IMP: Integrative Multi-species Prediction

Mus musculus

4 genes annotated in mouse

positive regulation of apoptotic process involved in mammary gland involution

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of apoptotic process involved in mammary gland involution"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "positive regulation of apoptotic process involved in mammary gland involution" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	1.000
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	1.000
Lepr	leptin receptor	1.000
Bcl2	B-cell leukemia/lymphoma 2	1.000	Mouse
Pten	phosphatase and tensin homolog	1.000
Rxra	retinoid X receptor alpha	0.999
Nos3	nitric oxide synthase 3, endothelial cell	0.998
Bax	BCL2-associated X protein	0.997
Tgfb1	transforming growth factor, beta 1	0.997
Esr1	estrogen receptor 1 (alpha)	0.997
Vhl	von Hippel-Lindau tumor suppressor	0.991
Lep	leptin	0.990
Col1a1	collagen, type I, alpha 1	0.982
Kit	kit oncogene	0.982
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.980
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.978
Smad3	MAD homolog 3 (Drosophila)	0.945
Ptgs2	prostaglandin-endoperoxide synthase 2	0.929
Apoe	apolipoprotein E	0.903
Vegfa	vascular endothelial growth factor A	0.902
Csf1	colony stimulating factor 1 (macrophage)	0.899
Apc	adenomatosis polyposis coli	0.899
Bak1	BCL2-antagonist/killer 1	0.891	Mouse
Mdm2	transformed mouse 3T3 cell double minute 2	0.867
Notch2	Notch gene homolog 2 (Drosophila)	0.841
Cav1	caveolin 1, caveolae protein	0.834
Nf1	neurofibromatosis 1	0.803
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.768
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.766
Pparg	peroxisome proliferator activated receptor gamma	0.753	Mouse
Ncoa3	nuclear receptor coactivator 3	0.741
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.741
Skil	SKI-like	0.716
Braf	Braf transforming gene	0.681
Stat3	signal transducer and activator of transcription 3	0.672
Fas	Fas (TNF receptor superfamily member 6)	0.650
Insr	insulin receptor	0.640
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.591
Wt1	Wilms tumor 1 homolog	0.502
Fgfr2	fibroblast growth factor receptor 2	0.447
Lyz2	lysozyme 2	0.446
Nos2	nitric oxide synthase 2, inducible	0.402
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.400
Ar	androgen receptor	0.395
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.387
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.381
Nos1	nitric oxide synthase 1, neuronal	0.340
Il6st	interleukin 6 signal transducer	0.329
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.319
Vav2	vav 2 oncogene	0.313
Tlr4	toll-like receptor 4	0.309
Rb1	retinoblastoma 1	0.254
Ctnnb1	catenin (cadherin associated protein), beta 1	0.248
Prkci	protein kinase C, iota	0.220
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.212
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.196
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.195
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.188
Rara	retinoic acid receptor, alpha	0.186
Hif1a	hypoxia inducible factor 1, alpha subunit	0.179
Smad4	MAD homolog 4 (Drosophila)	0.176
Ghr	growth hormone receptor	0.172
Lyst	lysosomal trafficking regulator	0.169
Esr2	estrogen receptor 2 (beta)	0.164
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.159
Thra	thyroid hormone receptor alpha	0.131
Hr	hairless	0.123
Gdnf	glial cell line derived neurotrophic factor	0.117
Tgfbr2	transforming growth factor, beta receptor II	0.116
Igf1	insulin-like growth factor 1	0.112
Daxx	Fas death domain-associated protein	0.108
Lif	leukemia inhibitory factor	0.101
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.101
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.100
Gata4	GATA binding protein 4	0.097
Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.094
Mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.093
Irs2	insulin receptor substrate 2	0.092
Lama5	laminin, alpha 5	0.090
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.089
Lmna	lamin A	0.088
Mmp9	matrix metallopeptidase 9	0.087
Cd151	CD151 antigen	0.087
Ret	ret proto-oncogene	0.087
Vdr	vitamin D receptor	0.086
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.083
Tlr2	toll-like receptor 2	0.081
Kl	klotho	0.080
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.078
Gata6	GATA binding protein 6	0.077
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.077
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.077
Kiss1r	KISS1 receptor	0.072
Bid	BH3 interacting domain death agonist	0.071
Plin1	perilipin 1	0.070
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.070
Egfr	epidermal growth factor receptor	0.069
Cd44	CD44 antigen	0.067
Runx1	runt related transcription factor 1	0.062
Bcl2l1	BCL2-like 1	0.062	Mouse
Il1r1	interleukin 1 receptor, type I	0.060
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.060
Ren1	renin 1 structural	0.058
Il10	interleukin 10	0.057
Thbs1	thrombospondin 1	0.057
Lipe	lipase, hormone sensitive	0.055
Stat5a	signal transducer and activator of transcription 5A	0.055
Spp1	secreted phosphoprotein 1	0.055
Adipoq	adiponectin, C1Q and collagen domain containing	0.055
Dok1	docking protein 1	0.055
Ikzf1	IKAROS family zinc finger 1	0.052
Tcrb	T-cell receptor beta chain	0.051
Agtr1a	angiotensin II receptor, type 1a	0.050
Cd19	CD19 antigen	0.049
Pkd1	polycystic kidney disease 1 homolog	0.049
Ifngr1	interferon gamma receptor 1	0.046
Prlr	prolactin receptor	0.045
Stk11	serine/threonine kinase 11	0.045
Sox9	SRY-box containing gene 9	0.044
Nphs2	nephrosis 2 homolog, podocin (human)	0.043
Gja1	gap junction protein, alpha 1	0.043
Ehd4	EH-domain containing 4	0.041
Bbc3	BCL2 binding component 3	0.041
Vav3	vav 3 oncogene	0.041
Psmd13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.041
Mfn2	mitofusin 2	0.040
Fam20c	family with sequence similarity 20, member C	0.039
Ep300	E1A binding protein p300	0.039
Ldlr	low density lipoprotein receptor	0.039
Pax2	paired box gene 2	0.039
Sik3	SIK family kinase 3	0.036
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.036
Pax8	paired box gene 8	0.036
Psen1	presenilin 1	0.036
Apoa4	apolipoprotein A-IV	0.036
Pnpla2	patatin-like phospholipase domain containing 2	0.035
Plxna1	plexin A1	0.035
Xpa	xeroderma pigmentosum, complementation group A	0.034
Rab17	RAB17, member RAS oncogene family	0.034
Lrp1	low density lipoprotein receptor-related protein 1	0.034
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.031
Adra1b	adrenergic receptor, alpha 1b	0.031
Axin1	axin 1	0.031
Fabp1	fatty acid binding protein 1, liver	0.031
Igh	immunoglobulin heavy chain complex	0.031
Ifng	interferon gamma	0.030
Ptch1	patched homolog 1	0.030
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.029
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.029
Myc	myelocytomatosis oncogene	0.029
Npc1	Niemann Pick type C1	0.029
E2f1	E2F transcription factor 1	0.029
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.029
Cdk4	cyclin-dependent kinase 4	0.028
Amhr2	anti-Mullerian hormone type 2 receptor	0.028
Gc	group specific component	0.027
Htatip2	HIV-1 tat interactive protein 2, homolog (human)	0.027
Scd1	stearoyl-Coenzyme A desaturase 1	0.026
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.026
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.026
Itga3	integrin alpha 3	0.026
Cidec	cell death-inducing DFFA-like effector c	0.026
Midn	midnolin	0.026
Lrp5	low density lipoprotein receptor-related protein 5	0.025
Zbtb7a	zinc finger and BTB domain containing 7a	0.025
Lipa	lysosomal acid lipase A	0.024
Ccnd1	cyclin D1	0.024
Kitl	kit ligand	0.024
Sult1b1	sulfotransferase family 1B, member 1	0.024
Thrb	thyroid hormone receptor beta	0.024
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.024
Spry4	sprouty homolog 4 (Drosophila)	0.023
Ahr	aryl-hydrocarbon receptor	0.023
Ehd3	EH-domain containing 3	0.023
Fam83g	family with sequence similarity 83, member G	0.023
Egr1	early growth response 1	0.023
Wwox	WW domain-containing oxidoreductase	0.022
Pthlh	parathyroid hormone-like peptide	0.022
Stat6	signal transducer and activator of transcription 6	0.022
Nr1h4	nuclear receptor subfamily 1, group H, member 4	0.022	Mouse
Prdm16	PR domain containing 16	0.022
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.022
Sh3pxd2a	SH3 and PX domains 2A	0.021
Ctnnd1	catenin (cadherin associated protein), delta 1	0.021
Stk4	serine/threonine kinase 4	0.021
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.021
Pfn1	profilin 1	0.021
Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.021
Polm	polymerase (DNA directed), mu	0.021
Phlda2	pleckstrin homology-like domain, family A, member 2	0.021
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.021
Tert	telomerase reverse transcriptase	0.020
P2ry2	purinergic receptor P2Y, G-protein coupled 2	0.020
Msh2	mutS homolog 2 (E. coli)	0.020
Tnf	tumor necrosis factor	0.020
Ilk	integrin linked kinase	0.020
Aldob	aldolase B, fructose-bisphosphate	0.020
Clip2	CAP-GLY domain containing linker protein 2	0.020
Fbp2	fructose bisphosphatase 2	0.020
Bche	butyrylcholinesterase	0.020
Sdsl	serine dehydratase-like	0.020
Rdh16	retinol dehydrogenase 16	0.020
Trp63	transformation related protein 63	0.020
Foxo1	forkhead box O1	0.019
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.019
Adam17	a disintegrin and metallopeptidase domain 17	0.019
Spsb1	splA/ryanodine receptor domain and SOCS box containing 1	0.019
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.019
N4bp1	NEDD4 binding protein 1	0.019
Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	0.019
Huwe1	HECT, UBA and WWE domain containing 1	0.018
Foxa2	forkhead box A2	0.018
2310036O22Rik	RIKEN cDNA 2310036O22 gene	0.018
Ano6	anoctamin 6	0.018
Apoa1	apolipoprotein A-I	0.018
Ykt6	YKT6 homolog (S. Cerevisiae)	0.018
Rint1	RAD50 interactor 1	0.018
Epha2	Eph receptor A2	0.018
Commd4	COMM domain containing 4	0.018
Arpc4	actin related protein 2/3 complex, subunit 4	0.018
Aprt	adenine phosphoribosyl transferase	0.018
Btg1	B-cell translocation gene 1, anti-proliferative	0.018
Prm2	protamine 2	0.017
Gpd2	glycerol phosphate dehydrogenase 2, mitochondrial	0.017
Sfn	stratifin	0.017
Gdf15	growth differentiation factor 15	0.017
Jag1	jagged 1	0.017
Bach1	BTB and CNC homology 1	0.017
Gcgr	glucagon receptor	0.017
Hnf4a	hepatic nuclear factor 4, alpha	0.017
Bscl2	Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)	0.017
Cdk6	cyclin-dependent kinase 6	0.017
Mark4	MAP/microtubule affinity-regulating kinase 4	0.017
Trim25	tripartite motif-containing 25	0.017
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.017
Tob2	transducer of ERBB2, 2	0.017
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.017
Foxo3	forkhead box O3	0.017
Dusp1	dual specificity phosphatase 1	0.017
Slc26a1	solute carrier family 26 (sulfate transporter), member 1	0.017
Yap1	yes-associated protein 1	0.017
Agrp	agouti related protein	0.017
Stat1	signal transducer and activator of transcription 1	0.017
Rhod	ras homolog gene family, member D	0.016
Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	0.016
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.016
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.016
Lpin1	lipin 1	0.016
Mapk13	mitogen-activated protein kinase 13	0.016
Cdhr5	cadherin-related family member 5	0.016
Pax3	paired box gene 3	0.015
Lrrc8a	leucine rich repeat containing 8A	0.015
Per2	period homolog 2 (Drosophila)	0.015
Mdm4	transformed mouse 3T3 cell double minute 4	0.015
Habp2	hyaluronic acid binding protein 2	0.015
Tead3	TEA domain family member 3	0.015
Tcf3	transcription factor 3	0.015
Aadac	arylacetamide deacetylase (esterase)	0.015
Col4a3	collagen, type IV, alpha 3	0.015
Arid5b	AT rich interactive domain 5B (MRF1-like)	0.015
Acsm3	acyl-CoA synthetase medium-chain family member 3	0.015
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.015
Irf8	interferon regulatory factor 8	0.015
Ltbr	lymphotoxin B receptor	0.014
Crtc3	CREB regulated transcription coactivator 3	0.014
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.014	Mouse
Krt7	keratin 7	0.014
Fam83h	family with sequence similarity 83, member H	0.014
Igf1r	insulin-like growth factor I receptor	0.014
Bmp4	bone morphogenetic protein 4	0.014
Smn1	survival motor neuron 1	0.014
Rxrg	retinoid X receptor gamma	0.014
C3	complement component 3	0.014
Plau	plasminogen activator, urokinase	0.014
Mafk	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	0.014
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.014
Pvrl2	poliovirus receptor-related 2	0.014
Notch1	Notch gene homolog 1 (Drosophila)	0.014
Ptrh1	peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)	0.014
Mgmt	O-6-methylguanine-DNA methyltransferase	0.013
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.013
Sult1d1	sulfotransferase family 1D, member 1	0.013
Iqgap1	IQ motif containing GTPase activating protein 1	0.013
Cbl	Casitas B-lineage lymphoma	0.013
Ahsg	alpha-2-HS-glycoprotein	0.013
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.013
Mcl1	myeloid cell leukemia sequence 1	0.013	Mouse
Tcrd	T-cell receptor delta chain	0.013
Fosl2	fos-like antigen 2	0.013
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.013
Zbtb7b	zinc finger and BTB domain containing 7B	0.013
Dhcr24	24-dehydrocholesterol reductase	0.013
Fstl3	follistatin-like 3	0.013
Efna5	ephrin A5	0.013
Pdzk1	PDZ domain containing 1	0.013
Slc3a1	solute carrier family 3, member 1	0.013
Grik3	glutamate receptor, ionotropic, kainate 3	0.012
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.012
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.012
Ces1c	carboxylesterase 1C	0.012
Tnip1	TNFAIP3 interacting protein 1	0.012
Hgd	homogentisate 1, 2-dioxygenase	0.012
Dbnl	drebrin-like	0.012
Asgr2	asialoglycoprotein receptor 2	0.012
Mitf	microphthalmia-associated transcription factor	0.012
Dusp9	dual specificity phosphatase 9	0.012
Ctsl	cathepsin L	0.012
Fabp2	fatty acid binding protein 2, intestinal	0.012
Cideb	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	0.012
Acy3	aspartoacylase (aminoacylase) 3	0.012
Ikzf3	IKAROS family zinc finger 3	0.012
Soat2	sterol O-acyltransferase 2	0.012
Stat5b	signal transducer and activator of transcription 5B	0.012
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.012
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.012
Tsc1	tuberous sclerosis 1	0.012
Nr0b2	nuclear receptor subfamily 0, group B, member 2	0.012
Slc12a1	solute carrier family 12, member 1	0.012
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.012
Cgnl1	cingulin-like 1	0.012
Aadat	aminoadipate aminotransferase	0.011
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.011
Nrg1	neuregulin 1	0.011
Eif6	eukaryotic translation initiation factor 6	0.011
Klk1b4	kallikrein 1-related pepidase b4	0.011
Prr5	proline rich 5 (renal)	0.011
Igfals	insulin-like growth factor binding protein, acid labile subunit	0.011
Src	Rous sarcoma oncogene	0.011
Gab2	growth factor receptor bound protein 2-associated protein 2	0.011
Pgf	placental growth factor	0.011
Apob	apolipoprotein B	0.011
Vil1	villin 1	0.011
Brca1	breast cancer 1	0.011
Npas2	neuronal PAS domain protein 2	0.011
Slc6a8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.011
Rrp36	ribosomal RNA processing 36 homolog (S. cerevisiae)	0.011
Nt5c	5',3'-nucleotidase, cytosolic	0.011
Slc39a1	solute carrier family 39 (zinc transporter), member 1	0.011
Cldn2	claudin 2	0.011
Sh3rf1	SH3 domain containing ring finger 1	0.011
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.011
Socs1	suppressor of cytokine signaling 1	0.011
Lgals2	lectin, galactose-binding, soluble 2	0.011
Iyd	iodotyrosine deiodinase	0.011
Aff1	AF4/FMR2 family, member 1	0.011
Pcx	pyruvate carboxylase	0.011
Guca2b	guanylate cyclase activator 2b (retina)	0.011
Galk1	galactokinase 1	0.011
C8g	complement component 8, gamma polypeptide	0.011
Cyld	cylindromatosis (turban tumor syndrome)	0.011
Mme	membrane metallo endopeptidase	0.011
Vnn1	vanin 1	0.011
Men1	multiple endocrine neoplasia 1	0.011
Rag1	recombination activating gene 1	0.011
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.010
Cish	cytokine inducible SH2-containing protein	0.010
Ogg1	8-oxoguanine DNA-glycosylase 1	0.010
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.010
Sdc3	syndecan 3	0.010
Gjb1	gap junction protein, beta 1	0.010
Prmt1	protein arginine N-methyltransferase 1	0.010
Flg	filaggrin	0.010
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.010
Bcl3	B-cell leukemia/lymphoma 3	0.010
Ugt2b34	UDP glucuronosyltransferase 2 family, polypeptide B34	0.010
Pxn	paxillin	0.010
Prkcd	protein kinase C, delta	0.010
Junb	Jun-B oncogene	0.010
Ang2	angiogenin, ribonuclease A family, member 2	0.010
Furin	furin (paired basic amino acid cleaving enzyme)	0.010