IMP: Integrative Multi-species Prediction

Mus musculus

1 genes annotated in mouse

cardiac pacemaker cell fate commitment

The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac pacemaker cell fate commitment"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "cardiac pacemaker cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
Hand2	heart and neural crest derivatives expressed transcript 2	1.000
Shh	sonic hedgehog	1.000
Fgf8	fibroblast growth factor 8	0.999
Hand1	heart and neural crest derivatives expressed transcript 1	0.998
Tbx1	T-box 1	0.980
Sox9	SRY-box containing gene 9	0.966
Mesp1	mesoderm posterior 1	0.956
Gata4	GATA binding protein 4	0.944
Pitx2	paired-like homeodomain transcription factor 2	0.926
Foxc2	forkhead box C2	0.915
Fgfr2	fibroblast growth factor receptor 2	0.901
Isl1	ISL1 transcription factor, LIM/homeodomain	0.839
Tbx5	T-box 5	0.780
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.706
Pax3	paired box gene 3	0.693
Foxc1	forkhead box C1	0.680
Tgfb2	transforming growth factor, beta 2	0.656
Tcfap2a	transcription factor AP-2, alpha	0.652
Gsc	goosecoid homeobox	0.641
Otp	orthopedia homolog (Drosophila)	0.640
Pitx1	paired-like homeodomain transcription factor 1	0.600
Nog	noggin	0.592
Msx1	homeobox, msh-like 1	0.586
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.582	Mouse
Nkx6-1	NK6 homeobox 1	0.531
Nkx3-2	NK3 homeobox 2	0.482	Mouse
Bmp4	bone morphogenetic protein 4	0.479
Gli2	GLI-Kruppel family member GLI2	0.466
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.454
Pitx3	paired-like homeodomain transcription factor 3	0.437
Pax9	paired box gene 9	0.401
Lmx1b	LIM homeobox transcription factor 1 beta	0.379
Fgf3	fibroblast growth factor 3	0.363
Vax1	ventral anterior homeobox containing gene 1	0.357
Jag1	jagged 1	0.340
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.328
Foxe3	forkhead box E3	0.307
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.296
Barx1	BarH-like homeobox 1	0.286
Vegfa	vascular endothelial growth factor A	0.278
Atoh7	atonal homolog 7 (Drosophila)	0.258
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.245	Mouse
Lhx3	LIM homeobox protein 3	0.239
Rxra	retinoid X receptor alpha	0.238
Gata6	GATA binding protein 6	0.223
Hoxa13	homeobox A13	0.214
Tlx2	T-cell leukemia, homeobox 2	0.212
Ntf3	neurotrophin 3	0.209
Scn5a	sodium channel, voltage-gated, type V, alpha	0.207
Alx3	aristaless-like homeobox 3	0.206
Hoxa1	homeobox A1	0.204
Eya1	eyes absent 1 homolog (Drosophila)	0.200
Gh	growth hormone	0.196
Odf3	outer dense fiber of sperm tails 3	0.188
Hoxd3	homeobox D3	0.182
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.170	Mouse
Alx4	aristaless-like homeobox 4	0.170
Fgf10	fibroblast growth factor 10	0.167
Wnt3a	wingless-related MMTV integration site 3A	0.158
Otx2	orthodenticle homolog 2 (Drosophila)	0.156
Hoxd13	homeobox D13	0.146
Hoxd12	homeobox D12	0.143
Gja5	gap junction protein, alpha 5	0.126
Akp3	alkaline phosphatase 3, intestine, not Mn requiring	0.126
Col2a1	collagen, type II, alpha 1	0.126
Dlx5	distal-less homeobox 5	0.123
Fgf17	fibroblast growth factor 17	0.123
Prrx1	paired related homeobox 1	0.120
Npas1	neuronal PAS domain protein 1	0.118
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.112
Hmx1	H6 homeobox 1	0.111
Wnt6	wingless-related MMTV integration site 6	0.111
Omp	olfactory marker protein	0.108
Rara	retinoic acid receptor, alpha	0.098
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.096
Pdx1	pancreatic and duodenal homeobox 1	0.094
Fgf22	fibroblast growth factor 22	0.094
Rarg	retinoic acid receptor, gamma	0.093
Etv2	ets variant gene 2	0.092
Ucn	urocortin	0.092
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.092
Evx2	even skipped homeotic gene 2 homolog	0.091
Hist1h1t	histone cluster 1, H1t	0.090
Tcf15	transcription factor 15	0.090
Grid2ip	glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1	0.089
Tbx3	T-box 3	0.088
Sall4	sal-like 4 (Drosophila)	0.087
Rax	retina and anterior neural fold homeobox	0.086
Btbd17	BTB (POZ) domain containing 17	0.086
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.086	Mouse
Mzf1	myeloid zinc finger 1	0.085
Ribc2	RIB43A domain with coiled-coils 2	0.084
Cckbr	cholecystokinin B receptor	0.084
Pthlh	parathyroid hormone-like peptide	0.082
Tlx3	T-cell leukemia, homeobox 3	0.082
Bdkrb2	bradykinin receptor, beta 2	0.081
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.081
Cabp2	calcium binding protein 2	0.077
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.075
Gipc3	GIPC PDZ domain containing family, member 3	0.075
Msx2	homeobox, msh-like 2	0.074
1700011A15Rik	RIKEN cDNA 1700011A15 gene	0.071
Tssk1	testis-specific serine kinase 1	0.070
Hoxd11	homeobox D11	0.070
Foxb1	forkhead box B1	0.070
Avp	arginine vasopressin	0.069
Gbx2	gastrulation brain homeobox 2	0.069
Lmx1a	LIM homeobox transcription factor 1 alpha	0.068
Neurog1	neurogenin 1	0.067
Pyy	peptide YY	0.066
Sox3	SRY-box containing gene 3	0.066
4930527J03Rik	RIKEN cDNA 4930527J03 gene	0.064
Hes3	hairy and enhancer of split 3 (Drosophila)	0.062
Cdx1	caudal type homeobox 1	0.061
Fgf15	fibroblast growth factor 15	0.061
Foxb2	forkhead box B2	0.061
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.060
Ptf1a	pancreas specific transcription factor, 1a	0.060
Hes2	hairy and enhancer of split 2 (Drosophila)	0.059
Bmp8b	bone morphogenetic protein 8b	0.058
Spert	spermatid associated	0.058
Amh	anti-Mullerian hormone	0.057
Fgfr1	fibroblast growth factor receptor 1	0.056
Smo	smoothened homolog (Drosophila)	0.056
Dlx2	distal-less homeobox 2	0.056
Pth2	parathyroid hormone 2	0.054
Sct	secretin	0.054
Sycn	syncollin	0.053
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.052
BC057022	cDNA sequence BC057022	0.051
Rsph6a	radial spoke head 6 homolog A (Chlamydomonas)	0.051
Hmx2	H6 homeobox 2	0.049
Efnb2	ephrin B2	0.048
Egr4	early growth response 4	0.048
Utf1	undifferentiated embryonic cell transcription factor 1	0.047
T	brachyury	0.047
Foxa2	forkhead box A2	0.046
Foxg1	forkhead box G1	0.044
Znrf4	zinc and ring finger 4	0.044
Pax6	paired box gene 6	0.043
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.043
Emx1	empty spiracles homolog 1 (Drosophila)	0.043
Oprd1	opioid receptor, delta 1	0.042
Pou4f3	POU domain, class 4, transcription factor 3	0.042
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.040
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.040
Prrx2	paired related homeobox 2	0.039
Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1	0.039
Spdef	SAM pointed domain containing ets transcription factor	0.038
Lhx5	LIM homeobox protein 5	0.037
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.037
Tcf21	transcription factor 21	0.037
Tmem210	transmembrane protein 210	0.036
Hcrt	hypocretin	0.036
Oc90	otoconin 90	0.036
Ednra	endothelin receptor type A	0.036
Onecut3	one cut domain, family member 3	0.036
Defa-rs12	defensin, alpha, related sequence 12	0.035
Socs1	suppressor of cytokine signaling 1	0.035
Krt15	keratin 15	0.034
Gp9	glycoprotein 9 (platelet)	0.034
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.034
Acvr1	activin A receptor, type 1	0.034
Fgfr3	fibroblast growth factor receptor 3	0.034
6030468B19Rik	RIKEN cDNA 6030468B19 gene	0.033
Pabpn1l	poly(A)binding protein nuclear 1-like	0.033
Gja1	gap junction protein, alpha 1	0.033
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.032
Hoxa3	homeobox A3	0.032
Neurog3	neurogenin 3	0.032
Msgn1	mesogenin 1	0.031
Gip	gastric inhibitory polypeptide	0.031
Foxe1	forkhead box E1	0.031
Sox4	SRY-box containing gene 4	0.031
Rtn4r	reticulon 4 receptor	0.030
Zfpm2	zinc finger protein, multitype 2	0.030
Defa-rs2	defensin, alpha, related sequence 2	0.030
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.030
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.030
Nodal	nodal	0.030
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.030
Foxh1	forkhead box H1	0.029
Hoxa7	homeobox A7	0.029
Foxl2	forkhead box L2	0.029
Figla	folliculogenesis specific basic helix-loop-helix	0.029
Mesp2	mesoderm posterior 2	0.029
Pou3f4	POU domain, class 3, transcription factor 4	0.028
Ccr10	chemokine (C-C motif) receptor 10	0.028
Gjc2	gap junction protein, gamma 2	0.028
Fam65c	family with sequence similarity 65, member C	0.028
Slc39a5	solute carrier family 39 (metal ion transporter), member 5	0.028
Ret	ret proto-oncogene	0.027
Bmp10	bone morphogenetic protein 10	0.027
Pax2	paired box gene 2	0.027
Pax8	paired box gene 8	0.027
Mdfi	MyoD family inhibitor	0.027
Foxn4	forkhead box N4	0.026
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.026
Cort	cortistatin	0.026
Vangl2	vang-like 2 (van gogh, Drosophila)	0.026
Zeb1	zinc finger E-box binding homeobox 1	0.026
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.026
Hrk	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.026
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.025
Tgfbr2	transforming growth factor, beta receptor II	0.025
Dlx6	distal-less homeobox 6	0.025
Isl2	insulin related protein 2 (islet 2)	0.024
Sall3	sal-like 3 (Drosophila)	0.024
Foxd3	forkhead box D3	0.024
Gja3	gap junction protein, alpha 3	0.024
Foxd2	forkhead box D2	0.024
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.024
Prss44	protease, serine, 44	0.024
Nobox	NOBOX oogenesis homeobox	0.023
Ppy	pancreatic polypeptide	0.023
Slurp1	secreted Ly6/Plaur domain containing 1	0.023
Nrtn	neurturin	0.023
Guca2b	guanylate cyclase activator 2b (retina)	0.023
Fgf16	fibroblast growth factor 16	0.023
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.023
Glis1	GLIS family zinc finger 1	0.023
Myl3	myosin, light polypeptide 3	0.022
Myo15	myosin XV	0.022
Pou2f2	POU domain, class 2, transcription factor 2	0.022
Espn	espin	0.022
Twist2	twist homolog 2 (Drosophila)	0.022
Ms4a15	membrane-spanning 4-domains, subfamily A, member 15	0.022
Cryba2	crystallin, beta A2	0.022
Pax1	paired box gene 1	0.021
Bmp7	bone morphogenetic protein 7	0.021
Sox14	SRY-box containing gene 14	0.021
Lrfn1	leucine rich repeat and fibronectin type III domain containing 1	0.021
Sox1	SRY-box containing gene 1	0.021
Gata1	GATA binding protein 1	0.021
Rarb	retinoic acid receptor, beta	0.021
Prop1	paired like homeodomain factor 1	0.021
Padi3	peptidyl arginine deiminase, type III	0.020
Col22a1	collagen, type XXII, alpha 1	0.020
BC024139	cDNA sequence BC024139	0.020
Sac3d1	SAC3 domain containing 1	0.020
Hmx3	H6 homeobox 3	0.020
Sox11	SRY-box containing gene 11	0.020
Gli3	GLI-Kruppel family member GLI3	0.020
Sfrp5	secreted frizzled-related sequence protein 5	0.020
Bhlhe23	basic helix-loop-helix family, member e23	0.020
Cabp7	calcium binding protein 7	0.020
Insm1	insulinoma-associated 1	0.020
Hoxb13	homeobox B13	0.020
Dlx1	distal-less homeobox 1	0.020
Prm1	protamine 1	0.020
Rhcg	Rhesus blood group-associated C glycoprotein	0.020
Ins2	insulin II	0.020
Wap	whey acidic protein	0.020
Pnoc	prepronociceptin	0.019
Foxl1	forkhead box L1	0.019
Art5	ADP-ribosyltransferase 5	0.019
1700065I17Rik	RIKEN cDNA 1700065I17 gene	0.019
Uncx	UNC homeobox	0.019
Lactbl1	lactamase, beta-like 1	0.018
Amelx	amelogenin X chromosome	0.018
Crybb2	crystallin, beta B2	0.018
Pcdh12	protocadherin 12	0.018
Tlx1	T-cell leukemia, homeobox 1	0.018
Gata5	GATA binding protein 5	0.018
Tctex1d4	Tctex1 domain containing 4	0.017
Pax4	paired box gene 4	0.017
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.017
Cdh15	cadherin 15	0.017
Atoh1	atonal homolog 1 (Drosophila)	0.017
Wnt11	wingless-related MMTV integration site 11	0.017
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.017
Efna2	ephrin A2	0.016
Tcam1	testicular cell adhesion molecule 1	0.016
Cdh23	cadherin 23 (otocadherin)	0.016
Theg	testicular haploid expressed gene	0.016
Foxf1a	forkhead box F1a	0.016
Adam17	a disintegrin and metallopeptidase domain 17	0.016
Cfc1	cripto, FRL-1, cryptic family 1	0.016
Fitm1	fat storage-inducing transmembrane protein 1	0.016
Dmbx1	diencephalon/mesencephalon homeobox 1	0.016
1700018B08Rik	RIKEN cDNA 1700018B08 gene	0.016
Lhx4	LIM homeobox protein 4	0.016
Cilp2	cartilage intermediate layer protein 2	0.016
Wnt2b	wingless related MMTV integration site 2b	0.016
Lalba	lactalbumin, alpha	0.015
Dusp13	dual specificity phosphatase 13	0.015
Mpl	myeloproliferative leukemia virus oncogene	0.015
Efna4	ephrin A4	0.015
Stra8	stimulated by retinoic acid gene 8	0.015
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.015
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.015
2310002J15Rik	RIKEN cDNA 2310002J15 gene	0.015
Kcnk3	potassium channel, subfamily K, member 3	0.015
Fam170a	family with sequence similarity 170, member A	0.015
Tll2	tolloid-like 2	0.015
Cdx2	caudal type homeobox 2	0.015
Tg	thyroglobulin	0.015
Fut2	fucosyltransferase 2	0.015
Klhl35	kelch-like 35 (Drosophila)	0.015
4921517D21Rik	RIKEN cDNA 4921517D21 gene	0.015
Wnt7a	wingless-related MMTV integration site 7A	0.014
Mmp24	matrix metallopeptidase 24	0.014
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.014
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.014
Hoxc9	homeobox C9	0.014
Papln	papilin, proteoglycan-like sulfated glycoprotein	0.014
Sftpb	surfactant associated protein B	0.014
Xirp1	xin actin-binding repeat containing 1	0.014
Dmrt3	doublesex and mab-3 related transcription factor 3	0.014
Barx2	BarH-like homeobox 2	0.014
Irx6	Iroquois related homeobox 6 (Drosophila)	0.014
Zscan2	zinc finger and SCAN domain containing 2	0.013
Pmfbp1	polyamine modulated factor 1 binding protein 1	0.013
Mnx1	motor neuron and pancreas homeobox 1	0.013
Fut7	fucosyltransferase 7	0.013
Nos3	nitric oxide synthase 3, endothelial cell	0.013
Arx	aristaless related homeobox	0.013
Klk6	kallikrein related-peptidase 6	0.013
Mybpc3	myosin binding protein C, cardiac	0.013
Hhat	hedgehog acyltransferase	0.013
Msx3	homeobox, msh-like 3	0.013
Zbtb7c	zinc finger and BTB domain containing 7C	0.013
Padi1	peptidyl arginine deiminase, type I	0.013
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.013
Tnf	tumor necrosis factor	0.012
Tmprss3	transmembrane protease, serine 3	0.012
Hapln3	hyaluronan and proteoglycan link protein 3	0.012
Slc26a5	solute carrier family 26, member 5	0.012
Cox8c	cytochrome c oxidase, subunit VIIIc	0.012
Sox10	SRY-box containing gene 10	0.012
Chrm4	cholinergic receptor, muscarinic 4	0.012
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.012
BC021785	cDNA sequence BC021785	0.012
Aqp12	aquaporin 12	0.012
Myoz3	myozenin 3	0.012
Fgf5	fibroblast growth factor 5	0.012
Adra1b	adrenergic receptor, alpha 1b	0.011
Klf1	Kruppel-like factor 1 (erythroid)	0.011
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.011
1700008P20Rik	RIKEN cDNA 1700008P20 gene	0.011
Adra2b	adrenergic receptor, alpha 2b	0.011
Tssk3	testis-specific serine kinase 3	0.011
Hsf4	heat shock transcription factor 4	0.011
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.011
Guca2a	guanylate cyclase activator 2a (guanylin)	0.011
Ptgdr	prostaglandin D receptor	0.011
Barhl1	BarH-like 1 (Drosophila)	0.011
Mmel1	membrane metallo-endopeptidase-like 1	0.011
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.011
Egfr	epidermal growth factor receptor	0.011
Fgf21	fibroblast growth factor 21	0.011
Asb9	ankyrin repeat and SOCS box-containing 9	0.011
Tigd5	tigger transposable element derived 5	0.011
Prm3	protamine 3	0.011
Sost	sclerostin	0.011
Hoxa4	homeobox A4	0.011
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.011
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.011
Tssk5	testis-specific serine kinase 5	0.011
Krtap3-1	keratin associated protein 3-1	0.011
Ins1	insulin I	0.011
Pgc	progastricsin (pepsinogen C)	0.011
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.011
Aym1	activator of yeast meiotic promoters 1	0.011
Chd7	chromodomain helicase DNA binding protein 7	0.011
Krt25	keratin 25	0.011
Muc5b	mucin 5, subtype B, tracheobronchial	0.011
Tff1	trefoil factor 1	0.011
Tecta	tectorin alpha	0.011
Snai3	snail homolog 3 (Drosophila)	0.011
Gzmm	granzyme M (lymphocyte met-ase 1)	0.011
Tmem121	transmembrane protein 121	0.010
Aanat	arylalkylamine N-acetyltransferase	0.010
Best2	bestrophin 2	0.010
Nags	N-acetylglutamate synthase	0.010
Il25	interleukin 25	0.010
Mycs	myc-like oncogene, s-myc protein	0.010
Gli1	GLI-Kruppel family member GLI1	0.010
Shank1	SH3/ankyrin domain gene 1	0.010
Tcfap2d	transcription factor AP-2, delta	0.010
Tbx20	T-box 20	0.010
Il17b	interleukin 17B	0.010
Gucy2e	guanylate cyclase 2e	0.010
Syngr4	synaptogyrin 4	0.010
Nkx2-1	NK2 homeobox 1	0.010	Mouse