IMP: Integrative Multi-species Prediction

Mus musculus

4 genes annotated in mouse

Multi-species View

negative regulation of keratinocyte differentiation

GO:0045617

Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of keratinocyte differentiation"

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "negative regulation of keratinocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Msx2	homeobox, msh-like 2	0.960
Pax3	paired box gene 3	0.951
Trp63	transformation related protein 63	0.950
Shh	sonic hedgehog	0.916
Fgfr2	fibroblast growth factor receptor 2	0.870
Pten	phosphatase and tensin homolog	0.807
Sox9	SRY-box containing gene 9	0.714
Prrx1	paired related homeobox 1	0.427
Dlx5	distal-less homeobox 5	0.411
Trp53	transformation related protein 53	0.368	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.362
Lef1	lymphoid enhancer binding factor 1	0.305
Runx2	runt related transcription factor 2	0.245
Esr1	estrogen receptor 1 (alpha)	0.226
Trp73	transformation related protein 73	0.224	Mouse
Bmp7	bone morphogenetic protein 7	0.213
Hr	hairless	0.205
Chrd	chordin	0.195
Alx4	aristaless-like homeobox 4	0.189
Hand1	heart and neural crest derivatives expressed transcript 1	0.168
Gli3	GLI-Kruppel family member GLI3	0.167
Pax9	paired box gene 9	0.167
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.163
Egfr	epidermal growth factor receptor	0.163
Eya1	eyes absent 1 homolog (Drosophila)	0.154
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.152
Reg1	regenerating islet-derived 1	0.146	Mouse
2210010C04Rik	RIKEN cDNA 2210010C04 gene	0.145
Foxc1	forkhead box C1	0.143
Nog	noggin	0.141
Otx2	orthodenticle homolog 2 (Drosophila)	0.139
Cdx2	caudal type homeobox 2	0.117
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.115
Reg2	regenerating islet-derived 2	0.106	Mouse
Sfn	stratifin	0.098
Pitx1	paired-like homeodomain transcription factor 1	0.093
Apc	adenomatosis polyposis coli	0.091
Zg16	zymogen granule protein 16	0.090
Reg3b	regenerating islet-derived 3 beta	0.089	Mouse
Reg3g	regenerating islet-derived 3 gamma	0.085
Rara	retinoic acid receptor, alpha	0.083
Wnt3a	wingless-related MMTV integration site 3A	0.074
Reg3d	regenerating islet-derived 3 delta	0.072	Mouse
Tbx3	T-box 3	0.070
Krt14	keratin 14	0.070
Dlx2	distal-less homeobox 2	0.069
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.068
Rxra	retinoid X receptor alpha	0.068
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.067
Alx1	ALX homeobox 1	0.062
Prss2	protease, serine, 2	0.062
Hoxa13	homeobox A13	0.061
Plac1	placental specific protein 1	0.059
Srsf2	serine/arginine-rich splicing factor 2	0.059
Sp6	trans-acting transcription factor 6	0.057
Dmbt1	deleted in malignant brain tumors 1	0.057
Gli2	GLI-Kruppel family member GLI2	0.056
Bmp4	bone morphogenetic protein 4	0.056
Muc13	mucin 13, epithelial transmembrane	0.055
Tcfap2a	transcription factor AP-2, alpha	0.052
Mmp7	matrix metallopeptidase 7	0.052
Prrx2	paired related homeobox 2	0.050
Pax6	paired box gene 6	0.048
Emx1	empty spiracles homolog 1 (Drosophila)	0.047
Meox2	mesenchyme homeobox 2	0.047
Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.046
Gp2	glycoprotein 2 (zymogen granule membrane)	0.046
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.046
Smo	smoothened homolog (Drosophila)	0.045
Ms4a10	membrane-spanning 4-domains, subfamily A, member 10	0.044
Ins1	insulin I	0.043
Fgf10	fibroblast growth factor 10	0.041
Prss32	protease, serine, 32	0.041
Cpa1	carboxypeptidase A1	0.041
Tff2	trefoil factor 2 (spasmolytic protein 1)	0.039
Yap1	yes-associated protein 1	0.039
Sycn	syncollin	0.039
Itga3	integrin alpha 3	0.039
Tbx15	T-box 15	0.039
Reg3a	regenerating islet-derived 3 alpha	0.038
Pklr	pyruvate kinase liver and red blood cell	0.038
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.038
Gucy2c	guanylate cyclase 2c	0.036
Krt4	keratin 4	0.034
Rb1	retinoblastoma 1	0.033
Tff3	trefoil factor 3, intestinal	0.033
Il10	interleukin 10	0.033
Ptf1a	pancreas specific transcription factor, 1a	0.032
Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.032
Gsc	goosecoid homeobox	0.031
Fut2	fucosyltransferase 2	0.031
Gpr87	G protein-coupled receptor 87	0.031
Rnase1	ribonuclease, RNase A family, 1 (pancreatic)	0.030
Foxe3	forkhead box E3	0.030
Dsc3	desmocollin 3	0.029
Ptch1	patched homolog 1	0.029
Braf	Braf transforming gene	0.029
Hoxa2	homeobox A2	0.028
Chuk	conserved helix-loop-helix ubiquitous kinase	0.028
Lrp6	low density lipoprotein receptor-related protein 6	0.028
1810030J14Rik	RIKEN cDNA 1810030J14 gene	0.028
Clps	colipase, pancreatic	0.028
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.027
Huwe1	HECT, UBA and WWE domain containing 1	0.027
Defa-rs12	defensin, alpha, related sequence 12	0.027
Hsd17b13	hydroxysteroid (17-beta) dehydrogenase 13	0.026
Krt32	keratin 32	0.025
Krtap3-1	keratin associated protein 3-1	0.024
Smad3	MAD homolog 3 (Drosophila)	0.024
Crb3	crumbs homolog 3 (Drosophila)	0.024
Hand2	heart and neural crest derivatives expressed transcript 2	0.024
Amelx	amelogenin X chromosome	0.024
Cuzd1	CUB and zona pellucida-like domains 1	0.024
Irf6	interferon regulatory factor 6	0.023
Nodal	nodal	0.023
Smn1	survival motor neuron 1	0.023
Galr1	galanin receptor 1	0.023
Prss29	protease, serine, 29	0.023
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.023
Mdm2	transformed mouse 3T3 cell double minute 2	0.023
Rnase4	ribonuclease, RNase A family 4	0.022
Gata5	GATA binding protein 5	0.022
Defa-rs2	defensin, alpha, related sequence 2	0.022
Pnliprp1	pancreatic lipase related protein 1	0.022
Ropn1	ropporin, rhophilin associated protein 1	0.022
Ces4a	carboxylesterase 4A	0.022
Sel1l2	sel-1 suppressor of lin-12-like 2 (C. elegans)	0.022
Tial1	Tia1 cytotoxic granule-associated RNA binding protein-like 1	0.021
Sry	sex determining region of Chr Y	0.020
Pla2g2a	phospholipase A2, group IIA (platelets, synovial fluid)	0.020
Nxf1	nuclear RNA export factor 1 homolog (S. cerevisiae)	0.020
Krt27	keratin 27	0.019
Vmn1r65	vomeronasal 1 receptor 65	0.019
Ctrc	chymotrypsin C (caldecrin)	0.019
Krtap16-4	keratin associated protein 16-4	0.019
Col1a1	collagen, type I, alpha 1	0.019
Pax4	paired box gene 4	0.019
Gast	gastrin	0.019
Fgfr3	fibroblast growth factor receptor 3	0.019
Ins2	insulin II	0.018
Serpini2	serine (or cysteine) peptidase inhibitor, clade I, member 2	0.018
Fgfr1	fibroblast growth factor receptor 1	0.018
Hoxc9	homeobox C9	0.018
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.018
Psen1	presenilin 1	0.018
Defa-rs1	defensin, alpha, related sequence 1	0.018
Klk1b24	kallikrein 1-related peptidase b24	0.018
Alx3	aristaless-like homeobox 3	0.018
Gja1	gap junction protein, alpha 1	0.018
Vangl2	vang-like 2 (van gogh, Drosophila)	0.018
Pla2g2d	phospholipase A2, group IID	0.018
Hhat	hedgehog acyltransferase	0.018
Nlrp6	NLR family, pyrin domain containing 6	0.017
Rag1	recombination activating gene 1	0.017
Krt6a	keratin 6A	0.017
Tardbp	TAR DNA binding protein	0.017
Wnt11	wingless-related MMTV integration site 11	0.017
2210407C18Rik	RIKEN cDNA 2210407C18 gene	0.017
Bhlha15	basic helix-loop-helix family, member a15	0.017
9930023K05Rik	RIKEN cDNA 9930023K05 gene	0.017
Olfr480	olfactory receptor 480	0.017
Tshz1	teashirt zinc finger family member 1	0.017
Ahr	aryl-hydrocarbon receptor	0.016
Aicda	activation-induced cytidine deaminase	0.016
Gabrp	gamma-aminobutyric acid (GABA) A receptor, pi	0.016
Epha1	Eph receptor A1	0.016
Zeb1	zinc finger E-box binding homeobox 1	0.016
Foxn1	forkhead box N1	0.016
Ctrb1	chymotrypsinogen B1	0.016
Crct1	cysteine-rich C-terminal 1	0.016
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.016
B4galnt2	beta-1,4-N-acetyl-galactosaminyl transferase 2	0.016
Cldn4	claudin 4	0.016
Spink3	serine peptidase inhibitor, Kazal type 3	0.016
Mep1b	meprin 1 beta	0.015
Dlx3	distal-less homeobox 3	0.015
Trim31	tripartite motif-containing 31	0.015
Tff1	trefoil factor 1	0.015
Sprr2a2	small proline-rich protein 2A2	0.015
Rarb	retinoic acid receptor, beta	0.015
H2-M9	histocompatibility 2, M region locus 9	0.015
Cela2a	chymotrypsin-like elastase family, member 2A	0.015
Lamc2	laminin, gamma 2	0.015
Nmur1	neuromedin U receptor 1	0.015
Mapk14	mitogen-activated protein kinase 14	0.014
Twist2	twist homolog 2 (Drosophila)	0.014
Tead4	TEA domain family member 4	0.014
Srsf7	serine/arginine-rich splicing factor 7	0.014
Srsf11	serine/arginine-rich splicing factor 11	0.014
Muc3	mucin 3, intestinal	0.014
Slc7a9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.014
Cldn7	claudin 7	0.014
Osta	organic solute transporter alpha	0.014
Psapl1	prosaposin-like 1	0.014
Rrs1	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	0.014
Cldn6	claudin 6	0.014
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.014
Hoxa11	homeobox A11	0.014
Aurkb	aurora kinase B	0.014
Emx2	empty spiracles homolog 2 (Drosophila)	0.013
Runx1	runt related transcription factor 1	0.013
Olfr870	olfactory receptor 870	0.013
Cela3b	chymotrypsin-like elastase family, member 3B	0.013
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.013
Rab25	RAB25, member RAS oncogene family	0.013
Syt8	synaptotagmin VIII	0.013
Edn3	endothelin 3	0.013
Trim29	tripartite motif-containing 29	0.013
Gip	gastric inhibitory polypeptide	0.013
Nkx2-1	NK2 homeobox 1	0.013
Cdca3	cell division cycle associated 3	0.013
Itgb4	integrin beta 4	0.013
Prss21	protease, serine, 21	0.013
Myc	myelocytomatosis oncogene	0.013
Klk7	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	0.013
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.013
Olfr15	olfactory receptor 15	0.013
En1	engrailed 1	0.013
Hoxa5	homeobox A5	0.013
Muc4	mucin 4	0.013
Sall4	sal-like 4 (Drosophila)	0.012
Il1f6	interleukin 1 family, member 6	0.012
Myl7	myosin, light polypeptide 7, regulatory	0.012
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.012
Lce1b	late cornified envelope 1B	0.012
Sox2	SRY-box containing gene 2	0.012
Tmem54	transmembrane protein 54	0.012
Krt33b	keratin 33B	0.012
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.012
Ly6g6c	lymphocyte antigen 6 complex, locus G6C	0.012
Edaradd	EDAR (ectodysplasin-A receptor)-associated death domain	0.012
Pnliprp2	pancreatic lipase-related protein 2	0.012
Tmem79	transmembrane protein 79	0.012
Bmp2	bone morphogenetic protein 2	0.012
Nmur2	neuromedin U receptor 2	0.012
Msgn1	mesogenin 1	0.012
Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	0.012
Alox12e	arachidonate lipoxygenase, epidermal	0.012
Mep1a	meprin 1 alpha	0.012
Adam3	a disintegrin and metallopeptidase domain 3 (cyritestin)	0.012
Brca2	breast cancer 2	0.012
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.012
Prss3	protease, serine, 3	0.012
Tbx1	T-box 1	0.012
Cyp2d34	cytochrome P450, family 2, subfamily d, polypeptide 34	0.012
Phox2b	paired-like homeobox 2b	0.012
Asb18	ankyrin repeat and SOCS box-containing 18	0.012
Fgf8	fibroblast growth factor 8	0.012
Gpa33	glycoprotein A33 (transmembrane)	0.012
Yipf7	Yip1 domain family, member 7	0.012
2010109I03Rik	RIKEN cDNA 2010109I03 gene	0.012
Dsg4	desmoglein 4	0.011
Acd	adrenocortical dysplasia	0.011
Trim15	tripartite motif-containing 15	0.011
Atp2c2	ATPase, Ca++ transporting, type 2C, member 2	0.011
Myo7b	myosin VIIB	0.011
Olfr1507	olfactory receptor 1507	0.011
Scgb3a2	secretoglobin, family 3A, member 2	0.011
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.011
Gpx2	glutathione peroxidase 2	0.011
Duoxa2	dual oxidase maturation factor 2	0.011
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Taf1d	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, D	0.011
Tubgcp3	tubulin, gamma complex associated protein 3	0.011
Pprc1	peroxisome proliferative activated receptor, gamma, coactivator-related 1	0.011
Hoxa9	homeobox A9	0.011
Foxp3	forkhead box P3	0.011
Atp6v0a4	ATPase, H+ transporting, lysosomal V0 subunit A4	0.011
Lce1i	late cornified envelope 1I	0.011
Akp3	alkaline phosphatase 3, intestine, not Mn requiring	0.011
Tcam1	testicular cell adhesion molecule 1	0.011
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.011
Lce3c	late cornified envelope 3C	0.011
Gbgt1	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1	0.011
Krt71	keratin 71	0.011
P2ry4	pyrimidinergic receptor P2Y, G-protein coupled, 4	0.011
Gprc6a	G protein-coupled receptor, family C, group 6, member A	0.011
Gjb3	gap junction protein, beta 3	0.011
Pnlip	pancreatic lipase	0.011
Pgrmc1	progesterone receptor membrane component 1	0.011
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.011
Gprc5d	G protein-coupled receptor, family C, group 5, member D	0.011
Gdf3	growth differentiation factor 3	0.011
Ptch2	patched homolog 2	0.011
Trim69	tripartite motif-containing 69	0.011
Osr2	odd-skipped related 2 (Drosophila)	0.010
Bfsp1	beaded filament structural protein 1, in lens-CP94	0.010
Fmr1nb	fragile X mental retardation 1 neighbor	0.010
Pla2g1b	phospholipase A2, group IB, pancreas	0.010
Rnf138	ring finger protein 138	0.010
Krt84	keratin 84	0.010
Evx1	even skipped homeotic gene 1 homolog	0.010
Agr2	anterior gradient 2 (Xenopus laevis)	0.010
Htr3a	5-hydroxytryptamine (serotonin) receptor 3A	0.010
Rep15	RAB15 effector protein	0.010
Plekhg6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	0.010
Tgfb2	transforming growth factor, beta 2	0.010
Parp2	poly (ADP-ribose) polymerase family, member 2	0.010
Htatip2	HIV-1 tat interactive protein 2, homolog (human)	0.010
Tmed11	transmembrane emp24 protein transport domain containing	0.010
Cyp2b13	cytochrome P450, family 2, subfamily b, polypeptide 13	0.010
Prss44	protease, serine, 44	0.010