IMP: Integrative Multi-species Prediction

Mus musculus

21 genes annotated in mouse

lysosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lysosome organization"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "lysosome organization" (in gray)

Name	Description	Probability	Func Analog Organism
Hexb	hexosaminidase B	0.995
Hexa	hexosaminidase A	0.991
Dpp7	dipeptidylpeptidase 7	0.990
Hps1	Hermansky-Pudlak syndrome 1 homolog (human)	0.966
Lyst	lysosomal trafficking regulator	0.942
0610031J06Rik	RIKEN cDNA 0610031J06 gene	0.868
Npc1	Niemann Pick type C1	0.859
Mitf	microphthalmia-associated transcription factor	0.836
Idua	iduronidase, alpha-L-	0.493
Pldn	pallidin	0.419
Lamp1	lysosomal-associated membrane protein 1	0.374
Naga	N-acetyl galactosaminidase, alpha	0.360
Rab27a	RAB27A, member RAS oncogene family	0.310
Mfsd1	major facilitator superfamily domain containing 1	0.302
Kit	kit oncogene	0.291
Naglu	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	0.259
Ush1g	Usher syndrome 1G homolog (human)	0.235
a	nonagouti	0.233
Gaa	glucosidase, alpha, acid	0.233
Pld3	phospholipase D family, member 3	0.216
Gns	glucosamine (N-acetyl)-6-sulfatase	0.216
Slc24a5	solute carrier family 24, member 5	0.208
Gba	glucosidase, beta, acid	0.194
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.183
Psap	prosaposin	0.182
Renbp	renin binding protein	0.175
Hps4	Hermansky-Pudlak syndrome 4 homolog (human)	0.174
Tpp1	tripeptidyl peptidase I	0.169
Asah1	N-acylsphingosine amidohydrolase 1	0.167
Apoe	apolipoprotein E	0.161
Tpra1	transmembrane protein, adipocyte asscociated 1	0.160
Adam17	a disintegrin and metallopeptidase domain 17	0.146
Tcn2	transcobalamin 2	0.142
Ctsa	cathepsin A	0.140
Ctsd	cathepsin D	0.138
Wdr81	WD repeat domain 81	0.132
Gopc	golgi associated PDZ and coiled-coil motif containing	0.130
Myo5a	myosin VA	0.121
Man2b1	mannosidase 2, alpha B1	0.117
Grn	granulin	0.109
Lamtor3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	0.106
Zbtb24	zinc finger and BTB domain containing 24	0.102
Neu1	neuraminidase 1	0.098
Ctsz	cathepsin Z	0.096
Arsa	arylsulfatase A	0.087
Hps6	Hermansky-Pudlak syndrome 6	0.084
Rbl2	retinoblastoma-like 2	0.083
Hps5	Hermansky-Pudlak syndrome 5 homolog (human)	0.083
Gusb	glucuronidase, beta	0.077
Pik3r2	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)	0.076
Rora	RAR-related orphan receptor alpha	0.075
Pik3c3	phosphoinositide-3-kinase, class 3	0.075
Kitl	kit ligand	0.074
AW549877	expressed sequence AW549877	0.072
Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E	0.070
Sgpl1	sphingosine phosphate lyase 1	0.070
Mcoln1	mucolipin 1	0.068	Worm
Lgmn	legumain	0.068
Snx14	sorting nexin 14	0.067
Itgb5	integrin beta 5	0.067
Rragc	Ras-related GTP binding C	0.067
Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B	0.067
Myo6	myosin VI	0.065
Siae	sialic acid acetylesterase	0.062
P2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.062	Mouse
Pcdh15	protocadherin 15	0.061
Dscr3	Down syndrome critical region gene 3	0.061
Heatr7a	HEAT repeat containing 7A	0.060
Yipf3	Yip1 domain family, member 3	0.059
Mertk	c-mer proto-oncogene tyrosine kinase	0.059
Cln3	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	0.059
Manba	mannosidase, beta A, lysosomal	0.058
Mapk9	mitogen-activated protein kinase 9	0.057
Coro1b	coronin, actin binding protein 1B	0.053
Lrpap1	low density lipoprotein receptor-related protein associated protein 1	0.053
Uap1l1	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	0.052
Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.050
Mtmr1	myotubularin related protein 1	0.050
Sirpa	signal-regulatory protein alpha	0.050
Ppt2	palmitoyl-protein thioesterase 2	0.049	Mouse
Arsb	arylsulfatase B	0.049
Lgals8	lectin, galactose binding, soluble 8	0.049
P2rx4	purinergic receptor P2X, ligand-gated ion channel 4	0.048	Mouse
Hltf	helicase-like transcription factor	0.046
Nucb1	nucleobindin 1	0.045
Mpv17	MpV17 mitochondrial inner membrane protein	0.045
Glb1	galactosidase, beta 1	0.044
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.043
Il10rb	interleukin 10 receptor, beta	0.043
Itm2c	integral membrane protein 2C	0.042
Stard3	START domain containing 3	0.042
Pla2g15	phospholipase A2, group XV	0.042
Lipa	lysosomal acid lipase A	0.042
Gm2a	GM2 ganglioside activator protein	0.041
Hs1bp3	HCLS1 binding protein 3	0.041
Clcn7	chloride channel 7	0.040
Man2b2	mannosidase 2, alpha B2	0.039
Abcd1	ATP-binding cassette, sub-family D (ALD), member 1	0.038
Bri3	brain protein I3	0.037
Galns	galactosamine (N-acetyl)-6-sulfate sulfatase	0.037
Abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0.037
Plbd2	phospholipase B domain containing 2	0.036
Zfp187	zinc finger protein 187	0.036
Pigs	phosphatidylinositol glycan anchor biosynthesis, class S	0.035
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.034
Twf2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.034
S1pr3	sphingosine-1-phosphate receptor 3	0.033
Pmel	premelanosome protein	0.033
Tex264	testis expressed gene 264	0.032
Vps41	vacuolar protein sorting 41 (yeast)	0.031
D4Wsu53e	DNA segment, Chr 4, Wayne State University 53, expressed	0.031
Gnpda1	glucosamine-6-phosphate deaminase 1	0.031
Uvrag	UV radiation resistance associated gene	0.030
Myo7a	myosin VIIA	0.030
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.029
Ate1	arginyltransferase 1	0.029
Mfap5	microfibrillar associated protein 5	0.029
Atp6ap2	ATPase, H+ transporting, lysosomal accessory protein 2	0.027
Atp13a2	ATPase type 13A2	0.027
Klhl24	kelch-like 24 (Drosophila)	0.027
Tmem86a	transmembrane protein 86A	0.027
Ccng2	cyclin G2	0.027
Edem2	ER degradation enhancer, mannosidase alpha-like 2	0.026
Gm12942	predicted gene 12942	0.026
S1pr2	sphingosine-1-phosphate receptor 2	0.026
Npc2	Niemann Pick type C2	0.026
Bckdk	branched chain ketoacid dehydrogenase kinase	0.025
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.025	Mouse
Tom1	target of myb1 homolog (chicken)	0.025
Ostm1	osteopetrosis associated transmembrane protein 1	0.024
Amdhd2	amidohydrolase domain containing 2	0.024
Slc35c2	solute carrier family 35, member C2	0.024
Sel1l	sel-1 suppressor of lin-12-like (C. elegans)	0.023
Cd38	CD38 antigen	0.023
Ergic3	ERGIC and golgi 3	0.023
Scamp3	secretory carrier membrane protein 3	0.023
Ap3d1	adaptor-related protein complex 3, delta 1 subunit	0.023
Tep1	telomerase associated protein 1	0.022
Atp6v1d	ATPase, H+ transporting, lysosomal V1 subunit D	0.022
Ap1g2	adaptor protein complex AP-1, gamma 2 subunit	0.022
Pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	0.022
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.022
Tgfbr1	transforming growth factor, beta receptor I	0.022
Vps26a	vacuolar protein sorting 26 homolog A (yeast)	0.022
Eif4a2	eukaryotic translation initiation factor 4A2	0.022
Slc50a1	solute carrier family 50 (sugar transporter), member 1	0.022
Ids	iduronate 2-sulfatase	0.021
Dynlt3	dynein light chain Tctex-type 3	0.021
Kif3b	kinesin family member 3B	0.021
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.021
Alg1	asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)	0.021
Spsb2	splA/ryanodine receptor domain and SOCS box containing 2	0.021
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.020
Abcg8	ATP-binding cassette, sub-family G (WHITE), member 8	0.020
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.020
Ogt	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.020
Paqr7	progestin and adipoQ receptor family member VII	0.020
Tyrp1	tyrosinase-related protein 1	0.019
Atp2c1	ATPase, Ca++-sequestering	0.019
Rab38	RAB38, member of RAS oncogene family	0.019	Worm
Galc	galactosylceramidase	0.019
Agtrap	angiotensin II, type I receptor-associated protein	0.019
C5ar1	complement component 5a receptor 1	0.019
AI413582	expressed sequence AI413582	0.019
Sat1	spermidine/spermine N1-acetyl transferase 1	0.019
1110014N23Rik	RIKEN cDNA 1110014N23 gene	0.019
Vps18	vacuolar protein sorting 18 (yeast)	0.018
Ikbkb	inhibitor of kappaB kinase beta	0.018
Tspyl1	testis-specific protein, Y-encoded-like 1	0.018
Daglb	diacylglycerol lipase, beta	0.018
Mylip	myosin regulatory light chain interacting protein	0.018
Pltp	phospholipid transfer protein	0.018
Cap1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.018
Zfand6	zinc finger, AN1-type domain 6	0.018
Txndc16	thioredoxin domain containing 16	0.018
Ppt1	palmitoyl-protein thioesterase 1	0.018
Slc24a6	solute carrier family 24 (sodium/potassium/calcium exchanger), member 6	0.018
Dmrt3	doublesex and mab-3 related transcription factor 3	0.018
Pot1a	protection of telomeres 1A	0.018
Stx7	syntaxin 7	0.017
5033414D02Rik	RIKEN cDNA 5033414D02 gene	0.017
Cyp4f13	cytochrome P450, family 4, subfamily f, polypeptide 13	0.017
Mknk1	MAP kinase-interacting serine/threonine kinase 1	0.017
Hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.017
Zfp385a	zinc finger protein 385A	0.017
Tyr	tyrosinase	0.017
Kdelr1	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1	0.017
ORF61	open reading frame 61	0.017
Cept1	choline/ethanolaminephosphotransferase 1	0.017
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.017
Flcn	folliculin	0.017
Hps3	Hermansky-Pudlak syndrome 3 homolog (human)	0.016
Dram2	VDNA-damage regulated autophagy modulator 2	0.016
Abhd4	abhydrolase domain containing 4	0.016
B3galt4	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	0.016
Ctns	cystinosis, nephropathic	0.016
Cpd	carboxypeptidase D	0.016
Stat6	signal transducer and activator of transcription 6	0.016
Paip2	polyadenylate-binding protein-interacting protein 2	0.016
Cpz	carboxypeptidase Z	0.016
Gnptab	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	0.016	Human
Ptgir	prostaglandin I receptor (IP)	0.016
Stxbp2	syntaxin binding protein 2	0.015
Acp2	acid phosphatase 2, lysosomal	0.015
Tmem62	transmembrane protein 62	0.015
Rab7l1	RAB7, member RAS oncogene family-like 1	0.015
Ctsb	cathepsin B	0.015
Slc7a8	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	0.015
Ghdc	GH3 domain containing	0.015
Pnrc2	proline-rich nuclear receptor coactivator 2	0.015
Gfap	glial fibrillary acidic protein	0.015
Gla	galactosidase, alpha	0.015
Nagk	N-acetylglucosamine kinase	0.015
Ccni	cyclin I	0.015
Klc4	kinesin light chain 4	0.015
Prkcd	protein kinase C, delta	0.015
Slc17a9	solute carrier family 17, member 9	0.014
Ccnl2	cyclin L2	0.014
2310044H10Rik	RIKEN cDNA 2310044H10 gene	0.014
Atp6v0d1	ATPase, H+ transporting, lysosomal V0 subunit D1	0.014
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.014
Fbxl3	F-box and leucine-rich repeat protein 3	0.014
Slc31a2	solute carrier family 31, member 2	0.014
Zfp865	zinc finger protein 865	0.014
Igsf8	immunoglobulin superfamily, member 8	0.014
Pqlc2	PQ loop repeat containing 2	0.014
Pex6	peroxisomal biogenesis factor 6	0.014
Acp5	acid phosphatase 5, tartrate resistant	0.014
Fastk	Fas-activated serine/threonine kinase	0.014
Usp8	ubiquitin specific peptidase 8	0.014
Cyfip2	cytoplasmic FMR1 interacting protein 2	0.014
Col11a1	collagen, type XI, alpha 1	0.014
Cx3cr1	chemokine (C-X3-C) receptor 1	0.014
Abca3	ATP-binding cassette, sub-family A (ABC1), member 3	0.013
Gpr137b	G protein-coupled receptor 137B	0.013
Prkcb	protein kinase C, beta	0.013
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.013
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.013
Def8	differentially expressed in FDCP 8	0.013
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.013	Worm
Ednrb	endothelin receptor type B	0.013
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.013
Lrrn2	leucine rich repeat protein 2, neuronal	0.013
Pofut2	protein O-fucosyltransferase 2	0.013
Osbpl9	oxysterol binding protein-like 9	0.013
Adcy4	adenylate cyclase 4	0.013
Xylt2	xylosyltransferase II	0.013
Inpp4a	inositol polyphosphate-4-phosphatase, type I	0.013
Pdzk1ip1	PDZK1 interacting protein 1	0.013
Coro7	coronin 7	0.012
Srpx2	sushi-repeat-containing protein, X-linked 2	0.012
Araf	v-raf murine sarcoma 3611 viral oncogene homolog	0.012
Tusc5	tumor suppressor candidate 5	0.012
Tpd52	tumor protein D52	0.012
Fundc1	FUN14 domain containing 1	0.012
Fzd8	frizzled homolog 8 (Drosophila)	0.012
Inppl1	inositol polyphosphate phosphatase-like 1	0.012
Slc17a5	solute carrier family 17 (anion/sugar transporter), member 5	0.012
Fcgrt	Fc receptor, IgG, alpha chain transporter	0.012
Hoxb4	homeobox B4	0.012
Atp8a1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	0.012	Worm
Nbr1	neighbor of Brca1 gene 1	0.012
BC017643	cDNA sequence BC017643	0.012
D6Wsu116e	DNA segment, Chr 6, Wayne State University 116, expressed	0.012
Plekhb1	pleckstrin homology domain containing, family B (evectins) member 1	0.012
Sorl1	sortilin-related receptor, LDLR class A repeats-containing	0.012
Slc39a13	solute carrier family 39 (metal ion transporter), member 13	0.012
Dtnbp1	dystrobrevin binding protein 1	0.012
Anpep	alanyl (membrane) aminopeptidase	0.012
Lat	linker for activation of T cells	0.012
BC026585	cDNA sequence BC026585	0.012
Smpd1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.012
Kcp	kielin/chordin-like protein	0.012
Cnp	2',3'-cyclic nucleotide 3' phosphodiesterase	0.012
Vipr2	vasoactive intestinal peptide receptor 2	0.012
Man2c1	mannosidase, alpha, class 2C, member 1	0.012
Hsd17b11	hydroxysteroid (17-beta) dehydrogenase 11	0.012
Abcg5	ATP-binding cassette, sub-family G (WHITE), member 5	0.012
Dennd1a	DENN/MADD domain containing 1A	0.012
Enpp1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.012
St6galnac6	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	0.012
Cd68	CD68 antigen	0.012
Col16a1	collagen, type XVI, alpha 1	0.012
Pold4	polymerase (DNA-directed), delta 4	0.012
Aldh3b1	aldehyde dehydrogenase 3 family, member B1	0.011
Mobkl1b	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.011
Soat1	sterol O-acyltransferase 1	0.011
Ppm1m	protein phosphatase 1M	0.011
Snx9	sorting nexin 9	0.011
Ikbkg	inhibitor of kappaB kinase gamma	0.011
Uckl1	uridine-cytidine kinase 1-like 1	0.011
Sepp1	selenoprotein P, plasma, 1	0.011
Gng2	guanine nucleotide binding protein (G protein), gamma 2	0.011
Pigt	phosphatidylinositol glycan anchor biosynthesis, class T	0.011
Lrp1	low density lipoprotein receptor-related protein 1	0.011
Nceh1	arylacetamide deacetylase-like 1	0.011
Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	0.011
Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.011
Hgsnat	heparan-alpha-glucosaminide N-acetyltransferase	0.011
Ush1c	Usher syndrome 1C homolog (human)	0.011
Os9	amplified in osteosarcoma	0.011
Oca2	oculocutaneous albinism II	0.011
Itga7	integrin alpha 7	0.011
Sgk3	serum/glucocorticoid regulated kinase 3	0.011
Abhd12	abhydrolase domain containing 12	0.011
Mcoln2	mucolipin 2	0.011
Stard5	StAR-related lipid transfer (START) domain containing 5	0.011
Elmo3	engulfment and cell motility 3, ced-12 homolog (C. elegans)	0.011
Adam10	a disintegrin and metallopeptidase domain 10	0.011
Xiap	X-linked inhibitor of apoptosis	0.011
Pld2	phospholipase D2	0.011
Acvrl1	activin A receptor, type II-like 1	0.011
Galk2	galactokinase 2	0.011
Cpne3	copine III	0.011
Heyl	hairy/enhancer-of-split related with YRPW motif-like	0.011
Cln6	ceroid-lipofuscinosis, neuronal 6	0.010
A930001N09Rik	RIKEN cDNA A930001N09 gene	0.010
Golph3l	golgi phosphoprotein 3-like	0.010
Hrh2	histamine receptor H2	0.010
Tbc1d22a	TBC1 domain family, member 22a	0.010
Tmub2	transmembrane and ubiquitin-like domain containing 2	0.010
Akap8l	A kinase (PRKA) anchor protein 8-like	0.010
Tmem176a	transmembrane protein 176A	0.010
Fgfr1op2	FGFR1 oncogene partner 2	0.010
Cnpy1	canopy 1 homolog (zebrafish)	0.010
Pdcd4	programmed cell death 4	0.010
Entpd2	ectonucleoside triphosphate diphosphohydrolase 2	0.010
Slc2a8	solute carrier family 2, (facilitated glucose transporter), member 8	0.010
Stx4a	syntaxin 4A (placental)	0.010
Matk	megakaryocyte-associated tyrosine kinase	0.010
Slc18a1	solute carrier family 18 (vesicular monoamine), member 1	0.010
Sntb1	syntrophin, basic 1	0.010
Hmox2	heme oxygenase (decycling) 2	0.010
Gm2382	predicted gene 2382	0.010
Galnt4	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4	0.010
Tsc2	tuberous sclerosis 2	0.010
Cyp4v3	cytochrome P450, family 4, subfamily v, polypeptide 3	0.010
Sdf2	stromal cell derived factor 2	0.010
Man1a	mannosidase 1, alpha	0.010
Scn2b	sodium channel, voltage-gated, type II, beta	0.010