IMP: Integrative Multi-species Prediction

Mus musculus

0 genes annotated in mouse

primary immunodeficiency disease

DOID:612

An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "primary immunodeficiency disease" (in gray)

Name	Description	Probability	Func Analog Organism
Igh	immunoglobulin heavy chain complex	1.000
Cd19	CD19 antigen	1.000	Human
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	1.000	Human
Tapbp	TAP binding protein	0.929
Btk	Bruton agammaglobulinemia tyrosine kinase	0.897	Human
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.860	Human
Blnk	B-cell linker	0.805	Human
Lat	linker for activation of T cells	0.805
Fas	Fas (TNF receptor superfamily member 6)	0.750
Cd22	CD22 antigen	0.729
Pou2af1	POU domain, class 2, associating factor 1	0.712
B2m	beta-2 microglobulin	0.681
Pnp2	purine-nucleoside phosphorylase 2	0.677
Ikzf1	IKAROS family zinc finger 1	0.604
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.450	Human
Cd79b	CD79B antigen	0.444	Human
Plcg2	phospholipase C, gamma 2	0.433
H2-K1	histocompatibility 2, K1, K region	0.414
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.351
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.334
Card11	caspase recruitment domain family, member 11	0.311
Tcra	T-cell receptor alpha chain	0.310
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.298
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.297
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.291
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.260
Cd40	CD40 antigen	0.259
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.255	Human
Ptprc	protein tyrosine phosphatase, receptor type, C	0.254
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.221
Tnf	tumor necrosis factor	0.201
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.187
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.184	Human
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.180
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.171
Prkcd	protein kinase C, delta	0.164	Human
Map4k1	mitogen-activated protein kinase kinase kinase kinase 1	0.160
Irf8	interferon regulatory factor 8	0.157
Sykb	spleen tyrosine kinase	0.143
Lck	lymphocyte protein tyrosine kinase	0.135
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.134
Ifng	interferon gamma	0.124
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.124
Vav2	vav 2 oncogene	0.108
Ncf4	neutrophil cytosolic factor 4	0.101
Rag1	recombination activating gene 1	0.100
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.099
Igk	immunoglobulin kappa chain complex	0.095
Cr2	complement receptor 2	0.095	Human
Ltb	lymphotoxin B	0.090
Sfpi1	SFFV proviral integration 1	0.089
Ikzf3	IKAROS family zinc finger 3	0.089
H2-D1	histocompatibility 2, D region locus 1	0.077
Blk	B lymphoid kinase	0.076
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.075
Icos	inducible T-cell co-stimulator	0.074
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.074
H2-Oa	histocompatibility 2, O region alpha locus	0.074
Bcl6	B-cell leukemia/lymphoma 6	0.073
Cd247	CD247 antigen	0.070
Vav1	vav 1 oncogene	0.068
Trp53	transformation related protein 53	0.068
H2-Ob	histocompatibility 2, O region beta locus	0.066
Capg	capping protein (actin filament), gelsolin-like	0.064
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.063
Igj	immunoglobulin joining chain	0.059
Lrmp	lymphoid-restricted membrane protein	0.056
Sh3kbp1	SH3-domain kinase binding protein 1	0.055
Ifi35	interferon-induced protein 35	0.054
Grb2	growth factor receptor bound protein 2	0.053
Bcl3	B-cell leukemia/lymphoma 3	0.052
Traf3ip2	TRAF3 interacting protein 2	0.052
Rac2	RAS-related C3 botulinum substrate 2	0.051
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.049
Irf1	interferon regulatory factor 1	0.049
Nup62-il4i1	Nup62-Il4i1 protein	0.048
Tcrd	T-cell receptor delta chain	0.048
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.047
Tyrobp	TYRO protein tyrosine kinase binding protein	0.046
Irf4	interferon regulatory factor 4	0.043
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.042
Tnip1	TNFAIP3 interacting protein 1	0.042
Myo1f	myosin IF	0.042
Il7r	interleukin 7 receptor	0.042
0610007C21Rik	RIKEN cDNA 0610007C21 gene	0.038
Irf5	interferon regulatory factor 5	0.038
Cd37	CD37 antigen	0.037
Cd52	CD52 antigen	0.037
Napsa	napsin A aspartic peptidase	0.036
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.036
Inpp5d	inositol polyphosphate-5-phosphatase D	0.036
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.036
Il2rb	interleukin 2 receptor, beta chain	0.035
Myd88	myeloid differentiation primary response gene 88	0.034
Jak3	Janus kinase 3	0.034
Cd72	CD72 antigen	0.033
Arid1b	AT rich interactive domain 1B (SWI-like)	0.033
Lcp1	lymphocyte cytosolic protein 1	0.032
Hcls1	hematopoietic cell specific Lyn substrate 1	0.032
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.031
Fcrla	Fc receptor-like A	0.031
Mcoln2	mucolipin 2	0.031
Lst1	leukocyte specific transcript 1	0.031
Fermt3	fermitin family homolog 3 (Drosophila)	0.030
Rag2	recombination activating gene 2	0.030
Ltbr	lymphotoxin B receptor	0.029
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.029
Vpreb3	pre-B lymphocyte gene 3	0.028
Ncoa3	nuclear receptor coactivator 3	0.028
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.028
Ncf1	neutrophil cytosolic factor 1	0.028	Human
Foxp3	forkhead box P3	0.027
Ly6d	lymphocyte antigen 6 complex, locus D	0.027
Fyn	Fyn proto-oncogene	0.027
Ncf2	neutrophil cytosolic factor 2	0.027	Human
Nckap1l	NCK associated protein 1 like	0.027
Il15	interleukin 15	0.026
Adar	adenosine deaminase, RNA-specific	0.024
Prdm1	PR domain containing 1, with ZNF domain	0.024
Tspan32	tetraspanin 32	0.024
Ctsz	cathepsin Z	0.023
Fcgr1	Fc receptor, IgG, high affinity I	0.023
Hck	hemopoietic cell kinase	0.023
Lgals1	lectin, galactose binding, soluble 1	0.023
Cnr2	cannabinoid receptor 2 (macrophage)	0.022
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.022
Adamdec1	ADAM-like, decysin 1	0.022
Mapk14	mitogen-activated protein kinase 14	0.021
Necap2	NECAP endocytosis associated 2	0.020
Tcrb	T-cell receptor beta chain	0.020
2010001M09Rik	RIKEN cDNA 2010001M09 gene	0.020
Ebf1	early B-cell factor 1	0.020
Ccr6	chemokine (C-C motif) receptor 6	0.020
Was	Wiskott-Aldrich syndrome homolog (human)	0.020
Itm2c	integral membrane protein 2C	0.020
Itgam	integrin alpha M	0.019
Prkd2	protein kinase D2	0.019
Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta	0.019
Ebi3	Epstein-Barr virus induced gene 3	0.019
Sla	src-like adaptor	0.019
Rasal3	RAS protein activator like 3	0.018
Il17ra	interleukin 17 receptor A	0.018
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.018
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.018
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.018
Cxcr5	chemokine (C-X-C motif) receptor 5	0.018
Gcnt1	glucosaminyl (N-acetyl) transferase 1, core 2	0.018
Prr13	proline rich 13	0.018
Arhgap9	Rho GTPase activating protein 9	0.017
Foxo3	forkhead box O3	0.017
Pml	promyelocytic leukemia	0.017
Traf2	TNF receptor-associated factor 2	0.017
Cd68	CD68 antigen	0.016
Gm14548	predicted gene 14548	0.016
Serpinb1a	serine (or cysteine) peptidase inhibitor, clade B, member 1a	0.016
Bank1	B-cell scaffold protein with ankyrin repeats 1	0.016
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.016
Renbp	renin binding protein	0.016
Faim3	Fas apoptotic inhibitory molecule 3	0.016
Coro1a	coronin, actin binding protein 1A	0.016
H2-Eb1	histocompatibility 2, class II antigen E beta	0.016
Pttg1ip	pituitary tumor-transforming 1 interacting protein	0.016
Cd180	CD180 antigen	0.016
Vav3	vav 3 oncogene	0.016
Man2b1	mannosidase 2, alpha B1	0.016
Ftl1	ferritin light chain 1	0.016
Sp100	nuclear antigen Sp100	0.015
Psme1	proteasome (prosome, macropain) 28 subunit, alpha	0.015
Ly86	lymphocyte antigen 86	0.015
Pxn	paxillin	0.015
Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	0.015
Scamp2	secretory carrier membrane protein 2	0.015
Cpne2	copine II	0.015
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.015
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.015
Rhoh	ras homolog gene family, member H	0.015
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.015
Lyl1	lymphoblastomic leukemia 1	0.015
Aplp2	amyloid beta (A4) precursor-like protein 2	0.015
Il27ra	interleukin 27 receptor, alpha	0.015
Cst3	cystatin C	0.015
Ptger3	prostaglandin E receptor 3 (subtype EP3)	0.014
Fcrl1	Fc receptor-like 1	0.014
Upb1	ureidopropionase, beta	0.014
Ephx1	epoxide hydrolase 1, microsomal	0.014
Bst1	bone marrow stromal cell antigen 1	0.014
Ikbke	inhibitor of kappaB kinase epsilon	0.014
Ly75	lymphocyte antigen 75	0.014
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.014
Nfil3	nuclear factor, interleukin 3, regulated	0.014
Pten	phosphatase and tensin homolog	0.014
Kit	kit oncogene	0.014
Ifitm6	interferon induced transmembrane protein 6	0.014
Sell	selectin, lymphocyte	0.014
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.014
Tspo	translocator protein	0.014
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.013
Slfn4	schlafen 4	0.013
Ahr	aryl-hydrocarbon receptor	0.013
Gpx1	glutathione peroxidase 1	0.013
P2ry14	purinergic receptor P2Y, G-protein coupled, 14	0.013
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.013
Clic1	chloride intracellular channel 1	0.013
Rgn	regucalcin	0.013
Ddit4	DNA-damage-inducible transcript 4	0.013
Cd209a	CD209a antigen	0.013
Slfn2	schlafen 2	0.013
Hhex	hematopoietically expressed homeobox	0.013
Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.013
Cd48	CD48 antigen	0.013
G6pdx	glucose-6-phosphate dehydrogenase X-linked	0.013
Ambp	alpha 1 microglobulin/bikunin	0.013
Gna15	guanine nucleotide binding protein, alpha 15	0.013
Cst7	cystatin F (leukocystatin)	0.013
Tmem176a	transmembrane protein 176A	0.013
Fam111a	family with sequence similarity 111, member A	0.013
Col4a2	collagen, type IV, alpha 2	0.013
Tmc6	transmembrane channel-like gene family 6	0.013
Huwe1	HECT, UBA and WWE domain containing 1	0.013
Cd1d1	CD1d1 antigen	0.013
Mis12	MIS12 homolog (yeast)	0.013
Hepacam2	HEPACAM family member 2	0.013
Plin2	perilipin 2	0.013
Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	0.012
Cd86	CD86 antigen	0.012
Kcnn4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	0.012
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.012
Npc2	Niemann Pick type C2	0.012
St14	suppression of tumorigenicity 14 (colon carcinoma)	0.012
Siae	sialic acid acetylesterase	0.012
Sema4d	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.012
Crip1	cysteine-rich protein 1 (intestinal)	0.012
Gpr65	G-protein coupled receptor 65	0.012
Pglyrp1	peptidoglycan recognition protein 1	0.012
Ripk3	receptor-interacting serine-threonine kinase 3	0.012
Sh3bp2	SH3-domain binding protein 2	0.012
Prdx6	peroxiredoxin 6	0.012
Pacrgl	PARK2 co-regulated-like	0.012
Errfi1	ERBB receptor feedback inhibitor 1	0.012
Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E	0.012
Dnase1l3	deoxyribonuclease 1-like 3	0.012
Serpina1b	serine (or cysteine) preptidase inhibitor, clade A, member 1B	0.012
Prkcb	protein kinase C, beta	0.012
Pold4	polymerase (DNA-directed), delta 4	0.012
Sh3yl1	Sh3 domain YSC-like 1	0.012
Cd7	CD7 antigen	0.012
Npl	N-acetylneuraminate pyruvate lyase	0.012
Itgax	integrin alpha X	0.012
Abca3	ATP-binding cassette, sub-family A (ABC1), member 3	0.012
Nadk	NAD kinase	0.011
Ifi30	interferon gamma inducible protein 30	0.011
Hexa	hexosaminidase A	0.011
Apoe	apolipoprotein E	0.011
St6gal1	beta galactoside alpha 2,6 sialyltransferase 1	0.011
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.011
Lta	lymphotoxin A	0.011
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.011
Hmha1	histocompatibility (minor) HA-1	0.011
Nfe2	nuclear factor, erythroid derived 2	0.011
Kynu	kynureninase (L-kynurenine hydrolase)	0.011
Serpina1c	serine (or cysteine) peptidase inhibitor, clade A, member 1C	0.011
Stap1	signal transducing adaptor family member 1	0.011
Clec2i	C-type lectin domain family 2, member i	0.011
Dusp2	dual specificity phosphatase 2	0.011
Sh3bgrl3	SH3 domain binding glutamic acid-rich protein-like 3	0.011
Dclre1c	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)	0.011
Ankrd46	ankyrin repeat domain 46	0.011
Gfod2	glucose-fructose oxidoreductase domain containing 2	0.011
Cdk6	cyclin-dependent kinase 6	0.011
Mfhas1	malignant fibrous histiocytoma amplified sequence 1	0.011
Fah	fumarylacetoacetate hydrolase	0.011
Btla	B and T lymphocyte associated	0.011
Tfpi2	tissue factor pathway inhibitor 2	0.011
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.011
Psap	prosaposin	0.011
Ero1lb	ERO1-like beta (S. cerevisiae)	0.011
Il15ra	interleukin 15 receptor, alpha chain	0.011
Zfp87	zinc finger protein 87	0.011
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.011
Galm	galactose mutarotase	0.011
Nckap1	NCK-associated protein 1	0.011
2810422O20Rik	RIKEN cDNA 2810422O20 gene	0.011
Gpld1	glycosylphosphatidylinositol specific phospholipase D1	0.011
Cd8b1	CD8 antigen, beta chain 1	0.011
Zcchc9	zinc finger, CCHC domain containing 9	0.011
Cyp2c44	cytochrome P450, family 2, subfamily c, polypeptide 44	0.011
Ehd4	EH-domain containing 4	0.011
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.010
Rdm1	RAD52 motif 1	0.010
Plac8	placenta-specific 8	0.010
Coro1b	coronin, actin binding protein 1B	0.010
Parp10	poly (ADP-ribose) polymerase family, member 10	0.010
Gpr34	G protein-coupled receptor 34	0.010
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.010
4933426M11Rik	RIKEN cDNA 4933426M11 gene	0.010
Hscb	HscB iron-sulfur cluster co-chaperone homolog (E. coli)	0.010
Fes	feline sarcoma oncogene	0.010
Hsph1	heat shock 105kDa/110kDa protein 1	0.010
Slc15a3	solute carrier family 15, member 3	0.010
Baz1a	bromodomain adjacent to zinc finger domain 1A	0.010
Grap2	GRB2-related adaptor protein 2	0.010
Ralgps2	Ral GEF with PH domain and SH3 binding motif 2	0.010
Bcl11a	B-cell CLL/lymphoma 11A (zinc finger protein)	0.010
Atp2a3	ATPase, Ca++ transporting, ubiquitous	0.010
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.010
Tor3a	torsin family 3, member A	0.010
Gimap9	GTPase, IMAP family member 9	0.010
Rhog	ras homolog gene family, member G	0.010
Sigirr	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	0.010
Slc7a7	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	0.010
Cd2	CD2 antigen	0.010
Clp1	CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae)	0.010
Tspan3	tetraspanin 3	0.010
Hax1	HCLS1 associated X-1	0.010
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.010
Fcgr3	Fc receptor, IgG, low affinity III	0.010