IMP: Integrative Multi-species Prediction

Mus musculus

0 genes annotated in mouse

motor neuron disease

DOID:231

A neurodegenerative disease that is located in the motor neurones.

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Known genes in the process in mouseInclude functional analogs

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Gene Predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Show only novel predictionsShow only unknown genesHighlight genes with functional analogs involved in "motor neuron disease" (in gray)

Name	Description	Probability	Func Analog Organism
Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like	0.687
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.453
Hnrnpa2b1	heterogeneous nuclear ribonucleoprotein A2/B1	0.425
Ang2	angiogenin, ribonuclease A family, member 2	0.353	Human
Esr1	estrogen receptor 1 (alpha)	0.313
Hnrnpa1	heterogeneous nuclear ribonucleoprotein A1	0.253	Human
Hnrnpa3	heterogeneous nuclear ribonucleoprotein A3	0.174
Cfl1	cofilin 1, non-muscle	0.144
Nr1i3	nuclear receptor subfamily 1, group I, member 3	0.124
Actb	actin, beta	0.102
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.095
Pnn	pinin	0.087
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.081
Srsf11	serine/arginine-rich splicing factor 11	0.080
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.077
Upf3b	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.075
Gzmg	granzyme G	0.074
Rnase4	ribonuclease, RNase A family 4	0.063
Hnrnpu	heterogeneous nuclear ribonucleoprotein U	0.060
Hnrnpk	heterogeneous nuclear ribonucleoprotein K	0.060
Ddx5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.057
Ap2m1	adaptor protein complex AP-2, mu1	0.057
Eif4a1	eukaryotic translation initiation factor 4A1	0.055
Nars	asparaginyl-tRNA synthetase	0.055
BC051019	cDNA sequence BC051019	0.051
Nap1l1	nucleosome assembly protein 1-like 1	0.051
Rnf2	ring finger protein 2	0.046
Amhr2	anti-Mullerian hormone type 2 receptor	0.045
Taf1d	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, D	0.045
Ghr	growth hormone receptor	0.045
Arpc4	actin related protein 2/3 complex, subunit 4	0.044
Bag3	BCL2-associated athanogene 3	0.043
Srsf10	serine/arginine-rich splicing factor 10	0.041
Rbm39	RNA binding motif protein 39	0.041
Ncl	nucleolin	0.037
Sars	seryl-aminoacyl-tRNA synthetase	0.036
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.036
Tubb5	tubulin, beta 5	0.035
Prlr	prolactin receptor	0.035
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.033
Srsf1	serine/arginine-rich splicing factor 1	0.032
Zranb2	zinc finger, RAN-binding domain containing 2	0.031
Fam76b	family with sequence similarity 76, member B	0.031
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.030
Gaa	glucosidase, alpha, acid	0.030
Dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36	0.030
Hdac6	histone deacetylase 6	0.029
Cryab	crystallin, alpha B	0.029
Baat	bile acid-Coenzyme A: amino acid N-acyltransferase	0.027
Dync1h1	dynein cytoplasmic 1 heavy chain 1	0.027
Cul3	cullin 3	0.027
Srsf7	serine/arginine-rich splicing factor 7	0.026
Rpgrip1l	Rpgrip1-like	0.026
Srsf6	serine/arginine-rich splicing factor 6	0.026
Ang	angiogenin, ribonuclease, RNase A family, 5	0.025	Human
Srsf5	serine/arginine-rich splicing factor 5	0.025
Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.025
Ywhaq	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.024
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.024
Myef2	myelin basic protein expression factor 2, repressor	0.024
Dhx15	DEAH (Asp-Glu-Ala-His) box polypeptide 15	0.024
Ube4b	ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)	0.023
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.023
Klk1b5	kallikrein 1-related peptidase b5	0.022
Hnrnpd	heterogeneous nuclear ribonucleoprotein D	0.022
Eed	embryonic ectoderm development	0.022
Dhh	desert hedgehog	0.021
Ivns1abp	influenza virus NS1A binding protein	0.021
Ewsr1	Ewing sarcoma breakpoint region 1	0.021
Akt1	thymoma viral proto-oncogene 1	0.021
Kiss1	KiSS-1 metastasis-suppressor	0.020
Psip1	PC4 and SFRS1 interacting protein 1	0.020
Klk1b1	kallikrein 1-related peptidase b1	0.020
Rbm25	RNA binding motif protein 25	0.019
Amfr	autocrine motility factor receptor	0.019
Otc	ornithine transcarbamylase	0.019
Gnrh1	gonadotropin releasing hormone 1	0.018
Msln	mesothelin	0.018
Ahr	aryl-hydrocarbon receptor	0.018
Snta1	syntrophin, acidic 1	0.018
Bglap	bone gamma carboxyglutamate protein	0.018
Cd99	CD99 antigen	0.017
Arf5	ADP-ribosylation factor 5	0.017
Bag6	BCL2-associated athanogene 6	0.017
Fstl3	follistatin-like 3	0.017
Fxyd1	FXYD domain-containing ion transport regulator 1	0.017
Rnf138	ring finger protein 138	0.017
Pigr	polymeric immunoglobulin receptor	0.017
Ufd1l	ubiquitin fusion degradation 1 like	0.016
Coro1b	coronin, actin binding protein 1B	0.016
Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a	0.016
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.016
Insl3	insulin-like 3	0.016
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.016
Eif5a	eukaryotic translation initiation factor 5A	0.016
Tcerg1	transcription elongation regulator 1 (CA150)	0.016
Lamc1	laminin, gamma 1	0.016
Ptbp2	polypyrimidine tract binding protein 2	0.016
Tyrobp	TYRO protein tyrosine kinase binding protein	0.016
Plekha5	pleckstrin homology domain containing, family A member 5	0.015
Ubc	ubiquitin C	0.015
Luc7l3	LUC7-like 3 (S. cerevisiae)	0.015
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.015
P4ha2	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide	0.015
Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.015
Gjb1	gap junction protein, beta 1	0.015
Nhlh2	nescient helix loop helix 2	0.015
2410002F23Rik	RIKEN cDNA 2410002F23 gene	0.015
Itfg1	integrin alpha FG-GAP repeat containing 1	0.015
Npm1	nucleophosmin 1	0.015
Cbr2	carbonyl reductase 2	0.015
Aes	amino-terminal enhancer of split	0.015
Akap8	A kinase (PRKA) anchor protein 8	0.015
Mtf2	metal response element binding transcription factor 2	0.015
Sqstm1	sequestosome 1	0.014
Capn1	calpain 1	0.014
Mapre3	microtubule-associated protein, RP/EB family, member 3	0.014
Chmp1a	chromatin modifying protein 1A	0.014
Prpf4b	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.014
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.014
Ccni	cyclin I	0.014
Smc5	structural maintenance of chromosomes 5	0.014
Prl7a1	prolactin family 7, subfamily a, member 1	0.014
Hdac5	histone deacetylase 5	0.014
Sec31a	Sec31 homolog A (S. cerevisiae)	0.014
Car5a	carbonic anhydrase 5a, mitochondrial	0.014
Mlf2	myeloid leukemia factor 2	0.014
Zfp942	zinc finger protein 942	0.014
Tpm3	tropomyosin 3, gamma	0.014
Hoxb13	homeobox B13	0.014
Actn2	actinin alpha 2	0.013
Cirbp	cold inducible RNA binding protein	0.013
Defb9	defensin beta 9	0.013
Dhx9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.013
Tnnt2	troponin T2, cardiac	0.013
Asns	asparagine synthetase	0.013
Sf3b1	splicing factor 3b, subunit 1	0.013
Lmna	lamin A	0.013
Eprs	glutamyl-prolyl-tRNA synthetase	0.013
Tenc1	tensin like C1 domain-containing phosphatase	0.013
Rbbp4	retinoblastoma binding protein 4	0.013
1700052M18Rik	RIKEN cDNA 1700052M18 gene	0.013
Ipo7	importin 7	0.013
Emp2	epithelial membrane protein 2	0.013
Gcfc1	GC-rich sequence DNA-binding factor 1	0.013
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.012
Lgals6	lectin, galactose binding, soluble 6	0.012
Dstn	destrin	0.012
Tdp2	tyrosyl-DNA phosphodiesterase 2	0.012
Pcm1	pericentriolar material 1	0.012
Zbtb33	zinc finger and BTB domain containing 33	0.012
Bcl2l2	BCL2-like 2	0.012
Dlg4	discs, large homolog 4 (Drosophila)	0.012
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.012
Mas1	MAS1 oncogene	0.012
Wdr1	WD repeat domain 1	0.012
Zfp326	zinc finger protein 326	0.012
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.012
Smc4	structural maintenance of chromosomes 4	0.012
Khdc1b	KH domain containing 1B	0.012
Rag2	recombination activating gene 2	0.012
Nfe2l1	nuclear factor, erythroid derived 2,-like 1	0.011
Hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	0.011
Ang3	angiogenin, ribonuclease A family, member 3	0.011	Human
Csnk1g2	casein kinase 1, gamma 2	0.011
Hnrnpm	heterogeneous nuclear ribonucleoprotein M	0.011
Obp1a	odorant binding protein Ia	0.011
Hmgb1	high mobility group box 1	0.011
Hmgb3	high mobility group box 3	0.011
Fus	fusion, derived from t(12;16) malignant liposarcoma (human)	0.011	Human
Epas1	endothelial PAS domain protein 1	0.011
Gzmd	granzyme D	0.011
Ctdspl2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	0.011
Tdo2	tryptophan 2,3-dioxygenase	0.011
Agrp	agouti related protein	0.011
Tra2b	transformer 2 beta homolog (Drosophila)	0.011
Cct5	chaperonin containing Tcp1, subunit 5 (epsilon)	0.011
Slc39a7	solute carrier family 39 (zinc transporter), member 7	0.011
Hspa1b	heat shock protein 1B	0.011
Pnpla2	patatin-like phospholipase domain containing 2	0.011
Fabp1	fatty acid binding protein 1, liver	0.011
Pkm2	pyruvate kinase, muscle	0.011
Nfic	nuclear factor I/C	0.011
Ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.011
Spna2	spectrin alpha 2	0.011
Fxr2	fragile X mental retardation, autosomal homolog 2	0.010
Apoc1	apolipoprotein C-I	0.010
Hnrnph2	heterogeneous nuclear ribonucleoprotein H2	0.010
Itga7	integrin alpha 7	0.010
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.010
Ctps	cytidine 5'-triphosphate synthase	0.010
Msh6	mutS homolog 6 (E. coli)	0.010
Vpreb1	pre-B lymphocyte gene 1	0.010
Igfbp6	insulin-like growth factor binding protein 6	0.010
Hspa1l	heat shock protein 1-like	0.010
Sp3	trans-acting transcription factor 3	0.010
Hspb1	heat shock protein 1	0.010	Human
Cc2d1a	coiled-coil and C2 domain containing 1A	0.010
Upp2	uridine phosphorylase 2	0.010
Map1lc3a	microtubule-associated protein 1 light chain 3 alpha	0.010
Plec	plectin	0.010