IMP
Process View
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Psen1 | presenilin 1 | 0.991 | Mouse | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.982 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.917 | ||
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.849 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.841 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.837 | ||
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.723 | ||
| Cd44 | CD44 antigen | 0.712 | ||
| Sfrp2 | secreted frizzled-related protein 2 | 0.677 | ||
| Sfrp1 | secreted frizzled-related protein 1 | 0.663 | Mouse | |
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.663 | ||
| Egfr | epidermal growth factor receptor | 0.648 | ||
| Apc | adenomatosis polyposis coli | 0.603 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.542 | ||
| Trp53 | transformation related protein 53 | 0.539 | ||
| Thbs1 | thrombospondin 1 | 0.521 | ||
| Plg | plasminogen | 0.486 | Mouse | |
| Nos2 | nitric oxide synthase 2, inducible | 0.419 | ||
| Psen2 | presenilin 2 | 0.359 | ||
| Rb1 | retinoblastoma 1 | 0.322 | ||
| Ncstn | nicastrin | 0.294 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.287 | ||
| Tnfrsf22 | tumor necrosis factor receptor superfamily, member 22 | 0.265 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.260 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.242 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.239 | ||
| Pten | phosphatase and tensin homolog | 0.212 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.175 | ||
| Lyz2 | lysozyme 2 | 0.159 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.151 | ||
| Plau | plasminogen activator, urokinase | 0.147 | Mouse | |
| Nos1 | nitric oxide synthase 1, neuronal | 0.138 | ||
| Fgg | fibrinogen gamma chain | 0.138 | ||
| Cav1 | caveolin 1, caveolae protein | 0.127 | ||
| Braf | Braf transforming gene | 0.123 | Mouse | |
| Runx1 | runt related transcription factor 1 | 0.116 | ||
| Tnfrsf23 | tumor necrosis factor receptor superfamily, member 23 | 0.109 | ||
| Csf1 | colony stimulating factor 1 (macrophage) | 0.096 | ||
| Itch | itchy, E3 ubiquitin protein ligase | 0.092 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.091 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.090 | ||
| Plaur | plasminogen activator, urokinase receptor | 0.080 | ||
| Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.079 | ||
| App | amyloid beta (A4) precursor protein | 0.074 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.074 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.074 | ||
| Ptma | prothymosin alpha | 0.069 | ||
| Il6 | interleukin 6 | 0.069 | ||
| Trp73 | transformation related protein 73 | 0.068 | ||
| Tlr4 | toll-like receptor 4 | 0.063 | ||
| Il4ra | interleukin 4 receptor, alpha | 0.060 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.060 | ||
| Vhl | von Hippel-Lindau tumor suppressor | 0.059 | ||
| Ambp | alpha 1 microglobulin/bikunin | 0.057 | ||
| Anp32e | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.056 | ||
| Pvr | poliovirus receptor | 0.055 | ||
| Kit | kit oncogene | 0.053 | ||
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.052 | ||
| Maff | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) | 0.051 | ||
| Lox | lysyl oxidase | 0.045 | ||
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.042 | ||
| Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 0.041 | ||
| Itga5 | integrin alpha 5 (fibronectin receptor alpha) | 0.041 | ||
| F2 | coagulation factor II | 0.040 | ||
| Il6st | interleukin 6 signal transducer | 0.035 | ||
| Slc12a4 | solute carrier family 12, member 4 | 0.035 | ||
| St3gal1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.035 | ||
| Mcm4 | minichromosome maintenance deficient 4 homolog (S. cerevisiae) | 0.034 | ||
| Cfi | complement component factor i | 0.034 | ||
| Brca2 | breast cancer 2 | 0.034 | ||
| Ikbkb | inhibitor of kappaB kinase beta | 0.034 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.033 | ||
| Lif | leukemia inhibitory factor | 0.030 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.029 | ||
| Cxcl1 | chemokine (C-X-C motif) ligand 1 | 0.029 | ||
| Traf6 | TNF receptor-associated factor 6 | 0.029 | ||
| Erlin2 | ER lipid raft associated 2 | 0.029 | ||
| Nf1 | neurofibromatosis 1 | 0.028 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.028 | ||
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.028 | ||
| Serpinc1 | serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 | 0.028 | ||
| Snai1 | snail homolog 1 (Drosophila) | 0.028 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.026 | ||
| Litaf | LPS-induced TN factor | 0.026 | ||
| Itgb3 | integrin beta 3 | 0.026 | ||
| Timp1 | tissue inhibitor of metalloproteinase 1 | 0.026 | ||
| Osmr | oncostatin M receptor | 0.026 | ||
| Msh2 | mutS homolog 2 (E. coli) | 0.025 | ||
| Apoa1 | apolipoprotein A-I | 0.025 | ||
| Tgm2 | transglutaminase 2, C polypeptide | 0.025 | ||
| Cyr61 | cysteine rich protein 61 | 0.024 | ||
| Il10 | interleukin 10 | 0.024 | ||
| Zfp36 | zinc finger protein 36 | 0.024 | ||
| Adm | adrenomedullin | 0.023 | ||
| Qsox1 | quiescin Q6 sulfhydryl oxidase 1 | 0.022 | ||
| Nbn | nibrin | 0.021 | ||
| Tlr2 | toll-like receptor 2 | 0.021 | ||
| Rbpj | recombination signal binding protein for immunoglobulin kappa J region | 0.020 | ||
| Serpina10 | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | 0.020 | ||
| Lepr | leptin receptor | 0.020 | ||
| Adam17 | a disintegrin and metallopeptidase domain 17 | 0.020 | ||
| Vegfa | vascular endothelial growth factor A | 0.019 | ||
| Rras | Harvey rat sarcoma oncogene, subgroup R | 0.019 | ||
| Arhgef2 | rho/rac guanine nucleotide exchange factor (GEF) 2 | 0.019 | ||
| Stk11 | serine/threonine kinase 11 | 0.019 | ||
| Tnip1 | TNFAIP3 interacting protein 1 | 0.019 | ||
| Cldn2 | claudin 2 | 0.019 | ||
| Atr | ataxia telangiectasia and Rad3 related | 0.019 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.019 | ||
| Fbln2 | fibulin 2 | 0.019 | ||
| Ccl7 | chemokine (C-C motif) ligand 7 | 0.019 | ||
| Cyld | cylindromatosis (turban tumor syndrome) | 0.018 | ||
| Ch25h | cholesterol 25-hydroxylase | 0.018 | ||
| Rhoc | ras homolog gene family, member C | 0.018 | ||
| Hnrnpa1 | heterogeneous nuclear ribonucleoprotein A1 | 0.018 | ||
| Fst | follistatin | 0.017 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.017 | ||
| Anxa5 | annexin A5 | 0.017 | ||
| Ptch1 | patched homolog 1 | 0.017 | ||
| Mapk3 | mitogen-activated protein kinase 3 | 0.017 | ||
| Asgr2 | asialoglycoprotein receptor 2 | 0.016 | ||
| Ahsg | alpha-2-HS-glycoprotein | 0.016 | ||
| Atf3 | activating transcription factor 3 | 0.016 | ||
| Ldlr | low density lipoprotein receptor | 0.016 | ||
| Ccnd1 | cyclin D1 | 0.016 | ||
| Socs3 | suppressor of cytokine signaling 3 | 0.016 | ||
| Lyst | lysosomal trafficking regulator | 0.016 | ||
| Spp1 | secreted phosphoprotein 1 | 0.015 | ||
| Meox2 | mesenchyme homeobox 2 | 0.015 | ||
| Pdpn | podoplanin | 0.015 | ||
| Hbegf | heparin-binding EGF-like growth factor | 0.015 | ||
| Kng1 | kininogen 1 | 0.015 | ||
| Mvp | major vault protein | 0.015 | ||
| Adam8 | a disintegrin and metallopeptidase domain 8 | 0.014 | ||
| Kitl | kit ligand | 0.014 | ||
| Mecp2 | methyl CpG binding protein 2 | 0.014 | ||
| Fosl1 | fos-like antigen 1 | 0.014 | ||
| Arid5a | AT rich interactive domain 5A (MRF1-like) | 0.014 | ||
| Psenen | presenilin enhancer 2 homolog (C. elegans) | 0.014 | ||
| Vasp | vasodilator-stimulated phosphoprotein | 0.014 | ||
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.014 | ||
| Apof | apolipoprotein F | 0.013 | ||
| Traf2 | TNF receptor-associated factor 2 | 0.013 | ||
| Errfi1 | ERBB receptor feedback inhibitor 1 | 0.013 | ||
| Dll1 | delta-like 1 (Drosophila) | 0.013 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.013 | ||
| Inhba | inhibin beta-A | 0.013 | ||
| Vav2 | vav 2 oncogene | 0.013 | ||
| Gc | group specific component | 0.013 | ||
| Gcnt2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme | 0.012 | ||
| Slc40a1 | solute carrier family 40 (iron-regulated transporter), member 1 | 0.012 | ||
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.012 | ||
| Ces1c | carboxylesterase 1C | 0.012 | ||
| Cnbp | cellular nucleic acid binding protein | 0.012 | ||
| Ier3 | immediate early response 3 | 0.012 | ||
| Gfpt2 | glutamine fructose-6-phosphate transaminase 2 | 0.012 | ||
| Ctnnd1 | catenin (cadherin associated protein), delta 1 | 0.012 | ||
| Gem | GTP binding protein (gene overexpressed in skeletal muscle) | 0.012 | ||
| Traf3ip2 | TRAF3 interacting protein 2 | 0.011 | ||
| Casp3 | caspase 3 | 0.011 | ||
| Emp1 | epithelial membrane protein 1 | 0.011 | ||
| Mid1 | midline 1 | 0.011 | ||
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.011 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.011 | ||
| Vdr | vitamin D receptor | 0.011 | ||
| Procr | protein C receptor, endothelial | 0.011 | ||
| Il1r1 | interleukin 1 receptor, type I | 0.011 | ||
| Irf1 | interferon regulatory factor 1 | 0.011 | ||
| Bcl3 | B-cell leukemia/lymphoma 3 | 0.010 | ||
| C77027 | expressed sequence C77027 | 0.010 | ||
| H2afz | H2A histone family, member Z | 0.010 | ||
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.010 |