IMP
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Mus musculus
0 genes annotated in mouse
osteogenesis imperfecta
DOID:12347
An osteochondrodysplasia that has material basis in a deficiency in type-I collagen which results in brittle bones and defective connective tissue.
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In addition to gene-name show these genes:
Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Bgn | biglycan | 0.583 | ||
| Sparc | secreted acidic cysteine rich glycoprotein | 0.521 | ||
| Col5a1 | collagen, type V, alpha 1 | 0.470 | ||
| Fstl1 | follistatin-like 1 | 0.342 | ||
| Col3a1 | collagen, type III, alpha 1 | 0.212 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.176 | Human | |
| Col1a2 | collagen, type I, alpha 2 | 0.157 | Human | |
| Col5a2 | collagen, type V, alpha 2 | 0.153 | ||
| Col6a2 | collagen, type VI, alpha 2 | 0.147 | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.122 | ||
| Serpinh1 | serine (or cysteine) peptidase inhibitor, clade H, member 1 | 0.115 | Human | |
| Fbn1 | fibrillin 1 | 0.106 | ||
| Txndc5 | thioredoxin domain containing 5 | 0.086 | ||
| Trp53 | transformation related protein 53 | 0.080 | ||
| Cd248 | CD248 antigen, endosialin | 0.073 | ||
| Hspg2 | perlecan (heparan sulfate proteoglycan 2) | 0.070 | ||
| Dap | death-associated protein | 0.068 | ||
| Emilin1 | elastin microfibril interfacer 1 | 0.067 | ||
| Col6a1 | collagen, type VI, alpha 1 | 0.060 | ||
| Surf4 | surfeit gene 4 | 0.055 | ||
| Mmp2 | matrix metallopeptidase 2 | 0.052 | ||
| Col6a3 | collagen, type VI, alpha 3 | 0.051 | ||
| Fkbp10 | FK506 binding protein 10 | 0.045 | ||
| Col4a2 | collagen, type IV, alpha 2 | 0.038 | ||
| Nucb1 | nucleobindin 1 | 0.038 | ||
| Col4a1 | collagen, type IV, alpha 1 | 0.035 | ||
| Ilk | integrin linked kinase | 0.034 | ||
| Kdelr3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.034 | ||
| Rcn3 | reticulocalbin 3, EF-hand calcium binding domain | 0.034 | ||
| Sec31a | Sec31 homolog A (S. cerevisiae) | 0.033 | ||
| Lmna | lamin A | 0.033 | ||
| Plod3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 0.032 | ||
| Prkcsh | protein kinase C substrate 80K-H | 0.029 | ||
| Sox9 | SRY-box containing gene 9 | 0.029 | ||
| Leprel2 | leprecan-like 2 | 0.027 | ||
| Slc12a4 | solute carrier family 12, member 4 | 0.027 | ||
| Col18a1 | collagen, type XVIII, alpha 1 | 0.027 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.026 | ||
| Kdelr1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.026 | ||
| Igf1 | insulin-like growth factor 1 | 0.026 | ||
| Il10 | interleukin 10 | 0.025 | ||
| Krtcap2 | keratinocyte associated protein 2 | 0.024 | ||
| Sepn1 | selenoprotein N, 1 | 0.024 | ||
| Bmp1 | bone morphogenetic protein 1 | 0.021 | Human | |
| Loxl1 | lysyl oxidase-like 1 | 0.021 | ||
| Copz2 | coatomer protein complex, subunit zeta 2 | 0.020 | ||
| Vkorc1 | vitamin K epoxide reductase complex, subunit 1 | 0.019 | ||
| Ckap4 | cytoskeleton-associated protein 4 | 0.019 | ||
| Smo | smoothened homolog (Drosophila) | 0.019 | ||
| Pax3 | paired box gene 3 | 0.019 | ||
| Ephb4 | Eph receptor B4 | 0.018 | ||
| Ltbr | lymphotoxin B receptor | 0.018 | ||
| Fn1 | fibronectin 1 | 0.017 | ||
| Wnt3a | wingless-related MMTV integration site 3A | 0.016 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.015 | ||
| Igfbp4 | insulin-like growth factor binding protein 4 | 0.015 | ||
| Col2a1 | collagen, type II, alpha 1 | 0.014 | ||
| Yif1a | Yip1 interacting factor homolog A (S. cerevisiae) | 0.014 | ||
| Galk1 | galactokinase 1 | 0.014 | ||
| Adam12 | a disintegrin and metallopeptidase domain 12 (meltrin alpha) | 0.014 | ||
| Slc39a7 | solute carrier family 39 (zinc transporter), member 7 | 0.013 | ||
| Crtap | cartilage associated protein | 0.013 | Human | |
| Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | 0.013 | ||
| Tmed3 | transmembrane emp24 domain containing 3 | 0.013 | ||
| Glt25d1 | glycosyltransferase 25 domain containing 1 | 0.012 | ||
| Slc4a2 | solute carrier family 4 (anion exchanger), member 2 | 0.012 | ||
| Pcolce | procollagen C-endopeptidase enhancer protein | 0.012 | ||
| Col15a1 | collagen, type XV, alpha 1 | 0.012 | ||
| Creb3l1 | cAMP responsive element binding protein 3-like 1 | 0.012 | ||
| Gpx7 | glutathione peroxidase 7 | 0.011 | ||
| Hic1 | hypermethylated in cancer 1 | 0.011 | ||
| Sec61a1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.011 | ||
| Kdelr2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.011 | ||
| Pparg | peroxisome proliferator activated receptor gamma | 0.011 | ||
| Flnc | filamin C, gamma | 0.011 | ||
| Cyb5r3 | cytochrome b5 reductase 3 | 0.010 | ||
| Adamts2 | a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 | 0.010 | ||
| Kcnj6 | potassium inwardly-rectifying channel, subfamily J, member 6 | 0.010 | ||
| Pdia5 | protein disulfide isomerase associated 5 | 0.010 |