 gene	0.011
Pdcl2	phosducin-like 2	0.011
Pcdhb8	protocadherin beta 8	0.011
Defb8	defensin beta 8	0.011
Cts3	cathepsin 3	0.011
Tmem54	transmembrane protein 54	0.010
Ppcdc	phosphopantothenoylcysteine decarboxylase	0.010
9930023K05Rik	RIKEN cDNA 9930023K05 gene	0.010
Srpk1	serine/arginine-rich protein specific kinase 1	0.010
Uimc1	ubiquitin interaction motif containing 1	0.010
Gm3106	predicted gene 3106	0.010
Spna1	spectrin alpha 1	0.010
Tulp2	tubby-like protein 2	0.010
Styk1	serine/threonine/tyrosine kinase 1	0.010
Pkhd1l1	polycystic kidney and hepatic disease 1-like 1	0.010
Rsad2	radical S-adenosyl methionine domain containing 2	0.010
Rnase6	ribonuclease, RNase A family, 6	0.010
Cyp2d12	cytochrome P450, family 2, subfamily d, polypeptide 12	0.010
Cxcr6	chemokine (C-X-C motif) receptor 6	0.010
A1cf	APOBEC1 complementation factor	0.010
Atp6v0a4	ATPase, H+ transporting, lysosomal V0 subunit A4	0.010
Uts2	urotensin 2	0.010
AI747448	expressed sequence AI747448	0.010
Krt36	keratin 36	0.010
Tm4sf20	transmembrane 4 L six family member 20	0.010
Slc19a3	solute carrier family 19 (sodium/hydrogen exchanger), member 3	0.010
Slamf8	SLAM family member 8	0.010