IMP: Integrative Multi-species Prediction

Mus musculus

2 genes annotated in mouse

Multi-species View

positive regulation of cholesterol homeostasis

GO:2000189

Any process that activates or increases the frequency, rate or extent of cholesterol homeostasis.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of cholesterol homeostasis"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of cholesterol homeostasis" (in gray)

Name	Description	Probability	Func Analog Organism
Esr1	estrogen receptor 1 (alpha)	0.936
Pten	phosphatase and tensin homolog	0.840
Ghr	growth hormone receptor	0.835
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.772	Mouse
Rara	retinoic acid receptor, alpha	0.642
Pax2	paired box gene 2	0.572
Vegfa	vascular endothelial growth factor A	0.505
Rarg	retinoic acid receptor, gamma	0.473
Jag1	jagged 1	0.404
Ece1	endothelin converting enzyme 1	0.356
Rxra	retinoid X receptor alpha	0.337	Mouse
Notch2	Notch gene homolog 2 (Drosophila)	0.284
Foxc1	forkhead box C1	0.263
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.218	Mouse
Pitx2	paired-like homeodomain transcription factor 2	0.186
Prox1	prospero-related homeobox 1	0.180
Akr7a5	aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)	0.179
Fgfr2	fibroblast growth factor receptor 2	0.164
Pcyt2	phosphate cytidylyltransferase 2, ethanolamine	0.151
Apoe	apolipoprotein E	0.132
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.128
Pex6	peroxisomal biogenesis factor 6	0.126
Tgfbr2	transforming growth factor, beta receptor II	0.117
Rarb	retinoic acid receptor, beta	0.111
Gnrh1	gonadotropin releasing hormone 1	0.111
Egfr	epidermal growth factor receptor	0.111
Fgfr1	fibroblast growth factor receptor 1	0.109
Tgfb2	transforming growth factor, beta 2	0.107
Gata5	GATA binding protein 5	0.097
Fgf8	fibroblast growth factor 8	0.086
Eya1	eyes absent 1 homolog (Drosophila)	0.083
Ppara	peroxisome proliferator activated receptor alpha	0.080
Apoa1	apolipoprotein A-I	0.077
Pparg	peroxisome proliferator activated receptor gamma	0.074
Vangl2	vang-like 2 (van gogh, Drosophila)	0.072
Foxg1	forkhead box G1	0.068
Nos3	nitric oxide synthase 3, endothelial cell	0.068
Amhr2	anti-Mullerian hormone type 2 receptor	0.062
Thrb	thyroid hormone receptor beta	0.058
Bmp4	bone morphogenetic protein 4	0.058
Lepr	leptin receptor	0.051
Shh	sonic hedgehog	0.050
Emx2	empty spiracles homolog 2 (Drosophila)	0.050
Hand2	heart and neural crest derivatives expressed transcript 2	0.049
Rxrb	retinoid X receptor beta	0.049	Mouse
Fgfr3	fibroblast growth factor receptor 3	0.048
Cyhr1	cysteine and histidine rich 1	0.047
Spry2	sprouty homolog 2 (Drosophila)	0.045
Mlycd	malonyl-CoA decarboxylase	0.045
Foxc2	forkhead box C2	0.043
Nr1i2	nuclear receptor subfamily 1, group I, member 2	0.041
Yipf3	Yip1 domain family, member 3	0.041
Zfpm2	zinc finger protein, multitype 2	0.041
Tbx1	T-box 1	0.038
Odz3	odd Oz/ten-m homolog 3 (Drosophila)	0.036
Sox9	SRY-box containing gene 9	0.035
Fgf10	fibroblast growth factor 10	0.033
Apoa4	apolipoprotein A-IV	0.033
Klc4	kinesin light chain 4	0.033
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.030
Cdhr5	cadherin-related family member 5	0.030
Psen1	presenilin 1	0.028
Nr1h3	nuclear receptor subfamily 1, group H, member 3	0.028	Human
Srebf1	sterol regulatory element binding transcription factor 1	0.027
Slc25a10	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	0.027
Med25	mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)	0.026
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.026
ORF61	open reading frame 61	0.025
Isl1	ISL1 transcription factor, LIM/homeodomain	0.025
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.025
Acads	acyl-Coenzyme A dehydrogenase, short chain	0.024
Sult1b1	sulfotransferase family 1B, member 1	0.024
Bckdha	branched chain ketoacid dehydrogenase E1, alpha polypeptide	0.023
Gpd1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.023
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.023
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.022
Npc1	Niemann Pick type C1	0.022
Lemd2	LEM domain containing 2	0.022
Plcb3	phospholipase C, beta 3	0.022
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.021
Rdh10	retinol dehydrogenase 10 (all-trans)	0.021
Fbp2	fructose bisphosphatase 2	0.021
Pax3	paired box gene 3	0.021
Gna11	guanine nucleotide binding protein, alpha 11	0.020
Thra	thyroid hormone receptor alpha	0.020
Rnpepl1	arginyl aminopeptidase (aminopeptidase B)-like 1	0.020
Prdm16	PR domain containing 16	0.020
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.019
Slc46a1	solute carrier family 46, member 1	0.019
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.019
Npepl1	aminopeptidase-like 1	0.018
Sox4	SRY-box containing gene 4	0.018
Ednra	endothelin receptor type A	0.017
Foxa3	forkhead box A3	0.017
Apom	apolipoprotein M	0.017
Efnb2	ephrin B2	0.017
Fam73b	family with sequence similarity 73, member B	0.017
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.017
Habp2	hyaluronic acid binding protein 2	0.017
Trim24	tripartite motif-containing 24	0.016
Aup1	ancient ubiquitous protein 1	0.016
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.016
Apba3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.016
Ptges2	prostaglandin E synthase 2	0.016
Cbs	cystathionine beta-synthase	0.016
Chd7	chromodomain helicase DNA binding protein 7	0.015
Polrmt	polymerase (RNA) mitochondrial (DNA directed)	0.015
Adipor2	adiponectin receptor 2	0.015
Gjb1	gap junction protein, beta 1	0.015
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.015
Pcx	pyruvate carboxylase	0.015
Zfp503	zinc finger protein 503	0.015
Crat	carnitine acetyltransferase	0.015
Foxa2	forkhead box A2	0.015
Cldn2	claudin 2	0.014
Tbx3	T-box 3	0.014
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.014
Nfib	nuclear factor I/B	0.014
Meis2	Meis homeobox 2	0.013
Mesp1	mesoderm posterior 1	0.013
Mmp15	matrix metallopeptidase 15	0.013
Hoxa3	homeobox A3	0.013
Slc22a18	solute carrier family 22 (organic cation transporter), member 18	0.013
Nr1h2	nuclear receptor subfamily 1, group H, member 2	0.013
Zfp524	zinc finger protein 524	0.012
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.012
Cpn1	carboxypeptidase N, polypeptide 1	0.012
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.012	Mouse
Phldb2	pleckstrin homology-like domain, family B, member 2	0.012
Fzd8	frizzled homolog 8 (Drosophila)	0.011
Aldob	aldolase B, fructose-bisphosphate	0.011
Pnpla2	patatin-like phospholipase domain containing 2	0.011
Clrn3	clarin 3	0.011
Pik3r2	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)	0.011
Cdx2	caudal type homeobox 2	0.011
Maf1	MAF1 homolog (S. cerevisiae)	0.011
Chuk	conserved helix-loop-helix ubiquitous kinase	0.011
Esrra	estrogen related receptor, alpha	0.011
Cideb	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	0.011
Acadm	acyl-Coenzyme A dehydrogenase, medium chain	0.011
Mpnd	MPN domain containing	0.011
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.011
Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.011
Dhcr7	7-dehydrocholesterol reductase	0.011
Nrp1	neuropilin 1	0.010
Lzts2	leucine zipper, putative tumor suppressor 2	0.010
Hsf2	heat shock factor 2	0.010