IMP: Integrative Multi-species Prediction

Mus musculus

4 genes annotated in mouse

t helper 17 cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t helper 17 cell lineage commitment"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "t helper 17 cell lineage commitment" (in gray)

Name	Description	Probability	Func Analog Organism
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.915
Stat2	signal transducer and activator of transcription 2	0.821
Tnf	tumor necrosis factor	0.765
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.680
Uba7	ubiquitin-like modifier activating enzyme 7	0.605
Irf4	interferon regulatory factor 4	0.586
Socs1	suppressor of cytokine signaling 1	0.535
Usp18	ubiquitin specific peptidase 18	0.530
Batf	basic leucine zipper transcription factor, ATF-like	0.513
Stat3	signal transducer and activator of transcription 3	0.496
Ccl2	chemokine (C-C motif) ligand 2	0.496
Ifng	interferon gamma	0.474
Isg15	ISG15 ubiquitin-like modifier	0.453
Cd40	CD40 antigen	0.453
Igtp	interferon gamma induced GTPase	0.418
Stat1	signal transducer and activator of transcription 1	0.381
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.351
Irf7	interferon regulatory factor 7	0.338	Mouse
Irgm2	immunity-related GTPase family M member 2	0.239
Mx2	myxovirus (influenza virus) resistance 2	0.220
Zbp1	Z-DNA binding protein 1	0.220
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.220
Pdcd1	programmed cell death 1	0.218
Irf9	interferon regulatory factor 9	0.204	Mouse
Sfpi1	SFFV proviral integration 1	0.186
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.184
Irgm1	immunity-related GTPase family M member 1	0.179
Il21r	interleukin 21 receptor	0.177
Foxp3	forkhead box P3	0.177
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.175
Tapbp	TAP binding protein	0.171
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.171
Fas	Fas (TNF receptor superfamily member 6)	0.168
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.163
Ccl4	chemokine (C-C motif) ligand 4	0.162
Rel	reticuloendotheliosis oncogene	0.158
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.149
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.147	Mouse
Irf5	interferon regulatory factor 5	0.139	Mouse
Tlr4	toll-like receptor 4	0.127
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.120
Iigp1	interferon inducible GTPase 1	0.115
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.111
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.105
Cxcl10	chemokine (C-X-C motif) ligand 10	0.101
Bcl3	B-cell leukemia/lymphoma 3	0.095
Icos	inducible T-cell co-stimulator	0.092
Il10	interleukin 10	0.091
Tor3a	torsin family 3, member A	0.089
Cd19	CD19 antigen	0.088
Myd88	myeloid differentiation primary response gene 88	0.085
Trim21	tripartite motif-containing 21	0.083
Socs3	suppressor of cytokine signaling 3	0.079
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.076
Stat6	signal transducer and activator of transcription 6	0.074
Ptgs2	prostaglandin-endoperoxide synthase 2	0.071
Rsad2	radical S-adenosyl methionine domain containing 2	0.070
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.065
Mx1	myxovirus (influenza virus) resistance 1	0.061
Ifnar2	interferon (alpha and beta) receptor 2	0.061
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.058
Il12b	interleukin 12b	0.055
Znfx1	zinc finger, NFX1-type containing 1	0.054
Hrh2	histamine receptor H2	0.053
Ifitm3	interferon induced transmembrane protein 3	0.050
Ifi47	interferon gamma inducible protein 47	0.049
Il1r1	interleukin 1 receptor, type I	0.048
Mcoln2	mucolipin 2	0.048
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.047
Ifi35	interferon-induced protein 35	0.047
Oas3	2'-5' oligoadenylate synthetase 3	0.046
Jak3	Janus kinase 3	0.045
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.045
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.043
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.042
Cxcl9	chemokine (C-X-C motif) ligand 9	0.041
Ikzf1	IKAROS family zinc finger 1	0.041
Oas2	2'-5' oligoadenylate synthetase 2	0.040
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.037
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.036
Ly6i	lymphocyte antigen 6 complex, locus I	0.035
Irg1	immunoresponsive gene 1	0.034
Mmp9	matrix metallopeptidase 9	0.034
Il17ra	interleukin 17 receptor A	0.034
Cd28	CD28 antigen	0.032
Parp10	poly (ADP-ribose) polymerase family, member 10	0.032
Il27ra	interleukin 27 receptor, alpha	0.032
Gbp7	guanylate binding protein 7	0.032
Gbp3	guanylate binding protein 3	0.032
Gdf15	growth differentiation factor 15	0.032
Lag3	lymphocyte-activation gene 3	0.031
Il6st	interleukin 6 signal transducer	0.030
Tmem173	transmembrane protein 173	0.030
Il1rn	interleukin 1 receptor antagonist	0.029
Lgals9	lectin, galactose binding, soluble 9	0.029
Bcl6	B-cell leukemia/lymphoma 6	0.028
Sfn	stratifin	0.027
Junb	Jun-B oncogene	0.027
Irf8	interferon regulatory factor 8	0.027	Mouse
Trim25	tripartite motif-containing 25	0.026
Trp53	transformation related protein 53	0.026
Trim30a	tripartite motif-containing 30A	0.026
Hmox1	heme oxygenase (decycling) 1	0.025
Odf3	outer dense fiber of sperm tails 3	0.025
Adar	adenosine deaminase, RNA-specific	0.024
Il1r2	interleukin 1 receptor, type II	0.024
Ccl7	chemokine (C-C motif) ligand 7	0.024
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.024
Pou2f2	POU domain, class 2, transcription factor 2	0.023
Tgtp2	T-cell specific GTPase 2	0.023
Ccl22	chemokine (C-C motif) ligand 22	0.023
Cxcl2	chemokine (C-X-C motif) ligand 2	0.023
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.022
Traf2	TNF receptor-associated factor 2	0.022
Il2rb	interleukin 2 receptor, beta chain	0.022
Il4ra	interleukin 4 receptor, alpha	0.022
Slfn2	schlafen 2	0.022
Has1	hyaluronan synthase1	0.021
H2-K1	histocompatibility 2, K1, K region	0.021
Daxx	Fas death domain-associated protein	0.021
Rtp4	receptor transporter protein 4	0.021
Il10ra	interleukin 10 receptor, alpha	0.021
Lta	lymphotoxin A	0.020
H2-Oa	histocompatibility 2, O region alpha locus	0.020
Nlrp3	NLR family, pyrin domain containing 3	0.020
Adam8	a disintegrin and metallopeptidase domain 8	0.019
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.019
Cd86	CD86 antigen	0.018
Pkp3	plakophilin 3	0.018
Pml	promyelocytic leukemia	0.018
Arhgap8	Rho GTPase activating protein 8	0.018
Fcgr1	Fc receptor, IgG, high affinity I	0.018
Ccrl2	chemokine (C-C motif) receptor-like 2	0.018
Traf1	TNF receptor-associated factor 1	0.017
Il4	interleukin 4	0.017
Cxcl1	chemokine (C-X-C motif) ligand 1	0.017
Stat5a	signal transducer and activator of transcription 5A	0.017
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.017
Cd274	CD274 antigen	0.017
Ccl12	chemokine (C-C motif) ligand 12	0.016
Plekho2	pleckstrin homology domain containing, family O member 2	0.016
Sh2d1a	SH2 domain protein 1A	0.016
Mefv	Mediterranean fever	0.016
Itgal	integrin alpha L	0.016
Snx20	sorting nexin 20	0.016
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.016
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.016
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	0.016
4833422F24Rik	RIKEN cDNA 4833422F24 gene	0.016
Pdcd1lg2	programmed cell death 1 ligand 2	0.016
Snai1	snail homolog 1 (Drosophila)	0.016
F10	coagulation factor X	0.016
Aicda	activation-induced cytidine deaminase	0.016
Mvp	major vault protein	0.016
C2	complement component 2 (within H-2S)	0.016
Birc3	baculoviral IAP repeat-containing 3	0.015
Irf1	interferon regulatory factor 1	0.015	Mouse
Ccl17	chemokine (C-C motif) ligand 17	0.015
9130017N09Rik	RIKEN cDNA 9130017N09 gene	0.015
BC006779	cDNA sequence BC006779	0.015
Il12rb1	interleukin 12 receptor, beta 1	0.015
AI607873	expressed sequence AI607873	0.014
Aim1	absent in melanoma 1	0.014
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.014
Rnf31	ring finger protein 31	0.014
Prkcd	protein kinase C, delta	0.014
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.014
Parp14	poly (ADP-ribose) polymerase family, member 14	0.014
Fmnl1	formin-like 1	0.014
Serpina3g	serine (or cysteine) peptidase inhibitor, clade A, member 3G	0.014
Il1b	interleukin 1 beta	0.014
Stx5a	syntaxin 5A	0.014
Gpr35	G protein-coupled receptor 35	0.014
Lcp2	lymphocyte cytosolic protein 2	0.014
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.014
Oas1a	2'-5' oligoadenylate synthetase 1A	0.013
Dusp2	dual specificity phosphatase 2	0.013
Pcyt2	phosphate cytidylyltransferase 2, ethanolamine	0.013
Fgf21	fibroblast growth factor 21	0.013
Fnip1	folliculin interacting protein 1	0.013
Sp100	nuclear antigen Sp100	0.013
Prss22	protease, serine, 22	0.013
4921513D23Rik	RIKEN cDNA 4921513D23 gene	0.013
Il18bp	interleukin 18 binding protein	0.013
Apol9a	apolipoprotein L 9a	0.013
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.013
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.013
Slamf8	SLAM family member 8	0.013
Nup62-il4i1	Nup62-Il4i1 protein	0.013
Saa3	serum amyloid A 3	0.013
Unc93b1	unc-93 homolog B1 (C. elegans)	0.012
Cxcl16	chemokine (C-X-C motif) ligand 16	0.012
Parp12	poly (ADP-ribose) polymerase family, member 12	0.012
Zfp36	zinc finger protein 36	0.012
Ifnar1	interferon (alpha and beta) receptor 1	0.012
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.012
Pla2g2e	phospholipase A2, group IIE	0.012
Sh3bp2	SH3-domain binding protein 2	0.012
Gzmb	granzyme B	0.012
Nos2	nitric oxide synthase 2, inducible	0.012
Ifih1	interferon induced with helicase C domain 1	0.012
Tmco4	transmembrane and coiled-coil domains 4	0.012
Parp9	poly (ADP-ribose) polymerase family, member 9	0.011
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.011
Pim1	proviral integration site 1	0.011
Nfil3	nuclear factor, interleukin 3, regulated	0.011
Cd4	CD4 antigen	0.011
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.011
Ubd	ubiquitin D	0.011
Gbp1	guanylate binding protein 1	0.011
Cd72	CD72 antigen	0.011
Vav1	vav 1 oncogene	0.011
H2-Q8	histocompatibility 2, Q region locus 8	0.011
Gbp2	guanylate binding protein 2	0.011
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.011
Il2ra	interleukin 2 receptor, alpha chain	0.011
Ifi44	interferon-induced protein 44	0.011
Fut7	fucosyltransferase 7	0.011
Lrrc45	leucine rich repeat containing 45	0.011
Tcl1b4	T-cell leukemia/lymphoma 1B, 4	0.011
Numa1	nuclear mitotic apparatus protein 1	0.011
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.011
Clk1	CDC-like kinase 1	0.011
H2-D1	histocompatibility 2, D region locus 1	0.011
Il3ra	interleukin 3 receptor, alpha chain	0.011
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.010
Cd6	CD6 antigen	0.010
Plcg2	phospholipase C, gamma 2	0.010
Ch25h	cholesterol 25-hydroxylase	0.010
Bst2	bone marrow stromal cell antigen 2	0.010
C1ra	complement component 1, r subcomponent A	0.010
Dock2	dedicator of cyto-kinesis 2	0.010
Rdh10	retinol dehydrogenase 10 (all-trans)	0.010
Zbtb48	zinc finger and BTB domain containing 48	0.010